ライフサイエンスコーパス: exportin

1 nsport factors (karyopherins, importins, and exportins).

2 e karyopherins (referred to as importins and exportins).

3 A), but export is not dependent on the Crm1p exportin.

4 ive to the drug leptomycin B, is mediated by Exportin.

5 spartate carbamoyltransferase, and a nuclear exportin.

6 nBP16 (approved gene symbol Xpo7), a nuclear exportin.

7 he drug leptomycin B, which inactivates Crm1/exportin.

8 n NES, which directly binds the NES receptor Exportin.

9 conversely is required for cargo binding to exportins.

10 opherins (Kaps), transportins, importins, or exportins.

11 pherin betas, including importins as well as exportins.

12 pherin-beta superfamily termed importins and exportins.

13 ns-alpha1, -alpha2, and -beta2 and different exportins.

14 the nuclear transporters, importins-beta and exportins.

15 e-rich export signal that interacts with the exportin 1 (CRM1) receptor.

16 or of the recently identified export factor, exportin 1 (CRM1).

17 geted inhibition of nuclear exporter protein exportin 1 (XPO1) also known as chromosome maintenance r

18 tor of nuclear export compound, which blocks exportin 1 (XPO1) function, leads to nuclear accumulatio

19 ected cells has been shown to be mediated by exportin 1 (XPO1) interaction with viral nuclear export

20 We propose CRM1 be renamed exportin 1 (XPO1).

21 ), a novel, oral small-molecule inhibitor of exportin 1 (XPO1/CRM1), and determined the recommended p

22 demonstrate that diverse RNA viruses trigger exportin 1 (XPO1/CRM1)-dependent Drosha translocation in

23 Targeting nuclear export receptor (exportin 1 [XPO1]) is a novel approach to restore tumor

24 ls (NESs) are recognized by the NES receptor exportin 1 and are central to the export of multiple shu

25 ed inhibition of senescence required Ran and exportin 1 and involved the activation of importin beta-

26 Thus CaMKI vies with CRM1/exportin 1 for access to a NES, and assembly of a CaMKI-

27 , functions independently of an NES receptor-exportin 1 interaction.

28 It can exit the nucleus either as cargo of exportin 1 or bound to mRNA.

29 -capped pre-miRNAs are exported via the PHAX-exportin 1 pathway.

30 CRM1/exportin 1 was required for CCTalpha nuclear export, and

31 CRM1 (also known as XPO1 and exportin 1) mediates nuclear export of hundreds of prote

32 The CRM1 (Exportin 1) protein is a receptor for leucine-rich nucle

33 e region maintenance 1 (CRM1) (also known as exportin 1) shuttling receptor.

34 the soluble cellular export receptor CRM 1 (exportin 1), which mediates nucleocytoplasmic translocat

35 r proteins, the nucleoporin NUP88 and hCRM1 (exportin 1), which was recently shown to function as a n

36 id region containing several consensus CRM1 (exportin 1)-dependent nuclear export signals (NESs).

37 sence of leptomycin B, an inhibitor of CRM1 (exportin 1)-dependent nuclear export, suggesting that it

38 ding receptor has been identified as CRM1 or exportin 1.

39 rt in maintaining localization, we inhibited Exportin 1.

40 leptomycin B and is reduced by knockdown of exportin 1.

41 ear export signal (NES) that also binds CRM1/exportin 1.

42 nuclear export by enhancing interaction with exportin 1.

43 by the NES receptor CRM1/Crm1p (also called exportin 1/Xpo1p).

44 gh specificity to the nuclear export factor, exportin-1 (CRM1).

45 Exportin-1 (XPO1) is the key mediator of nuclear export

46 Exportin-1 (XPO1), also known as chromosome maintenance

47 ate the preclinical potential of KPT-330, an exportin-1 (XPO1, also known as chromosome maintenance p

48 the human counterpart and are sufficient for exportin-1 association with RanBP2.

