ライフサイエンスコーパス: extracellular loop

1 lycosylated at five asparagines in the first extracellular loop.

2 the principal contact point with the CNIH-3 extracellular loop.

3 g primarily with glutamate 175 in the second extracellular loop.

4 transmembrane region and 5 A for the second extracellular loop.

5 interaction involves predominantly the beta1 extracellular loop.

6 integrins with traceable tags inserted in an extracellular loop.

7 receptor residue Trp(297) within the second extracellular loop.

8 position 6 probe was localized to the first extracellular loop.

9 terminants of OCLN were mapped to its second extracellular loop.

10 volving residues on H6 and within the second extracellular loop.

11 unction of transmembrane domain V and second extracellular loop.

12 e of the receptor, and further stabilized by extracellular loops.

13 ng site located between the second and third extracellular loops.

14 and an extended binding pocket close to the extracellular loops.

15 r and inducing structural alterations in the extracellular loops.

16 to two mutations in different putative XPR1 extracellular loops.

17 ry cysteine scanning of intracellular versus extracellular loops.

18 R1 involves both amino-terminal residues and extracellular loops.

19 gle membrane-spanning domain and without any extracellular loops.

20 n to interact with binding partners in these extracellular loops.

21 y a horizontal binding pocket near the GPR55 extracellular loops.

22 beta-barrel wall with residues in one of the extracellular loops.

23 nt features of the ligand binding pocket and extracellular loops.

24 encompassed the entire cork domain and four extracellular loops.

25 ularly in regions corresponding to predicted extracellular loops.

26 has four transmembrane domains and two large extracellular loops.

27 tope of the receptor that includes all three extracellular loops.

28 ons serve to stabilize key substrate-binding extracellular loops.

29 ing to the eIF4F complex with its two middle extracellular loops.

30 and indicates that rearrangement of the ECD/extracellular loop 1 (ECL1) interface is a critical step

31 ional changes in transmembrane segment 2 and extracellular loop 1 (EL1), which amplify the divergence

32 nal gate, the lumen of LptD channel, and the extracellular loop 1 and 4, providing the first direct e

33 A 7-amino acid CCR2 binding peptide (extracellular loop 1 inverso [ECL1i]) was conjugated to

34 esidues in the human MC4R--such as Leu106 of extracellular loop 1, and Asp122, Ile125, and Asp126 of

35 act cells, reporter cysteines were placed in extracellular loops 1 (A80C, N half) and 4 (R741C, C hal

36 r disulfide bridges and aromatic residues in extracellular loop 2 (ECL-2) for ligand binding and acti

37 way A, the D192-K305 salt bridge between the extracellular loop 2 (ECL2) and the apex of the transmem

38 e (TM) bundle, prior studies have implicated extracellular loop 2 (ECL2) as having a significant role

39 eport that N-linked glycosylation of PAR1 at extracellular loop 2 (ECL2) controls G12/13 versus Gq co

40 cellular side of transmembrane 3 (TM3), TM4, extracellular loop 2 (ECL2), and ECL3 to be involved in

41 e between transmembrane segment 3 (TMS3) and extracellular loop 2 (ECL2), as playing a role in odoran

42 the hydrogen-bonding networks (HBNs) in the extracellular loop 2 (EII).

43 ing kinetics may be due to a "lid" formed by extracellular loop 2 (EL2) at the entrance to the bindin

44 F194 in extracellular loop 2 and R304 in extracellular loop 3 al

45 pon flexibility in the C-terminal segment of extracellular loop 2 and that mutations or ligand bindin

46 this, we identified key residues within both extracellular loop 2 and the transmembrane domain region

47 e to a similar salt bridge found between the extracellular loop 2 and TM7 in beta2AR reported recentl

48 g receptor structure, a beta-hairpin fold in extracellular loop 2 in conjunction with two extracellul

49 for the position of NLX and of the receptor extracellular loop 2 in relation to the DOR binding pock

50 lphide bridge in GPCRs between helix III and extracellular loop 2 is not observed and appears to be d

51 f CPE in complex with a peptide derived from extracellular loop 2 of a modified, CPE-binding Claudin-

52 introducing an HA (hemagglutinin) tag in the extracellular loop 2 of SERT (HA-SERT).

53 Thus, CPM binding to extracellular loop 2 of the B1R results in positive allo

54 d by mutating as few as four residues in the extracellular loop 2 region of glycine receptors (GlyRs)

55 main(aa 363-458) interacts with the occludin extracellular loop 2(aa 194-241).

