ライフサイエンスコーパス: extracellular space

1 of oxygen with high resolution in the brain extracellular space.

2 ma membrane and causing acidification of the extracellular space.

3 n during its simultaneous extrusion into the extracellular space.

4 a negligible ambient glutamate level in the extracellular space.

5 are small vesicles released from cells into extracellular space.

6 s that allow metalloprotease cleavage in the extracellular space.

7 S proteins have never been identified in the extracellular space.

8 e question of the role of these sRNAs in the extracellular space.

9 ng protein during collagen maturation in the extracellular space.

10 make use of a similar mechanism to reach the extracellular space.

11 ssue distortion including a reduction in the extracellular space.

12 l accumulation of Eu-HPDO3A in the increased extracellular space.

13 tein isoform (sGP) that is secreted into the extracellular space.

14 various compartments of the cell or from the extracellular space.

15 s and causes prolonged ATP release into the extracellular space.

16 , but extending more than 30 microm into the extracellular space.

17 sition and identifying those secreted in the extracellular space.

18 hat are surrounded by large, open regions of extracellular space.

19 plasma membrane and is not uploaded from the extracellular space.

20 sense and respond to neuromodulators in the extracellular space.

21 minutes after calcein-AM is removed from the extracellular space.

22 aluronan (HA) directly into cell surface and extracellular space.

23 inflammatory activity upon release into the extracellular space.

24 asma membrane and deliver their cargo to the extracellular space.

25 by mediating reuptake of serotonin from the extracellular space.

26 cilium that projects from the soma into the extracellular space.

27 by deposition of various protein fibrills in extracellular space.

28 vation fragments C3a and C3b confined to the extracellular space.

29 n reaching the neutral-pH environment of the extracellular space.

30 -to-cell communication and remodeling of the extracellular space.

31 of synaptically-released glutamate from the extracellular space.

32 s the release of protein aggregates into the extracellular space.

33 increasing the diffusion of dopamine in the extracellular space.

34 interior due to fluid phase uptake from the extracellular space.

35 nexons) of apposed cells dock head-on in the extracellular space.

36 release of synaptic vesicle content into the extracellular space.

37 he exchange of deeper tubule lumina with the extracellular space.

38 onment by secreting soluble factors into the extracellular space.

39 otransmission by removing serotonin from the extracellular space.

40 ignaling molecules such as D-serine into the extracellular space.

41 of astrocytes as they absorb water from the extracellular space.

42 in reduces the release of proteasomes in the extracellular space.

43 to ~1000-fold higher than in the surrounding extracellular space.

44 al monolayer into a hydrogel that models the extracellular space.

45 -index channels that are continuous with the extracellular space.

46 plasmic reticulum and become oxidized in the extracellular space.

47 ibited a regular striated arrangement of the extracellular space.

48 o isolate exosomes secreted into mouse brain extracellular space.

49 e of molecules between the cytoplasm and the extracellular space.

50 hat modulates BMP ligand availability in the extracellular space.

51 ts to become a potent Zn(II) chelator in the extracellular space.

52 ic matrix rich in sugars and proteins in the extracellular space.

53 as transport ligand exit gates opened to the extracellular space.

54 ibuted between lysosomes, cell membrane, and extracellular space.

55 ates that can be released to function in the extracellular space.

56 ensitive to water molecules diffusing in the extracellular space.

57 s involves the release of particles into the extracellular space.

58 pendent uptake of neurotransmitters from the extracellular space.

59 equestering essential metal nutrients in the extracellular space.

60 generating osmotic pressure gradients in the extracellular space.

61 ering pH shifts in the broader, macroscopic, extracellular space.

62 ed on the cell surface and secreted into the extracellular space.

63 GABA levels that are known to be present in extracellular space.

64 ort occurs by simple, rapid diffusion in the extracellular space.

65 of such growth factors are controlled in the extracellular space.

66 Ca(2+) stores triggers Ca(2+) entry from the extracellular space.

67 ules is greater than diffusional loss to the extracellular space.

68 ng the availability of growth factors in the extracellular space.

69 iding PAD2 and PAD2 substrates access to the extracellular space.

70 ranslocation of HMGB1 into the cytoplasm and extracellular space.

71 sicles, some of which were released into the extracellular space.

72 ause fluid exchange between the t-system and extracellular space.

73 VLVs are produced and are released into the extracellular space.

74 ellular compartments and are released in the extracellular space.

75 s and facilitates import of the ion from the extracellular space.

76 e endoplasmic reticulum, the cytosol and the extracellular space.

77 of incorporated C3(H2O) was returned to the extracellular space.

