ライフサイエンスコーパス: extracellular

1 calculated from simultaneous measurements of extracellular acidification and oxygen consumption.

2 The extracellular, active 180 amino acid Nogo-A region, name

3 matory cytokine of the IL-1 family, has both extracellular and intracellular functions.

4 l CyCs identified, CyC 17 exhibited the best extracellular antitubercular activity (MIC50 = 500 nM).

5 and investigated its tissue distribution and extracellular assembly by immunohistochemistry and immun

6 We previously described the accumulation of extracellular ATP /AMP during chemotherapy-induced apopt

7 2Y2 nucleotide receptor (P2Y2R) activated by extracellular ATP and UTP molecules released following i

8 We examined whether extracellular ATP impacts the stability of JAZ1 in Arabi

9 also known as DORN1), have demonstrated that extracellular ATP is a signal involved in plant stress r

10 Taken together, these results suggest that extracellular ATP signaling directly impacts the JA sign

11 enotype, we demonstrate its dependency on an extracellular bacterium housed in specialized organs con

12 oteins by CP, and molecular insight into the extracellular battle for metal nutrients that occurs dur

13 Nrp1) was recently identified as an aberrant extracellular binding partner of mutant GlyRS.

14 ytoskeleton at the leading edge of cells and extracellular Ca(2+) entry is essential for this reorgan

15 We showed that ICWs were initiated by an extracellular calcium influx across the cell membrane ne

16 Removal of extracellular calcium, or chelation of intracellular cal

17 responses requires the continued presence of extracellular calcium.

18 level by reintroducing Flower or by raising extracellular calcium.

19 Ester hydrolysis by extracellular carboxylesterases is considered the rate-l

20 d (TRAIL) and by visualizing and quantifying extracellular changes in endothelial cell layer integrit

21 by further observations that replacement of extracellular Cl(-) with gluconate(-) diminishes the inw

22 During development, extracellular cues guiding cell fate determination are p

23 ing, and telomere capping can be impacted by extracellular cues in a fashion independent of telomeras

24 f receptors that can be activated by several extracellular cues, including antigen-immunoglobulin E (

25 n of NMDA EPSCs, which was rescued by adding extracellular D-serine.

26 urthermore, HSPGs do not act by transporting extracellular diffusible ligands or require leukocyte an

27 Extracellular DNA (eDNA) has been identified in the matr

28 Colocalization of H3Cit with extracellular DNA released from neutrophils confirmed th

29 architecture through ionic interactions with extracellular DNA.

30 tions "mark" different regions in the Notch1 extracellular domain for activation or inhibition.

31 oton release complex (PRC), a complex in the extracellular domain of bacteriorhodopsin where an exces

32 We also found that the extracellular domain of IL1RAPL1 is required for this ef

33 crystal structure of the isolated N-terminal extracellular domain of the GLP-1R in complex with exend

34 tion of original cysteine pairs in the CSF3R extracellular domain resulted in either gain- or loss-of

35 and cornichon 3, are located not only in the extracellular domains but also in the lipid-accessible s

36 It is not clear why so many extracellular domains need to be evolved through natural

37 annexinA2 as a potential interactor with the extracellular domains of PLA2R.

38 The lack of EFhd2 reduced extracellular dopamine levels in the brain, but enhanced

39 dministration of clozapine rapidly increased extracellular dopamine levels in the mPFC and improved a

40 ation can modulate cell-to-cell coupling via extracellular electric fields and depletion of local sod

41 dox-active antibiotics, which can be used as extracellular electron shuttles by resistant microbes.

42 While structures of several extracellular electron transfer proteins are known, an u

43 Extracellular electron-transfer mechanisms involved in t

44 Using extracellular electrophysiological recordings from anaes

45 tein interaction networks in a fully defined extracellular environment at a library-on-library scale.

46 Enamel crystals form de novo in a rich extracellular environment in a stage-dependent manner pr

47 Cells interact with the extracellular environment through molecules expressed on

48 lity that can explore mechanical cues in the extracellular environment.

49 mpaired substrate binding both in the ER and extracellular environments and reduced interactions with

50 eceptors, which survey the intracellular and extracellular environments for microbial products.

51 other cell types to actively regulate their extracellular environments for tissue maintenance and ad

52 any lineage of ECM fungi actively expresses extracellular enzymes in order to degrade SOM and transf

53 ells, which in turn mediates the decrease in extracellular ET-1 concentration.