56 vel interactions at Cys196 (TM5) and Asp189 (extracellular loop 2).

57 r-138/Phe-139), and the transition of TM3 to extracellular loop 2, ECL2 (Thr-141/Ile-142) and ECL2 (A

58 These cysteines are located in extracellular loop 2, the role of which in the structure

59 action of its C-terminal domain with the B1R extracellular loop 2.

60 of transmembrane helices V, VI, VII and the extracellular loop 2.

61 ending on residues in the N-terminus and the extracellular loop 2.

62 d in the tyrosine-sulfated amino terminus or extracellular loop 2.

63 nsmembrane regions 2 and 7 (TM2 and TM7) and extracellular loops 2 and 3 (EL2 and EL3).

64 The D186-R317 salt bridge (in extracellular loops 2 and 3) is stabilized in the cyanop

65 mino acid moieties were coordinated close to extracellular loops 2 and 3.

66 ) adrenergic receptor: a salt bridge linking extracellular loops 2 and 3.

67 Our data suggest that extracellular loops 2 and 4 come into close proximity to

68 nce of antibodies against the N terminus and extracellular loops 2/3 of CXCR4 confirm that the ubiqui

69 erminal receptor domain, whereas blockade of extracellular loops 2/3 prevents receptor binding and ac

70 residues after the conserved Cys residue in extracellular loop 2b (ECL2b) associated with selective

71 the propensity for the C-terminal segment of extracellular loop 2b to form an extended alpha-helix wa

72 Extracellular loop 3 (and specifically amino acid K305)

73 brane helix 6 (TMH6) and TMH7 at the base of extracellular loop 3 (ECL3) is sufficient to allosterica

74 The extracellular loop 3 (EL-3) of SLC4 Na(+)-coupled transp

75 F194 in extracellular loop 2 and R304 in extracellular loop 3 also had minor effects.

76 we demonstrate that transmembrane helix VI, extracellular loop 3 and the HD play a central role in t

77 seesaw movement of helix VII and a shift of extracellular loop 3 are likely specific to A(2A)AR and

78 Glu mutation at position 406 (L406E) in the extracellular loop 4 (EL4) of human SERT, which induced

79 were introduced at positions 359 and 448 of extracellular loop 4 and transmembrane helix 10, respect

80 n the bacterial homologue LeuT suggests that extracellular loop 4 closes the extracellular solvent pa

81 binding, conformational changes mediated by extracellular loop 4, and cation-pi interactions.

82 occlusion of the extracellular vestibule by extracellular loop 4.

83 ins 1, 2 and 6, together with translation of extracellular loop 4.

84 extracellular vestibule, interposed between extracellular loops 4 and 6 and transmembrane helices 1,

85 The cork domain and four large extracellular loops (4L) were deleted to obtain an unusu

86 We obtained evidence that the predicted extracellular loop 5 of FadLSm and further alpha-rhizobi

87 In these structures, extracellular loop 6 extends away from the barrel wall a

88 of altering the structural rearrangements of extracellular loop A.

89 rate, which harbors mutations in a conserved extracellular loop, accumulates on BamD during assembly,

90 allowed the first high resolution mapping of extracellular loop amino acids critical for NMO-IgG bind

91 ) epitope tag was introduced into the second extracellular loop and GFP was attached to the carboxyl

92 ith N-terminal residues (binding site-I) and extracellular loop and helical residues (binding site-II

93 ty of the channel, which is supported by the extracellular loop and involves two arginines (R68 and R

94 ) cotransporter NBCe1-A, EL-3 is the largest extracellular loop and is predicted to consist of 82 ami

95 or we found that E172 and E175 in the second extracellular loop and N419 in the third extracellular l

96 rface alters the configuration of the second extracellular loop and partially dissociates a spin-labe

97 study identifies subunit interactions in the extracellular loop and shows that dynamic changes of the

98 s comprise cylindrical beta-sheets with long extracellular loops and create pores to allow passage of

99 charged amino acids in the first and second extracellular loops and found that mutating Glu-361 in t

100 sis of a number of potential partners in the extracellular loops and outer parts of the transmembrane

101 double, and multiple deletions of the large extracellular loops and the cork domain.