49 interaction with RanBP2-exportin-1 complex, exportin-1 binding to the zinc finger cluster domain of

50 In contrast to Ran interaction with RanBP2-exportin-1 complex, exportin-1 binding to the zinc finge

51 ain of RanBP2 constitutes a docking site for exportin-1 during nuclear export.

52 s known to bind Exportin-1, and knockdown of Exportin-1 or trimethylguanosine synthase 1, responsible

53 via interaction with 14-3-3 proteins, CRM-1 (exportin-1 or XPO-1), or importins.

54 association of C/EBPbeta-PSer239 with CRM1 (exportin-1) in TNF-alpha-treated hepatocytes was inhibit

55 tive for their export through the XPO1 (CRM1/Exportin-1) receptor pathway, but retain nucleocytoplasm

56 We report that mutations of CRM1 (Exportin-1), MEX67/MTR2 (TAP/p15), and five nucleoporins

57 cally with the nuclear export receptor, CRM1/exportin-1, and components of the 19 S regulatory partic

58 lguanosine (TMG)-cap, which is known to bind Exportin-1, and knockdown of Exportin-1 or trimethylguan

59 Selinexor covalently binds exportin-1, causing nuclear sequestration of cargo prote

60 ains two novel nuclear import signals and an exportin-1-dependent nuclear export signal (NES).

61 Surprisingly, in quiescent cells Exportin-1-dependent pri-miR-34a is present in the cytop

62 rylation of Ser-271 serves to interfere with exportin-1-mediated nuclear export.

63 pendent of Exportin-5 and depends instead on Exportin-1.

64 ctor, is inactivated when it associates with exportin-1/Crm1.

65 fied cellular apoptosis susceptibility (CAS, exportin-2) and its transport substrate importin-alpha1

66 We further have identified exportin 4 as the specific transporter mediating PKM2 nu

67 can identified a 13q12.11 duplication in the exportin-4 (XPO4) gene to be associated with non-alcohol

68 o impaired nuclear import (V60L; mediated by Exportin-4) or export (I90M; mediated by chromosome regi

69 ammalian cells, the nuclear export receptor, Exportin 5 (Exp5), exports pre-microRNAs (pre-miRNAs) as

70 nuclear export of pre-microRNA precursors by Exportin 5 (Exp5).

71 sulting precursor miRNA hairpins exported by exportin 5 and processed by cytoplasmic Dicer to yield t

72 a-like nucleocytoplasmic transport receptors exportin 5 in mammals and MSN5 in yeast.

73 We demonstrate that NUP93 and exportin 5 interact with the signaling protein SMAD4 and

74 premicro-RNA precursors, competition for the Exportin 5 nuclear export factor, and inhibition of Dice

75 interaction partner NUP205 or XPO5 (encoding exportin 5) as hitherto unrecognized monogenic causes of

76 r psd and hasty, the Arabidopsis ortholog of exportin 5, are viable but have a more severe phenotype

77 xported from the nucleus to the cytoplasm by Exportin 5, where they are processed a second time to ge

78 EBER1 does not bind exportin 5; therefore, it is unlikely to act by interfer

79 We show that Exportin-5 (Exp5) mediates efficient nuclear export of s

80 f endogenous cellular RNAi factors including exportin-5 (Xpo-5).

81 from the nucleus through phosphorylation of exportin-5 (XPO5) at T345/S416/S497.

82 Recombinant exportin-5 also stimulates nuclear export of JAZ in perm

83 quiescence-induced miRNAs is independent of Exportin-5 and depends instead on Exportin-1.

84 Exportin-5 and Dicer are then required to generate matur

85 , these data suggest that JAZ is exported by exportin-5 but translocates back into nuclei by a facili

86 Exportin-5 can bind pre-miRNAs specifically in vitro, bu

87 hat determine which RNA binding proteins are exportin-5 cargoes remain unclear.

88 press small interfering RNAs, also depend on Exportin-5 for nuclear export.

89 We found that JAZ binds to exportin-5 in a Ran-GTP- and dsRNA-dependent manner.

90 Exportin-5 is a nuclear export receptor for certain clas

91 We propose that exportin-5 is not an RNA export factor but instead parti

92 l miRNA biogenesis components, DGCR8, Dicer, Exportin-5 or Argonaute 2.

