ライフサイエンスコーパス: exportin

1 e karyopherins (referred to as importins and exportins).

2 nsport factors (karyopherins, importins, and exportins).

3 he drug leptomycin B, which inactivates Crm1/exportin.

4 n NES, which directly binds the NES receptor Exportin.

5 A), but export is not dependent on the Crm1p exportin.

6 ive to the drug leptomycin B, is mediated by Exportin.

7 spartate carbamoyltransferase, and a nuclear exportin.

8 nBP16 (approved gene symbol Xpo7), a nuclear exportin.

9 conversely is required for cargo binding to exportins.

10 opherins (Kaps), transportins, importins, or exportins.

11 pherin betas, including importins as well as exportins.

12 pherin-beta superfamily termed importins and exportins.

13 ns-alpha1, -alpha2, and -beta2 and different exportins.

14 the nuclear transporters, importins-beta and exportins.

15 e-rich export signal that interacts with the exportin 1 (CRM1) receptor.

16 or of the recently identified export factor, exportin 1 (CRM1).

17 ective inhibitor of nuclear export targeting Exportin 1 (selinexor, Xpovio), an ATP-competitive CSF-1

18 e that the conserved nuclear export receptor Exportin 1 (XPO-1/XPO1) modulates proteostasis and life

19 geted inhibition of nuclear exporter protein exportin 1 (XPO1) also known as chromosome maintenance r

20 bitor of nuclear export compound that blocks exportin 1 (XPO1) and forces nuclear accumulation and ac

21 hat inhibition of the nuclear export protein exportin 1 (XPO1) causes nuclear accumulation of p53 and

22 tor of nuclear export compound, which blocks exportin 1 (XPO1) function, leads to nuclear accumulatio

23 ected cells has been shown to be mediated by exportin 1 (XPO1) interaction with viral nuclear export

24 Exportin 1 (XPO1) is responsible for the nuclear export

25 nformational p53-WT and the nuclear exporter exportin 1 (XPO1) reduce the transcriptional activities

26 Exportin 1 (XPO1), a key nuclear export protein, has not

27 Exportin 1 (XPO1), also known as chromosome region maint

28 tein, mediated by the nuclear export protein exportin 1 (XPO1), is crucial for RSV assembly and buddi

29 whereas RGS14 nuclear export is regulated by Exportin 1 (XPO1).

30 We propose CRM1 be renamed exportin 1 (XPO1).

31 whereas RGS14 nuclear export is regulated by Exportin 1 (XPO1).

32 raction of TIM and nuclear export component, Exportin 1 (XPO1).

33 Overexpression of exportin 1 (XPO1/CRM1) in cancer cells mislocalizes nume

34 ), a novel, oral small-molecule inhibitor of exportin 1 (XPO1/CRM1), and determined the recommended p

35 demonstrate that diverse RNA viruses trigger exportin 1 (XPO1/CRM1)-dependent Drosha translocation in

36 Targeting nuclear export receptor (exportin 1 [XPO1]) is a novel approach to restore tumor

37 ls (NESs) are recognized by the NES receptor exportin 1 and are central to the export of multiple shu

38 ed inhibition of senescence required Ran and exportin 1 and involved the activation of importin beta-

39 Thus CaMKI vies with CRM1/exportin 1 for access to a NES, and assembly of a CaMKI-

40 We observed up-regulated exportin 1 in lung and prostate pretransformation adenoc

41 Here, we explored the role of exportin 1 in NE transformation.

42 Together, these data nominate exportin 1 inhibition as a potential therapeutic target

43 Exportin 1 inhibition prevented NE transformation in dif

44 accompanied by increased sensitivity to the exportin 1 inhibitor selinexor in vitro.

45 , functions independently of an NES receptor-exportin 1 interaction.

46 ound that inhibitors of the nuclear exporter Exportin 1 modulate the fate of intestinal stem cells, i

47 It can exit the nucleus either as cargo of exportin 1 or bound to mRNA.

48 -capped pre-miRNAs are exported via the PHAX-exportin 1 pathway.

49 CRM1/exportin 1 was required for CCTalpha nuclear export, and

50 Exportin 1 was up-regulated after genetic inactivation o

51 CRM1 (also known as XPO1 and exportin 1) mediates nuclear export of hundreds of prote

52 The CRM1 (Exportin 1) protein is a receptor for leucine-rich nucle

53 e region maintenance 1 (CRM1) (also known as exportin 1) shuttling receptor.

