ライフサイエンスコーパス: expression site

1 a monocistronic variant surface glycoprotein expression site.

2 ycoprotein (VSG), encoded in a telomeric VSG expression site.

3 bination into a single operon-linked genomic expression site.

4 oding nucleotide sequences into the singular expression site.

5 or VSG copies into the actively transcribed expression site.

6 iple silent vls cassette sites into the vlsE expression site.

7 tion of silent donor cassettes with the tprK expression site.

8 nefficiently direct recombination in the VSG expression site.

9 eater the switch rate of that locus into the expression site.

10 ci form a hierarchy of switch rates into the expression site.

11 s of variants at silent sites and the single expression site.

12 s and the generation of novel alleles at the expression site.

13 gial variant surface glycoprotein (VSG) gene expression site.

14 lycoproteins (VSGs) from telomere-linked VSG expression sites.

15 equences representing the VSG 10.1 donor and expression sites.

16 urface protein through switching between two expression sites.

17 of the CGRP receptor at endogenous or novel expression sites.

18 ibition between individual elements or novel expression sites.

19 activated by recombination into specialized expression sites.

20 are recombined in various combinations into expression sites.

21 t archive, by recombination into specialized expression sites.

22 at a time from one of multiple telomeric VSG expression sites.

23 rsion of chromosomal pseudogenes into single-expression sites.

24 cei is encoded by genes located in different expression sites.

25 ysis of the donor sites, as well as the tprK expression sites, among eight T. pallidum subsp. pallidu

26 cus, a complex system consisting of the vlsE expression site and an adjacent set of 11 to 15 silent v

27 nreciprocal gene conversion between the tprK expression site and donor sites.

28 The structure of the expression site and flanking regions was conserved excep

29 SG and its corresponding telomere-linked VSG expression site and forms the basis for studies on antig

30 achieved by recombination between the MG192 expression site and MgPar sequences via gene cross-over

31 explained by recombination between the mgpB expression site and putative donor MgPar sequences.

32 of pseudogenes into the single operon linked expression site and the diversity of variants is defined

33 the variants following recombination into an expression site and the donor loci themselves are under

34 silenced variant surface glycoprotein (VSG) expression sites and procyclin loci, indicating a disrup

35 owed that p44 multigenes have several active expression sites and the expression is regulated at tran

36 have strengthened the proposal that the VSG expression sites and the PARP genes represent naturally

37 genes-the variant surface glycoprotein (VSG) expression sites and the procyclin or the procyclic acid

38 We found that most of the YAC expression sites and tissues are directly reflective of

39 pe 4 variant surface glycoprotein (VSG) gene expression site, and some appear to come from pseudogene

40 nked donor VSG 10.1 resembles metacyclic VSG expression sites, and is preceded by a cluster of 35 or

41 T. brucei has about 20 VSG expression sites, and it has been proposed that their ge

42 ncated RNA polymerase pseudogenes as well as expression site associated (pseudo)genes (ESAGs) 3 and 4

43 n units, containing a variety of families of expression site associated genes (ESAGs) in addition to

44 mRNA species encoding related members of the expression site-associated gene I (ESAG-I) family occur

45 VSG expression sites (BESs), also containing expression site-associated genes (ESAGs) involved in hos

46 n site contains a promoter followed by seven expression site-associated genes (ESAGs), three pseudo E

47 A BES is a tandem array of expression site-associated genes and a terminal VSG gene

48 The other chromosome end carries VSG and expression site-associated genes and pseudogenes over 50

49 Two expression site-associated genes ESAG6 and ESAG7, encode

50 Three conserved expression-site-associated genes (ESAGs) appear to serve

51 s, which are co-transcribed with a number of expression-site-associated genes (ESAGs) from loci terme

52 loci of variant antigens copy into a single expression site at rates determined by extragenic featur

53 Monoallelic expression of BF Expression Site (BES)-linked VSGs and silencing of metac

54 glycoprotein (VSG) from 1 of 15 bloodstream expression sites (BESs) by virtue of a multifunctional R

55 n one of many telomeric bloodstream form VSG expression sites (BESs), also containing expression site

56 ream form Variant Surface Glycoprotein (VSG) expression sites (BESs), of which one is expressed at a

57 mere at one of fifteen so-called bloodstream expression sites (BESs).

