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1 ng the polypeptide chains of Tmods and Lmods exquisitely adapt their functions for capping versus nuc
3 of whiskers, as well as their movements, are exquisitely adapted for tactile exploration in the dark
4 causative agent of tuberculosis (TB), is an exquisitely adapted human pathogen capable of surviving
5 resident chondrocytes in human cartilage are exquisitely adapted to hypoxia and use it to regulate ti
8 selectively binds c-di-AMP and discriminates exquisitely against other cyclic dinucleotides, such as
9 eral roots, and the CnAIP2 gene promoter was exquisitely auxin sensitive; and (3) CnAIP2 promoted the
12 ate granule cells (DGCs), which is regulated exquisitely by brain activity, renders the hippocampus p
15 t of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative transcriptional p
16 ulature the largest organ system, it is also exquisitely complex, with single muscles existing in dif
17 ments suggests that substrate recognition is exquisitely conserved among eukaryotic UGMs and distinct
18 e-like crystallites and show archeopyles and exquisitely constructed opercula, demonstrating the dino
19 proteins (MPs) embedded in lipid bilayers to exquisitely control communications across the insulating
21 , the firing dynamics of hippocampal PCs are exquisitely controlled at subcellular and microcircuit l
23 ntial for immunity, their generation must be exquisitely controlled because a class-switched B cell c
24 mes with designer geometry: all of which are exquisitely controlled by a set of modular, reconfigurab
25 the mechanical response to dynamic shear are exquisitely controlled by the relative concentrations of
29 gy, a platform within which reactions can be exquisitely controlled, has made the development of arti
35 s endure and proliferate during infection by exquisitely coping with the many stresses imposed by the
37 lesions on which different myeloma subtypes exquisitely depend, and by informative preclinical model
38 viruses and suggests that miRNA function is exquisitely dependent not only on viral genomic context
42 e, demonstrating that increased activity was exquisitely dependent on physiologic levels of Oct-1.
44 scuous use of the available Gi/o proteins is exquisitely dependent on sequences within the H3C and su
45 NF90(+/-) mice showed that HS4 activity was exquisitely dependent on the levels of endogenous NF45 (
46 id tumors carrying BRAF(V600E) mutations are exquisitely dependent on the oncoprotein for viability a
47 ure B cells, mature anti-insulin B cells are exquisitely dependent upon BTK, because their numbers ar
50 In contrast, TRIM21 antiviral activity was exquisitely dependent upon off-rate, with sub-muM affini
51 dues found derivatized, and their reactivity exquisitely depends on the direction of the azido moiety
52 Emerging data from these efforts offers an exquisitely detailed picture of disease-relevant neural
53 ditions, fibrin-alpha2-PI1-8-VEGF164 allowed exquisitely dose-dependent angiogenesis: concentrations
55 f the order Chlamydiales comprise a group of exquisitely evolved parasites of eukaryotic hosts that e
60 hioredoxin-interacting protein (TXNIP) is an exquisitely glucose-sensitive gene that is overexpressed
61 s telomeric single-stranded DNA (ssDNA) with exquisitely high affinity to coordinate telomere mainten
63 g from the retina to the brain that exhibits exquisitely high sensitivity to high spatial frequency p
64 es, but also because they represent the most exquisitely investigated examples of highly correlated e
66 as BQCA offer an attractive solution, being exquisitely M1-selective over other muscarinic subtypes.
