ライフサイエンスコーパス: extensive

1 y when the number of samples to be tested is extensive.

2 ucanase, whereupon microfibril labelling was extensive.

3 nd the expression of target genes undergoing extensive 3'UTR editing.

4 pattern of brain reorganization may be more extensive [3].

5 proteins, we found Golgi mislocalization and extensive aberrant dendrite formation.

6 ogical opportunity, may facilitate rapid and extensive adaptive radiation.

7 1a-Cre(ERTM);LSL-Kras(G12D) mice formed more extensive ADM than Ptf1a-Cre(ERTM);LSL-Kras(G12D);Klf5(f

8 s Northern India/Myanmar, having experienced extensive admixture that reshuffled the ancestral Tibeto

9 asal area) on tree mortality patterns, using extensive aerial mortality surveys conducted throughout

10 ulations of Drosophila melanogaster We found extensive allelic heterogeneity, with a sample of seven

11 This fine-grain mapping uncovered extensive allelic interactions within enhancers that hav

12 Noting that DMV neurons display extensive alpha-synucleinopathies earlier than SN dopami

13 oordination of internal exons is found to be extensive among protein coding genes: 23.5%-59.3% (95% c

14 Extensive analyses of TCGA data demonstrate that our met

15 To our knowledge, this is the most extensive analysis of primary renal epithelial cells fro

16 aggressive nature of KRAS-mutated CRLM, more extensive anatomical hepatectomies may be warranted.

17 ment has been changed accordingly, with more extensive and detailed guidance regarding decision makin

18 While an extensive and heterogeneous set of computational tools i

19 ieties, linked to large-scale deforestation, extensive and intensive agriculture, resource mining, li

20 ten-used 50 mM ammonium chloride causes more extensive and persistent changes, including membrane dep

21 uencies of somatic hypermutation, suggesting extensive and serial rounds of clonal expansion and sele

22 atic nerves from mice of either sex triggers extensive and unexpected Schwann cell elongation and bra

23 hat the last glaciation of South Georgia was extensive, and the sensitivity of its glaciers to climat

24 Despite the extensive animal studies on how amblyopia emerges, we kn

25 oader definition of markables, connection to extensive annotation of several domain-relevant semantic

26 re, the multispecificity of the VSTs ensures extensive antiviral coverage, which facilitates the trea

27 ggers prominent G1 cell-cycle arrest without extensive apoptosis.

28 HERS from the crown, associated with a more extensive area of proliferation of the neighboring root

29 Extensive areas of AES were found in the right ventricle

30 lled flow in the regenerated capillaries and extensive arteriolar-venular shunting.

31 of human impacts on natural systems and the extensive associated health effects across nearly every

32 Progerin causes extensive atherosclerosis and cardiac electrophysiologic

33 Importantly, mutational analyses revealed extensive auto-inhibitory mechanisms that prevent free F

34 produce highly oxygenated intermediates via extensive autooxidation of hydroperoxyalkylperoxy radica

35 ting accounts by testing the hypothesis that extensive behavioral training alters the neural mechanis

36 Extensive benchmarking experiments based on both five-fo

37 r type 1 diabetes, but success is limited by extensive beta-cell death in the immediate posttransplan

38 We found extensive binding of PPARalpha near genes involved in gl

39 ding on 3' UTRs and coding exons followed by extensive binding to other genic and non-genic sites.

40 capabilities of YcaO proteins to conduct an extensive bioinformatic survey to classify known YcaO ch

41 Tropical savannas are a globally extensive biome prone to rapid vegetation change in resp

42 The extensive biophysical and topological diversity of membr

43 Despite this extensive body of research, many basic epidemiologic que

44 A recurring finding in this extensive body of work is that stimulus information is d

45 ption factors and that SRC-2 loss results in extensive cardiac transcriptional remodeling.

46 c vertebrae before giving rise to a long and extensive cauda equina.