58 genes (ESAGs) from loci termed 'bloodstream expression sites' (BESs).

59 in an extranucleolar compartment termed the expression site body (ESB), whereas silent BESs, located

60 ers and is abundant in the nucleolus and the expression site body subnuclear compartments.

61 d from one of approximately 20 subtelomeric 'Expression Sites', but the role telomeres might play in

62 lesions in, neurons that project to the gene expression site, but not in nearby structures that would

63 eric variant surface glycoprotein (VSG) gene expression sites, but not in the active expression site,

64 l segments of pseudogenes recombine into the expression site by gene conversion.

65 F-mediated conversion of a single MSP2 (P44) expression site by partially homologous donor sequences.

66 y combinatorial gene conversion of a genomic expression site by truncated pseudogenes.

67 The 45 kb telomere-linked VSG 10.1 expression site contains a promoter followed by seven ex

68 rived from the pseudogenes into the existing expression site copy, resulting in a combinatorial incre

69 somally encoded AphA protein activates tcpPH expression, site-directed mutagenesis was used to identi

70 Using expression/site-directed mutagenesis approaches, we now

71 ariant surface glycoprotein (VSG) genes into expression sites during immune evasion by antigenic vari

72 The various expression sites encode slightly different transferrin r

73 d substitutions in the region of the genomic expression site encoding the central hypervariable regio

74 oposed that T. brucei has developed multiple expression sites encoding different transferrin receptor

75 , but only one is expressed from a telomeric expression site (ES) at any given time.

76 one variant surface glycoprotein gene (VSG) expression site (ES) is active at any time.

77 nes, under the control of either rRNA or vsg expression site (ES) promoters, into various chromosomal

78 metacyclic variant antigen type 4 (MVAT) vsg expression site (ES) revealed an ES-associated gene (esa

79 VSG gene is in a Pol I-transcribed telomeric expression site (ES).

80 polycistronic transcription unit known as an expression site (ES).

81 only one VSG gene at a time from a telomeric expression site (ES).

82 chanism using marker genes in the active VSG expression site (ES).

83 Owing to developmental silencing of the VSG Expression Sites (ES), no VSG is transcribed in the inse

84 sg) among an estimated 20-40 telomere-linked expression sites (ES), only one of which is fully active

85 its variant surface glycoprotein (VSG) gene expression sites (ESs) in a monoallelic fashion using RN

86 t only one of approximately 15 telomeric VSG expression sites (ESs) is transcribed at a time.

87 anscribed variant surface glycoprotein (VSG) expression sites (ESs) of Trypanosoma brucei.

88 eric variant surface glycoprotein (VSG) gene-expression sites (ESs) while multiplying in the mammalia

89 monoallelically expressed from subtelomeric expression sites (ESs), and VSG switching exploits subte

90 -proximal variant surface glycoprotein (VSG) expression sites (ESs), suggesting a role in controlling

91 ibed variant surface glycoprotein (VSG) gene expression sites (ESs), which are monoallelically expres

92 found adjacent to telomeres in polycistronic expression sites (ESs).

93 anscribed from one of about 15 telomeric VSG expression sites (ESs).

94 e I in one of approximately 15 telomeric VSG expression sites (ESs).

95 plex and a major regulator for silencing VSG expression sites (ESs).

96 gene at a time from 1 of about 20 telomeric expression sites (ESs).

97 d in one of 15 telomeric regions termed "VSG expression sites" (ESs), each of which contains a polyci

98 onserved domains, which are identical to the expression site flanking domains.

99 ombination of msp2 pseudogenes into the msp2 expression site, followed by sequential segmental gene c

100 s surface antigen variation by acting as the expression site for a family of genes encoding isoforms

101 These variations in structure of an expression site for a major, immunoprotective outer memb

102 We define here a genomic expression site for MSP2(P44) in A. phagocytophilum.

103 hen the vsp33 expression site was active, an expression site for other variable proteins was silent.

