ライフサイエンスコーパス: extracellular domain

1 mbrane segments, which are linked by a large extracellular domain.

2 ion through trans interactions formed by its extracellular domain.

3 b2p was induced by underglycosylation of its extracellular domain.

4 l epidermal growth factor-like repeat in the extracellular domain.

5 rphisms at positions 58 and 92 within the D0 extracellular domain.

6 ades upon ligand-induced dimerization of the extracellular domain.

7 rs shedding of the signalling-competent NRG2 extracellular domain.

8 ini-Gamma by deleting a large portion of the extracellular domain.

9 cated near the N-terminal alpha-helix of the extracellular domain.

10 ranscriptional activation domain and a large extracellular domain.

11 n cancer patients, in complex with the ErbB3 extracellular domain.

12 otein expression and secretion of the gammac extracellular domain.

13 ich is structurally remarkable for its large extracellular domain.

14 at the interface between the subunits in the extracellular domain.

15 e kinase 1 (AKIK1), an active kinase with an extracellular domain.

16 al adhesive fragment of the zebrafish Pcdh19 extracellular domain.

17 which are missense mutations in the adhesive extracellular domain.

18 odulators requires additional cytoplasmic or extracellular domains.

19 ries of PLA2R1 deletion mutants covering the extracellular domains.

20 irectly to the Sema3A sema domain or to Nrp1 extracellular domains.

21 known convulsant sites in the ion channel or extracellular domains.

22 ity involves homophilic interactions between extracellular domains.

23 The importance of the extracellular domain 2 (ECL2) in the selectivity toward

24 36 in the kinase domain, and C300stop in the extracellular domain, a new mutation causing CIPA diagno

25 ndependently of the lipid-binding Smoothened extracellular domain, a region that is dispensable for P

26 ta1 integrins carrying traceable tags in the extracellular domain; a pH-sensitive pHlourin tag or a H

27 iderable conformational changes in nicastrin extracellular domain after substrate recruitment.

28 Functionally, MICA-B2 contains two extracellular domains (alpha1 and alpha2) and is a novel

29 ved and the binding affinities between their extracellular domains, an improved kinetic assay is need

30 The two receptor protomers, extracellular domain and amino terminal fragment (NTF),

31 modality whereby the LAIR1 exon encoding the extracellular domain and flanking intronic sequences are

32 TpoR activation was dependent on its extracellular domain and its N-glycosylation, especially

33 ts suggest that both the conformation of the extracellular domain and phosphorylation status of the r

34 m the size difference between the large CD45 extracellular domain and the smaller TCR-pMHC complex, a

35 ansition can be initiated by "unzipping" the extracellular domain and the transmembrane domain, media

36 GFR functions; however, modifications to the extracellular domain and their effects remain relatively

37 t of monoclonal antibodies against the KCNK9 extracellular domain and their functional effects.

38 ture of full-length GCGR containing both the extracellular domain and transmembrane domain in an inac

39 omoted membrane fusion activity, with the SH extracellular domain and transmembrane domain playing a

40 udokinase1 (ARLPK1) and ARLPK2, both lacking extracellular domains and kinase activity, through mRNA

41 guidance roles by recognizing cues via their extracellular domains and transducing signals via their

42 no terminus, first transmembrane domain, and extracellular domain) and sites (residues 130-132 and 13

43 nce of the "compact" conformation of the MET extracellular domain, and the relevance of this conforma

44 bes the roles of potential pH sensors in two extracellular domains, and it proposes a model of acidif

45 The CpsC extracellular domain appeared necessary for the producti

46 (-/-)) or selectively expressing its soluble extracellular domain (APPsalpha-KI).

47 ites of CD46 cassette exons 7 and 8 encoding extracellular domains are defined by noncanonical mechan

48 Their N-terminal extracellular domains are exported through a C-terminal

49 In this protocol, receptor extracellular domains are fused with the Fc region of Ig

50 sting that all of the domains, including the extracellular domain, are necessary for complete rescue.

51 roof, membrane-tethered AREG cytoplasmic and extracellular domains (AREG-CTD and AREG-ECD), as well a

52 we solved the crystal structure of the beta2 extracellular domain at 1.35A.

