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1 ributes to the enhanced trafficking of MMP-9 extracellularly.
2 capsid proteolysis (uncoating) is initiated extracellularly.
3 howed no fluorescent signal either intra- or extracellularly.
4 ost of the FFA produced by E. coli are found extracellularly.
5 livering multiple types of membrane capsules extracellularly.
6 oforms in the effective trafficking of MMP-9 extracellularly.
7 on when administered intracellularly but not extracellularly.
8 appeared in acidic vesicles and was released extracellularly.
9 an ectonucleotidase, and generates adenosine extracellularly.
10 ucose is converted into lactate and released extracellularly.
11 pressing anchorless PrP-sen may be occurring extracellularly.
12 omer efficiently, and it does not accumulate extracellularly.
13 t innate inflammatory mediator when released extracellularly.
14 alert the host of infection both intra- and extracellularly.
15 the cell surface with the Gla domain exposed extracellularly.
16 thogen, Y. enterocolitica survives primarily extracellularly.
17 these cutaneous infections appears to occur extracellularly.
18 S. mitis appear to release mitilysin extracellularly.
19 es while the responses of RGCs were recorded extracellularly.
20 rectional Abeta kinesis, reducing its levels extracellularly.
21 etylspermine accumulated intracellularly and extracellularly.
22 r expressed on the plasma membrane, nor shed extracellularly.
23 lasm to the cell surface, and to be secreted extracellularly.
24 hat CAT processes Cm intracellularly but not extracellularly.
25 iation pathways regulate toxicity intra- and extracellularly.
26 the cytoplasm, in the periplasmic space, or extracellularly.
27 al water in the spin-dried sample, intra- or extracellularly.
28 f the fact that the mutant C termini project extracellularly.
29 proteins, being important to kill pathogens extracellularly.
30 e SPI2 and maintain virulence by replicating extracellularly.
31 rmined binding site of SR141716A but extends extracellularly.
32 by the presence of VEGFA intracellularly or extracellularly.
33 M-2 was reversed by reducing agents that act extracellularly.
34 gluconate, pyruvate, and acetate) accumulate extracellularly.
35 that some obscurin kinase isoforms localize extracellularly.
36 de exosomes, which are nanovesicles secreted extracellularly.
37 ested that quaternary amines can bind to two extracellularly accessible sites, one of them located at
38 metry fills this gap, it is limited to sites extracellularly accessible, when the key region for gati
40 ss to the large number of subunits composing extracellularly activated ligand-gated ion channels, suc
41 or targeted and site-specific delivery of an extracellularly active drug and an intracellular functio
42 GI is a multifunctional dimeric protein that extracellularly acts as a cytokine [autocrine motility f
43 GI is a multifunctional dimeric protein that extracellularly acts as a cytokine with properties that
44 GI is a multifunctional dimeric protein that extracellularly acts as a cytokine with properties that
45 esistance of disulfide bonds to reduction by extracellularly added DTT and Triton X-114 detergent pha
46 d class II-restricted epitopes from the same extracellularly added precursor peptide complexed to HSP
50 ed lipids inhibits cell penetration, whereas extracellularly administered pure oxidized lipids enhanc
53 choline and its breakdown product G3P occurs extracellularly allowing other bacteria to benefit from
54 In contrast, large microbes triggered ROS extracellularly, amplifying IL-1beta expression to recru
55 toxicity by modulating IAPP fibril formation extracellularly and also, after uptake by the cells, by
56 Invasin may cluster integrin heterodimers extracellularly and cause the integrin alpha and beta ch
57 detection of bacteria that typically reside extracellularly and demonstrate that this microbial sens
58 use yeast use invertase to hydrolyze sucrose extracellularly and import the resulting monosaccharides
59 c1 mutant strain is almost exclusively found extracellularly and in a hyperencapsulated form, and its
61 ion of cardiac and vascular KATP channels by extracellularly and intracellularly applied 11,12-EET.