54 cytoplasmic domains, as well as for the TARP extracellular EX2 loop.

55 Abeta was then exposed to the extracellular face of excised membranes, and transmembra

56 y of ion channels that evolved to respond to extracellular factors.

57 ier separates the circulating blood from the extracellular fluid in the central nervous system and th

58 may open and connect the cytoplasm with the extracellular fluid.

59 xperimental measurements of growth rates and extracellular fluxes from a set of perturbed reference s

60 ere two parameters, the fractional volume of extracellular free-water (FW) and cellular tissue FA (FA

61 The extracellular function, important for resistance to myco

62 T enables metabolism of otherwise neurotoxic extracellular Glu through a truncated tricarboxylic acid

63 gesting that EAAT3 internalization increases extracellular glutamate concentrations and activates Glu

64 Sxc contributes the majority of nonsynaptic extracellular glutamate in the NAc, while GLT-1 is respo

65 the capacity of metastatic cells to utilize extracellular glutamine, leading to cytosolic accumulati

66 freely or wrapped FKRP might circulate as an extracellular glycosyltransferase, able to exert a "glyc

67 We describe an extracellular GlyR alpha1 subunit mutation (Q177K) in a

68 erived growth factor receptor (PDGFR) senses extracellular growth factors and transfer the signals in

69 this previously unobserved conformation, the extracellular-half of the pore-lining M2 is splayed open

70 e findings support the pathogenic effects of extracellular histones in that pulmonary injury during i

71 nal SH-SY5Y cells release significantly less extracellular HSV-1 by 24 h postinfection (hpi), suggest

72 ting that K. mikimotoi cells were expressing extracellular hydrolases to hydrolyse ATP.

73 t interactions between the cell membrane and extracellular ice result in IIF.

74 hysically plausible consensus that the brain extracellular impedance is low and approximately resisti

75 ular tryptophan, and some Ct strains utilize extracellular indole to restore tryptophan levels.

76 Thus, we propose that HNF-1beta links extracellular inflammatory signals to mitochondrial dysf

77 However, how cells integrate extracellular information at the molecular level to regu

78 and teeth is tightly regulated by levels of extracellular inorganic phosphate (Pi) and pyrophosphate

79 es contributing to the alpha4:alpha4 subunit extracellular interface in nAChR potentiation.

80 ructure of GLIC shows R-ketamine bound to an extracellular intersubunit cavity.

81 nts showed activation of inward current when extracellular K(+) ([K(+) ]o ) was increased.

82 sting membrane potential at subphysiological extracellular K(+) concentrations or pathological hypoka

83 altered KCNQ ion selectivity, sensitivity to extracellular K(+), and pharmacology, consistent with an

84 cellular depolarization imposed by elevating extracellular [K(+)], and KCNQ2 was required for potenti

85 Extracellular lactate levels strongly correlated with T

86 We conclude that the use of extracellular lactate measurements can be a sensitive, s

87 be used as an NMR shift reagent for imaging extracellular lactate produced by cancer cells using CES

88 r potentiation depended on the source of the extracellular ligand binding domain of the subunit.

89 res Toll pathway components ranging from the extracellular ligand Spatzle to the Dif transcription fa

90 Succinate functions as an extracellular ligand through binding to its specific rec

91 SEC61G, yielding products lacking the entire extracellular ligand-binding domain of the receptor whil

92 ired immune receptors display near-identical extracellular ligand-binding regions but have intracellu

93 lagen, elastin) and lipids (e.g. foam cells, extracellular lipids) in the first 200 mum of the intima

94 Proteomic analysis of isolated extracellular lipoprotein particles revealed that apolip

95 ing kinetics may be due to a "lid" formed by extracellular loop 2 (EL2) at the entrance to the bindin

96 The second extracellular loop domain (E2) is primarily responsible

97 al role of arginine(172), located in the 2nd extracellular loop, in the action of decanoic acid but n

98 genesis approach to identify residues in the extracellular loops and transmembrane segments of hERG1

99 The structure and dynamics of the extracellular loops of OprH show distinct behaviors in d

100 ed a diversity of action by acting either on extracellular M. tb bacterial growth only, or both intra

101 entially associated with the host, including extracellular magnesium limitation, low pH, and the pres

102 d tumour growth, aberrant remodelling of the extracellular matrix (ECM) and increased local invasion

103 the effect of migrating cells on underlying extracellular matrix (ECM) and test possible therapeutic

104 sensing switches by sensing modifications in extracellular matrix (ECM) composition and mechanics.