54 the soluble cellular export receptor CRM 1 (exportin 1), which mediates nucleocytoplasmic translocat

55 r proteins, the nucleoporin NUP88 and hCRM1 (exportin 1), which was recently shown to function as a n

56 id region containing several consensus CRM1 (exportin 1)-dependent nuclear export signals (NESs).

57 sence of leptomycin B, an inhibitor of CRM1 (exportin 1)-dependent nuclear export, suggesting that it

58 utic approaches for T-PLL by targeting IAPs, exportin 1, and autophagy, highlighting potential candid

59 CRM1 (Exportin 1, XPO1), the best-characterized nuclear export

60 TAF7 nuclear export signal and occurs by an exportin 1-dependent pathway.

61 ding receptor has been identified as CRM1 or exportin 1.

62 ependency of SCLC on the nuclear transporter exportin 1.

63 rt in maintaining localization, we inhibited Exportin 1.

64 leptomycin B and is reduced by knockdown of exportin 1.

65 ear export signal (NES) that also binds CRM1/exportin 1.

66 nuclear export by enhancing interaction with exportin 1.

67 mportinbeta1/karyopherinbeta1 (Kapbeta1) and exportin 1/chromosomal maintenance 1 (CRM1), are require

68 by the NES receptor CRM1/Crm1p (also called exportin 1/Xpo1p).

69 gh specificity to the nuclear export factor, exportin-1 (CRM1).

70 in their TME, are sensitive to the selective exportin-1 (XPO1) antagonist selinexor.

71 Inhibiting Exportin-1 (XPO1) in vivo induces marked tumor regressio

72 Exportin-1 (XPO1) is a mediator of nuclear-to-cytoplasmi

73 Exportin-1 (XPO1) is a nuclear export receptor that is e

74 into the cytoplasm by the nuclear exporter, exportin-1 (XPO1) is essential for RSV assembly.

75 Exportin-1 (XPO1) is the key mediator of nuclear export

76 ge of nuclear export of p27 by inhibition of Exportin-1 (XPO1) promoted growth arrest, demonstrating

77 Selinexor inhibits exportin-1 (XPO1) resulting in nuclear accumulation of t

78 Exportin-1 (XPO1), also known as chromosome maintenance

79 Exportin-1 (XPO1), also known as chromosome region maint

80 Exportin-1 (XPO1), the main soluble nuclear export recep

81 ate the preclinical potential of KPT-330, an exportin-1 (XPO1, also known as chromosome maintenance p

82 diverse electrophilic small molecules target exportin-1 (XPO1/CRM1) at cysteine 528, including the se

83 Exportin-1 (XPO1/CRM1) plays a central role in the nucle

84 Together these data identify exportin-1 as a promising therapeutic target in SCLC, wi

85 CRISPR-Cas9 screening nominates exportin-1 as a therapeutic target in SCLC, and exportin

86 the human counterpart and are sufficient for exportin-1 association with RanBP2.

87 interaction with RanBP2-exportin-1 complex, exportin-1 binding to the zinc finger cluster domain of

88 In contrast to Ran interaction with RanBP2-exportin-1 complex, exportin-1 binding to the zinc finge

89 ain of RanBP2 constitutes a docking site for exportin-1 during nuclear export.

90 XPO1 knockout enhanced chemosensitivity, and exportin-1 inhibition demonstrated synergy with both fir

91 ortin-1 as a therapeutic target in SCLC, and exportin-1 inhibition enhances chemotherapy efficacy in

92 Promoting FOXO1 nuclear entry by the Exportin-1 inhibitor KPT-330 enhances cold tolerance in

93 The small molecule exportin-1 inhibitor selinexor in combination with cispl

94 Inhibiting exportin-1 or overexpressing Polkappa increased the abun

95 s known to bind Exportin-1, and knockdown of Exportin-1 or trimethylguanosine synthase 1, responsible

96 via interaction with 14-3-3 proteins, CRM-1 (exportin-1 or XPO-1), or importins.

97 RR interacts with the nuclear export protein Exportin-1 through a nuclear export signal.

98 association of C/EBPbeta-PSer239 with CRM1 (exportin-1) in TNF-alpha-treated hepatocytes was inhibit

99 tive for their export through the XPO1 (CRM1/Exportin-1) receptor pathway, but retain nucleocytoplasm

100 We report that mutations of CRM1 (Exportin-1), MEX67/MTR2 (TAP/p15), and five nucleoporins

101 ation of transporter proteins Importin-7 and Exportin-1, and a SUMO-interacting motif on FOXO1.