78 hat acidifies subcellular organelles and the extracellular space.

79 E cells, rather than being extruded into the extracellular space.

80 protease-2 (MMP-2) and MMP-9 activity in the extracellular space.

81 cell surface and releasing material into the extracellular space.

82 and deposition of EMILIN-1 and -2 within the extracellular space.

83 he cytoplasm and subsequent release into the extracellular space.

84 to maintain intracellular pH, acidifying the extracellular space.

85 tosis releases intracellular bacteria to the extracellular space.

86 clusions and their subsequent release to the extracellular space.

87 t its ATPase activity is not required in the extracellular space.

88 r than the extended diffusion throughout the extracellular space.

89 y Ca(2+), which is then extruded back to the extracellular space.

90 once it is released into the poorly perfused extracellular space.

91 s also secreted and modifies collagen in the extracellular space.

92 ain cells due to the entry of water from the extracellular space.

93 30-100nm in diameter) secreted by cells into extracellular space.

94 lular membrane to liberate exosomes into the extracellular space.

95 chanism by which tau can transfer is via the extracellular space.

96 , a maximum of 10% may be extracted from the extracellular space.

97 sociated histones that are extruded into the extracellular space.

98 omas and it exists in both intracellular and extracellular spaces.

99 this: (1) the presence of melanocores in the extracellular space; (2) within keratinocytes, melanin w

100 een placed on limiting Ca(2+) entry from the extracellular space across cell membranes, and emphasize

101 A moves Na(+) ions from the cytoplasm to the extracellular space against their gradient by utilizing

102 ing synaptically released glutamate from the extracellular space, allowing repeated rounds of signall

103 passenger domain") that is secreted into the extracellular space and a C-terminal beta-barrel domain

104 esmosomal remodeling, seen as an increase in extracellular space and a loss of the desmosomal interce

105 Acetylcholine is released into the extracellular space and acts through diffuse transmissio

106 the amino and carboxyl termini reside in the extracellular space and are initially linked by two tran

107 cytoplasmic structures were secreted to the extracellular space and endocytosed by neighboring cells

108 potent mammalian proteases secreted into the extracellular space and have been implicated in elastin

109 In vivo, amyloid deposits are found in the extracellular space and involve a variety of accessory m

110 The domain is found in the extracellular space and is likely to be composed of four

111 plasmic membrane material protrudes into the extracellular space and is released as MVs.

112 These analyses demonstrate the importance of extracellular space and lipid metabolism in atopic skin

113 -regulated genes known to have impact in the extracellular space and on the supporting stroma and wit

114 -soluble proteins that are secreted into the extracellular space and presented in the context of MHC

115 egate propagation by trapping fibrils in the extracellular space and preventing their uptake.

116 P binding opens the transport pathway to the extracellular space and reconfigures the substrate-bindi

117 d, the catalytic domain is secreted into the extracellular space and so serves as a functional extrac

118 Given that p-tau can be released to the extracellular space and that the astroglial water transp

119 ulating ion mobility, the volume fraction of extracellular space and the viscosity of matrix componen

120 naptically released glutamate remains in the extracellular space and, consequently, the duration and

121 lular tissue structures (vacuole, cytoplasm, extracellular spaces and cell wall) was investigated by

122 Gene ontology terms for "extracellular space" and "defense response" were enriche

123 m (ER) and mitochondria, (ii) the ER and the extracellular space, and (iii) the ER and cytoplasmic Ca

124 nt (100 kDa, s100), which is released in the extracellular space, and a residual C-terminal part (130

125 ionic polysaccharides, are ubiquitous in the extracellular space, and important extrinsic regulators

126 d by vasopressin's ability to diffuse in the extracellular space, and involved activation of CAN chan

127 labyrinthine cavities communicating with the extracellular space, and macrophages, containing promine

128 ue to conjugation, confining the drug to the extracellular space, and the requirement for a circulati

129 iation with serum albumin in circulatory and extracellular spaces, and association with intracellular

130 The extracellular space (apoplast) of plant tissue represent

131 on of Hyal1 and concurrent reuptake from the extracellular space are critical for rapid HA internaliz

132 t receptors encounter nucleic acids from the extracellular space are largely undefined.

133 r mechanisms regulating tau release into the extracellular space are not well understood.

134 Determining the electrical properties of the extracellular space around neurons is important for unde

135 We identify the extracellular space as an important compartment for mali

136 asL and TRAIL are formed and released in the extracellular space as exosomes.

137 culating miRNAs using the gene ontology term extracellular space as part of blood plasma.