93 h as miR-122 and let-7a, suggesting that the exportin-5 pathway was not affected.

94 mulates JAZ shuttling, and gene silencing of exportin-5 reduces shuttling.

95 Exportin-5 stimulates JAZ shuttling, and gene silencing

96 family members, Los1 (exportin-t) and Msn5 (exportin-5), serve overlapping but distinct roles in tRN

97 cence despite markedly reduced expression of Exportin-5, a protein required for canonical miRNA bioge

98 nical miRNA pathway during hairpin export by Exportin-5, and both types of hairpins are subsequently

99 Exportin-5, JAZ, and ILF3 can form a heteromeric complex

100 and dsRNA, and JAZ increases ILF3 binding to exportin-5.

101 with the nucleocytoplasmic shuttling protein exportin-5.

102 export, and miRNA function, are dependent on Exportin-5.

103 dsRNA binding proteins, we named the protein exportin-5.

104 6 snRNA requires the nuclear export receptor Exportin-5.

105 eadily saturated, is the nuclear karyopherin exportin-5.

106 tRNA exporters (Los1 [exportin-t] and Msn5 [exportin-5]) are unessential.

107 that nuclear export of actin is mediated by exportin 6, and not by Crm1.

108 the fact that two export receptors, Crm1 and exportin 6, have been linked to nuclear export of actin,

109 d as targets of miR-106b, Bim of miR-32, and exportin-6 and protein tyrosine kinase 9 of miR-1.

110 Expression of the nuclear export protein, Exportin 7 (Xpo7), is highly erythroid-specific, induced

111 leptomycin B (LMB), an inhibitor of the CRM1/exportin-alpha pathway.

112 Unlike Xpo1p/Crm1p/exportin, an NES receptor, Yrb2p does not shuttle betwee

113 contributions of an exceedingly promiscuous exportin and it provides a new basis for NES prediction.

114 p relocalization requires both the CRM1/XPO1 exportin and the FPS1 glycerol transporter genes but is

115 ires specialized transport receptors, called exportins and importins, that interact with cargo protei

116 Thus, importin and exportin, another member of this family involved in expo

117 ignal within STAT2 is recognized by the CRM1 exportin carrier.

118 tins carry cargoes into the nucleus, whereas exportins carry cargoes to the cytoplasm.

119 The highly versatile exportin chromosome region maintenance 1 (CRM1) is essen

120 the nuclear basket nucleoporin Nup2p and the exportin complex Cse1p.Gsp1p.GTP function as karyopherin

121 sis indicated that conformational changes in exportins couple cargo binding to high affinity for RanG

122 R was inhibited by overexpression of nuclear exportin Crm-1, while that by AT1a-i2m was restored by l

123 export of Vgl-4 is dependent on the nuclear exportin CRM-1.

124 osolic localization, the cytosolic levels of exportin (Crm)-1 were increased.

125 The nuclear exportin Crm1 reduced nuclear expression of GATA4, and t

126 is actively excluded from the nucleus by an exportin CRM1-dependent pathway.

127 he association of cyclin D1 with the nuclear exportin CRM1.

128 wn to require microtubule attachment and the exportin CRM1.

129 tion of association of Yap1 with the nuclear exportin Crm1.

130 ished, mediated at least in part through the exportin CRM1.

131 B1 by serving as an adaptor between LKB1 and exportins CRM1 and exportin7.

132 at least one putative Ran:L(M) partner as an exportin, Crm1, or CAS.

133 hat NT-PGC-1alpha interacts with the nuclear exportin, CRM1, through a specific leucine-rich domain (

134 n turn promotes association with the nuclear exportin, CRM1.

135 ture of the nuclear export complex formed by exportin Cse1p complexed with its cargo (Kap60p) and Ran

136 oskeleton but instead through an active Crm1/exportin-dependent nuclear export mechanism.

