ライフサイエンスコーパス: expression

1 al activators of TET1, and thus repress TET1 expression.

2 and hypoxia, respectively, which drive VEGF expression.

3 dition in gp93-expressing cells improved TLR expression.

4 tion is a key step in the regulation of gene expression.

5 oxidative promoter lesions may modulate gene expression.

6 h as a repressor and as an activator of gene expression.

7 ve a lower CpG content and a higher level of expression.

8 LC3-I/II conversion as well as reduced Tfeb expression.

9 poor survival in HCC and interleukin-6 (IL6) expression.

10 itro and in vivo upon downregulation of OCT4 expression.

11 inclusion and thus increases full length SMN expression.

12 romoters is an important determinant of gene expression.

13 s direct transcriptional activators of Brn3b expression.

14 that had Cre-recombinase driven by OTR gene expression.

15 ein BACH1, and BACH1 knockdown reduces BZLF1 expression.

16 t, high-sucrose diet increased hepatic mIndy expression.

17 therapy was inversely correlated with SAMHD1 expression.

18 promoter site are integrated to modify pqsR expression.

19 demonstrates that the region regulates CHSY1 expression.

20 o3alpha and downregulation of acetylated p53 expression.

21 hway inversely affected by miR-519d or EphA4 expression.

22 pressive functions in the regulation of gene expression.

23 approximately 5% of the variance in protein expression.

24 r level, and importantly no aberrant protein expression.

25 since dogs do not display human-like facial expressions.

26 RR (94% [17/18]) than patients with low BCL2 expression (59% [16/27]).

27 results refute the commonality of emotional expression across mammals, since dogs do not display hum

28 Meta-analysis of RD3 transcriptional expression across normal tissues confirmed tissue-specif

29 Genetic elevation of MeCP2 T158M expression ameliorated multiple RTT-like features, inclu

30 Differential gene-expression analysis has allowed us to confirm the releva

31 High expression and activation of EGFR and/or ErbB2 were rece

32 plicing potential at the RI, hypoxia-induced expression and binding of the splicing factor SRSF3, and

33 indicate that loss of DDRGK1 decreases SOX9 expression and causes a human skeletal dysplasia, identi

34 ell types across samples, while differential expression and coexpression network analyses revealed tr

35 during positive selection eliminated Runx3d expression and completely abolished the generation of CD

36 rypsin protein (a serine protease inhibitor) expression and downregulation of neutrophil elastase (NE

37 s C96Y Ins2 mutation, exhibit elevated PLIN2 expression and ER stress in their beta cells.

38 activator inhibitor-1 (PAI-1), S. aureusclfA expression and fibrin-encapsulated abscess communities i

39 To systematically study the expression and function of H1 subtypes, we generated kno

40 MEAN suppressed C-MYC expression and increased expression of several tumor sup

41 of glioblastoma (GBM) are defined using gene expression and mutation profiles, we identify a unique s

42 R cells despite appropriate receptor protein expression and nuclear localization.

43 tic leukemia, inhibits TNFalpha induced gene expression and phosphorylation of NF-kappaB.

44 3alpha with downregulation of acetylated p53 expression and prevented downregulation of Sirtuin-1 and

45 ited Ca(2+) concentration, hormone secretion/expression and proliferation.

46 -in reporter mice confirmed increased Cldn14 expression and promoter activity in the TAL of Ksp-cre;P

47 Gene expression and protein expression were analyzed with qua

48 The sequence of gene activation/expression and receptor editing of these isotypes have n

49 le exhibiting suppressed aromatase (Cyp19a1) expression and reduced circulating 17beta-estradiol leve

50 -dependent changes in hippocampal PSD CaMKII expression and S831 GluA1 phosphorylation.

51 lammatory mediators assessed in splenic gene expression and serum proteins.

52 inverse association between immune metagene expression and somatic copy number alteration levels (rh

53 to generate cell type-specific levels of dve expression and stable photoreceptor fate.

54 developmentally regulated gamma-globin gene expression and the ability to control oxidative stress a

55 nd a strong association between hexokinase-2 expression and this negativity: a finding which may also

56 romatin regulation modulates stochastic gene expression and transcriptional bursting, with implicatio

57 sistently, PI3Kdelta inhibitors enhanced AID expression and translocation frequency to IGH and AID of

58 Cell aggregation, gtfP gene expression and water-insoluble glucan production were al

59 genetic regulators may act to facilitate the expression and/or repression of genes that are necessary

60 tion, facilitates D1 dopamine receptor (D1R) expression, and ensures long-term synaptic plasticity.