62 acroscopic and single-channel currents using extracellularly and intracellularly applied methanethios
63 dase that has been proposed to function both extracellularly and intracellularly to activate oncogeni
64 is a bioactive lipid that can function both extracellularly and intracellularly to mediate a variety
68 rate that a sub-population of Alix localizes extracellularly and regulates integrin-mediated cell adh
69 prise glycerol and FFA formation and release extracellularly and the diversion of glucose carbons to
70 functional matrix biogenesis is coordinated extracellularly and thus reflects the cooperative action
72 whether IAPP toxic oligomers form intra- or extracellularly and whether vaccination to induce anti-t
74 ns can be expressed both intracellularly and extracellularly, and extracellular galectins mediate the
75 m is fibronectin independent, can take place extracellularly, and is demonstrated to be direct in vit
76 shock protein 90 beta (HSP90beta) is present extracellularly, and its interaction with the hemopexin
77 was localized on the cell surface, activated extracellularly, and required propeptide processing befo
78 hod takes advantage of the unique ability of extracellularly applied Abeta oligomers to rapidly induc
80 erometry that SERT has the capacity to clear extracellularly applied DA in the hippocampal CA3 region
82 -to-basal fluid transport in response to the extracellularly applied membrane-permeable cGMP analog p
84 ositions 106, 107, and 109 indeed react with extracellularly applied MTS probes, but not to intracell
86 selectivity filter are easily accessible to extracellularly applied sulfhydryl reagents and select f
87 n unprecedented level of detail by examining extracellularly applied tubular system markers in skelet
88 y of the cysteine-substituted amino acids to extracellularly applied, membrane-impermeant sulfhydryl
90 obility group box 1 (HMGB1) is a NF released extracellularly as a late mediator of lethality in sepsi
91 (HMGB1) is a nuclear factor that is released extracellularly as a late mediator of lethality in sepsi
94 42) fragments are found intracellularly, and extracellularly as amyloid plaques, in Alzheimer's disea
95 t stony corals precipitate calcium carbonate extracellularly as aragonite in a calcifying medium betw
97 lularly as part of fatty acid metabolism and extracellularly as diazepam binding inhibitor, the precu
98 an acute phase plasma protein, is deposited extracellularly as insoluble amyloid fibrils that damage
99 tive globular proteins, which then aggregate extracellularly as insoluble fibrils, damaging the struc
101 xed circular (RC) DNA genome can be secreted extracellularly as virions after envelopment with the vi
102 iral envelope proteins, leading to secretion extracellularly as virions, or (ii) disassembly (uncoati
103 ) stimulated further activation of caspase-1 extracellularly, as well as intracellularly after phagoc
104 wild-type HSV-1(F) virus intracellularly and extracellularly at late times postinfection, with the ex
107 ched polyethylene imine coated Ag NPs/mL the extracellularly bound Ag varied from 79 to 560 fg and ce
109 duces an autoregulatory peptide that matures extracellularly but functions intracellularly to regulat
110 icated that both GGT1 and GGT2 are localized extracellularly but have different physical or chemical
112 he actions of AEA were apparent when applied extracellularly but not during intracellular dialysis.
113 synthesis and metabolism intracellularly and extracellularly, but also in the macroenvironment via di
114 neoformans is found both intracellularly and extracellularly, but how these two components contribute
115 tic transmission and plasticity when applied extracellularly, but induced synaptic depression and LTP
117 mpeding the reuptake of bicarbonate produced extracellularly by CA9 could exacerbate the intracellula
119 trate that VEGF bioavailability is regulated extracellularly by matrix metalloproteinases (MMPs) thro
122 hat the precursor of NGF (proNGF) is cleaved extracellularly by plasmin to form mature NGF (mNGF) and
123 tudy, we demonstrate that LOXL2 is processed extracellularly by serine proteases, generating a 65-kDa
124 e mechanism of VEGF/Fn synergism is mediated extracellularly by the formation of a novel VEGF/Fn comp
125 x, and secreted pro-myostatin can be cleaved extracellularly by the proprotein convertase furin.
127 eted as a 46-kDa proenzyme that is activated extracellularly by the removal of an approximately 10-kD
128 el suggests that oligomerization is mediated extracellularly by unoccupied ligand-binding sites and t
130 an EPEC tryptophanase mutant when presented extracellularly, complementation was achieved with the e
131 d to the loss of the accessory toxins may be extracellularly complemented by inoculation of the defec
132 IP4a indicate that the N terminus is exposed extracellularly, consistent with a transmembrane KISD.
133 r geminin, in vitro, providing evidence that extracellularly delivered SMoC-geminin can have an antip
134 point to a possible mechanism through which extracellularly delivered ssRNA contributes to CNS damag
141 d proteins were detected in cell lysates and extracellularly, either as soluble proteins or in lympho
142 of presynaptic NMDARs depressed unitary and extracellularly evoked EPSCs at L4-L2/3 synapses, accomp
143 on method has the advantage of being able to extracellularly excite any neuron in a network regardles
144 , unique to Dictyostelia, mostly consists of extracellularly exposed and secreted proteins, with role
145 cyclable enzyme via direct immobilization of extracellularly expressed SrtA in the fermentation super
147 in the intact salamander retina, we recorded extracellularly from a population of ganglion cells with
148 ed to the extracellular space or it may form extracellularly from adenine nucleotides released from i
149 hese results indicate that adenosine, formed extracellularly from adenine nucleotides, plays a major
150 al plasticity in the AF pathway by recording extracellularly from individual M/T cells and presumed g
151 -dependent vestibular behaviors by recording extracellularly from neurons in the vestibular nuclear c
154 dine (4-AP)-evoked network activity recorded extracellularly from substantia gelatinosa (SG) of young
155 otentials of CRD-sensitive SNs were recorded extracellularly from the lumbar (L(2)-L(5)) spinal cord.