138 ion of a dramatic opening of the TMDs to the extracellular space as the ATP hydrolysis transition sta

139 lactate followed by lactate release into the extracellular space, as detected by a lactate-sniffer.

140 on with serum albumin in the circulatory and extracellular spaces, association with FABP in the liver

141 lucuronidase by activated microglia into the extracellular space at the site of neuroinflammation.

142 s a balance between Fickian diffusion in the extracellular spaces at the brain surface and convective

143 ls to contract by transiently acidifying the extracellular space between the intestine and muscle.

144 ific lens membrane protein) interaction, (b) extracellular spaces between outer cortical fiber cells,

145 tivation and function is not confined to the extracellular space but also occurs within cells.

146 ptake transporter (SERT) to uptake 5-HT from extracellular space but do not synthesize it.

147 rich N-terminal domain is not exposed to the extracellular space but is localized intracellularly, an

148 ctivates EGFR only when it is present in the extracellular space, but that PEPD is released from inju

149 measurements also allow for an estimation of extracellular space by calculation of extracellular volu

150 zed secretion of lysosomal contents into the extracellular space by directing lysosomes to fuse with

151 CKB is released into the extracellular space by metastatic cells encountering hep

152 ncreases the persistence of glutamate in the extracellular space by slowing its clearance by astrocyt

153 leavable to mature bioactive IL-1beta in the extracellular space by the protease caspase-1.

154 and macromolecules are distributed into the extracellular space by virtue of their association with

155 ls to starve intracellular pathogens; in the extracellular space, calprotectin chelates Mn and Zn.

156 aracteristics and cellular biomarkers of the extracellular space can provide significant information

157 The transport of calcium to the extracellular space carried out by plasma membrane Ca(2+

158 he finding that LH2 modifies collagen in the extracellular space challenges the current view that LH2

159 The leaf extracellular space contains several peptidases, most of

160 d access to the LPA1 binding pocket from the extracellular space contrasting with the proposed access

161 thus increase the half-life of TIMP-3 in the extracellular space, controlling the bioavailability of

162 axonal cytoskeletal protein tau in the brain extracellular space correlated well with diffusion tenso

163 ) four structural parameters: fibre numbers, extracellular spaces, cross section area, and connective

164 As well as preserving a physiological extracellular space, cryo fixation reveals larger number

165 of synaptically released glutamate, whereas extracellular space decreases, thereby slowing dilution.

166 OLZ was then exocytosed to the extracellular space due to a high calcium ion (Ca(2+)) c

167 fraction decrease could reflect expansion of extracellular space due to tissue loss, intracellular so

168 causing non-vesicular GABA release into the extracellular space during intense network activity.

169 hway to rapidly recover Ca(2+) ions from the extracellular space during repetitive muscle activity.

170 et-dense granule component released into the extracellular space during the second wave of platelet a

171 heir ability to recapture glutamate from the extracellular space, EAATs exhibit a sodium- and glutama

172 We explored preserving extracellular space (ECS) during chemical tissue fixatio

173 Extracellular space (ECS) is a major channel transportin

174 IgG diffusion within brain extracellular space (ECS) may also play a role in limiti

175 re greatly and significantly enriched in the extracellular space (even in non-mammary cell lines), wh

176 t vectorial folding of the beta-helix in the extracellular space facilitates unidirectional secretion

177 sites that influence neurotransmission: the extracellular space, fine astrocytic processes, and neur

178 bules, similar to shedding vesicles into the extracellular space, followed by uptake by keratinocytes

179 cultures to different flow conditions in the extracellular space (for example, expression of atherosc

180 acts as an effective DAMP when released into extracellular space from damaged cells.

181 irst differentiated membranes exposed to the extracellular space from intracellular membranes; the se

182 lasmalemmal monoamine transporters clear the extracellular space from their cognate substrates and su

183 at is able to separate changes affecting the extracellular space from those that reflect changes in n

184 n also release transmitter directly into the extracellular space, from 'ectopic' release sites.

185 ich is rapidly converted to adenosine in the extracellular space, from astrocytes in a process termed

186 superoxide produced within cells and in the extracellular space, generating peroxynitrite.

187 Chloride is the major free anion in the extracellular space (>100 mM) and within the cytoplasm i

188 AAT expression, glutamate clearance from the extracellular space has been thought to have invariant k

189 nism of FGF2 membrane translocation into the extracellular space has remained elusive.