67 r machinery for solar energy conversion that exquisitely manages photon capture and conversion proces
70 function of human regulatory regions depends exquisitely on their local genomic environment and on ce
71 ulobacter cell cycle control system has been exquisitely optimized as a total system for robust opera
72 ptive field maps of the olfactory system are exquisitely organized and respond dynamically to cues in
73 ourishment and communication, as well as the exquisitely organized bone extracellular matrix, also de
76 reconcile an obligate aerobic lifestyle with exquisitely oxygen-sensitive processes, A. vinelandii is
81 lieu and chromatin environment, allowing for exquisitely precise spatiotemporal control of gene expre
82 spite extensive serial passaging and display exquisitely precise, cell-autonomous commitment to epith
86 ing p53 C-terminal modification renders mice exquisitely radiosensitive due to defects in HSC/progeni
89 utes the major barrier to a cure for AIDS is exquisitely redox sensitive and could be selectively tar
90 tein kinases encoded in the human genome are exquisitely regulated and their aberrant function(s) are
93 rticular interest that Ca(v)3.2 channels are exquisitely regulated by G protein-coupled receptors and
95 tenin/Wnt signaling in early development are exquisitely regulated by stage-dependent mechanisms.
96 ver, excess iron is toxic, and its uptake is exquisitely regulated by the ferric uptake regulator, Fu
97 es suggest that individual Pol III genes are exquisitely regulated by transcription and epigenetic fa
100 llular triglyceride (TG) stores requires the exquisitely regulated interaction of lipolytic enzymes w
102 ermeability of the endothelial barrier is an exquisitely regulated process in the resting state and i
104 uter medullary potassium (ROMK) channels are exquisitely regulated to adjust renal potassium excretio
107 that LTB(4) is a signal-relay molecule that exquisitely regulates neutrophil chemotaxis to formyl pe
108 rial respiratory chain by MCJ in macrophages exquisitely regulates the response of macrophages to inf
109 ndings underscore the critical importance of exquisitely regulating epithelial plasticity in developm
111 evidence suggests that cancer stem cells are exquisitely resistant to conventional therapy and are th
114 shed, and the electrical conductance becomes exquisitely responsive to the structure of the surface a
115 xamination, magnetic resonance imaging (MRI) exquisitely reveals soft tissue changes such as muscle e
116 ula syndrome, which is a clinical diagnosis, exquisitely reveals soft tissue changes such as muscle e
117 strate that 4-phenylquinolin-2(1H)-one is an exquisitely selective Akt inhibitor with a distinctive m
119 clic molecules that has led to SAR156497, an exquisitely selective Aurora A, B, and C inhibitor with
121 54 pseudogene lncRNAs, several of which show exquisitely selective expression in response to specific
123 We show using competitive-ABPP that ABLs are exquisitely selective for PME-1 in living cells and mice
125 The most potent compounds in the series were exquisitely selective for T. brucei over a panel of othe
126 nlinear responses to whole faces, and can be exquisitely selective for very specific parts of faces s
127 1b), a small cystine knot protein that shows exquisitely selective inhibition of insect V-ATPases.
128 inhibitors examined in an initial study, an exquisitely selective inhibitor for a poorly characteriz
129 -specific polymer conjugation resulted in an exquisitely selective Kv1.3 antagonist (>1000x over Kv1.
130 ray crystallographic studies, we identify an exquisitely selective PDK1 inhibitor (compound 7) that u
134 tals to bear on phononic crystals, providing exquisitely sensitive (near quantum-limited), optical me
135 eak intensity changes and show that they are exquisitely sensitive and can provide detailed insights
138 force microscopy (EFM) method to develop an exquisitely sensitive dual-resonance-frequency-enhanced
139 controlled luciferase expression detected by exquisitely sensitive EM-CCD imaging, to enable simultan
141 hanical oscillators and may form the core of exquisitely sensitive force and displacement detectors.
143 pendence of ovarian cancer TICs renders them exquisitely sensitive in vivo to agents that induce iron
144 cal electronic structure of the proton is an exquisitely sensitive indicator of the limiting state in
146 rster resonance energy transfer (FRET) is an exquisitely sensitive method for detection of molecular
147 ortant physiological oxidant H(2)O(2) in the exquisitely sensitive oxyR mutant bacteria is based not
148 rostatic forces, this reaction represents an exquisitely sensitive probe of these effects in protein-
150 resulted in remarkable adaptations enabling exquisitely sensitive sound detection by the ear and sop
153 t self-tolerant T cell repertoire, but it is exquisitely sensitive to a range of insults during the t
155 Dn (Ts) mouse model of Down syndrome (DS) is exquisitely sensitive to an infantile spasms phenotype i
157 ally active metarhodopsin II conformation is exquisitely sensitive to bilayer hydrophobic thickness.