105 Here, we observed that the extracellular matrix (ECM) constructed by AKAP12+ colon

106 mechanical stimuli such as stiffness of the extracellular matrix (ECM) contribute to MSC phenotype i

107 scales in wood, fungal hyphae with the dried extracellular matrix (ECM) from the fungus, and Ca oxala

108 ean vessel density and poorly differentiated extracellular matrix (ECM) in MDA-MB-231 tumors relative

109 emergence onto damaged or organized fibrous extracellular matrix (ECM) is a crucial precursor to col

110 s characterized by excessive accumulation of extracellular matrix (ECM) proteins.

111 The extracellular matrix (ECM) regulates cell migration and

112 Fibronectin (FN) is a critical regulator of extracellular matrix (ECM) remodeling through its availa

113 y act as a mechanotransduction signal in the extracellular matrix (ECM) to coordinate the cross-talk

114 but relatively little is known about how the extracellular matrix (ECM), and particularly the mechani

115 e cancer cells interact with the surrounding extracellular matrix (ECM), remodeling ECM fiber network

116 s can expose epithelial cells to the stromal extracellular matrix (ECM), which is distinct from the E

117 mbrane assemblies that connect a cell to its extracellular matrix (ECM).

118 ght to target the proteins that comprise the extracellular matrix (ECM).

119 ts and the interaction between cells and the extracellular matrix (ECM).

120 zation of elastin, indicating defects in the extracellular matrix (ECM).

121 ity, and the physical characteristics of the extracellular matrix (ECM).

122 tissues, adapts to mechanical strains in the extracellular matrix (ECM).

123 composition and explored PEG and islet-like extracellular matrix (Matrigel; MG) islet encapsulation

124 proteins required for interactions with the extracellular matrix and for proteolysis.

125 non-lymphoid tissue sites, maneuver through extracellular matrix and form lasting inflammatory micro

126 nic acid-binding proteoglycan present in the extracellular matrix and in ocular vitreous body.

127 The cellular organisation, extracellular matrix and microvascular network mimic hum

128 vbeta3, is activated through HSC adhesion to extracellular matrix and niche cells.

129 sis and cancer progression by processing the extracellular matrix and promoting angiogenesis.

130 Despite its relevant role in extracellular matrix biosynthesis, little is known about

131 Thus, binding to GAGs in the extracellular matrix can direct and regulate vaspin inte

132 revealed remodelling and degradation of core extracellular matrix components.

133 ocesses including inflammatory signaling and extracellular matrix composition.

134 ige differentiation marker and a decrease in extracellular matrix gene expression.

135 mulation of hyaluronic acid-a high molecular extracellular matrix glycosaminoglycan implicated in pla

136 ation and highlight fundamental roles of the extracellular matrix in cardiac repair.

137 ophils remodel and migrate on periostin-rich extracellular matrix in the asthmatic airway in an ADAM8

138 ammary clock is controlled by the periductal extracellular matrix in vivo, which contributes to a dam

139 development requires integrin-dependent cell-extracellular matrix interactions.

140 Tenascin-C is an extracellular matrix molecule that drives progression of

141 ng heterogeneous mechanical signaling in the extracellular matrix of developing and regenerating tiss

142 ns specifically recognized each other in the extracellular matrix of fibroblasts.

143 cant part of secreted vaspin is bound in the extracellular matrix on the cell surface.

144 ssociated proteomics analysis indicated that extracellular matrix organization, small molecule metabo

145 ay between tumour cells and their neoplastic extracellular matrix plays a decisive role in malignant

146 or parathyroid hormone 2 receptor (PTH2R) in extracellular matrix production in wounds.

147 Here, we identified the secreted extracellular matrix protein Del-1 as a component and re

148 used by mutations in FBN1, which encodes the extracellular matrix protein fibrillin-1.