47 ed in significantly enhanced tumor necrosis, extensive CD4 T cell accumulation, and high levels of th

48 Here we report on the extensive changes in distribution of mRNAs in the cell b

49 progression and genome stability and display extensive changes in genome organization.

50 species by biomass relative to baseline, but extensive changes in recruitment distribution.

51 tmosphere over the last 30,000 y that led to extensive changes in subseafloor carbon storage that for

52 Extensive characterization has not revealed any differen

53 Here we report the most extensive characterization of the molecular pharmacology

54 re, we present the solution-phase synthesis, extensive characterization, and conformational analysis

55 Results of extensive characterizations, extensions to 2D and 3D tra

56 Extensive chemical processing ensures allergen-free poll

57 st that distinct H1 subtypes may mediate the extensive chromatin remodeling occurring during epigenet

58 rature, ongoing natural history studies, and extensive clinical experience.

59 Consistent with this possibility, extensive coarse-grained molecular dynamics simulations

60 We isolated an extensive collection of antibodies that were differentia

61 eed with this work, in which we report on an extensive comparative evaluation of several tools.

62 We undertook an extensive computational analysis using a unique and comp

63 in recent years, driven in large part by its extensive connections with various regions of the cerebr

64 Cohort samples had extensive copy-number alterations and highly recurrent s

65 between different plants, they are prone to extensive cross-reactivity among allergen pollen extract

66 All antigens 5 showed extensive cross-reactivity in sIgE analyses, inhibition

67 tazoan signalling networks are complex, with extensive crosstalk between pathways.

68 Proteus mirabilis forms extensive crystalline biofilms on indwelling urethral ca

69 for the first time substantial evidence for extensive Cu metallurgy already during these early cultu

70 Recent improvements include extensive curation of additional reference sequences and

71 tors include secreted toxins responsible for extensive damage to host tissues and evasion of the immu

72 We used extensive data from a long-term study of great tits (Par

73 ted biological and environmental samples and extensive data on potential breast cancer risk factors.

74 Our extensive data resources include evidence-based gene and

75 by employing Machine Learning methods on an extensive data set of proprietary bioactivity data combi

76 Extensive data suggest that TRF2 in shelterin remodels t

77 e Harderian gland tumor experiment, the only extensive data-set for dose response modelling with a va

78 Tropical rainforests are subject to extensive degradation by commercial selective logging.

79 , Py-GC/FID, Py-GC/MS and SEM imaging reveal extensive degradation of the wood polymers during the ei

80 production that requires CD63 and provide an extensive demonstration of CD63-mediated exosomal LMP1 r

81 phology, reduced dendritic arborization, and extensive dendritic varicosities in the cortical neurons

82 There is extensive depletion of Mycobacterium tuberculosis-specif

83 g differing durations of juvenile phase, and extensive deposition of wall ingrowths was observed in r

84 Despite the extensive description of numerous molecular changes asso

85 c lesions in human and mouse lungs, we found extensive desialylation of glycoconjugates, and upregula

86 . moieties could be significantly reduced by extensive dialysis.

87 e extensive disease versus no change or less extensive disease for POM; and worse prognosis versus no

88 for osseous metastasis for IS and FOM; more extensive disease versus no change or less extensive dis

89 ods Patients with confirmed SCLC (limited or extensive disease) and performance status 0 to 3 were ra

90 Cells with extensive DNA damage should die and not grow into malign

91 are deficient in DNA repair correlating with extensive DNA processing, but this defect in srs2Delta m

92 Extensive DNA sequence data have made it possible to rec

93 is downregulated during puberty, a period of extensive ductal outgrowth and branching.

94 al/intermetallic interfaces accounts for the extensive ductility observed.

95 Extensive dysregulation of chromatin-modifying genes in

96 eting and control of enhancer activity cause extensive dysregulation of gene expression.