102 genesis approach to identify residues in the extracellular loops and transmembrane segments of hERG1

103 egree of conformational rearrangement in the extracellular loop, and desensitization was faster from

104 omprises the first 45 amino acids, the third extracellular loop, and seventh transmembrane domain.

105 ted against the CCR5 amino terminus (NT) and extracellular loops, and CCR5 point mutants revealed tha

106 ond extracellular loop and N419 in the third extracellular loop are involved in allosteric binding of

107 Interestingly, most of the extracellular loops are also found to be involved in hom

108 me-scale dynamics measurements show that the extracellular loops are disordered and unstructured.

109 Extracellular loops are not necessary for generating the

110 ng in the second phase, leaving the flexible extracellular loops as the likely site of unfolding.

111 in, is composed of three immunoglobulin-like extracellular loops as well as a cytoplasmic tail contai

112 receptor residue Tyr(205), within the first extracellular loop, as the site of labeling by the posit

113 es) are predicted in an environment of other extracellular loops being fully flexible and the transme

114 -spanning domains one and two and the second extracellular loop between membrane-spanning domains thr

115 an immunoprecipitation method, we found that extracellular loops between the first and second transme

116 gments of TRPP2 and TRPP3 associate with the extracellular loops between the sixth and seventh transm

117 In contrast, the extracellular loop-binding or class 2 monovalent nanobod

118 Mutation of all four cysteines in the extracellular loops blocked disulfide bond formation and

119 E702 and E705 are predicted to be in an extracellular loop, but antigenic epitopes introduced in

120 wn that the ligand is tethered to the second extracellular loop by hydrophobic contacts.

121 ivity to neutralizing antibody or CD81 large extracellular loop (CD81-LEL) inhibition, entry factor u

122 ted to contain a highly conserved additional extracellular loop compared to the remaining strains and

123 hat an ambient-exposed region comprising the extracellular loop connecting TM4-TM5 and ambient-proxim

124 of exon 29 coding for 19 amino acids in the extracellular loop connecting transmembrane domains IVS3

125 these peptides often bind to hyper-variable extracellular loops, creating the potential for subtype

126 ions of our findings on the functions of the extracellular loop cysteines in SR-BI and compare our re

127 ain-of-function Stg carrying mutation in its extracellular loop, demonstrating that both the extracel

128 The second extracellular loop domain (E2) is primarily responsible

129 AR synaptic transmission relies on the first extracellular loop domain and its carboxyl-terminus.

130 N and C termini and a large N-glycosylated, extracellular loop domain.

131 The transmembrane and the extracellular loop domains are highly conserved among di

132 There are three extracellular loop domains, and among them, the second l

133 Claudins contain two extracellular loop domains, with the second loop (ECL-2)

134 and PPADS was conferred by the nature of the extracellular loop (e.g. nanomolar for NF449 at P2X1 and

135 barrier is formed by a segment of the first extracellular loop (E1) (the parahelix) and appears to b

136 D2, and that a binding region on the second extracellular loop (E2) may play a role in both enantios

137 ted by specific mutations in the CD151 large extracellular loop (EC2 domain) or in intracellular CD15

138 we identified the second half of the second extracellular loop (EC2) and specific amino acids within

139 arated pairs of helices, capped by the large extracellular loop (EC2) at the outer membrane leaflet.

140 tors contain a cysteine residue in the third extracellular loop (EC3) and a complementary cysteine re

141 duced into the conserved motif in the second extracellular loop (ECII) of EP3, resulting in acquisiti

142 op model by showing that the putative fourth extracellular loop (ECL 4) is intracellular and may cont

143 To assess involvement of the extracellular loop (ECL) 2 in ligand-receptor interactio

144 alanine-scanning mutagenesis, a key role for extracellular loop (ECL) 2 of the receptor in propagatin

145 ating cysteines in every position along each extracellular loop (ECL) and adjacent parts of transmemb

146 L11 depends on the ACKR3 N terminus and some extracellular loop (ECL) positions for primary binding,

147 ridge between transmembrane (TM) helix 3 and extracellular loop (ECL)-2, chemokine receptors (CCR) co

148 tudy first provided evidence that the second extracellular loop (ECL-2) of claudins is specifically i

149 eric receptors was created by exchanging the extracellular loops (ECL) of human NHE1 (huNHE1) and chN

150 The first extracellular loop (ECL1) of claudins forms paracellular

151 The topology of the second extracellular loop (ECL2) and its interaction with ligan

152 actions with residues Tyr-179, in the second extracellular loop (ECL2) and Trp-400(7.35) in transmemb

153 in transmembrane helix (TM) 2 and the second extracellular loop (ECL2) discriminated between the diff

154 the importance of its N terminus and second extracellular loop (ECL2) in binding gp120 and mediating

155 The second extracellular loop (ECL2) is a functionally important re

156 The orientation of the second extracellular loop (ECL2) is divergent in G-protein coup

157 ngens enterotoxin (cCPE) binds to the second extracellular loop (ECL2) of a subset of claudins, e.g.