149 served that proteolytic cleavage of the host extracellular matrix protein fibronectin by peritoneal c

150 e provide evidence that tenascin-C (TNC), an extracellular matrix protein prominent in malignant glio

151 phil adhesion and migration on periostin, an extracellular matrix protein upregulated in asthma by ty

152 We designed an approach to target an extracellular matrix protein, the fibronectin extra doma

153 oglycan functions as a receptor for multiple extracellular matrix proteins and its dysfunction leads

154 Fibrosis involves the production of extracellular matrix proteins in tissues and is often pr

155 nt HSCs to HSC myofibroblasts, which secrete extracellular matrix proteins responsible for the fibrot

156 oteomics from WS revealed an upregulation of extracellular matrix remodeling and focal adhesion proce

157 Micu2(-/-) mice had increased expression of extracellular matrix remodeling genes, while single-cell

158 inhibited the gene program for fibrosis and extracellular matrix remodeling, although deletion of Tg

159 othelial cells, with decreased expression of extracellular matrix remodeling-enzyme coding genes and

160 Collectively, our results indicate that PDAC extracellular matrix represents a nutrient reservoir for

161 aling pathways, as well as downregulation of extracellular matrix signaling pathways.

162 In response to extracellular matrix signalling, these cells undergo epi

163 ellular renal scaffold while maintaining the extracellular matrix structure and composition in terms

164 et tenascin C retention in connective tissue extracellular matrix suggests the rigidity laid down for

165 dense sheets of specialized, self-assembled extracellular matrix that surround most animal tissues (

166 atriptase, induces potent destruction of the extracellular matrix whilst displaying distinct efficien

167 , major components of connective tissues and extracellular matrix, are significantly and irreversibly

168 rough the synthesis of connective tissue and extracellular matrix, inducing local pancreatic fibrosis

169 e relationships between the pancreatic tumor extracellular matrix, the vasculature, the immune system

170 th activated mast cell supernatants produced extracellular matrix, which enhanced subsequent airway s

171 hoton-excited 3D printing technique produces extracellular matrix-based scaffolds with exceptional re

172 roblast differentiation into contractile and extracellular matrix-producing myofibroblasts.

173 ibers like collagen, all of which makeup the extracellular matrix.

174 crobial communities surrounded by a secreted extracellular matrix.

175 hor the intracellular keratin network to the extracellular matrix.

176 , surface-attached communities encased in an extracellular matrix.

177 A new study, however, demonstrates that an extracellular-matrix-based stiffness gradient in the Dro

178 s was rescued by addition of D-serine in the extracellular medium.

179 dy was to characterize the intracellular and extracellular metabolic profiles of four prostate cancer

180 all size, dense growth and frequent need for extracellular metabolism, microbes face persistent publi

181 We propose that gradients of extracellular metabolites act as tumor morphogens that i

182 this is proposed to limit the replication of extracellular microbes, but could also promote infection

183 Together our data fuels the view that the extracellular microenvironment regulates synaptic NMDAR

184 view the factors within the cellular and the extracellular microenvironment regulating oligodendrocyt

185 t, spongin, are primordial components of the extracellular microenvironment, and as a component of BM

186 negative pathogens secrete proteins into the extracellular milieu and/or host organisms.

187 no-sized vesicles actively released into the extracellular milieu that can harbor genomic, proteomic

188 culosis replication before escaping into the extracellular milieu.

189 en their practical, in-vitro application for extracellular monoamine neurotransmitters detection in l

190 Unexpectedly, the extracellular mouth of the ion pore remains closed, indi

191 ts of SMIT1 co-expression, in the absence of extracellular myo-inositol or other SMIT1 substrates, on

192 ntracellular surface of the beta1AR, but the extracellular N-terminus, which is a target for post-tra

193 , we demonstrate that mouse GBM cell-derived extracellular nanovesicles resembling exosomes from an H

194 tu and in vitro preparations based on paired extracellular nerve recordings and videography to identi

195 duced a slow-onset, long-lasting increase in extracellular nucleus accumbens DA, locomotion, and brai

196 An extracellular O2 concentration of approximately 0.007 mm

197 In extracellular ookinetes, sporozoites, and merozoites, My

198 he lamina terminalis (OVLT) sense changes in extracellular osmolarity and NaCl.