61 mmatory therapy, meibomian gland heating and expression, and scleral contact lenses are some of the l

62 Early perturbations in tissue-wide gene expression, as observed here, may underpin a profound im

63 L-33 increases NK-1 gene and surface protein expression, as well as IKbeta-alpha phosphorylation.

64 diploid organisms may cause allele specific expression (ASE) - unequal expression of the two chromos

65 ative trait loci (eQTLs) and allele-specific expression (ASE).

66 IFN-gamma treatment to GCSCs induced ZEB1 expression, attenuating LIF activities.

67 to Purkinje cells, reduced cerebellar ATXN2 expression below 75% for more than 10 weeks without micr

68 s, but found no striking differences in gene expression between male and female mice, neither before

69 esterone receptor, beta-catenin, or vimentin expression between placebo and R-ketorolac treatment gro

70 Cmya5 is an expression biomarker for a number of diseases affecting

71 the AppA (activation of photopigment and puc expression) BLUF domain before and following photoexcita

72 ng pathway inhibit activation of lytic viral expression but do not inhibit several other lytic activa

73 isproportionately influences sex-biased gene expression but show that the direction of change is dyna

74 udies suggest that a reduction in SK channel expression, but not changes in Ca(2+) -mediated activati

75 We focused on FOXP1 and assessed its protein expression by immunohistochemistry (IHC) in 763 tissue b

76 actin expression by stellate cells and CD34 expression by liver sinusoidal endothelial cells remaine

77 iral gene activator ICP0, inhibition of ICP0 expression by miR-H2 has been a major hypothesis to help

78 tion of Th17-type CD4 T cells, reduced T-bet expression by natural killer cells, and expansion of blo

79 he 3'UTR composition of mRNAs can alter gene expression by regulating transcript localization, stabil

80 Smooth-muscle actin expression by stellate cells and CD34 expression by live

81 in the environment lead to distinctive gene expression changes within a cell.

82 the data for variance as a function of mean expression collapse onto a single master curve independe

83 and genetic evidence that reductions in Reln expression contribute to GCp proliferative defects and c

84 We demonstrate that elevated Ctnnd1 expression contributes to maintenance of murine B-ALL ce

85 Restoration of let-7 expression could provide a new target for an anti-inflam

86 nostring human v2 miRNA microarray array and expression data were analyzed on nSolver analysis softwa

87 echnologies and decreasing costs, large gene expression datasets are being generated at an accelerati

88 chemotherapy regimen, and incremental COX-2 expression did not demonstrate any advantage for COX-2 i

89 > mIggamma1 > mIgepsilon, and that these BCR expression differences influence respective developmenta

90 Finally, we show that knockdown of EmMBD2/3 expression disrupts normal cellular architecture and dev

91 to help explain the repression of lytic gene expression during latency.

92 AP2-G expression during this 'commitment cycle' prepares gene

93 ment by integrating in vivo analysis of gene expression dynamics with a reverse engineering approach

94 egulatory foundation for spatiotemporal gene expression evolved prior to the divergence of sponges an

95 e before and after stimulation and FOXP3mRNA expression ex vivo decreased from age 4.5 to 6 years (P(

96 We used cross-species expression experiments to show that Alx1 proteins from d

97 Patients with high BCL2 expression had a higher ORR (94% [17/18]) than patients

98 GPR44 expression has recently been described as highly beta-ce

99 g860Trp]) was overrepresented due to allelic expression imbalance (AEI).

100 indicates epigenetic control of Sp1 targets' expression in a cell/tissue specific manner.

101 he ability of dexamethasone to modulate gene expression in airway epithelial cells coincided with its

102 iptional regulatory mechanisms control PD-L1 expression in cancer, it remains unknown whether such re

103 THEMIS, a T cell-specific protein with high expression in CD4(+)CD8(+) thymocytes, has a crucial rol

104 vitamin D receptor (VDR) enhanced Claudin-2 expression in colon and that bile salt receptors VDR and

105 correlation between serum E2 levels and pLTF expression in cycling female rats.

