ライフサイエンスコーパス: exquisite

1 The exquisite ability of primates to grasp and manipulate ob

2 Our work underscores the exquisite ability of viral domains to uncover new regula

3 CANCE STATEMENT The vertebrate retina has an exquisite ability to adjust information processing to ev

4 ochemical and structural data that reveal an exquisite activation mechanism of SAMHD1 via combined ac

5 under different oxygen conditions, providing exquisite adaptation to different conditions encountered

6 a calcium-dependent mechanism suggesting an exquisite adaptation to their natural substrate in the c

7 hese conformers hybridize to each other with exquisite affinity, sequence selectivity, and level of o

8 ied the molecular mechanisms underlying this exquisite alignment at the C. elegans inhibitory synapse

9 yields of the corresponding sialosides with exquisite alpha-selectivity.

10 other regulatory proteins, illustrating the exquisite and complex regulation of these molecular mach

11 al that Atm deficiency is associated with an exquisite and genotype-specific sensitivity against PARP

12 Taken together, our results reveal an exquisite and highly specific mechanism by which Srs2 re

13 ls (CAR T cells), these entities combine the exquisite antigen specificity of antibodies with the pol

14 The exquisite architecture of cortex incorporates a myriad o

15 the developing neural tissue demonstrate an exquisite balance between proliferation and differentiat

16 filaments surface and that ComP displays an exquisite binding preference for DNA uptake sequence.

17 a wide range of human disorders due to their exquisite binding specificity and high binding affinity.

18 d C-terminal modifications that preserve the exquisite biological activity of acid 1 and offer the op

19 Soft-tissue fossils capture exquisite biological detail and provide our clearest vie

20 xploiting the blood coagulation system as an exquisite biological sensor, the fibrin clot end-product

21 Inspired by biology, exquisite biomolecular nanoarchitectures have been forme

22 We showed that these exquisite biosensors report on changes in cholesterol re

23 que biophysical fingerprint characterized by exquisite Ca(2+) selectivity, store-operated gating, and

24 This is the result of exquisite catalyst controlled regioselectivity enabling

25 Using an exquisite cell imaging approach based on DNA nanosensors

26 onfer unique regulatory functions, including exquisite cell- and tissue-specific expression and the c

27 The exquisite cell-type specificity of global lncRNA express

28 This highlights the exquisite cell/tissue-specific actions of the ERalpha su

29 n or mismetallation, suggesting the need for exquisite cellular control of Mn-dependent metabolic pro

30 Loss of BOD1L confers exquisite cellular sensitivity to replication stress and

31 ding the enzymes largely responsible for the exquisite chemodiversity of more than 80000 terpenoid na

32 Purpose Owing to its exquisite chemotherapy sensitivity, most patients with m

33 The exquisite codon-by-codon translational modulation uncove

34 arch mechanism is yet another example of the exquisite coevolution of lambda with its host.

35 a rare combination of attributes: They have exquisite coherence properties, they can be prepared and

36 en left- and right-handed helices, while the exquisite conformational sensitivity of the helical rela

37 Thus, the exquisite connectivity of ChCs not only mediates directi

38 The exquisite control afforded by microfluidics can be used

39 Here we employ the exquisite control afforded by state-of-the-art supercond

40 The exquisite control afforded by the DNA origami technology

41 delocalization of the iminium charge lead to exquisite control in the regulation of chromophoric abso

42 Such exquisite control is clearly demonstrated through in sit

43 Productive biomolecular recognition requires exquisite control of affinity and specificity.

44 , DAH7PS and CM from M. tuberculosis provide exquisite control of aromatic amino acid biosynthesis, n

45 r allosteric step, this mechanism allows for exquisite control of eEF-2K output.