190 that allows recovery of Ca(2+) ions from the extracellular space, has been proposed to limit fatigue

191 The reservoir was released to the extracellular space immediately after exposure of astroc

192 red the coordinated release of zinc into the extracellular space in a prominent "zinc spark." The abi

193 cede its formation as amyloid plaques in the extracellular space in Alzheimer's disease (AD) patients

194 ion translocation between intracellular and extracellular space in association with recurrent transi

195 H2 co-localized with collagen fibrils in the extracellular space in human lung cancer specimens and i

196 Few dense bodies were observed in the extracellular space in mutant virus-infected cells in th

197 w ambient GABA concentrations present in the extracellular space in order to generate a form of tonic

198 microglia continuously scan the surrounding extracellular space in order to respond to damage or inf

199 r organelles in all eukaryotic cells and the extracellular space in some tissues.

200 of Abeta(40) and Abeta(42) peptides, in the extracellular space in the brain is a major characterist

201 s the accumulation of amyloid plaques in the extracellular space in the brain.

202 to the cell surface and its release into the extracellular space in the form of exosomes.

203 Although the extracellular space in the neuropil of the brain is an i

204 tion, and was continuously released into the extracellular space in the presence of glucose and fell

205 tical model of ion movement in the intra and extracellular space in the presence of ionic, potential

206 g eosinophils, as well as increased Gal-1 in extracellular spaces in the lungs.

207 microdomains, and probe the complex neuronal-extracellular space interactions that regulate neural ex

208 Fluorescently labeled dsRNA is imported from extracellular space into oocytes along with yolk and acc

209 AT-1 lines an accessibility pathway from the extracellular space into the binding pocket and plays a

210 The extracellular space is an exciting area for research tha

211 by which morphogens are proposed to traverse extracellular space is by traveling along specialized fi

212 In contrast, their function in the extracellular space is different.

213 l imaging illustrated that Zn(2+) entry from extracellular space is essential for translocation of MG

214 e either the characteristic dimension of the extracellular space is larger/comparable with the spatia

215 by diffusion of unbleached dextran from the extracellular space is monitored.

216 of astrocytes in releasing lactate into the extracellular space is not affected by MeCP2 deficiency,

217 ogical significance of miRNAs present in the extracellular space is not currently well understood.

218 ion of amyloid-beta (Abeta) within the brain extracellular space is one determinant of whether the pe

219 metazoan chaperone whose secretion into the extracellular space is regulated by the UPR, revealing a

220 et al. has claimed that the impedance of the extracellular space is some three orders of magnitude gr

221 Proper balance of ions in intracellular and extracellular space is the key for normal cell functioni

222 Brain extracellular space is the narrow microenvironment that

223 The release of nucleotides into extracellular space is triggered by insults like woundin

224 he increased persistence of glutamate in the extracellular space, is reflected by increased decay tim

225 GAPDH protofibrils could be assembled in the extracellular space kidnapping alpha-synuclein toxic oli

226 stribution of phosphatidylserine (PS) to the extracellular space, leading to a disruption of plasma m

227 ECV uses gadolinium contrast as an extracellular space marker based on T1 measures of blood

228 rnalization and/or micro-vesicle loss to the extracellular space may also contribute.

229 Thus, the non-uniformity found in the extracellular space may have specialized functions for s

230 ii) transport of dextrans in the parenchymal extracellular space, measured by 2-photon fluorescence r

231 ier radiotracer methods, have shown that the extracellular space occupies approximately 20% of brain

232 PPP1R1A was discharged into the extracellular space of chemically injured rat and human

233 accumulation of product in the much greater extracellular space of fermentors.

234 tracellular concentrations of solutes in the extracellular space of mammalian tissue, e.g., brain.

235 ysteamine, homocysteine, and cysteine in the extracellular space of OHSCs are 10.6 +/- 1.0 nM (n = 70

236 lism of cystamine, pantethine and CoA in the extracellular space of organotypic hippocampal slice cul

237 Plaques are found in the extracellular space of telencephalic structures, and hav

238 However, it is also found in the extracellular space of the brain at appreciable concentr

239 rm for multisite O2 recording in vivo in the extracellular space of the brain, demonstrated in anaest

240 the rat, the time course of dopamine in the extracellular space of the guinea pig determined the dur

241 2D patients IAPP is found aggregating in the extracellular space of the islets of Langerhans.

242 Vmax and Km for an enzymatic reaction in the extracellular space of the tissue.

243 in showed that the protein is located in the extracellular space of tobacco leaves and culture cells.

244 oxyproline-rich glycoproteins present in the extracellular spaces of plant cells.

245 red in regions of low blood flow such as the extracellular spaces of the bone marrow.