102 cally with the nuclear export receptor, CRM1/exportin-1, and components of the 19 S regulatory partic

103 lguanosine (TMG)-cap, which is known to bind Exportin-1, and knockdown of Exportin-1 or trimethylguan

104 Selinexor covalently binds exportin-1, causing nuclear sequestration of cargo prote

105 This screen nominated exportin-1, encoded by XPO1, as a therapeutic target.

106 ains two novel nuclear import signals and an exportin-1-dependent nuclear export signal (NES).

107 Surprisingly, in quiescent cells Exportin-1-dependent pri-miR-34a is present in the cytop

108 rylation of Ser-271 serves to interfere with exportin-1-mediated nuclear export.

109 pendent of Exportin-5 and depends instead on Exportin-1.

110 ontinually transported out of the nucleus by exportin-1.

111 XPO1 (Exportin-1/CRM1) is a nuclear export protein that is fre

112 ctor, is inactivated when it associates with exportin-1/Crm1.

113 fied cellular apoptosis susceptibility (CAS, exportin-2) and its transport substrate importin-alpha1

114 We further have identified exportin 4 as the specific transporter mediating PKM2 nu

115 r compared with the mammalian eIF5A-exporter Exportin 4.

116 can identified a 13q12.11 duplication in the exportin-4 (XPO4) gene to be associated with non-alcohol

117 o impaired nuclear import (V60L; mediated by Exportin-4) or export (I90M; mediated by chromosome regi

118 ammalian cells, the nuclear export receptor, Exportin 5 (Exp5), exports pre-microRNAs (pre-miRNAs) as

119 nuclear export of pre-microRNA precursors by Exportin 5 (Exp5).

120 sulting precursor miRNA hairpins exported by exportin 5 and processed by cytoplasmic Dicer to yield t

121 a-like nucleocytoplasmic transport receptors exportin 5 in mammals and MSN5 in yeast.

122 We demonstrate that NUP93 and exportin 5 interact with the signaling protein SMAD4 and

123 premicro-RNA precursors, competition for the Exportin 5 nuclear export factor, and inhibition of Dice

124 interaction partner NUP205 or XPO5 (encoding exportin 5) as hitherto unrecognized monogenic causes of

125 r psd and hasty, the Arabidopsis ortholog of exportin 5, are viable but have a more severe phenotype

126 xported from the nucleus to the cytoplasm by Exportin 5, where they are processed a second time to ge

127 EBER1 does not bind exportin 5; therefore, it is unlikely to act by interfer

128 We show that Exportin-5 (Exp5) mediates efficient nuclear export of s

129 f endogenous cellular RNAi factors including exportin-5 (Xpo-5).

130 from the nucleus through phosphorylation of exportin-5 (XPO5) at T345/S416/S497.

131 Recombinant exportin-5 also stimulates nuclear export of JAZ in perm

132 quiescence-induced miRNAs is independent of Exportin-5 and depends instead on Exportin-1.

133 Exportin-5 and Dicer are then required to generate matur

134 , these data suggest that JAZ is exported by exportin-5 but translocates back into nuclei by a facili

135 Exportin-5 can bind pre-miRNAs specifically in vitro, bu

136 hat determine which RNA binding proteins are exportin-5 cargoes remain unclear.

137 Vs involving the dissociation of a pre-miRNA/Exportin-5 complex from Ran-GTP following nuclear export

138 press small interfering RNAs, also depend on Exportin-5 for nuclear export.

139 We found that JAZ binds to exportin-5 in a Ran-GTP- and dsRNA-dependent manner.

140 Exportin-5 is a nuclear export receptor for certain clas

141 We propose that exportin-5 is not an RNA export factor but instead parti

142 l miRNA biogenesis components, DGCR8, Dicer, Exportin-5 or Argonaute 2.

143 h as miR-122 and let-7a, suggesting that the exportin-5 pathway was not affected.

144 mulates JAZ shuttling, and gene silencing of exportin-5 reduces shuttling.

145 Exportin-5 stimulates JAZ shuttling, and gene silencing

146 family members, Los1 (exportin-t) and Msn5 (exportin-5), serve overlapping but distinct roles in tRN

147 cence despite markedly reduced expression of Exportin-5, a protein required for canonical miRNA bioge

148 nical miRNA pathway during hairpin export by Exportin-5, and both types of hairpins are subsequently

149 g the Drosha-DGCR8 complex (Microprocessor), exportin-5, Dicer and Argonaute.