53 BP cleaves L1 as a serine protease in the L1 extracellular domain at Arg(687) yielding a transmembran

54 ve energetic coupling to GABA binding in the extracellular domain at the beta(+)-alpha(-) subunit int

55 terminal portion of GpIbalpha and the entire extracellular domain bind exclusively to thrombin's exos

56 EC14A and CD93 binding region blocks CLEC14A extracellular domain binding to the endothelial cell sur

57 The purified FtsX extracellular domain binds the PG peptidase Rv2190c/RipC

58 nits are, therefore, located not only in the extracellular domains but also in the lipid accessible s

59 and cornichon 3, are located not only in the extracellular domains but also in the lipid-accessible s

60 amples bound live hippocampal neurons or Kv1 extracellular domains, but 16 (59%) bound to permeabilis

61 hat methylation at R198 and R200 of the EGFR extracellular domain by protein arginine methyltransfera

62 hKCNE3 and hKCNE4 that extend their encoded extracellular domains by 44 and 51 residues, which yield

63 molar concentration of zinc that binds to an extracellular domain called an amino-terminal domain (AT

64 ed in ovarian cancer tumors, and its cleaved extracellular domain can be detected in the serum of ova

65 We found that their purified extracellular domains co-exist in stable dimeric and mon

66 receptor family members, which share similar extracellular domain compositions but form covalent dime

67 of plant signaling proteins consisting of an extracellular domain connected by a single-pass transmem

68 embrane (TM) domain, RXFP1 possesses a large extracellular domain consisting of 10 leucine-rich repea

69 aGPCR extracellular domains contain a conserved subdomain that

70 This C-terminal extracellular domain could be a target for developing su

71 Proper amino acid sequences in the extracellular domains (D1 to D3) of PRG5 were a prerequi

72 fferent domains of the protein; L213P in the extracellular domain, Delta736 in the kinase domain, and

73 epidermal growth factor repeats in the Notch extracellular domain, during pathogenesis of Kras-induce

74 protein-coupled receptors are composed of an extracellular domain (ECD) and a seven-transmembrane (7T

75 MY2 (CTR.RAMP2) receptors using purified CTR extracellular domain (ECD) and tethered RAMP1- and RAMP2

76 The soluble LGR4 extracellular domain (ECD) binds RANKL and inhibits oste

77 The PknB extracellular domain (ECD) consists of four repeats homo

78 19 transmembrane segments (TMs), and a large extracellular domain (ECD) from nicastrin, which sits im

79 inding site 1 within the hinge region of the extracellular domain (ECD) of CaSR and its interaction w

80 Based on the crystal structure of the extracellular domain (ECD) of human alpha9 nAChR, we mod

81 We hypothesized that the soluble extracellular domain (ECD) of long isoform of death rece

82 and subsequent permeation, we expressed the extracellular domain (ECD) of SID-1 and purified it to n

83 onal studies have indicated that the dimeric extracellular domain (ECD) of the CaSR plays a crucial r

84 we report the X-ray crystal structure of the extracellular domain (ECD) of the human neuronal alpha2

85 In the extracellular domain (ECD), a marked quaternary change i

86 ing puzzle regarding RTKs centers on how the extracellular domain (ECD), which detects and binds to g

87 t trastuzumab and chemotherapy augments HER2 extracellular domain (ECD)-specific antibodies.

88 MD or changes involving both the TMD and the extracellular domain (ECD)-TMD interface.

89 human ZIP proteins, is featured with a large extracellular domain (ECD).

90 receptor (GPCR) with a characteristic large extracellular domain (ECD).

91 n of the noncovalently bound GPR56 or GPR110 extracellular domains (ECDs) from the respective seven-t

92 racterize this process, the large N-terminal extracellular domains (ECDs) of alpha1, alpha2, beta2, a

93 ons of the RSPO Fu1-Fu2 domain module to the extracellular domains (ECDs) of the LGR4 G protein-coupl

94 activation and what structural role the CD3 extracellular domains (ECDs) play in the assembled TCR-C

95 Regions of the extracellular domain essential to this phenotype were id

96 s with ASDs and all of these reside in their extracellular domains except for a single point mutation

97 rd isoform, Nrxn1gamma, that lacks all Nrxn1 extracellular domains except for the membrane-proximal s

98 mpact of a soluble TGF-beta type II receptor extracellular domain expressed as an immunoglobulin-Fc f

99 , active kinase lacking the transmembrane or extracellular domain fails to complement conditional mut

100 Stimulation with an EphB2 extracellular domain-Fc fusion protein (EphB2-Fc) induce

101 und states revealed molecular motions of the extracellular domain following agonist binding.

102 all GDD mutations known so far locate in an extracellular domain following the first transmembrane d

103 tions "mark" different regions in the Notch1 extracellular domain for activation or inhibition.