46 Cardiogenesis in mammals requires exquisite control of gene expression and faulty regulati

47 The exquisite control of growth factor function by heparan s

48 In spite of its long-standing importance, exquisite control of hydrogen bonding in molecule-based

49 the activities of other ion channels lead to exquisite control of intracellular ion concentrations in

50 tly regulated processes, nature demonstrates exquisite control of light-matter interactions at variou

51 orming methyltransferases and highlights the exquisite control of product formation by active site re

52 ographic characterization and theory enables exquisite control of superstructure in highly ordered po

53 Exquisite control of the chain folding in PSCs allows us

54 ellular components can ensure economical and exquisite control of the ECF sigma factor protein level

55 Our system provides exquisite control of the level, timing, and cell-type sp

56 nd Pd(II) single sites on zeolite Y, with an exquisite control of the Lewis acidity, to catalyze diff

57 emonstrating that the INPACT system provides exquisite control of transgene expression and can be ada

58 Site-selective reactions require exquisite control over both chemo- and regioselectivity,

59 hough it is not known how cells maintain the exquisite control over caspase activity in order to reta

60 iments in Rydberg atomic gases have achieved exquisite control over non-local interactions, allowing

61 oswitch uses an unusual mechanism to harness exquisite control over queuosine metabolism.

62 Yet, this exquisite control over selectivity comes at an operation

63 mplex type of material, nanocomposites, with exquisite control over structural and chemical parameter

64 The hydrogel allows exquisite control over the chemical and physical in vitr

65 xial growth in an alcoholic solvent, we show exquisite control over the dimensions and dispersity of

66 stimuli-responsive materials design enables exquisite control over the locations of responsive sites

67 in the Ogston sieving regime do not require exquisite control over the microstructure to maximize th

68 High selectivity and exquisite control over the outcome of reactions entice c

69 el-free single-molecule analysis but require exquisite control over the physical arrangement of metal

70 trapping 'tags' for downstream modification, exquisite control over the site of subsequent modificati

71 and promises new opportunities for achieving exquisite control over the surface chemistry and propert

72 ly available methodologies arguably lack the exquisite control required for producing metal-organic f

73 Epstein-Barr virus (EBV) has evolved exquisite controls over its host cells, human B lymphocy

74 DNA double-strand breaks (DSBs) involves the exquisite coordination of multiple signaling and repair

75 abolic and cell signaling events that enable exquisite crosstalk and cooperation between competing su

76 tforward preparation, stoichiometric use and exquisite cysteine selectivity of the carbonylacrylic re

77 Exactly how the exquisite cytoarchitecture and underlying circuitry beco

78 Similar exquisite degree of control at the individual polymeric

79 acterized by reduced SIRT6 expression and an exquisite dependence on Lin28b for tumor growth.

80 educes cellular UBB levels and results in an exquisite dependence on ubiquitin C (UBC), the second po

81 The exquisite dependency on CRAF kinase in KRAS mutant tumor

82 tissue characterization ability and provides exquisite detail about myocardial structure and composit

83 xities of cell biology have been analyzed in exquisite detail and much is known about how these organ

84 al. (2017) offer new insights by mapping in exquisite detail chromatin accessibility dynamics as mou

85 surement of phenotypic outcomes to match the exquisite detail emerging at the molecular level.

86 power of language derives not only from the exquisite detail of the signal itself but also from its

87 llular behaviour can now be characterised in exquisite detail using live single-cell imaging experime

88 sing of rotatory optic flow is understood in exquisite detail, how they process translatory optic flo

89 s we describe the immune system in ever more exquisite detail, we might find that no matter how succe

90 binding and the hydrogen bonding network in exquisite detail.

91 ng one to observe the population dynamics in exquisite detail.

92 acterize these neurons' upstream circuits in exquisite detail.

93 Together with the exquisite detection sensitivity observed, the contributi

94 pole-Orbitrap high-resolution instrument for exquisite detection specificity.

95 expensive primer design method that provides exquisite discrimination between SNPs.

96 MIP can be performed with exquisite disease control and without significant effect

97 substrate scope under mild conditions and an exquisite divergence in site selectivity that can be eas

98 Proton therapy generates even more exquisite dose distribution in some patients, thus poten

99 ly and even within the same family, exhibits exquisite drug specificity.

100 Topological insulators give rise to exquisite electronic properties because of their spin-mo

101 nction, and biochemically relevant for their exquisite enzymatic cyclization mechanism.