199 Oxidative stress, a state in which intra- or extracellular oxidant production outweighs the antioxida

200 reactive oxidative species (ROS) oxidation, extracellular oxidative metabolism (EXOMET), and inorgan

201 ntrol cases in all compartments studied (ie, extracellular [p = 0.001], cell body [p = 0.003], and ne

202 P has instrumental roles in the clearance of extracellular particles including apoptotic cells and pa

203 e 1 (Ripk1) increased both intracellular and extracellular PGRN protein levels by increasing the tran

204 Importantly, beta1 integrins containing an extracellular pH-sensitive pHluorin tag allow direct vis

205 However, the functional significance of extracellular phosphorylation of specific residues in th

206 T2 heterodimerization was still regulated by extracellular Pi levels.

207 ong 13 mutants screened, a mutant lacking an extracellular polysaccharide (EPS) locus consistently fa

208 from the positively charged Arg-1119 in the extracellular pore region in repeat III of CaV1.2.

209 One variant comprised the full extracellular portion of CD23, including the stalk and h

210 ytes with the NLRP3 inhibitor MCC950 or with extracellular potassium significantly reduced IL-1beta c

211 e potentials, we simultaneously recorded the extracellular potential of presynaptic thalamic cells an

212 g early regrowth, and negative regulation of extracellular proteases in late stage regeneration.

213 tory factors such as R-spondin 1 (Rspo1), an extracellular protein that enhances beta-catenin-depende

214 s the prominent characteristic of emphysema, extracellular proteinases, particularly those with elast

215 S aureus extracellular proteins targeted by human serum IgG4 were

216 ature suggesting expression and secretion of extracellular proteins, while mature RRCs express genes

217 electrogenic ion transport are regulated by extracellular purinergic signals that signal through G p

218 ses now promote the generation of intra- and extracellular reactive oxygen species (ROS).

219 eactive oxygen species, lower phosphorylated extracellular receptor kinase and phosphorylated AKT lev

220 eds light on the mechanism of selectivity in extracellular recognition of GPCRs by monoclonal antibod

221 sing this technology, we have made the first extracellular recordings of body-wall muscle electrophys

222 tical interaction, we have re-engineered the extracellular regions of beta, designated as beta-c1, fo

223 The stimulatory effect on extracellular regulated kinase (ERK1/2) was blocked by t

224 uxiliary protein, Nef, which is suspected of extracellular release by infected CD4+ T cells on protei

225 In this study, total extracellular RNA (exRNA) was isolated and sequenced fro

226 hod for the high-throughput determination of extracellular segments of transmembrane proteins based o

227 ensor perturbs the potassium affinity at the extracellular selectivity filter by more than three orde

228 The mechanisms that control extracellular serotonin levels in vivo are not well-defi

229 ttling and reveal that proton binding to the extracellular side of the transporter facilitates a reor

230 ed protein kinase C (PKC) in the cytosol and extracellular signal regulated kinase (ERK) in the cytos

231 Here we address this question for extracellular signal regulated kinase (Erk) signaling, a

232 reased phosphorylation level of both Src and extracellular signal regulated kinase proteins and with

233 cardiovascular disease, is known to activate extracellular signal regulated kinases 1 and 2 (ERK1/2).

234 Evidence demonstrates that extracellular signal-regulated kinase (ERK 1/2) activati

235 ositide 3-kinase (PI3Kgamma) plays a role in extracellular signal-regulated kinase (ERK) activation f

236 Although deregulation of MEK/extracellular signal-regulated kinase (ERK) activity is

237 by combined treatment with rapamycin and an extracellular signal-regulated kinase (ERK) inhibitor.

238 integrin-mediated phosphorylation of Src and extracellular signal-regulated kinase (ERK).

239 U50,488H-induced activation of extracellular signal-regulated kinase 1/2 (ERK1/2) was G

240 C cells and resulted in potent inhibition of extracellular signal-regulated kinase 1/2 activation.

241 hosphates) in some signaling events, such as extracellular signal-regulated kinase 1/2 and label free

242 Strategies to inhibit extracellular signal-regulated kinase 1/2, ribosomal S6

243 nib and the mitogen-activated protein kinase/extracellular signal-regulated kinase inhibitor selumeti

244 6 on both MEK-ERK (mitogen-activated protein/extracellular signal-regulated kinase kinase-extracellul

245 extracellular signal-regulated kinase kinase-extracellular signal-regulated kinase) and S6K-RPS6 (rib

246 of K-Ras effectors, including phosphorylated extracellular signal-regulated kinase, phosphorylated pr

247 (JNK), the Axl receptor tyrosine kinase and extracellular signal-regulated kinases (ERK).