246 ided by lipids and proteins delivered to the extracellular spaces of the stratum corneum by the secre

247 dy effects of oscillatory convective flow in extracellular space on the velocity of chemical signal p

248 ese molecules are diffusely expressed in the extracellular space or aggregated as perineuronal nets a

249 occur either by a cell-free mode through the extracellular space or by cell-to-cell transmission invo

250 lasmic Zn balance by exporting Zn out to the extracellular space or by sequestering cytoplasmic Zn in

251 IDUA can be released directly into extracellular space or within microparticles during mega

252 SLC4A4 is involved in brain extracellular space pH regulation.

253 nding to NMDA receptor activation, or in the extracellular space, producing oxidative stress in neigh

254 nd escape of the cytosolic bacteria into the extracellular space, providing a potential mechanism of

255 of the formation and release of ROL into the extracellular space quantitatively describes this novel

256 es are segregated for their release into the extracellular space remains a challenge.

257 Most proteins destined for the extracellular space require disulfide bonds for folding

258 nic drift and diffusion within the intra and extracellular space, respectively, which contributed to

259 ntents through the glial syncytia and to the extracellular space, respectively.

260 extracellular sodium due to expansion of the extracellular space secondary to neuroaxonal loss.

261 accounted for resistive heterogeneity in the extracellular space showed similar HS distributions to t

262 ons suggest that these local enlargements in extracellular space speed transmitter clearance and redu

263 Nucleotides released to the extracellular space stimulate purinergic receptors, and

264 creted ERdj3 binds misfolded proteins in the extracellular space, substoichiometrically inhibits prot

265 ses when levels of glutamate are high in the extracellular space, such as following demyelination.

266 r glycoproteins with unique functions in the extracellular space, such as modulation of pro-transform

267 eater proportion of intracellular water into extracellular spaces than US.

268 tant for protein-protein interactions in the extracellular space that are instrumental in cell adhesi

269 n of the highly reactive N-terminus into the extracellular space that may be vulnerable to aggregatio

270 n control of protein distribution within the extracellular space that serves to regulate the protein-

271 cgl seeds, which is mainly secreted into the extracellular spaces, the addition of the SEKDEL sequenc

272 the diffusion of soluble receptors into the extracellular space; these then bind and neutralize thei

273 t neurons and release of seeded tau into the extracellular space to complete the cycle.

274 ators of Egfr signaling that function in the extracellular space to influence ligand activity.

275 Both routes deliver AGs from the extracellular space to lysosomes, and structural differe

276 ly participating in their transport from the extracellular space to the photoreceptors.

277 ms a unidirectional transit pathway from the extracellular space to the venous system.

278 bosis, particularly when accumulating in the extracellular space under tissue-damaging or pathologica

279 phages remove modified lipoproteins from the extracellular space until the cholesterol overload leads

280 mpts to reveal the size and structure of the extracellular space using electron microscopy have had l

281 ) and fractional volume of the extravascular extracellular space (v(e)) (P = .025) of ovarian lesions

282 ng the release of intracellular ATP into the extracellular space via regulation of as-yet unidentifie

283 arenchyma and subsequently secreted into the extracellular space via SWEET9, where sucrose is hydroly

284 reflux rate (Kep), fractional extravascular extracellular space volume (Ve), fractional plasma volum

285 For a long time, protein transport into the extracellular space was believed to strictly depend on s

286 ate conformations that were wide open to the extracellular space were studied.

287 Dally-like, we propose that LTL acts in the extracellular space where it completes a novel auto-regu

288 ffinity transition metal ion chelator in the extracellular space where it inhibits microbial growth.

289 seases leads to redistribution of MPO to the extracellular space, where it can mediate tissue damage

290 Cells release adenine nucleotides into the extracellular space, where these mediators are converted

291 er pyroptosis, ASC specks accumulated in the extracellular space, where they promoted further maturat

292 ted in decreased secretion of alpha-syn into extracellular space, whereas overexpressed PARK9 promote

293 te depends primarily on diffusion into large extracellular spaces, whereas later in development it re

294 d for constitutive D-serine release into the extracellular space, which contributes to NMDA receptor-

295 epithelial cells released histones into the extracellular space, which directly interacted with Toll

296 umulation or depletion, respectively, in the extracellular space, which we attributed to a residual c

297 itate the transport of molecules through the extracellular space while also regulating interstitial h

298 control over the chemical composition of the extracellular space with high spatiotemporal resolution.

299 s acts to clear this harmful enzyme from the extracellular space, with lysosomal-delivered MPO exhibi

300 ia gap junction hemichannels into the narrow extracellular spaces within a taste bud.