102 displaced to the bladder wall, represents an exquisite example of morphogenetic apoptosis, requiring

103 One of the most exquisite examples of membrane remodeling is myelination

104 In particular, the exquisite Fe/Co system displays tuneable optical and mag

105 ion in neural circuits, which often requires exquisite fine-tuning of inhibitory connections.

106 scrimination among very similar analytes and exquisite fingerprinting of extremely similar mixtures o

107 Although exquisite fossil and geological records provide insight

108 and no protection from obesity but retained exquisite hepatic insulin sensitivity.

109 in a morphological mutant reveal some of the exquisite hydraulic engineering necessary to create the

110 ide chain and polar side chains that provide exquisite hydrogen bonding recognition.

111 Analogue 33 possesses exquisite in vitro RBP4 binding affinity and favorable d

112 These findings highlight the exquisite in vivo specificity of organellar targeting me

113 kely a major contributor responsible for the exquisite inhibitor selectivity.

114 pecific stable isotope tracers has permitted exquisite insight into amino acid, fatty-acid and carboh

115 conventional procedures and give access and exquisite insight into on-surface tetrapyrrole chemistry

116 Although the exquisite interplay between metal ions and protein scaff

117 k-Starling law and the Anrep effect describe exquisite intrinsic mechanisms the heart has for autoreg

118 Exploiting the exquisite intrinsic optical absorption contrast of circu

119 The exquisite isoform selectivity of lynx1 interactions prov

120 cellent mTOR kinase inhibitory potency, with exquisite kinase selectivity over the related lipid kina

121 Compound 5 potently binds to RIP1 with exquisite kinase specificity and has excellent activity

122 These studies demonstrate an exquisite level of control of scaffold bioactivity by re

123 nd a full-length monoclonal antibody with an exquisite level of control over the site of conjugation.

124 Our results define an exquisite level of precision in the reader-writer interp

125 o multicellular organisms and are subject to exquisite levels of control.

126 With the realization that bacteria achieve exquisite levels of spatiotemporal organization has come

127 d within nanoscale environments that exhibit exquisite levels of specificity to particular molecules.

128 GLIC, however, does not possess the same exquisite lipid sensitivity.

129 Exactin shows exquisite macromolecular specificity to FX activation as

130 s human host for over 50 000 years and is an exquisite manipulator of the human immune response.

131 The findings identify an exquisite mechanism of metered secretory output that pre

132 t also present a new tool to investigate the exquisite mechanism of PPIs.

133 it is unclear why the bacterium has evolved exquisite mechanisms to avoid host immunity.

134 Cells have evolved exquisite mechanisms to fine-tune the rate of protein sy

135 her survival and remarkable recovery to both exquisite medical critical care and support she received

136 1,000 odorant receptor genes, reflecting an exquisite mode of gene regulation.

137 Primary immunodeficiencies (PIDs) represent exquisite models for studying mechanisms of human host d

138 FM combines exquisite molecular discrimination capacities with high

139 itude of polymeric macromolecules capable of exquisite molecular recognition.

140 ile and widely applicable method that allows exquisite N-terminal specific modification of proteins.

141 The exquisite nanoscale shape control of this inherently bio

142 The exquisite NMR spectral sensitivity and negligible reacti

143 Their exquisite NPC-typical sorting selectivity and strong int

144 f biological photosynthesis results from the exquisite organization of photoactive elements that prom

145 key protein constituents responsible for the exquisite organization of the calcium phosphate crystals

146 On clinical examination, exquisite pain was generated by simple light pressure ov

147 the molecular mechanisms that can govern the exquisite peptide specificity characteristic of TCR reco

148 The exquisite periodicity of their firing has led to the sug

149 n, we describe a novel strategy that enabled exquisite point mutation discrimination with isothermal

150 The resulting transcriptomes paint an exquisite portrait of human lactation.

151 g blood vessel morphogenesis that highlights exquisite post-translational regulation of mVEGFR1 in it

152 Compound 8 has exquisite potency at PDE4B, good selectivity over PDE4D,

153 This work demonstrates the exquisite power of combining cell-type-specific perturba

154 cks with responses that can be tailored with exquisite precision by varying size, geometry, and the i