158 Thus, cholesteryl ester hydrolysis can occur extracellularly in a specialized compartment, a lysosoma
159 RTN CO(2)-activated neurons were recorded extracellularly in anaesthetized intact or vagotomized r
160 l transfer of information occurs, RNAs found extracellularly in animals are candidate molecules that
161 er, we have determined that it can also grow extracellularly in animals, in the lumen of the gallblad
163 Here we show that this pathway operates extracellularly in cultured Rosa cells, proceeds via sev
164 otoreceptor degeneration) rats were recorded extracellularly in flattened eye cup preparations, to as
165 nt procyclin, while in the mammal it resides extracellularly in its bloodstream form (BF) and is dens
166 l cells and putative stellate cells recorded extracellularly in layer II of the medial entorhinal cor
168 side hydrolases are public goods transported extracellularly in outer membrane vesicles allowing for
170 es as an inflammatory cytokine when secreted extracellularly in psoriatic lesions and is involved in
172 n (RT-PCR), and it was subsequently released extracellularly in Tat-expressing and HIV-infected astro
173 late and dense-cored cells, and it was found extracellularly in the fibrillar matrix and associated w
175 ulate and dense-core cells, and it was found extracellularly in the morula fibrillar matrix and assoc
177 AD) and before beta-amyloid (Abeta) deposits extracellularly in the presenilin (PS) 1/Abeta precursor
182 re found as intact membrane-bound structures extracellularly in tissue sites of eosinophil-associated
183 which soluble proteins aggregate and deposit extracellularly in tissues as insoluble fibrils, causing
185 male rats, trigeminal ganglia were explored extracellularly in vivo to identify the corneal neurons
188 ording CST-evoked focal synaptic potentials, extracellularly, in the cervical enlargement of cats bef
189 In contrast, 11,12-EET (5 microm) applied extracellularly increased KATP currents by 520% in mesen
192 study, alpha-MSH, instead of being delivered extracellularly, is targeted to the endoplasmic reticulu
193 ontrast, PAL-E-reactive vimentin is secreted extracellularly, its synthesis is restricted to a distin
195 The presence of dsRNA, intracellularly or extracellularly, leads to the induction of innate inflam
196 E containing only the PGRP domain functioned extracellularly, like the mammalian CD14 molecule, to en
197 regulator of the Toll pathway and functions extracellularly, likely by blocking the proteolytic acti
198 g properties of Cav1.3 channels, the largely extracellularly localized alpha2delta2 subunit moreover
199 c accessory proteins, like HrpZ1, may not be extracellularly localized, resulting in disabled translo
201 that the FhaB prodomain is required for the extracellularly located mature C-terminal domain (MCD) o
204 tion of the trivalent cation La(3+) (50 muM) extracellularly markedly prolongs the lag that precedes
205 g the early preictal phase, synchronous with extracellularly measured recurrent field potentials (FPs
206 this organism digests these polysaccharides extracellularly, mutants lacking this ability are outcom
207 ether fibrils are initially formed intra- or extracellularly, nor it is understood what determines wh
208 ellularly on infected macrophages as well as extracellularly on bacterial growth with very low toxici
210 port that matrix metalloproteinase-9 (MMP-9, extracellularly operating enzyme) in the central nucleus
211 yloid-beta (Abeta) oligomers, either applied extracellularly or accumulated intraneuronally, is an im
216 d their accessibility to intracellularly and extracellularly placed positively charged methanethiosul
217 binding affinity and selectivity of the more extracellularly positioned Na(+) binding site (Na1 site)
218 and compartmentalized analysis of intra- and extracellularly produced oxidants, respectively, using a
219 6-0-endosulfatase that is present and active extracellularly, providing a further mechanism to genera
220 w spatiotemporal ensemble spiking is encoded extracellularly, providing a window for efficient, LFP-b
221 molar ratios, provided that they were added extracellularly rather than being overexpressed in the c
222 in V1 in macaque monkeys and in humans that extracellularly recorded action potentials (spikes) and
223 els, as determined by their ability to block extracellularly recorded action potentials in three prep
225 valent use, the proper interpretation of the extracellularly recorded local field potential (LFP) is
226 aken place in recent years in the use of the extracellularly recorded local field potential (LFP) to
228 ursting firing nature, and was coherent with extracellularly recorded oscillatory field activity.