104 teases is a common process that releases the extracellular domain from the cell and activates cell si

105 Additionally, removal of the extracellular domains from the receptor did not affect m

106 protective domain and permit proteolysis, on extracellular domain glycosylation to tune the forces ex

107 nalog-bound CLR:RAMP1 and AM-bound CLR:RAMP2 extracellular domain heterodimers at 2.5 and 1.8 A resol

108 the necessity for broader screening of CSF3R extracellular domain in leukemia patients.

109 ding endostatin/collagen 18alpha1 and Notch3 extracellular domain in mice with the C455R mutation, a

110 on strain, demonstrating the key role of the extracellular domain in virulence of GBS.

111 g in the large class of receptors built from extracellular domains in tandem with single-span transme

112 We identify and characterize novel FGFR2 extracellular domain insertion mutations and demonstrate

113 analyses raise the possibility that the Lrp4 extracellular domain interacts with Wnt ligands, as well

114 lter the signal that is transmitted from the extracellular domain inward.

115 onformational changes in the agonist-binding extracellular domain, ion-conducting transmembrane domai

116 ferent receptor chains, and reveals that the extracellular domain is merely the tip of a molecular ic

117 easurements in keratinocytes showed the Dsg3 extracellular domain is ordered at the individual desmos

118 rminal domains, indicating that the IL1RAPL1 extracellular domain is required for regulating dendrite

119 by binding of epidermal growth factor to the extracellular domain it dimerizes, followed by autophosp

120 of antiaging membrane Klotho that contains 2 extracellular domains KL1 and KL2, each of which shares

121 l alterations of the whole trimeric langerin extracellular domain (Lg-ECD).

122 ugh a calcium-dependent interaction of their extracellular domains made of multiple extracellular cad

123 ctivating mutations in the intracellular and extracellular domains may be subdivided into classes wit

124 d the transmembrane domains, rather than the extracellular domain, mediate the ligand-independent FGF

125 we functionally characterize HER2 kinase and extracellular domain mutations through gene editing of t

126 e-derived RNA from subjects harboring NOTCH1 extracellular domain mutations, we observed significant

127 It is not clear why so many extracellular domains need to be evolved through natural

128 naling from the cell surface by engaging the extracellular domain of a GPCR and suggest that SMO acti

129 Initial studies conducted on the extracellular domain of acetylcholine receptors, ion cha

130 However, chimeras with the extracellular domain of ADAM10 and the transmembrane dom

131 The mutations reside in the extracellular domain of ALK and are potently transformin

132 otent ligands for human ALK that bind to the extracellular domain of ALK and in addition to activatio

133 In summary, a mutation in the extracellular domain of alphaENaC causes Liddle syndrome

134 hibitors (RU-301 and RU-302) that target the extracellular domain of Axl at the interface of the Ig-1

135 Our findings suggest that while the extracellular domain of AXL has the highest affinity for

136 oton release complex (PRC), a complex in the extracellular domain of bacteriorhodopsin where an exces

137 We determine that the extracellular domain of CADM1 mediates these effects by

138 present study, we purified the glycosylated extracellular domain of calcium-sensing receptor (CaSR)

139 ted at histidine or cysteine residues in the extracellular domain of CaR attenuated pHo sensitivity.

140 nal data that relate the architecture of the extracellular domain of CASPR2 to a previously unknown l

141 .2 identified protein interfaces between the extracellular domain of CaValpha2delta1 and the extracel

142 function of the large, alternatively spliced extracellular domain of CD45 has remained elusive.

143 Given the large size of the full extracellular domain of class I MHC molecules such as H-

144 cells, yet other evidence suggests that the extracellular domain of CTLA-4 is sufficient to elicit s

145 in composed of the Fc region of IgG1 and the extracellular domain of CTLA4 (also known as abatacept,

146 Here we show that the extracellular domain of DivIB is able to bind peptidogly

147 ADAM17, in turn, cleaves the extracellular domain of DSG2 that links epithelial cells

148 aling that culminates in the cleavage of the extracellular domain of DSG2, thereby disrupting DSG2 ho

149 en native E-cadherin in living cells and the extracellular domain of E-cadherin (E-cad-ECD) in a supp

150 acrylamide (PA) gels functionalized with the extracellular domain of E-cadherin (Ecad-Fc), we showed

151 The extracellular domain of E-cadherin is cleaved by proteas

152 and a vertical surface coated with purified extracellular domain of E-cadherin, and was designed for