155 signed to target specific DNA sequences with exquisite precision in vitro; yet, the biological outcom

156 plexity in GTPase signaling patterns enables exquisite precision over the control of cellular process

157 and manipulating this heterogeneity with an exquisite precision previously reserved only for physica

158 Flagellar tracking with exquisite precision reveals waveform changes that result

159 A (dsDNA) mechanics have been dissected with exquisite precision, much less is known about dsRNA.

160 NMR residual dipolar couplings (RDCs) are exquisite probes of protein structure and dynamics.

161 Despite their exquisite programmability, DNA-based walkers are challen

162 Although nanoparticles with exquisite properties have been synthesized for a variety

163 ic subunit of V-ATPase with high potency and exquisite proteomic selectivity as revealed by fluoresce

164 Lysosomal cathepsins regulate an exquisite range of biological functions, and their dereg

165 unique class of mesoionic dipoles displaying exquisite reactivity towards both copper-catalyzed and s

166 Recent studies in mammalian brain reveal an exquisite refinement of KCh subcellular localization.

167 ronically unbiased alkene substrates exhibit exquisite regio- and diastereoselectivity for the title

168 h no easily observable recognition motif and exquisite regioselectivity.

169 While the exquisite regulation of lncRNA transcription can provide

170 indings highlight the physiological need for exquisite regulation of neutral lipid storage within adi

171 utnumber eventual COs, this process requires exquisite regulation to narrow down the pool of DSB inte

172 er the decades, many studies have shown that exquisite regulatory mechanisms at multiple levels contr

173 er the decades, many studies have shown that exquisite regulatory mechanisms at multiple levels contr

174 produce and structurally manipulate, exhibit exquisite SARs, are nontoxic, and elicit improved and qu

175 , biorecognition ligands that are capable of exquisite selective binding, and seamless integration at

176 ng Michael adducts in a couple of hours with exquisite selectivities (up to 98% ee).

177 a next-generation RIP2 inhibitor possessing exquisite selectivity and potency.

178 vity filter is critical for both endowing an exquisite selectivity for potassium ions, as well as for

179 cause the proton concentration is minuscule, exquisite selectivity for protons over other ions is cri

180 operativity with acetylcholine, and retained exquisite selectivity for the M1 mAChR.

181 e) promotes a high-affinity interaction with exquisite selectivity for this sequence.

182 l membrane channels with high efficiency and exquisite selectivity for transporting ions and molecule

183 This molecule displays potent activity, an exquisite selectivity for Vps34 with excellent propertie

184 To discover the principles underlying the exquisite selectivity LuxN has for its ligand, we identi

185 Here, we reveal the structural basis for the exquisite selectivity of CENP-N for centromeres.

186 from binding to convertases and explain the exquisite selectivity of eculizumab for human C5 and how

187 terogeneous labeling and cannot approach the exquisite selectivity of enzymatic reactions.

188 For MMA, there exhibits an exquisite selectivity of the NHC structure for the three

189 The exquisite selectivity of this catalyst system is evident

190 hydroxyls to polar side chains explains the exquisite selectivity of VLRB.aGPA.23.

191 ionally simple method is characterized by an exquisite selectivity profile that is dictated by the li

192 ophiles that are sequentially activated with exquisite selectivity under mild reaction conditions.

193 Exquisite selectivity was observed despite several compe

194 Our data highlight the exquisite selectivity with which members of the KRAB-ZFP

195 between agonist and endogenous ligands with exquisite selectivity, and show extraordinary sensitivit

196 he oxidized form of its target proteins with exquisite selectivity, compared with their reduced count

197 ll differentiation and activation, requiring exquisite sensitivity and discrimination.

198 The exquisite sensitivity and frequency discrimination of ma

199 o the cochlear amplifier, which provides the exquisite sensitivity and frequency selectivity of the m

200 Medical diagnostic assays provide exquisite sensitivity and precision in the diagnoses of

201 e-independent growth, demonstrating Helios's exquisite sensitivity and specificity.