137 One subdomain is an Exportin-dependent nuclear export signal requiring three

138 ined roles in the nucleus, as well as a CRM1/exportin-dependent nuclear export signal; however, the N

139 Exportins exclude target proteins from the nucleus and a

140 he patterns of interacting proteins changed; exportins exhibited enhanced binding to FG Nups, and imp

141 a genetic approach, we identify Msn5p as the exportin for Crz1p.

142 (also known as Xpo-t), encoding the nuclear exportin for tRNA, suppresses the reduction in pre-tRNA

143 Redistribution of tRNA exportins from the nucleus to the cytoplasm likely provi

144 more, the data indicate that an importin and exportin have overlapping pathways through the NPC.

145 We show that both PRY-1/Axin and the nuclear exportin homolog IMB-4/CRM-1 antagonize signaling.

146 f the chromosome region maintenance 1 (CRM1) exportin, inhibited PCNA relocalization during granulocy

147 ly, treatment of cells with leptomycin B, an exportin inhibitor, results in the nuclear accumulation

148 Surprisingly, fusions of Mex67, the tRNA exportin Los1, Mtr2, Cse1, or Msn5 to Nmd3, lacking its

149 Because the tRNA nuclear exportin, Los1p, is also unessential, we tested whether

150 The Ran-GTP-binding exportin, Los1p/Xpo-t, and additional pathway(s) mediate

151 , causing it to be recognized by the nuclear exportin Msn5 and carried out of the nucleus into the cy

152 r entry, but not Kap60 (importin-alpha), and exportin Msn5 was required for nuclear exit.

153 NPC for the related importin Pse1/Kap121 and exportin Msn5.

154 , rather than import, and involves the Crm1 (exportin) nuclear export factor and the dcd1+/pim1+ gene

155 tact falters in the absence of the principal exportin of nascent tRNA, Los1, and genetic assays indic

156 ediated by soluble receptors of the importin/exportin or karyopherin family.

157 es through the nuclear pore by importins and exportins plays a critical role in the spatial regulatio

158 uclear envelope owing to engagement with the exportin protein Crm1.

159 discovered a critical role for importins and exportins, Ran-GTP cycle regulators, nuclear pore compon

160 yopherin superfamily including importins and exportins represent an essential part of the nucleocytop

161 lation status may mediate Ran's selection of exportin(s) and cargo(s), perverting these native traffi

162 Remarkably, a CIITA GBD mutant binds CRM1/exportin significantly better than does wild-type CIITA,

163 ung carcinoma cell lines do not, even though Exportin still functions in these cells.

164 Los1p/exportin-t (XPOT) mediates the nuclear export of tRNAs i

165 Exportin-t (Xpot) transports mature 5'- and 3'-end proce

166 The mutant phenotypes indicate that exportin-t acts pleiotropically in plant development.

167 The data support the notion that Los1p and exportin-t are functional homologues.

168 ar organisms, the developmental functions of exportin-t have not been determined.

169 tions in Los1p, the Saccharomyces cerevisiae exportin-t homolog, result in nuclear accumulation of tR

170 Los1p, the Saccharomyces cerevisiae exportin-t homologue, binds tRNA and functions in pre-tR

171 sed mutations confirm the important roles of exportin-t in gene expression in multicellular organisms

172 Because no exportin-t mutants have been reported in multicellular o

173 tion and characterization of two Arabidopsis exportin-t mutants, paused-5 and paused-6.

174 Exportin-t was first identified in humans as a protein t

175 that two beta-importin family members, Los1 (exportin-t) and Msn5 (exportin-5), serve overlapping but

176 conserved beta-importin family member Los1 (Exportin-t) has been the only exporter known to execute

177 dopsis ortholog of the tRNA export receptor, Exportin-t, interfered with the processing of tRNA-Tyr b

178 Los1p is similar to exportin-t, which facilitates vertebrate tRNA export.

179 cells likely involves factors in addition to exportin-t.

180 sential, but the known tRNA exporters (Los1 [exportin-t] and Msn5 [exportin-5]) are unessential.

181 CRM1 is a highly conserved, RanGTPase-driven exportin that carries proteins and RNPs from the nucleus