97 Ethanol has extensive effects on sleep and daytime alertness, causin

98 Despite extensive efforts, structural data for PR photointermedi

99 though generic, many-body states have large, extensive entropy, ground states of reasonable local Ham

100 of the regional stress fields, which show an extensive environment.

101 sessment of symptoms, can be started without extensive evaluation.

102 Despite extensive evidence demonstrating the beneficial effects

103 The finding of extensive evidence of genome-wide mediation effects sugg

104 Extensive evidence supports the clinical value of noninv

105 Considering its extensive evolutionary conservation, our results suggest

106 Extensive ex vivo analysis was performed via RNA analysi

107 expansion of the facial midline, cleft lip, extensive exencephaly, and microphthalmia or anophthalmi

108 ddition, the recommendations include our own extensive experience in the management of these patients

109 Despite extensive experimental and computational efforts to unde

110 Through extensive experimental studies on both simulation datase

111 Extensive experimental validation showed that AtRTD2 and

112 Extensive experiments on synthetic and real-world networ

113 n Im9 (referred to as H1, H2, H3, and H4) by extensive explicit-water molecular dynamics simulations

114 es within the parasite cytosol and labels an extensive F-actin network that connects parasites within

115 e forest recovery dynamics could bring about extensive forest loss, with associated effects on biodiv

116 Extensive functional analysis showed that intrinsic cell

117 Despite the extensive functional characterization, the molecular mec

118 re derived from a much smaller virus through extensive gain of host genes.

119 Here, we performed an extensive gene expression analysis in ER+ breast cancer

120 ected to domesticated rice by continuous and extensive gene flow.

121 that intracellular gene transfer may lead to extensive gene reshuffling and increased diversity.The c

122 n histamine H3 receptor (hH3R) is subject to extensive gene splicing that gives rise to a large numbe

123 The extensive generation of fragment ions in AI-ETD+ substan

124 Here, we identify extensive genome-wide modification of sites bearing the

125 We report extensive, global loss of c-Fos and Arc/Arg3.1 immunorea

126 on of lactate from glucose (Warburg effect), extensive glutamine utilization and impaired mitochondri

127 cells, even during a period coincident with extensive hemoglobin degradation by the parasite.

128 the population, individual neurons displayed extensive heterogeneity in the dynamics of responses to

129 wing concern, the mechanisms underlying this extensive HGT remain poorly understood.

130 of developing cities, with an emphasis on an extensive, high-resolution analysis of the urban areas o

131 ein evolution or balancing selection, but by extensive hitchhiking of linked variants on the mimetic

132 characterisation of PSC activation has been extensive, however one aspect that has been overlooked i

133 This study reveals, for the first time, the extensive human protein interactome of arenavirus nucleo

134 Using extensive in silico analyses and comparison to cytometry

135 Flow loss was more extensive in the temporal and nasal parafoveal subfields

136 inetics and pharmacodynamics and is based on extensive in vitro and in vivo data.

137 development candidate was selected for which extensive in vitro and in vivo profiling is reported.

138 large effective population sizes, leading to extensive incomplete lineage sorting (ILS).

139 and their associated wave functions provide extensive information for predicting the physics of quan

140 small excitatory centers, combined with very extensive inhibitory surrounds that reduce their sensiti

141 Our experiments reveal the extensive integration of signals concerning the light en

142 al intramural gas, portomesenteric vein gas, extensive intraperitoneal gas and intraabdominal free fl

143 Nanoparticles (NPs) have undergone extensive investigation as drug delivery and targeting v

144 such as Creb, GABA B R and Ip3k, indicating extensive involvement of DNA methylation in honeybee olf

145 Leveraging the extensive knowledge of yeast transcriptional regulation,

146 An extensive lipidomic screen of choline derivatives showed

147 An extensive literature has evaluated the prevalence, predi

148 Despite there being an extensive literature on the topic, the acoustic features

149 o use the PCC approach as a framework for an extensive literature review evaluating the current statu

150 h the incorporation of all lung segments and extensive lobar and segmental pulmonary artery reconstru

151 Our data demonstrates that extensive long-term culture-induced MSC aging impaired t

152 These tracer injections also revealed extensive longitudinal projections throughout the rostro

153 analyzed viral gp120 sequences obtained from extensive longitudinal sampling of multiple tissues and

154 s disease (HD) is typically characterized by extensive loss of striatal neurons and the midlife onset

155 zed by exacerbated inflammatory response and extensive lung pathology.