202 o1 responds to lateral membrane tension with exquisite sensitivity as compared to other mechanically

203 n this same reductionist tradition but offer exquisite sensitivity in space and time along with the a

204 Our findings demonstrate the exquisite sensitivity of delayed rectifier Kv1 channels

205 The exquisite sensitivity of mitotic cancer cells to ionizin

206 The defining example is the exquisite sensitivity of multiple myeloma (MM) to 20S pr

207 The exquisite sensitivity of neurons at each processing stag

208 to inaccuracies in energy functions, is the exquisite sensitivity of protein-ligand interactions to

209 Taken together, our data uncover the exquisite sensitivity of regenerative cardiomyocyte prol

210 ing cells and mouse models, the authors show exquisite sensitivity of SCLC to transcriptional inhibit

211 These studies highlight the exquisite sensitivity of the cellular response to low-le

212 The sharp frequency tuning and exquisite sensitivity of the mammalian cochlea is due to

213 of an active process that might underlie the exquisite sensitivity of the sacculus to mechanical stim

214 We demonstrate exquisite sensitivity of the striatum to IFN-alpha, impl

215 We document exquisite sensitivity of Vgamma9Vdelta2 T cells, which r

216 bacilli DNA input material, having shown its exquisite sensitivity over a conventional gel based read

217 ymodal nociceptor that responds to heat with exquisite sensitivity through an unknown mechanism.

218 er and manifested as cardiac fibrosis and an exquisite sensitivity to alcohol, leading to sudden arrh

219 lonic (YAMC) epithelial cells demonstrate an exquisite sensitivity to both toxins with phenotypes tha

220 ue clinicopathologic features and an initial exquisite sensitivity to chemotherapy with purine analog

221 ay have a critical role in the endothelium's exquisite sensitivity to complex shear stress frequency

222 The results reveal an exquisite sensitivity to diameter and substantially larg

223 ut the molecular mechanisms underlying their exquisite sensitivity to different forces within the mem

224 egulator of mTOR, suggesting a mechanism for exquisite sensitivity to everolimus.

225 drogen-depleted media, LNCaP-AI cells showed exquisite sensitivity to growth inhibition by subnanomol

226 Finally, myosin-1b, which demonstrates exquisite sensitivity to mechanical load, exhibited dyna

227 dvantages for metabolite analysis, including exquisite sensitivity, high speed and reproducibility, a

228 vidual cellular metabolite profiles with its exquisite sensitivity, large dynamic range, and ability

229 Our sense of hearing boasts exquisite sensitivity, precise frequency discrimination,

230 ction together to mediate thermosensation of exquisite sensitivity.

231 hanical and mechanoelectric conversions with exquisite sensitivity.

232 plex model of host-symbiont interaction with exquisite sensitivity.

233 Macrophages are exquisite sensors of tissue homeostasis that can rapidly

234 neural signal transduction and must maintain exquisite signal fidelity while also accommodating the p

235 us of movements (tics) and high performance (exquisite singing).

236 s is the pairing of powerful reactivity with exquisite site selectivity.

237 The simplicity and exquisite site-selectivity of the aza-Michael ligation d

238 f pressure and denaturant concentration with exquisite site-specific resolution.

239 insight into protein folding reactions with exquisite site-specific temporal information.

240 red synthesis of metal-ICO heterodimers with exquisite size, shape, and composition control, facilita

241 Iteratively executed with exquisite spatial and temporal control, the selective is

242 developments show how MAPK pathways perform exquisite spatial and temporal signal processing and und

243 is endowed by unique features, including an exquisite spatial nonlocality.

244 ct this to be one of many examples where the exquisite spatial organization of the eukaryotic cell en

245 With exquisite spatial selectivity and capability for depth p

246 oom body modulate synaptic transmission with exquisite spatial specificity, allowing individual neuro

247 ted by excitatory inputs and in turn provide exquisite spatiotemporal control over GC activity.