248 d cyst epithelial cell proliferation through extracellular signal-related kinase/MAPK inactivation.

249 e (NAD(+)) participates in intracellular and extracellular signaling events unrelated to metabolism.

250 Adenosine, a key extracellular signaling mediator, regulates several aspe

251 The effects of soluble extracellular signals on these cellular functions are fa

252 Subsequently, self-generated extracellular signals provide morphological cues that re

253 les responsible for receiving and processing extracellular signals.

254 e strength of this gradient is a function of extracellular solution pH, the pH-dependence on Mg isoto

255 The extracellular space (apoplast) of plant tissue represent

256 the amino and carboxyl termini reside in the extracellular space and are initially linked by two tran

257 leavable to mature bioactive IL-1beta in the extracellular space by the protease caspase-1.

258 umulation or depletion, respectively, in the extracellular space, which we attributed to a residual c

259 of oxygen with high resolution in the brain extracellular space.

260 protease-2 (MMP-2) and MMP-9 activity in the extracellular space.

261 Efficient extracellular SrtA expression was achieved in Escherichi

262 pplication causes a global compaction of the extracellular subunit interface, coupled to an outward m

263 active oxygen species production, neutrophil extracellular trap (NET) formation, and neutrophil elast

264 ate cell activation that included neutrophil extracellular trap generation and elevated surface expre

265 r nuclear material in the form of neutrophil extracellular traps (NETs).

266 eveloped computational pipelines to identify extracellular traps from an in vitro human samples visua

267 nt findings of the involvement of neutrophil extracellular traps in atherogenesis and atherothrombosi

268 d by limited tools to quantify occurrence of extracellular traps in experimental models and human sam

269 echanisms, including formation of neutrophil extracellular traps through a recently described distinc

270 ils displayed a greater tendency to protrude extracellular traps, which were more strongly incorporat

271 We argue that the field of extracellular vesicle (EV) biology needs more transparen

272 tba-6 also influences several aspects of extracellular vesicle biology, including cargo sorting,

273 Desmoglein 2 modulates extracellular vesicle release from squamous cell carcino

274 Extracellular vesicle-associated hsa-miR-483-5p thus app

275 s study was to investigate the expression of extracellular vesicle-associated microRNAs and their dia

276 s and incomplete mRNAs) undergo transfer via extracellular vesicles (e.g., exosomes).

277 Circulating endogenous extracellular vesicles (EVs) are increased after brain i

278 Extracellular vesicles (EVs) are proposed to play import

279 oded oncoprotein that is packaged into small extracellular vesicles (EVs) called exosomes.

280 In this context, extracellular vesicles (EVs) may represent novel effecto

281 cific proteins would be reflected in urinary extracellular vesicles (EVs) of podocyte origin and acco

282 Extracellular vesicles (EVs) released during cell stress

283 Although the mechanism by which extracellular vesicles are internalized is incompletely

284 ew, we summarize the current knowledge about extracellular vesicles as diagnostic and prognostic biom

285 identified that miR-195 was packaged in the extracellular vesicles from EC-CM.

286 ticular chondrocytes treated with OA derived extracellular vesicles had decreased expression of anabo

287 qRT-PCR of pathogen miRNAs isolated from extracellular vesicles in sera from infected individuals

288 Extracellular vesicles, including exosomes, have immedia

289 ised with S100A10 at the cell surface and in extracellular vesicles.

290 me, resulted in the generation of infectious extracellular virions (HSV(des)) that lack cholesterol a

291 n of FAS resulted in decreased production of extracellular virions but did not reduce intracellular g

292 Myocardial fibrosis quantified by extracellular volume (ECV) CMR measures.

293 osmotic diuresis, and results in concurrent extracellular volume conservation and concentration of s

294 d cardiac magnetic resonance measurements of extracellular volume fraction (ECV) to discover and quan

295 For two different geometries with the same extracellular volume fraction the geometry with the most

296 ing myocardial fibrosis (MF) with myocardial extracellular volume measures acquired during cardiovasc

297 rTOF do not have elevated LV native T1 or LV extracellular volume, but show evidence of increased RV

298 hizophrenia identified significantly greater extracellular water volume in the early stages of the di

299 In Notum null flies, we find upregulated extracellular Wg ligand and nuclear trans-synaptic signa

300 s transmembrane domain that is accessible to extracellular ZnT8 antibody (ZnT8A).