156 PHIP had extensive lymphocytosis marked by massive expansion of n

157 ement, half under medium and one-fifth under extensive management.

158 ites, and a smooth, ventral girdle flanks an extensive mantle cavity.

159 Despite extensive mechanistic and functional studies on both reg

160 this represents the current end-point of an extensive medicinal chemistry endeavor that spans almost

161 findings also connect insulin resistance to extensive metabolic cross-talk between the liver, adipos

162 te that the phenotype of TIH involves a more extensive metabolic derangement than previously recogniz

163 Despite an extensive microscopy and radiography network at middle l

164 ced inflammation, sinusoidal congestion, and extensive midzonal hepatocyte death in control mice, whi

165 high-resolution fibre-FISH and conclude that extensive molecular analysis is required to fully unders

166 and BRI1-associated kinase 1 (BAK1), through extensive molecular dynamics simulations of their fully

167 ance and stereoselectivity were explained by extensive molecular modeling (MM) and molecular dynamics

168 Here, we perform extensive molecular simulations in an enhanced sampling

169 econd phase, no differentiation occurs while extensive morphogenesis, including splanchnic mesoderm s

170 ive control, chromatin remodeling as well as extensive morphological alterations.

171 by Smarcal1 into reversed forks, triggering extensive Mre11-dependent nascent DNA degradation.

172 ad smaller myocardial salvage index and more extensive MVO than non-QW despite treatment within 12 ho

173 aging frequently demonstrated longitudinally extensive myelitic lesions.

174 es NMOSD from other causes of longitudinally extensive myelopathies but not from MS.

175 values were highest for Central Karoo, Semi-extensive, Namibia and Hantam Karoo, while Ruens and Fee

176 predicted human isoform interactome reveals extensive network remodeling by alternative splicing.

177 Mitochondria form extensive networks constantly remodeled by fission and f

178 Traumatic brain injury (TBI) causes extensive neural damage, often resulting in long-term co

179 al cortex develop inclusions associated with extensive neuronal loss.

180 Here, we analyse an extensive new database of alien birds to explore what de

181 haracterized by highly polymorphic loci with extensive nucleotide diversity, copy number variation of

182 Using extensive numerical simulations and theoretical analyses

183 Our extensive omics analyses provide a high-quality resource

184 We found no improvement in EFS with more extensive or serial resections.

185 which were biochemically validated, show an extensive overlap of regulatory circuitry between cell t

186 Using an extensive palynological dataset, that has been statistic

187 However, tropical mountain peatlands contain extensive peat soils that have yet to be mapped or inclu

188 Through extensive performance evaluation based on biological net

189 s to show that the S672R mutation results in extensive perturbations of the dynamics in both apo- and

190 uired for natural selection, and enables the extensive phenotypic diversity that is frequently observ

191 ratory by means of nucleotide sequencing and extensive phylogenetic analyses of a 400-nucleotide regi

192 Although extensive physicochemical characterization of targeting

193 500 elections, and a separate data set with extensive polling data from 146 election rounds.

194 orescence intensity, carbonyl formation, and extensive polymerization of myosin.

195 ranges from a few differences (Allotropa) to extensive population divergences (Monotropa, Hypopitys),

196 verage grain size of 140 nm, as confirmed by extensive post-impact microscopy analyses.

197 d peptide secondary metabolites that undergo extensive posttranslational modification.