106 Heterologous gene expression in E. coli confirmed its functions for hydrol

107 ty to both attract and induce virulence gene expression in EHEC, we propose that DHMA acts as a molec

108 es of hagfish tissues and blood revealed Vwf expression in endothelial cells and thrombocytes.

109 .2] years) detected increased PD-1 and PD-L2 expression in high-risk cSCC.

110 051 was also associated with reduced ADAMTS7 expression in human aortic endothelial cells and lymphob

111 chemokines and in modulating Rab7B and P2RX7 expression in human DCs.

112 d downregulation of Sirtuin-1 and Foxo3alpha expression in IRPTCs by high glucose plus palmitate.

113 d fine-mapped separate enhancers controlling expression in joints versus growing ends of long bones.

114 -seq analysis demonstrates differential gene expression in Lsh-/- NSPCs and suggests multiple aberran

115 type 1 (mrc1a) promoter to drive strong EGFP expression in lymphatic vessels at all stages of develop

116 The induction of EBI3 protein expression in mouse NK cells is a late activation event.

117 , we identify promoters able to drive strong expression in multiple tissue/organs.

118 -wide cardiac DNA methylation on global gene expression in myocardial samples from end-stage CCC pati

119 during this 'commitment cycle' prepares gene expression in nascent merozoites to initiate sexual deve

120 hosphorylation cooperate in regulating NKG2D expression in NK cells.

121 e model legume Medicago truncatula and their expression in nodules was determined.

122 are widespread RNA motifs that regulate gene expression in response to fluctuating metabolite concent

123 In contrast, suppressing HT expression in SC.

124 e phenocopied by transgenically reducing pr4 expression in sitters.

125 laser, for reproducible heat-dependent gene expression in small sublineages (one to four cells) with

126 re induction of interferon-gamma (IFN-gamma) expression in T cells and to generate pathogenic TH17 ce

127 analyses reveal that IFN-gamma induces CD70 expression in T cells, and CD70 limits T cell expansion

128 w of these areas, a detailed analysis of p11 expression in the brain is warranted.

129 to increase proopiomelanocortin (POMC) gene expression in the hypothalamus.

130 angiogenesis, both of which stimulated SRC-2 expression in vitro Furthermore, SRC-2 coactivated the t

131 mediated the effects of age and sex on gene expression, including CD8(+) T cells for age and CD4(+)

132 lly upregulate additional regulators of gene expression, including other AP2 transcription factors, h

133 tive regulatory loop, in which ectopic DNMT1 expression increases, whereas targeted DNMT1 depletion a

134 d downregulation of neutrophil elastase (NE) expression induced by obstructive injury.

135 a that can be targeted to block ERalpha gene expression is a critical topic of endocrine therapy.

136 al different cancer types and their elevated expression is associated with an advanced tumor state an

137 We show that RARRES2 expression is downregulated in ACC as compared with norm

138 surprisingly little is known about how LMP1 expression is regulated in epithelial cells, and there a

139 We further showed that Tnc expression is repressed by the transcription factor Nkx2

140 Surprisingly, dnGluN1 expression led to an enhancement in the motivation to se

141 t-effective PET discovery process, involving expression level (Bmax) and biodistribution determinatio

142 BAX expression levels and cytosolic conformation regulate se

143 ealing substantial cell-to-cell variation in expression levels and propagation of this variation betw

144 orithm that was based on polymorphism-driven expression levels and specificities, we predicted and te

145 Indeed, high Blimp1 expression levels are detected in invasive p130Cas/ErbB2

146 In mice, subcutaneous AT Tshb expression levels correlated directly with circulating c

147 s differentially recruited to fine-tune gene expression levels in each cardiac chamber.

148 y, we trained a classifier based on the gene expression levels in the non-infected cells, and demonst

149 ion, we verified miR-449b could regulate the expression levels of CDK6, c-MYC, HDAC1 and BCL-2.

150 a molecular signature measuring the relative expression levels of four host messenger RNAs, was devel

151 The expression levels of some markers for AML subtypes and c

152 The expression levels of tau and TDP-43 were inverse in the

153 At least six miRNAs show cycling expression levels within the pigment dispersing factor (

154 d1 complexes are strongly influenced by Hrd1 expression levels.