248 temporally specific manner and thereby exert exquisite spatiotemporal control over its protein bindin

249 production and cell entry and emphasize the exquisite spatiotemporal regulation governing adenovirus

250 three-dimensional imaging, thereby providing exquisite spatiotemporal resolutions of the order of 10-

251 Microribonucleic acids (miRNAs) work with exquisite specificity and are able to distinguish a targ

252 titative characterization demonstrated their exquisite specificity and high affinity, and they perfor

253 is-Phe-Arg-Trp-Asp-Arg-Phe-Gly-OH), with its exquisite specificity and potency, has recently created

254 stry, biology, and medicine because of their exquisite specificity and sustained duration of inhibiti

255 a CD4(dim) CD8(+) phenotype, both exhibiting exquisite specificity for conserved epitopes of JCV larg

256 he ubiquitin-conjugating enzyme Ube2R1/2 has exquisite specificity for Lys 48, and computational dock

257 eferred TCRalphabeta pairing that determined exquisite specificity for the D(b)PA224 epitope from inf

258 rk of kinase-substrate interactions provides exquisite specificity in cell signaling pathways, but al

259 As therapeutics, they combine the exquisite specificity of antibodies, enabling discrimina

260 How the exquisite specificity of high-avidity T cells is achieve

261 ts provide a mechanistic explanation for the exquisite specificity of Hydractinia allorecognition.

262 members, single-molecule analysis reveals an exquisite specificity of interactions between cavin1, ca

263 and provide a molecular explanation for the exquisite specificity of PA function.

264 ched the question by taking advantage of the exquisite specificity of T and B lymphocytes and combine

265 However, as a result of this exquisite specificity, it is blind to changes that may b

266 dually bind different basic amino acids with exquisite specificity.

267 ing, with both classes of enzymes displaying exquisite specificity.

268 ght chain into presynaptic compartments with exquisite specificity.

269 sine peptides, which may contribute to their exquisite specificity.

270 he substrate-binding centre to achieve their exquisite specificity.

271 nts at the allylic position shown to provide exquisite stereocontrol (generally 98-99% chirality tran

272 lylic alcohols, deliver syn-dichlorides with exquisite stereocontrol.

273 shielded by organic ligands possessing both exquisite structural aesthetics and intriguing propertie

274 these full-length NS1 structures provide an exquisite structural sampling of various conformational

275 s in solution due to a desire to emulate the exquisite structure and function of Nature's equivalents

276 ar images of picrosirius stained skin reveal exquisite structure, allowing changes in the basketweave

277 d to prokaryotic cell biology, revealing the exquisite subcellular organization of bacterial cells.

278 The exquisite substrate specificity of Dus enzymes is theref

279 re domains of the protein, thereby providing exquisite substrate specificity.

280 P reveal a tight interaction that depends on exquisite surface shape and charge complementarity betwe

281 MX2, and TRIM25, which may contribute to the exquisite susceptibility of these cells to SIV infection

282 Taking the exquisite synthesis techniques in oxide electronics into

283 amorphous, microporous organic polymers with exquisite synthetic control over the optical gap in the

284 These data demonstrate exquisite targeting of distinct commensal bacteria by mu

285 ew form of targeted immunotherapy merges the exquisite targeting specificity of monoclonal antibodies

286 offer the promise of controlled release with exquisite temporal and spatial resolution.

287 hways at specific subcellular locations with exquisite temporal control.

288 cells and tissues, and its execution demands exquisite temporal coordination of functionally diverse

289 Such networks work together with exquisite temporal precision to generate each action pot

290 Tissue clearing methods promise to provide exquisite three-dimensional imaging information; however

291 In addition to their exquisite tumor homing capabilities, MSCs overexpress ef

292 m for multiple cancer types combined with an exquisite tumor specificity opens a new door to widespre

293 que advancement in BiTE technology given its exquisite tumor specificity, which enables precise elimi

294 Here, however, we report exquisite tumor type specificity for different histone H

295 ds as a promising approach to harnessing the exquisite tumor-targeting properties of antibodies for n

296 rticles are versatile materials that provide exquisite, tunable control over the sequestration and de

297 f the groups would open up possibilities for exquisite tuning of the siting and performance of subseq

298 Here, by developing an exquisite ultra-sensitive NGS (USNGS) platform "EasyMF"

299 Herpesviruses have evolved exquisite virus-host interactions that co-opt or evade a

300 ances marking fluorescent HSPCs have allowed exquisite visualization of HSPCs in the caudal hematopoi