158 s an epitope in the N terminus of the second extracellular loop (ECL2) of beta2AR.

159 ined the effects of low pH and of the second extracellular loop (ECL2) of CD81, one of the four entry

160 nine-scanning mutagenesis of the A1AR second extracellular loop (ECL2) with radioligand binding and f

161 2 (TMII), Tyr-179 and Phe-182 in the second extracellular loop (ECL2), and Glu-397(7.32) and Trp-400

162 accurately restore the extremely long second extracellular loop (ECL2), which is also key for GPCR li

163 d two localized on the surface of the second extracellular loop (ECL2).

164 o acid residues located within the predicted extracellular loop (ECL3 and ECL4) sequences of Xpr1 are

165 n the N-terminal (Nt) segment and the second extracellular loop (ECLII) of NK1.

166 reestablishing an interaction with the CXCR4 extracellular loops (ECLs) and rendering it highly susce

167 between the open inward-facing (NBDs apart, extracellular loops (ECLs) close together) and the close

168 to a coreceptor and inducing changes in the extracellular loops (ECLs) of CCR5.

169 in and in every position within the receptor extracellular loops (ECLs).

170 or receptors have also been described [e.g., extracellular loop (EL) 3 in the A(2A) adenosine recepto

171 TM6, Ala419 in the interface between TM8 and extracellular loop (EL) 4, and Leu481 in EL5.

172 hodopsin triggers displacement of the second extracellular loop (EL2) and motion of transmembrane hel

173 nsmembrane helices (TMs) 1a and 7 as well as extracellular loops (ELs) 2 and 4.

174 ted lower affinity interaction involving the extracellular loops (ELs).

175 The first extracellular loop exhibits a beta-hairpin conformation

176 ancers bind to a pocket formed by the second extracellular loop, flanked by residues S150 and M162.

177 Extracellular loops followed a well defined path through

178 The C-terminal and extracellular loop GFP insertions did not interfere with

179 r membrane protein A (OmpA), a molecule with extracellular loops has been shown to contribute to the

180 studies suggest that the stalk and the first extracellular loop have critical roles in modulating pep

181 eas the small molecule compound 43 activated extracellular loop I with downstream signaling dependent

182 loid A non-genomic responses were reliant on extracellular loops I and II, whereas the small molecule

183 Sequence alignments of the second extracellular loop identified single negatively charged

184 cells) to identify the N-terminal region and extracellular loop II as the FPR2/ALX domain required fo

185 rst transmembrane (TM) segment and the first extracellular loop in sensing zinc.

186 e sixth transmembrane helix and the adjacent extracellular loop in the pore region of mouse TRPV3.

187 caution against excluding the N terminus and extracellular loops in structural studies of this 7 tran

188 ial role of these functionally underexplored extracellular loops in the assembly and function of the

189 al role of arginine(172), located in the 2nd extracellular loop, in the action of decanoic acid but n

190 Various positions in the first extracellular loop, in the fifth, seventh, eighth, ninth

191 the C165-E166-S167-F168 motif at the second extracellular loop is critical for GPR81 function, and t

192 correct position of the cap relative to the extracellular loops is also required for optimal photoch

193 ed beta-barrel with a constriction formed by extracellular loops L2 and L3.

194 This site is located in the extracellular loop L3, showing that it is highly accessi

195 e of surface exposure of the conserved sixth extracellular loop (L6).

196 Protein fragments corresponding to the large extracellular loop (LEL) of each TSP were produced in re

197 Their rod-shaped structure includes a large extracellular loop (LEL) that plays a pivotal role in te

198 wer affinity for LqhII, indicating that this extracellular loop may form a secondary component of the

199 etion mutant (DeltagraS strain), a nonameric extracellular loop mutant (DeltaEL strain), and four res

200 teral frontoparietal polymicrogyria-inducing extracellular loop mutations (R565W and L640R) in the co

201 Hence, the C-terminal part of the first extracellular loop not only determines VRAC inactivation

202 green fluorescent protein is inserted in an extracellular loop of a voltage-sensing domain, renderin

203 or between Val-141 and Val-142 in the second extracellular loop of AQP4.