158 ervations suggest that endothelial cells are exquisitely sensitive to both magnitude and spatial grad
160 Cardiorespiratory functions in mammals are exquisitely sensitive to changes in arterial O(2) levels
161 TP-sensitive potassium (K(ATP)) channels are exquisitely sensitive to changes in cellular energy meta
162 nitude of the current, which makes the cells exquisitely sensitive to changes in intracellular pH.
163 ioles in the peripheral microcirculation are exquisitely sensitive to changes in PO2 in their environ
164 from the intestinal epithelium renders mice exquisitely sensitive to chemically induced colon carcin
166 ancement or inhibition of efferocytosis, was exquisitely sensitive to concentration effects of these
168 n stage V gametocytes, rendering these cells exquisitely sensitive to decreases in NADPH concentratio
169 ression of a cell-cell coupling protein were exquisitely sensitive to differences in the substratum n
170 cts of Rac2 deficiency and MLL-AF9 cells are exquisitely sensitive to direct inhibition of Bcl-2 fami
172 ing within the endoplasmic reticulum (ER) is exquisitely sensitive to energy supply and amino acid so
177 neoplasms, chronic myeloid leukemia (CML) is exquisitely sensitive to graft-versus-leukemia (GVL) bec
180 arotid bodies of AMPK-knockout mice remained exquisitely sensitive to hypoxia, contrary to the view t
187 t the intensity of templated mutation can be exquisitely sensitive to its local sequence, that the do
188 nicotinic acetylcholine receptor (nAChR) is exquisitely sensitive to its membrane environment, the u
190 T5BN642H-expressing CD8+ T cells, which were exquisitely sensitive to JAK and Aurora kinase inhibitor
193 ation enhancement (PRE), a technique that is exquisitely sensitive to lowly populated states in the f
196 atients with TT genotype at rs116855232 were exquisitely sensitive to MP, with an average dose intens
198 termed TA1, retained the V3 truncation, was exquisitely sensitive to neutralization by the CD4 bindi
199 ltiple hepatitis C virus (HCV) genotypes are exquisitely sensitive to oxidative membrane damage, a pr
200 n that these synergy-dependent integrins are exquisitely sensitive to perturbations in the Fn integri
201 compositionally distinct lipid assemblies is exquisitely sensitive to plasma membrane phosphatidylser
207 inase 5 (ERK5), a protein kinase known to be exquisitely sensitive to redox stress, through a signali
212 Our data suggest that the hypothalamus is exquisitely sensitive to small decrements in systemic gl
214 ese results suggest that reassortment is not exquisitely sensitive to stochastic effects associated w
218 forms, Na(V)1.1, 1.2, 1.3, 1.6, and 1.7, are exquisitely sensitive to tetrodotoxin (TTX), and a funct
219 ations that impair DAF-12 ligand binding are exquisitely sensitive to the absence of lin-42, whereas
220 amily member ratio by acidosis renders cells exquisitely sensitive to the Bcl-2/Bcl-xL antagonist ABT
222 ility of a compact RNA tertiary structure is exquisitely sensitive to the concentrations and types of
223 th depletion of the NFARs in the thymus were exquisitely sensitive to the cytoplasmic replicating vir
224 Earth shows that the nonbiological world is exquisitely sensitive to the direct effects of temperatu
225 hermore, AML1-ETO-expressing cell lines were exquisitely sensitive to the effects of corticosteroids
226 at NF-kappaB activation mediated by LUBAC is exquisitely sensitive to the expression level of UBE2L3.