229 ically defined neuronal characteristics from extracellularly recorded physiological signatures has be
230 nt (20-40%) decrease in the amplitude of the extracellularly recorded postganglionic compound action
233 ntial (LFP) and multiunit activity (MUA) are extracellularly recorded signals that describe local neu
235 ike distance-to-threshold trajectory from an extracellularly recorded spontaneous spike train, using
236 ments of the NMDA dependent component in the extracellularly recorded stratum radiatum CA(1) field po
238 ices were then prepared and the amplitude of extracellularly recorded, orthodromically evoked, CA1 po
241 dition, TCDD treatment resulted in increased extracellularly regulated kinase phosphorylation and lym
242 types the mTOR inhibitor rapamycin activates extracellularly regulated kinases (Erk1/2) signaling.
243 D98089, a compound that blocks activation of extracellularly regulated kinases1/2, suppressed statin-
244 at all tested strains maximally produce, and extracellularly release, TpeL at the late-log or early-s
245 tigates the molecular mechanism of action of extracellularly released HMGB1 in airway epithelial cell
246 to better control the deleterious effects of extracellularly released neutrophil serine proteases and
247 n mRNA generates a truncated, nonfunctional, extracellularly released protein that binds to but does
249 um hydrolyzes the Wnt palmitoleoylate adduct extracellularly, resulting in inactivated Wnt proteins t
251 time reverse transcription-PCR shows that an extracellularly secreted form of tTLL, tTLLs, is transie
252 l identification and characterization of 908 extracellularly secreted proteins will advance our under
253 t study to demonstrate that expression of an extracellularly secreted tolloid-like metalloproteinase
254 ask whether nutrients that must be digested extracellularly select for the evolution of undifferenti
255 usion proteins are successfully secreted and extracellularly self-assemble into amyloid nanofibre net
258 arising from the intracellular hydration of extracellularly supplied CO2, overall CA activity in the
263 Eosinophils release their granule proteins extracellularly through exocytosis, piecemeal degranulat
264 o vesicle carrier intermediates and released extracellularly through incompletely understood mechanis
265 intracellularly from adenine nucleotides or extracellularly through sequential phosphohydrolysis of
266 the counter-regulation mechanism is mediated extracellularly through the type I IL-1 receptor alone.
270 trate that the N terminus of BAI1 is cleaved extracellularly to generate a truncated receptor and a 4
271 Sulf2 (XtSulf2), which like XtSulf1, can act extracellularly to inhibit BMP4 and FGF4 signalling.
273 ecreted inactive pro-KLKs are then activated extracellularly to mature peptidases by specific proteol
274 led compounds, we confirm NMN is metabolized extracellularly to NR that is then taken up by the cell
275 hese transmembrane molecules bind each other extracellularly to promote adhesion between dendrites an
276 ins, galectin-15 is hypothesized to function extracellularly to regulate Tr migration and adhesion to
277 secreted enzymes attack the polysaccharides extracellularly to remove the side-chains, exposing the
278 esponse in the neck connectives was recorded extracellularly to reveal the precise response-timing of
279 dryl reagents, as well as Cd(2+), were added extracellularly to test accessibility of the engineered
280 gineered Zn2+-binding site that was situated extracellularly to the predicted common binding pocket.
281 Using FLAG-tagged constructs that expressed extracellularly truncated APP, Notch-1, or CD44, we foun
282 We demonstrated that episomal expression of extracellularly truncated CpsA causes a dominant-negativ
283 igh-mobility group box 1 (HMGB1) is released extracellularly upon cell necrosis acting as a mediator
286 onas and Acinetobacter transferred electrons extracellularly via electron shuttles, and the consequen
288 In both systems, its actions are exerted extracellularly via membrane-bound receptors on adjacent
289 s of uric acid either intracellularly and/or extracellularly, we found that uric acid depletion subst
290 ial intracellularly, and motor neuron spikes extracellularly, we show that initiation of motor neuron
291 zyme acid sphingomyelinase (ASM) is released extracellularly when cells are wounded in the presence o
293 n kinase isoform that contains SK1 localizes extracellularly, where it undergoes N-glycosylation.
294 found in CCh fibroblasts intracellularly and extracellularly, whereas only proMMP-1 was found intrace
295 cal inhibition of the PCSK9-LDLR interaction extracellularly will increase hepatic LDLR expression an
297 e de novo IL-12-like activities by combining extracellularly with p35 released from other cells.
299 ous effects on presumptive MT cells recorded extracellularly, with an overall modest increase in rest
300 ysis revealed multiple spirochetes localized extracellularly within the tissue, and their identity wa
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