155 uplex that is essential for buffering Nkx2.1 expression, lung epithelial cell identity, and tissue ho

156 SZ and BD, interpreted here as decreased SST expression, may disrupt responses to fear and anxiety re

157 F-FDHT and (18)F-FES PET and tumor AR and ER expression measured immunohistochemically in patients wi

158 We have built PC gene and lincRNA co-expression networks, unraveling key biological processes

159 h-throughput proteomic analysis that detects expression of 1129 protein targets.

160 We measured the expression of 45 confirmed and putative restriction fact

161 Thus, expression of a 5' extended mRNA isoform causes transcri

162 Moreover, exogenous expression of ACTRT1 reduced the in vitro and in vivo pr

163 l-D-aspartate (NMDA) receptors and decreased expression of alpha-amino-3-hydroxy-5-methylisoxazole-4-

164 Here we demonstrate that the expression of an endogenous Braf(D631A) kinase-inactive

165 r data reveal that tissue and stage-specific expression of ankyrin isoforms relies on differential ac

166 resistance to viral replication is marked by expression of antiviral restriction factors, it was intu

167 Intriguingly, increased expression of Arf in tumor stromal cells, as in tumor ke

168 nes) that contrasted the preferential allele expression of between 2180 and 3502 and 3367 and 5270 ge

169 Expression of both genes was elevated in obese mice, and

170 sent the first comprehensive description and expression of both major classes of drug transporters, S

171 Ectopic expression of Cdh1 leads to premature differentiation of

172 in human primary glioblastoma cells enabled expression of CDK inhibitors and decreased p53 protein t

173 rther linking fibrin deposition to S. aureus expression of clfA and infection severity.

174 Next, we characterized the unique expression of coding, noncoding, and intergenic RNAs in

175 xplored the genetic mechanism underlying the expression of discrete mating strategies in the rock-pap

176 ns of parasite virulence have associated the expression of distinct variants of the major surface ant

177 r of transcription 3 phosphorylation and the expression of downstream genes, such as Bcl-2 (B-cell ly

178 e for ALK2 in the BMP9/BMP10-induced surface expression of E-selectin, and both ALK1 and ALK2 in the

179 Constitutive Akt signalling increases expression of EC morphogenesis genes, including Sox17, s

180 Increased expression of EGFR in myeloid cells from the colorectal

181 rigenesis have been interested and increased expression of FAM83H and MYC in hepatocellular carcinoma

182 cible adeno-associated virus that drives the expression of fluorescent marker into the VTA of male mi

183 f Gene 33 with histone H2AX and that ectopic expression of Gene 33 promotes the interaction between A

184 -dependent increase in LPC proliferation and expression of genes associated with cholangiocyte differ

185 on, elevating neuritogenic Rac1 activity and expression of genes encoding the endocytic machinery.

186 ESCd display a high level of expression of genes implicated in migration and invasion

187 pair enzyme involved in genome stability and expression of genes involved in oxidative stress respons

188 n alter calcium/phosphorus levels and affect expression of genes involved in phosphate homeostasis.

189 life-history phases, and for the underlying expression of genes related to morphological feature for

190 ess (P = 0.02), correlating with significant expression of genes related to skin barrier repair.

191 bind to specific DNA sequences and regulate expression of genes.

192 associated with increased phrenic motoneuron expression of glutamatergic N-methyl-D-aspartate (NMDA)

193 which is regulated, at least in part, by the expression of GRF1 and possibly other transcription fact

194 nterferon-signalling pathway and an aberrant expression of host genes associated with pregnancy compl

195 act of IS drugs on gut microbiota and on the expression of ileal antimicrobial peptides.

196 ear CREB phosphorylation and, in most cases, expression of immediate early genes.

197 , HDAC inhibitors did not interfere with the expression of immuno-dominant viral proteins.

198 tivity of MDSCs in tumors, and inhibited the expression of immunosuppressive factors arginase I and i

199 engage the striatum and promote a shift from expression of innate defensive responses toward more ada

200 everse transcriptase activity suppressed the expression of interferon genes in uhrf1 mutants.

201 Here, we show that BDV infection induces expression of key enzymes of the kynurenine pathway in b

202 gain-of-function CRY1 variant causes reduced expression of key transcriptional targets and lengthens

203 electively modulate let-7 activity and hence expression of let-7-regulated mRNAs.