204 cterize conformational changes in the second extracellular loop of BtuB upon ligand binding and compa

205 By stabilizing the first extracellular loop of CaV1.2, CaValpha2delta1 may up-reg

206 ne residues predicted to reside on the first extracellular loop of CD133.

207 rst structural characterization of the large extracellular loop of CD81, expressed in mammalian cells

208 t to the exposed HCV interaction site in the extracellular loop of CD81.

209 e findings demonstrate the importance of the extracellular loop of CD98 in the innate host defense re

210 icts an amino acid substitution in the first extracellular loop of choline transporter-like protein 2

211 t E1E2 complexes can interact with the first extracellular loop of Claudin-1, whereas soluble E2 did

212 In addition, residues in the extracellular loop of CNIH-2/3 absent in CNIH-1/4 are cr

213 Chimeragenesis demonstrates that the first extracellular loop of Cx36 contains a Mg(2+)-sensitive d

214 C by binding to glycosylated residues in the extracellular loop of ENaC-alpha, as well as to a hither

215 his interaction was likely through the large extracellular loop of FtsX(Spn) and the amino terminal c

216 ed motif, C165-E166-S167-F168, at the second extracellular loop of GPR81.

217 We also demonstrated that the partial extracellular loop of hCD98 was sufficient for direct bi

218 e residues experimentally introduced into an extracellular loop of hERG1a and hERG1b subunits and pro

219 These antibodies bound to the first extracellular loop of KIR4.1.

220 cific interaction, LptE contacts a predicted extracellular loop of LptD through the lumen of the beta

221 that this loop makes contact with the first extracellular loop of MC1R through a series of key hydro

222 Introduction of the HA tag into the second extracellular loop of mouse DAT did not perturb its expr

223 resent study, 21 amino acids in TM11 and the extracellular loop of NaDC1 were mutated one at a time t

224 causes significant structural changes in the extracellular loop of p22(phox) and reduces its interact

225 ne-aspartic acid (RGD) sequence in the first extracellular loop of P2Y2R.

226 hat are predicted to contribute to the first extracellular loop of Patched2.

227 After mutagenizing the predicted extracellular loop of SaeS, we discovered one methionine

228 Autoantibodies directed against the second extracellular loop of the cardiac beta1-adrenergic recep

229 resulting p.Glu391Lys variation in the last extracellular loop of the equilibrative nucleoside trans

230 th a peptide sequence derived from the third extracellular loop of the first domain of NaV1.5.

231 s simultaneously at defined positions in the extracellular loop of the human P2X1 receptor during not

232 lso demonstrate that lysine 523 in the third extracellular loop of the M(3) receptors forms a hydroge

233 ve glycosylation sites situated in the large extracellular loop of the protein have been identified;

234 e ECD involves an interaction with the third extracellular loop of the receptor and suggest that gluc

235 n 2 probe labeled a residue within the first extracellular loop of the receptor, a region not previou

236 We detected a T352P mutation in the third extracellular loop of the voltage-gated potassium channe

237 pan14 constructs demonstrated that the large extracellular loop of Tspan14 mediated its co-immunoprec

238 activity of ENaC depends on cleavage of the extracellular loops of alpha and gamma subunits.

239 binding both stabilizes and repositions key extracellular loops of BtuB, optimizing interactions wit

240 onstructed knock-in mice in which the second extracellular loops of CD81 and OCLN were replaced with

241 have been identified in the S1-S2 and S3-S4 extracellular loops of domain II.

242 The extracellular loops of domain III are also involved in t

243 ll crystallographically available intra- and extracellular loops of four G-protein-coupled receptors

244 eal that disease-associated mutations to the extracellular loops of G1 differentially alter receptor

245 f these allosteric modulators associate with extracellular loops of GPCRs.

246 Concomitant sequence-based analysis of the extracellular loops of Na(v)s suggests that alpha-toxins

247 me, the roles played by different regions of extracellular loops of OmpA of E. coli K1 in the pathoge

248 he first time the different contributions of extracellular loops of OmpA to the pathogenesis of E. co

249 The size and dynamics of the extracellular loops of Opa60 required a hybrid refinemen

250 The structure and dynamics of the extracellular loops of OprH show distinct behaviors in d

251 ral analysis in a membrane revealed that all extracellular loops of rhomboid make stabilizing interac

252 iple interactions between GluA2 and variable extracellular loops of TARPs.