153 Recently, the extracellular domain of EGFR was also shown to be methyl

154 C479 is a highly conserved residue in the extracellular domain of ENaC and likely involved in a di

155 iol self-assembled monolayers (SAMs) against extracellular domain of epidermal growth factor receptor

156 EPS interacts with the extracellular domain of EpsA, which is a receptor, to co

157 sely related dipeptidyl peptidase DPPIV, the extracellular domain of FAP can be released into circula

158 Only SNP V39I, located in the extracellular domain of FcgammaRI, reduces immune-comple

159 Two candidate therapies target the extracellular domain of FGFR3.

160 Unexpectedly, the extracellular domain of Fn14 is necessary and sufficient

161 f the human alpha1GlyR could be fused to the extracellular domain of GLIC, a bacterial pLGIC, to form

162 hese data indicate that glycosylation of the extracellular domain of hCAR plays no role in CVB3 recep

163 ping fusion protein (ACE-536) containing the extracellular domain of human activin receptor type IIB

164 a humanized monoclonal antibody against the extracellular domain of human epidermal growth factor re

165 te, comprised of amino acids 210-240, in the extracellular domain of human Sdc1, and EGFR is captured

166 serine residues (but not 2 or 4) between the extracellular domain of IFNAR1 and the TMD had some effe

167 We also found that the extracellular domain of IL1RAPL1 is required for this ef

168 a well characterized B-cell epitope from the extracellular domain of influenza A virus M2 protein (M2

169 Two independent mutations in the extracellular domain of KIR, away from the HLA-C binding

170 The extracellular domain of KOR1 contains eight N-glycosylat

171 In two previously described donors, the extracellular domain of LAIR1, a collagen-binding inhibi

172 Here we characterize the structure of the extracellular domain of MapZ and show that it displays a

173 magglutinin (HA), neuraminidase (NA) and the extracellular domain of matrix protein 2 (M2e) fused to

174 to the predicted Ca(2+)-binding site in the extracellular domain of mGluR1alpha modulates not only g

175 ed that a single amino acid (Thr(24)) in the extracellular domain of MICA018 was essential for the N-

176 The structure of an extended portion of the extracellular domain of mincle, beyond the minimal C-typ

177 We find that mutant CALR binds to the extracellular domain of MPL and that 3 tyrosine residues

178 a sequence of hydrophobic amino acids in the extracellular domain of NKG2E.

179 ed the O-GlcNAc signal on Lec1 cells and the extracellular domain of NOTCH1.

180 receptor construct, comprising the truncated extracellular domain of PD1 and the transmembrane and cy

181 atumab) is a monoclonal antibody against the extracellular domain of PDGFRA.

182 ted mutagenesis of basic residues within the extracellular domain of PECAM-1.

183 and Ab37 to distinct epitopes on the distal extracellular domain of PECAM.

184 The extracellular domain of PKD2, a hotspot for ADPKD pathog

185 thesized that fusion of CD19L to the soluble extracellular domain of proapoptotic TNF-related apoptos

186 monoclonal antibody D2B, directed against an extracellular domain of prostate-specific membrane antig

187 ding, they were also cocrystallized with the extracellular domain of PSMA.

188 er relapses and metastases by binding to the extracellular domain of PSMA.

189 re we report that a lysine-rich motif in the extracellular domain of PSR-1, the Caenorhabditis elegan

190 roduced novel chimeric envelopes bearing the extracellular domain of rabies fused to the cytoplasmic

191 Ligand binding at the extracellular domain of RAGE initiates a complex intrace

192 ally (half-maximal binding, 3 mug/mL) to the extracellular domain of SR-AI.

193 in-11/syndecan-4 complexes requires both the extracellular domain of syndecan-4, and the transmembran

194 own-regulate Smad2 signaling by shedding the extracellular domain of TGFbetaRI, and we show that the

195 pt), a soluble fusion protein containing the extracellular domain of the BAFF-APRIL receptor TACI, wa

196 to install the boronic acid reagent onto the extracellular domain of the Beta-2 adrenergic receptor i

197 his interaction is enhanced upon binding the extracellular domain of the cognate EphB2 receptor.