198 contrast, perceptual learning often requires extensive practice within a day for performance to impro

199 analysis and economic evaluation, we applied extensive primary cost and patient event data from the X

200 uspected in only 1 patient who had undergone extensive prior laser treatments.

201 Extensive prior research focused on somatic copy-number

202 his enhanced signal quality and capacity for extensive probe multiplexing permits quantitative analys

203 ed screening in human cells thus provides an extensive proteome-wide map of protein ligandability and

204 Twelve patients with extensive pure DCIS were included as a representation of

205 l analyses based on 20 individuals following extensive quality control.

206 We have also performed an extensive quantitative proteomics analysis to compare th

207 ce fundus spectral sections by leveraging an extensive range of discrete monochromatic light sources

208 gh fusion of six ancestral chromosomes, with extensive rearrangement among neighboring regions.

209 that converts to a conjugated polymer via an extensive rearrangement of the macromolecular structure

210 The rfMRI has revealed extensive reductions of VMHC associated with ALS in brai

211 ds millennial-scale AIS dynamics across this extensive region.

212 Thus, while previous studies have described extensive regulation by nuclear Esrp1 to promote epithel

213 Picornavirus replication is known to cause extensive remodeling of Golgi and endoplasmic reticulum

214 However, most tumour types express extensive repertoires of NRs, whose interactions provide

215 Although extensive research endeavors are pursued to target ideal

216 f flexible graphene monolayers has triggered extensive research interest for the development of III-V

217 Extensive research over the past two decades has establi

218 Despite extensive research, the learning-related role of place c

219 Despite extensive research, the mechanisms that subtend the mann

220 Despite decades of extensive research, the spatio-mechanical processes of d

221 ition and culture remain contentious despite extensive research.

222 ial homologous recombination (HR) posit that extensive resection of a DNA double-strand break (DSB) b

223 Extensive results comparing miRvial and six existing mic

224 treat only short distances before they reach extensive retrograde slopes.

225 However, consistent with the extensive rewiring of Esrp-dependent splicing programs b

226 tiary structures, but another displayed more extensive rigid-body shifts as well as dramatic secondar

227 ABSTRACT: Extensive rodent studies have shown that reduced perinat

228 ging data indicate that polysaccharides play extensive roles in host-gut microbiota symbiosis beyond

229 the absence of intensive purification and/or extensive rounds of design optimization.

230 o NO2(-) in conjunction with ischemia led to extensive S-nitrosation of protein thiols across all cel

231 the need for expensive labelling methods or extensive sample pre-treatment.

232 tro and in vivo with the advantage of a less extensive sample pretreatment.

233 od or tissue from PrEP Participant A despite extensive sampling from ileum, rectum, lymph nodes, bone

234 Results show that extensive sampling of force spectra, facilitated by robo

235 Despite extensive sampling we found no relatives of the totiviru

236 We found that extensive SCIN ablation results in exacerbated social in

237 nce of cancer was higher in patients who had extensive screening than in those who had more limited s

238 letion of the synthesis without the need for extensive screening.

239 male canaries (Serinus canaria), which show extensive seasonal vocal plasticity as adults.

240 Viral IRES, in general, contain extensive secondary structure that is critical for activ

241 However, these approaches typically demand extensive sectioning and reconstruction for a brain samp

242 This perspective provides an extensive set of slurry solvents, hardware designs, and

243 Notably, GI tract clones display extensive sharing of sequence variants among different p

244 fulness of this approach is demonstrated via extensive simulation studies using real genotype data an

245 stently improved prediction accuracy in both extensive simulations and real data.

246 rker LD mapping and the SKAT_C, we performed extensive simulations under various scenarios.