227 ow that the mechanical profile of biofilm is exquisitely sensitive to the expression of different sur
228 d within the actin-binding cleft and is thus exquisitely sensitive to the global orientation and rota
229 (PGONs) showed that curvature generation is exquisitely sensitive to the guanidinium group spacing w
231 cating that dendrite size and complexity are exquisitely sensitive to the level of endogenous GDF5 sy
232 ave spectroscopic (PWS) microscopy, which is exquisitely sensitive to the nanoarchitectural manifesta
234 ding site surrounding this C5 substituent is exquisitely sensitive to the presence (Et > H, 10-fold),
235 relaxation enhancement, a technique that is exquisitely sensitive to the presence of minor species,
236 esults illustrate how splicing modulation is exquisitely sensitive to the sequence context of 3' spli
238 esults indicate that Ag43 gene expression is exquisitely sensitive to the status of the Sec machinery
239 t the transcriptional response in neurons is exquisitely sensitive to the temporal nature of action p
240 ytes isolated from horses, a species that is exquisitely sensitive to the TLR4 ligand, LPS, and that
241 ssile lifestyle means that plants have to be exquisitely sensitive to their environment, integrating
242 t to a particular microscale trajectory, are exquisitely sensitive to their microenvironment, and off
244 igand-, and H(+)-gated cationic channels are exquisitely sensitive to transient fluctuations in pH el
246 entire animal, the pancreatic beta-cells are exquisitely sensitive to VAD-associated apoptosis compar
247 As an example, a single organoid culture was exquisitely sensitive to Wnt secretion (porcupine) inhib
249 y on antibody-based platforms that, although exquisitely sensitive, are slow and costly to generate a
250 odel system, to show that this technology is exquisitely sensitive, capable of differentiating as lit
252 germline stem cells (GSCs) are maintained by exquisitely short-range BMP signalling from the niche.
253 tein, we generate with high yield and purity exquisitely site specific and selective bio-conjugates o
254 etworks of activators and repressors lead to exquisitely specific cell-type determination during deve
255 ters together produce the highly dynamic and exquisitely specific expression patterns of the two gene
259 the CD4-lineage-specific c-Krox (Th-POK), is exquisitely specific to CD1d-restricted NKT cells and hu
261 many natural ligands, antibodies are stable, exquisitely specific, and are unaffected by the regulato
263 and that the transcriptome of thymic MCs is exquisitely suited for interactions with epithelial and
266 ariant natural killer T (iNKT) cells and are exquisitely susceptible to Epstein-Barr virus (EBV) infe
267 rated that IFN-alphabetagammaR(-/-) mice are exquisitely susceptible to liver infection following cor
269 ocytes, the myelin-forming cells of the CNS, exquisitely tailor the thickness of individual myelin sh
270 V-1 and its simian counterpart SIV have been exquisitely tailored by evolution to evade host immunity
272 offering alluring opportunities to generate exquisitely tailored materials with unparalleled control
273 nt hormones are specialized metabolites with exquisitely tailored perception and signaling systems, b
274 ape enables their resulting properties to be exquisitely tailored, which has led to the use of these
277 for malaria parasites within the mosquito is exquisitely temperature-sensitive, so that temperature i
283 complex and dynamic process orchestrated by exquisitely timed cell lineage commitment, divisions, mi
285 trate that DNA as a building block offers an exquisitely tunable means to engineer a potentially rich
286 d using DNA-programmable assembly, unveiling exquisitely tunable optical properties that are predicte
289 criptional regulatory site on DNA by BirA is exquisitely tuned by the equilibrium constant governing
293 CT-projecting cells are ultrasparse firing, exquisitely tuned to orientation and direction informati
294 NK receptors are key components of a system exquisitely tuned to sense any dysregulation in MHC clas
295 that dynamics in dihydrofolate reductase are exquisitely "tuned" for every intermediate in the cataly
297 ly unaffected, and why the immature brain is exquisitely vulnerable, whereas the mature brain seems r
298 e about protein cores; they are hydrophobic, exquisitely well packed, and nearly all hydrogen bonds a
299 ain and the peroxide substrate and how it is exquisitely well suited to stabilize the transition stat
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