198 A soluble variant of the extracellular domain of the coxsackievirus-adenovirus re

199 In this study, we examined the role of the extracellular domain of the CpsA protein of the zoonotic

200 is (PV), in which autoantibodies against the extracellular domain of the desmosomal cadherin desmogle

201 ons are used to examine the structure of the extracellular domain of the EPOR dimer in the presence a

202 ved two immunoglobulin-like domains from the extracellular domain of the full-length rat TrkB recepto

203 8I), functionally defective mutations in the extracellular domain of the G-CSF receptor (CSF3R) have

204 ed a critical cleavage site (Lys-189) in the extracellular domain of the gamma-subunit.

205 crystal structure of the isolated N-terminal extracellular domain of the GLP-1R in complex with exend

206 fluorescent protein, pHluorin, tagged to the extracellular domain of the GluA2 subunit of AMPARs, we

207 of the novel mutants localized in the large extracellular domain of the GlyR alpha1 have reduced cel

208 gellin and multiple repeats of the conserved extracellular domain of the influenza matrix protein 2 (

209 Through binding to the extracellular domain of the IR, 4548-G05 induces activat

210 ) and the Myc epitope were introduced to the extracellular domain of the mature receptor alpha2 subun

211 c domains, serves as a homology model of the extracellular domain of the nAChRs.

212 tage of a recently identified chimera of the extracellular domain of the native alpha7 nicotinic acet

213 This peptide bound in vivo to the extracellular domain of the plasma membrane-localized, a

214 strongly and specifically interacts with the extracellular domain of the receptor-like kinase FERONIA

215 osteric agonists and antagonists bind on the extracellular domain of the receptor.

216 epidermal growth factor-like repeats in the extracellular domain of the receptor: O-fucosylation, O-

217 ding of tumor necrosis factor ligands to the extracellular domain of their corresponding receptors tr

218 e1-deficient mice with a soluble form of the extracellular domain of Tie2, which blocks Angpt activit

219 acellular site of action, which requires the extracellular domain of TLR4 to stimulate a NF-kappaB re

220 The extracellular domain of TMIGD1 contains two putative imm

221 In the present study, the recombinant extracellular domain of TREM-1 (rTREM-1) and an agonisti

222 ver two TspanC8-specific motifs in the large extracellular domain of Tspan5 that are important for AD

223 tion, many of which encoded proteins with an extracellular Domain of Unknown Function26.

224 n IgG-1 monoclonal antibody that targets the extracellular domain of VEGF receptor 2.

225 an IgG1 monoclonal antibody that targets the extracellular domain of VEGFR-2.

226 Sequence comparison showed that the extracellular domain of ZmWAK-RLK1 is highly diverse bet

227 he intramolecular contacts between different extracellular domains of a CAM.

228 At the interface of the extracellular domains of adjacent subunits lies the acet

229 that electrostatic interactions between the extracellular domains of AMPAR and STZ play an important

230 In particular, in our simulations the extracellular domains of an EGFR dimer spontaneously lay

231 Sequential deletion of extracellular domains of apoER2 surprisingly identified

232 ted after immunization of an alpaca with the extracellular domains of both human and mouse MMR.

233 cellular approaches we demonstrate that the extracellular domains of BTN3A1 adopt a V-shaped conform

234 ated autoantibodies are directed against the extracellular domains of cell-surface-expressed neuronal

235 How the large extracellular domains of GPCRs regulate signalling by th

236 , we determined the crystal structure of the extracellular domains of human FcgammaRI in complex with

237 Our results suggest that IFN binding to the extracellular domains of IFNAR1 and IFNAR2 promotes prox

238 etermined the 2.8 A crystal structure of the extracellular domains of KIR2DL4.

239 likely pathogenic entities, which target the extracellular domains of leucine-rich glioma-inactivated

240 of these (56%) had antibodies targeting the extracellular domains of LGI1 or CASPR2.

241 or detection of the O-GlcNAc modification on extracellular domains of membrane or secreted glycoprote

242 annexinA2 as a potential interactor with the extracellular domains of PLA2R.

243 opy and x-ray crystallization studies of the extracellular domains of RAGE indicate that RAGE ligands

244 eolytic cleavage of specific segments in the extracellular domains of the alpha- and gamma-subunits.

245 ells of NMO patients produce antibody to the extracellular domains of the AQP4 protein and that recom

246 e A-Q complex) is an interaction between the extracellular domains of the forespore membrane protein

247 f a chimeric adaptor molecule comprising the extracellular domains of the human FcgammaRI (CD64) fuse

248 a clustering algorithm that groups together extracellular domains of the IgSF with similar binding p

249 Among the 15 extracellular domains of the mannose 6-phosphate/insulin

250 ed a synthetic signaling system in which the extracellular domains of the TCR and pMHC were replaced

251 Autoantibodies against the extracellular domains of the voltage-gated potassium cha

252 r in the absence of ligand, via both TIR and extracellular domains of TLR4.