150 Exportin-5, JAZ, and ILF3 can form a heteromeric complex

151 and dsRNA, and JAZ increases ILF3 binding to exportin-5.

152 with the nucleocytoplasmic shuttling protein exportin-5.

153 export, and miRNA function, are dependent on Exportin-5.

154 dsRNA binding proteins, we named the protein exportin-5.

155 6 snRNA requires the nuclear export receptor Exportin-5.

156 eadily saturated, is the nuclear karyopherin exportin-5.

157 tRNA exporters (Los1 [exportin-t] and Msn5 [exportin-5]) are unessential.

158 that nuclear export of actin is mediated by exportin 6, and not by Crm1.

159 the fact that two export receptors, Crm1 and exportin 6, have been linked to nuclear export of actin,

160 r actin levels through supporting binding of exportin-6 (XPO6) to RAN GTPase.

161 d as targets of miR-106b, Bim of miR-32, and exportin-6 and protein tyrosine kinase 9 of miR-1.

162 dedicated transport receptors importin-9 and exportin-6, but how this transport is regulated remains

163 Here, we describe exportin 7 (XPO7) as a novel regulator of senescence and

164 Expression of the nuclear export protein, Exportin 7 (Xpo7), is highly erythroid-specific, induced

165 leptomycin B (LMB), an inhibitor of the CRM1/exportin-alpha pathway.

166 Unlike Xpo1p/Crm1p/exportin, an NES receptor, Yrb2p does not shuttle betwee

167 contributions of an exceedingly promiscuous exportin and it provides a new basis for NES prediction.

168 p relocalization requires both the CRM1/XPO1 exportin and the FPS1 glycerol transporter genes but is

169 ires specialized transport receptors, called exportins and importins, that interact with cargo protei

170 Thus, importin and exportin, another member of this family involved in expo

171 ignal within STAT2 is recognized by the CRM1 exportin carrier.

172 tins carry cargoes into the nucleus, whereas exportins carry cargoes to the cytoplasm.

173 nuclear export protein (NEP) to the cellular exportin chromosomal maintenance 1 (CRM1).

174 The highly versatile exportin chromosome region maintenance 1 (CRM1) is essen

175 rotein Rev with the highly conserved nuclear exportin chromosome region maintenance 1(CRM1), which ex

176 the nuclear basket nucleoporin Nup2p and the exportin complex Cse1p.Gsp1p.GTP function as karyopherin

177 sis indicated that conformational changes in exportins couple cargo binding to high affinity for RanG

178 R was inhibited by overexpression of nuclear exportin Crm-1, while that by AT1a-i2m was restored by l

179 export of Vgl-4 is dependent on the nuclear exportin CRM-1.

180 osolic localization, the cytosolic levels of exportin (Crm)-1 were increased.

181 The nuclear exportin Crm1 reduced nuclear expression of GATA4, and t

182 is actively excluded from the nucleus by an exportin CRM1-dependent pathway.

183 he association of cyclin D1 with the nuclear exportin CRM1.

184 wn to require microtubule attachment and the exportin CRM1.

185 tion of association of Yap1 with the nuclear exportin Crm1.

186 ished, mediated at least in part through the exportin CRM1.

187 x (NPC) to promote export and disassembly of exportin Crm1/Ran(GTP)/cargo complexes.

188 B1 by serving as an adaptor between LKB1 and exportins CRM1 and exportin7.

189 at least one putative Ran:L(M) partner as an exportin, Crm1, or CAS.

190 hat NT-PGC-1alpha interacts with the nuclear exportin, CRM1, through a specific leucine-rich domain (

191 n turn promotes association with the nuclear exportin, CRM1.

192 Among the known nuclear exportins, CRM1 is the most studied prototype.

193 Induction of the exportin CSE1L inhibits nuclear accumulation of ErbBs, w

194 ture of the nuclear export complex formed by exportin Cse1p complexed with its cargo (Kap60p) and Ran

195 oskeleton but instead through an active Crm1/exportin-dependent nuclear export mechanism.

196 One subdomain is an Exportin-dependent nuclear export signal requiring three

197 ined roles in the nucleus, as well as a CRM1/exportin-dependent nuclear export signal; however, the N

198 Exportins exclude target proteins from the nucleus and a

199 he patterns of interacting proteins changed; exportins exhibited enhanced binding to FG Nups, and imp

200 a genetic approach, we identify Msn5p as the exportin for Crz1p.