253 pe III domains of L1 and the first and third extracellular loops of the ANT proteins.

254 racellular domain of CaValpha2delta1 and the extracellular loops of the CaValpha1 protein in repeats

255 mprehensive mutational analysis of the three extracellular loops of the M23 isoform of human AQP4 usi

256 bled by conformational rearrangements of the extracellular loops of the protein.

257 pocket is occluded by the amino terminus and extracellular loops of the receptor.

258 against chimeric channels, we identified the extracellular loops of the TRPA1 S1-S4 gating domain as

259 s that negatively charged amino acids in the extracellular loops of TRPML3 may interfere with the obs

260 eight-stranded beta-barrel protein with four extracellular loops of unequal size.

261 rs is the presence of highly conserved, long extracellular loops or domains (ECDs) with unknown funct

262 Mutation of CopA extracellular loops or the electropositive surface of Cu

263 The amino terminus of S1P(1), but not any extracellular loop, prevented anti-S1P(1) Ab suppression

264 intramembranous pocket as well as the second extracellular loop region (ECL2).

265 eptide (E-pore peptide) corresponding to the extracellular loop region connecting the S5 and S6 segme

266 , was site-selectively incorporated into the extracellular loop regions (ECLs) of GCGR and GLP-1R, tw

267 the helical bundle, whereas the role of the extracellular loops remains undefined.

268 an additional unique segment in the CNIH-2/3 extracellular loop required for both physical interactio

269 electrostatic interaction between the third extracellular loop residue Lys-373 and D2.63(176).

270 We mutated extracellular loop residues hypothesized to compromise H

271 C requires precedent binding to glycosylated extracellular loop(s).

272 Based upon the conserved transmembrane and extracellular loop segments, our focus was on identifyin

273 als an unusually complex arrangement of long extracellular loops stabilized by four disulphide bonds.

274 identified seven novel residues in the first extracellular loop that are critical for entry of HCV is

275 solely in the length and composition of the extracellular loop that connects S4 to S3.

276 69 sterically blocks movements of the second extracellular loop that have been linked to receptor act

277 drogen bond with glutamate 219 of the second extracellular loop that hinders methoctramine binding to

278 ents initially identified a site in the long extracellular loop that stretches between helices 3 and

279 ) and M(3) receptors in the second and third extracellular loops that are involved in the binding of

280 he separate engineering of each of the seven extracellular loops that control access to the pore.

281 ing of ferredoxin occurs through specialized extracellular loops that form extensive interactions wit

282 beta-barrel outer membrane protein with four extracellular loops that mediates cell binding and resis

283 We identified four large extracellular loops that partially occlude the lumen whe

284 Following the deletion of each of the four extracellular loops that potentially interact with host

285 rs, but it has substantial rearrangements in extracellular loop three and the extracellular tip of tr

286 demonstrate that Y. pestis Ail uses multiple extracellular loops to interact with substrates importan

287 at the oligosaccharides of LPS stabilize the extracellular loops to some degree, apparently obviating

288 f the substrate, which ultimately becomes an extracellular loop, to the lumen of the forming beta-bar

289 The CASP first extracellular loop was found conserved in euphyllophytes

290 to localize correctly when either one of the extracellular loops was deleted.

291 containing a hemagglutinin tag in the second extracellular loop, we developed an assay to detect tran

292 pore-lining amino acid residues in the first extracellular loop were mutated to cysteine and screened

293 which three or four amino acids from various extracellular loops were changed to alanines, and we exa

294 The resulting ensemble revealed that the extracellular loops, which bind host receptors, occupy c

295 ors is intertwined by three intra- and three extracellular loops, whose local conformations are impor

296 omains that constitute the pore, and a large extracellular loop with defined domains termed the finge

297 than were donors to replacement of the CCR5 extracellular loops with corresponding regions of CCR2b,

298 four times and has one intracellular and two extracellular loops with the amino and carboxyl termini

299 ved N-linked glycosylation site in the first extracellular loop, with complex glycosylation in COS-7

300 ion of beta-barrel proteins is burial of the extracellular loops within the forming beta-barrel.