247 We have carried out an extensive site-directed mutagenesis analysis of the CD16

248 Extensive site-directed mutagenesis studies supported th

249 Extensive smAFM and SMD data both indicate the distincti

250 competed in germinal centers (GC), underwent extensive somatic hypermutation, and differentiated into

251 The IUCN Red List is the most extensive source of conservation status assessments for

252 , IFN-gamma, TNF-alpha, CXCL1, and CCL2) and extensive splenic damage with dramatic reduction of sple

253 We observe extensive splicing diversity leading to the formation of

254 Here, we study Esrp genes, which regulate extensive splicing programs and are essential for mammal

255 s of genetic group animal models and provide extensive, step-by-step tutorials that demonstrate how t

256 Here, an overview of the extensive strategies which have been developed to improv

257 al adenocarcinoma (PDAC) is characterized by extensive stroma and pathogenic modifications to the per

258 Structure-based vaccine design depends on extensive structural analyses of antigen-antibody comple

259 This work constitutes the most extensive structural characterization of a viral lncRNA

260 ural information on chemokine receptors with extensive structure-activity relationship and site-direc

261 Specifically, extensive structure-activity relationships (SARs) invest

262 Extensive structure-activity studies led to the discover

263 Extensive studies have shown that CME proteins actively

264 Despite extensive studies on APOBEC proteins, questions regardin

265 Here we conduct an extensive study analysing a broad spectrum of RNA-seq wo

266 dominant retinal dystrophy, characterised by extensive sub-retinal pigment epithelium (RPE) deposits,

267 This paves an expressway to extensive subclonal diversification, elevated intratumor

268 Extensive subnational differences in patient pathways to

269 We show via an extensive survey of GhSWEET transcriptional responsivene

270 ot with either T3 or Dex alone, developed an extensive T-tubule network.

271 We found extensive TCR clonotype sharing in Ag-activated cells, e

272 ons, yet the functional significance of this extensive thalamocortical connectivity remains largely u

273 the progenitor ecotropic MLV genome are more extensive than previously appreciated, covering 100% of

274 Bastin et al infer forest as more globally extensive than previously estimated using tree cover dat

275 hat transfer by these mechanisms may be more extensive than previously thought, in terms of the range

276 es from the 2016 drought are more severe and extensive than the 2005 and 2010 droughts.

277 Despite extensive theoretical and laboratory studies, this 'crit

278 brightness, selection apparently resulted in extensive thickening of the carotenoid-laden barb cortex

279 cularly to study non-model organisms, is the extensive time required to produce a high-quality GENRE.

280 apoptosis is delayed, neutrophils can cause extensive tissue damage and chronic disease.

281 This study highlights the surprising and extensive transcriptional control GATA4 exercises over s

282 several RNA-binding proteins, which implies extensive translational regulatory networks.

283 the southern Hikurangi subduction interface; extensive uplift along much of the coastline; and widesp

284 nhibited by a 3' to 5' pathway that requires extensive uridylation of mRNA decay intermediates.

285 st to animals, plants apparently do not make extensive use of cyclic-nucleotide-based signalling.

286 The extensive use of fluconazole (FLC) and other azole drugs

287 Despite the extensive use of Saccharomyces cerevisiae as a platform

288 Despite the extensive use of zebrafish as a model organism in develo

289 Despite the extensive utility of these tools, locus-specific deliver

290 was assessed using several instruments with extensive validity evidence, including the Nontechnical

291 The results reveal extensive variation in the amount of DNA gained via line

292 n of GMP to normal microvessels, all without extensive vascular killing.

293 issemination, dysregulated immune responses, extensive virus- and host-mediated tissue damage, and di

294 since mutating N58 to alanine (N58A) caused extensive virus-induced cell fusion.

295 his conclusion, the abundance of PP TCs with extensive wall ingrowths varied across rosette developme

296 e is highly prevalent and that reuse is more extensive when the length threshold for identifying a th

297 e birth of new hypomethylated regions and by extensive widening of hypomethylated intervals in ancest

298 Despite extensive work carried out on this celebrated molecule s

299 y dynamic regions of the ocean, and they are extensive worldwide, especially in the western North Pac

300 acilitates DSB repair and which is framed by extensive ZMYND8 domains on the flanking chromatin.