253 While the extracellular domains of TNFRs form trimeric complexes w

254 pretreated with a soluble langerin trimeric extracellular domain or by a CRD homolog.

255 ative bacteria that consist of an N-terminal extracellular domain ('passenger domain') and a C-termin

256 rangement of 19 transmembrane helices and an extracellular domain positioned for substrate recognitio

257 The variant in the extracellular domain potentially interferes with the bin

258 s have been restricted to the amino-terminal extracellular domain, providing little understanding of

259 (Ndr)-expressing cells, bound soluble Notch1 extracellular domain, quantified by flow cytometry.

260 e motions featuring shearing/twisting of the extracellular domains relative to the TMD, reveal subuni

261 We show that the extracellular domains required for binding to Robo1 are

262 CarO has a substantial extracellular domain resembling a glove that contains al

263 tion of original cysteine pairs in the CSF3R extracellular domain resulted in either gain- or loss-of

264 uctures of the ternary complex formed by the extracellular domains reveal that Lphn3 dimerizes when b

265 The crystal structure of the FtsX extracellular domain reveals an unprecedented fold conta

266 The Tiki extracellular domain shares homology with bacterial TraB

267 serum human epidermal growth factor 2 (HER2) extracellular domain (sHER2) in patients with advanced b

268 Excess of P-selectin extracellular domain significantly impaired Efb binding

269 Amyloid precursor protein (APP) and its extracellular domain, soluble APP alpha (sAPPalpha) play

270 The shed soluble VLDLR extracellular domain (sVLDLR-N) was detected in the cond

271 acids comprising the Na(+)/K(+)-ATPase H1-H2 extracellular domain that constitutes a core part of the

272 plate AChR is linked to a beta-strand of the extracellular domain that extends to a neurotransmitter

273 nsion of the orthosteric binding site in the extracellular domain that is coupled to closure of the i

274 the N-terminal domain of LCN2-R is a soluble extracellular domain that is intrinsically disordered an

275 identified the minimal region of the ASIC2a extracellular domain that is required for ASIC2 proton a

276 noclonal antibodies to its intracellular and extracellular domains that enable the immunostaining of

277 d interactions involving both the kinase and extracellular domains that lead to enhanced dimerization

278 n the membrane after ligand binding to their extracellular domain, the TLR4-TLR6-CD36 complex assembl

279 ation sharply limit access of the gamma-ENaC extracellular domain to proteases.

280 -37 binds to CsrS, we used the purified CsrS extracellular domain to pull down LL-37 in vitro, a resu

281 ugh the removal or addition of cysteine-rich extracellular domains to produce a panel of chimeric mol

282 teract with nanomolar affinity through their extracellular domains to synergistically promote synapse

283 of domain motions, which propagate from the extracellular domains to the TMD.

284 n, is likely to be solvent-accessible at the extracellular domain vestibule.

285 Interaction of orthosteric ligands with extracellular domain was described at several aminergic

286 rthermore, a binding site in a groove of the extracellular domain was proposed but not experimentally

287 Using recombinant CL-12 full length or CL-12 extracellular domain, we determined the occurrence of so

288 of trans binding between soluble E-cadherin extracellular domains, we conducted simulations of cadhe

289 The FSHR extracellular domains were observed in the crystal struc

290 ically, IL-17R interacts with NOTCH1 via the extracellular domain, which facilitates the cleavage of

291 ntified seven atypical FG-GAP domains in the extracellular domain, which potentially folds into a bet

292 bute this function to a cleavage of the TLR2 extracellular domain, which prevented TLR2-induced trans

293 oposed model for the interaction of langerin extracellular domain with 6 kDa HEP.

294 indicated that the agonists bind the IL-36R extracellular domain with micromolar affinity but do not

295 Neutralizing the Ncad extracellular domain with the monoclonal antibody GC-4 s

296 receptor dimer, substitution of the receptor extracellular domains with Jun zippers to control the po

297 in PLA2R by probing isolated truncated PLA2R extracellular domains with sera from patients with IMN t

298 hat 7,8-DHF interacts robustly with the TrkB extracellular domain, with a Kd of approximately 10 nm.

299 found structural rearrangements in the AMPAR extracellular domain, with ligand-binding domain dimers

300 r also photolabeled amino acids in the nAChR extracellular domain within binding pockets identified p