204 nd the environmental signals controlling the expression of Longus-encoding genes are unknown.

205 nd commercial PGE2 in modulating LPS-induced expression of many cytokines and chemokines and in modul

206 We show that the expression of many miRNAs is dramatically regulated duri

207 Expression of mERbeta2 mRNA was detected in mouse reprod

208 Expression of miss-regulated mutant variants of RabA2 re

209 Ubiquitous expression of mutant Cu/Zn-superoxide dismutase (SOD1) s

210 the context of Rb inactivation increased the expression of MYC-, E2F-, and ribosome-related gene sets

211 ncers, where bromodomain proteins impact the expression of oncogenes and anti-apoptotic proteins.

212 rated that the epithelial cells with surface expression of PD-L1, E-cadherin, CD24, and VEGFR2 rapidl

213 king agents were tested by investigating the expression of PGK1, one of the glycolytic genes most aff

214 ctivity by small hairpin ribonucleic acid or expression of phospho-deficient LDHA Y10F sensitized the

215 horylation of STAT3 on Ser727, and increased expression of PML, a STAT3 transcriptional target.

216 MIR34A reduces expression of PPP1R11 to prevent activation of STAT3 and

217 le of reactivating mutated p53 to induce the expression of pro-apoptotic genes in breast cancer with

218 on of nuclear factor kappa B and reduced the expression of proinflammatory proteins (inducible nitric

219 These phenotypes are rescued by re-expression of Ptprg only in liver of mice lacking Ptprg

220 is brought about by changes in the levels of expression of relatively few genes, but this is sufficie

221 AN suppressed C-MYC expression and increased expression of several tumor suppressor genes, including

222 nisms underlying the formation, storage, and expression of such models remain unknown.

223 ed in females and marked a reorganization of expression of synaptic and schizophrenia-susceptibility

224 ment (P = 0.007) demonstrated increased skin expression of the anti-inflammatory mediator arginase-1

225 crophages from female mice exhibited greater expression of the IL-4Ralpha and estrogen receptor (ER)

226 In Drosophila, graded expression of the maternal transcription factor Bicoid (

227 BACKGROUD: Variations in the expression of the Netrin-1 guidance cue receptor DCC (de

228 is a devastating pediatric disease driven by expression of the oncogenic fusion gene PAX3-FOXO1A.

229 ncreased ferritin protein levels promote the expression of the promitotic transcription factor FOXM1

230 amated E-box and GATA motifs (+9.5) controls expression of the regulator of hematopoiesis GATA-2.

231 orsal splanchnic mesoderm accompanied by the expression of the secondary heart field marker, Islet1.

232 itionally, T-bet-deficient Treg cells lacked expression of the Th1-characteristic trafficking recepto

233 was sufficient to suppress the induction of expression of the transcription factor Foxp3 in T cells,

234 e allele specific expression (ASE) - unequal expression of the two chromosomal gene copies.

235 tate levels of circular RNAs increased while expression of their associated linear mRNAs concomitantl

236 Our results show that a reduction in the expression of this molecular chaperone accelerates prion

237 utoreactive T cells by promoting the ectopic expression of tissue-specific genes in the thymic medull

238 The expression of TRU1 and TB1 overlap in axillary buds, and

239 ogenic avian influenza A (H5N1) virus induce expression of tumor necrosis factor alpha, interleukin-6

240 orders (interferonopathies) characterized by expression of type I interferon in the brain.

241 show, in a quad-transgenic model, that over-expression of VEGF-A165 b alone is sufficient to rescue

242 Additionally, significant alterations in the expression of well characterized cellular proliferation

243 inases (CDKs) and CDK inhibitors (CKIs), the expression of which is often dysregulated in cancer cell

244 Ectopic expression of wild-type Pdcd4 and Pdcd4(157-469), a dele

245 Expression of XBP1 by hepatocytes increased immediately

246 Here we determined that increased expression of XRN2 induced EMT and promoted metastasis i

247 s study, we have observed increased endoglin expression on the cell surface of an HCV core-expressing

248 tamoxifen is restored only by reducing eIF4E expression or mTOR activity and also blocking MNK1 phosp

249 and pattern, with consequent impact on dand5 expression pattern and left-right (L-R) axis establishme

250 tion between the Eda haplotype block and the expression pattern of key immune system genes.