104 The genomic expression site for this mRNA is polymorphic and encodes

105 ale and defined the structure of the genomic expression site for this transcript.

106 appear to have been the acquisition of novel expression sites for developmental genes, with its accom

107 examples of potential uses, we report novel expression sites for four potential therapeutic targets-

108 on of whole pseudogenes into the single msp2 expression site has been previously identified as one me

109 The 80 kb preceding the expression site has few, if any, functional ORFs, but co

110 lso analyzed the variability of this genomic expression site in Oklahoma strain A. marginale transmit

111 he structure and diversity of the MSP2 (P44) expression site in strains derived from the United State

112 locus encoding major outer membrane protein expression sites in both Anaplasma marginale and Anaplas

113 e at many, or even any, of a gene's specific expression sites in homozygous null mutant embryos.

114 ut not in some areas that are among the main expression sites in rodents, such as the brain areas whe

115 -trimester fetus, but has a limited range of expression sites in the adult.

116 erted into the mafF locus revealed prominent expression sites in the gut, lung, liver, outflow tract

117 Such interstrain diversity at the vlhA expression site, including major differences in the pred

118 milies colocalize within the same subnuclear expression site, indicating that the role that nuclear a

119 in A. marginale, the msp2(p44) gene in this expression site is polymorphic in all populations of org

120 The results show that a syntenic expression site is present in all strains of A. phagocyt

121 dynamics, we reveal that the transcribed VSG expression site is the only telomeric site that is early

122 In this study, we show that the same expression site is utilized in stages of A. marginale in

123 The alternative to this expression site model is that mRNAs acquire the UCS by R

124 elements were applied to the analysis of the expression site of relapse serotypes from 60 infected mi

125 Variation in the tandem repeats in the expression site of the human-derived Pneumocystis carini

126 1 closely reports most of the body and brain expression sites of the Satb1 chromatin remodeling gene

127 This supports the hypothesis that the expression sites of these important immunogenic proteins

128 The vlsE expression sites of these two strains have not been isol

129 ariation through gene conversion of a unique expression site on a linear plasmid by an archived varia

130 The second set of elements flanks the expression site on the 3' side and occurs at variable di

131 th a single targeting vector into permissive expression sites on all autosomes.

132 ant effect of locus position relative to the expression site or origin of replication.

133 f VSG expression, called the bloodstream VSG expression site, or recombination reactions that move si

134 nking sequences tightly align and anchor the expression site sequence to the pseudogene.

135 gene expression sites, but not in the active expression site, suggesting a role for J in regulating t

136 , regulation of MSG expression uses a single expression site, termed the upstream conserved sequence

137 form variant surface glycoprotein (VSG) gene expression site that appears truncated and degenerate.

138 laborate, plasmid-encoded system involves an expression site that can acquire either variable large p

139 nit area of extracellular matrix protein low expression sites, the size of these regions was enlarged

140 of silent msp2 alleles into a single active expression site to encode unique Msp2 variants.

141 rom multiple alleles are recombined into the expression site to generate a novel msp2 mosaic not repr

142 ogenes can be recombined into the functional expression site to generate new antigenic variants.

143 sistence is segmental gene conversion of the expression site to link hypervariable msp2 sequences to

144 from a completely sequenced U.S. strain) and expression site variants infecting sheep and dogs in Nor

145 invariance of the pseudogenes, indicate that expression site variation is generated using gene conver

146 possesses 15 silent vls cassettes and a vls expression site (vlsE) encoding a surface-exposed lipopr

147 B31 consists of 15 silent cassettes and one expression site (vlsE), and the presence of the encoding

148 vel of transcription and that when the vsp33 expression site was active, an expression site for other

149 nation between this reservoir and its single expression site was predicted to result in lineages of M

150 origin of sequences recombined into the msp2 expression site, we demonstrated that the complexity of

151 e transcribed from polycistronic bloodstream expression sites with promoters which are located 45-60