201 (also known as Xpo-t), encoding the nuclear exportin for tRNA, suppresses the reduction in pre-tRNA

202 Redistribution of tRNA exportins from the nucleus to the cytoplasm likely provi

203 more, the data indicate that an importin and exportin have overlapping pathways through the NPC.

204 We show that both PRY-1/Axin and the nuclear exportin homolog IMB-4/CRM-1 antagonize signaling.

205 We confirmed that Pdr6 functions as an exportin in vivo and depletes eIF5A and eEF2 from cell n

206 functional role in selectively partitioning exportins in the cell nucleus.

207 f the chromosome region maintenance 1 (CRM1) exportin, inhibited PCNA relocalization during granulocy

208 ly, treatment of cells with leptomycin B, an exportin inhibitor, results in the nuclear accumulation

209 Surprisingly, fusions of Mex67, the tRNA exportin Los1, Mtr2, Cse1, or Msn5 to Nmd3, lacking its

210 ain unknown since the canonical tRNA nuclear exportin, Los1/Exportin-t, is unessential in all tested

211 Because the tRNA nuclear exportin, Los1p, is also unessential, we tested whether

212 The Ran-GTP-binding exportin, Los1p/Xpo-t, and additional pathway(s) mediate

213 , causing it to be recognized by the nuclear exportin Msn5 and carried out of the nucleus into the cy

214 r entry, but not Kap60 (importin-alpha), and exportin Msn5 was required for nuclear exit.

215 NPC for the related importin Pse1/Kap121 and exportin Msn5.

216 , rather than import, and involves the Crm1 (exportin) nuclear export factor and the dcd1+/pim1+ gene

217 tact falters in the absence of the principal exportin of nascent tRNA, Los1, and genetic assays indic

218 ediated by soluble receptors of the importin/exportin or karyopherin family.

219 es through the nuclear pore by importins and exportins plays a critical role in the spatial regulatio

220 uclear envelope owing to engagement with the exportin protein Crm1.

221 discovered a critical role for importins and exportins, Ran-GTP cycle regulators, nuclear pore compon

222 Exportin receptors are concentrated in the nucleus to tr

223 nonspecific macromolecules from importin and exportin receptors, collectively termed "karyopherins" (

224 yopherin superfamily including importins and exportins represent an essential part of the nucleocytop

225 lation status may mediate Ran's selection of exportin(s) and cargo(s), perverting these native traffi

226 Remarkably, a CIITA GBD mutant binds CRM1/exportin significantly better than does wild-type CIITA,

227 ung carcinoma cell lines do not, even though Exportin still functions in these cells.

228 Los1p/exportin-t (XPOT) mediates the nuclear export of tRNAs i

229 Exportin-t (Xpot) transports mature 5'- and 3'-end proce

230 The mutant phenotypes indicate that exportin-t acts pleiotropically in plant development.

231 The data support the notion that Los1p and exportin-t are functional homologues.

232 ar organisms, the developmental functions of exportin-t have not been determined.

233 tions in Los1p, the Saccharomyces cerevisiae exportin-t homolog, result in nuclear accumulation of tR

234 Los1p, the Saccharomyces cerevisiae exportin-t homologue, binds tRNA and functions in pre-tR

235 sed mutations confirm the important roles of exportin-t in gene expression in multicellular organisms

236 Because no exportin-t mutants have been reported in multicellular o

237 tion and characterization of two Arabidopsis exportin-t mutants, paused-5 and paused-6.

238 Exportin-t was first identified in humans as a protein t

239 that two beta-importin family members, Los1 (exportin-t) and Msn5 (exportin-5), serve overlapping but

240 conserved beta-importin family member Los1 (Exportin-t) has been the only exporter known to execute

241 dopsis ortholog of the tRNA export receptor, Exportin-t, interfered with the processing of tRNA-Tyr b

242 ce the canonical tRNA nuclear exportin, Los1/Exportin-t, is unessential in all tested organisms.

243 Los1p is similar to exportin-t, which facilitates vertebrate tRNA export.

244 cells likely involves factors in addition to exportin-t.

245 sential, but the known tRNA exporters (Los1 [exportin-t] and Msn5 [exportin-5]) are unessential.

246 CRM1 is a highly conserved, RanGTPase-driven exportin that carries proteins and RNPs from the nucleus

247 A mislocalization of exportins to the cytoplasm is linked to disease.

248 reveals that WUSCHEL directly interacts with EXPORTINS via EAR-like domain which is also required for