251 y inducing an early myogenesis -related gene expression pattern which includes myogenin and Myf5 up-r

252 d major differences in the immune checkpoint expression patterns across tumor types and individual tu

253 We report that RFRP-3 immunofluorescence expression patterns and RFRP-3/GnRH cross-talk are large

254 ns between HNF4A and microbiota promote gene expression patterns associated with human inflammatory b

255 ted with distinctive organellar features and expression patterns indicative of cellular stress.

256 Profiling the expression patterns of snoRNAs is the initial step in de

257 vide a high-quality resource of altered gene expression patterns under severe OXPHOS deficiency compa

258 Silencing MYC expression phenocopied the CSC depletion effects of C157

259 Identification of genes whose basal mRNA expression predicts the sensitivity of tumor cells to cy

260 In this article, we show that CXCL8 expression, prior to proliferation, is common in newly a

261 nted an automatically generated RN with gene expression profiles (GEP) from a cohort of multiple myel

262 Hierarchical clustering based on gene expression profiles delineated brain regions into struct

263 stering of participants based on global gene expression profiles revealed that participants with sign

264 stant to Gyrodactylus and had different gene expression profiles than lake sticklebacks.

265 validated by RT-qPCR, often showed opposite expression profiles than the related miRNAs.

266 ogether with a new dataset of 265 ccRCC gene expression profiles.

267 art disease by integrating gene and microRNA expression profiling data from hearts of T. cruzi infect

268 d when p16 is inactivated by looking at gene expression profiling studies.

269 CtBP modulates oncogenic gene expression programs and is an emerging drug target, but

270 ature and by collaborations with large-scale expression projects, GXD collects and integrates data fr

271 like cells (HLCs) for genome-wide mapping of expression quantitative trait loci (eQTLs) and allele-sp

272 Fifteen of the associated variants had expression quantitative trait loci in whole blood.

273 We performed expression quantitative trait locus (eQTL) analyses by u

274 l common regulation and conservation of gene expression regionally along the length of the intestine

275 More specifically, we found that GnT-III expression regulates the levels and activation of the he

276 n interactions are essential for proper gene expression regulation, particularly in neurons with uniq

277 actors (TFs) is crucial to the study of gene expression regulation.

278 Megalin expression remained unaltered in adult WT and KO mouse b

279 associated with activated and repressed gene expression, respectively.

280 FliP expression sensitizes cells to a number of chemical agen

281 metastasis in vivo Overall, we identify gene expression signatures and candidate therapeutics that co

282 miRNA-193a-5p level, and its related targets expression, similar to that observed in healthy controls

283 Genetic mosaic and cell type-specific expression studies indicate that vpr-1 activity is impor

284 1beta, and is associated with increased MyoD expression, suggesting that Hmox1(-/-) SCs are shifted t

285 ichia coli protein solubility in a cell-free expression system, 35 sequence-based properties are calc

286 ng, triggering a major reprogramming of gene expression that includes components of the virulence-cri

287 yoD-regulated and skeletal muscle-restricted expression that promotes the activation of the myogenic

288 Computational analysis of gene expression to determine both the sequence of lineage cho

289 Megalin expression was about the same in both WT and KO mouse vi

290 hat CNOT3 was bound primarily to genes whose expression was affected by CNOT3 loss, and also at sites

291 induction of IL6 in resistant cells and the expression was further increased in response to cisplati

292 beta-catenin and Snail1 expression was generally high in all subjects throughout

293 Additive gene expression was observed in leaves (3605 genes) and tuber

294 Indeed, a reduced HLA class-I expression was observed in MCC tumor tissues and MCC cel

295 Gene expression and protein expression were analyzed with quantitative polymerase ch

296 vascular endothelial growth factor (VEGF)-C expression were measured.

297 stimulated to secrete IgG and increase CD27 expression when cultured with soluble piperacillin.

298 the context of p53 loss and novel NF-kappaB expression, whereas increased tissue rigidity and cell m

299 led that microglia selectively enhanced CCL2 expression, while monocytes expressed the pro-inflammato

300 different drugs known to regulate alpha-SYN expression; while exogenous promoter-reporter assays fai