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1 the site of insulin action to control EGP is extrahepatic.
3 te of recurrence (intrahepatic: 16.9 months; extrahepatic: 16.6 months; intra- and extrahepatic: 16.2
5 ography in the detection and localization of extrahepatic (99m)Tc-MAA and to evaluate the typical and
9 on, new hepatic lesions) progression or (ii) extrahepatic (adrenal/bone/lung/lymph node) metastases.
10 C finding on ERCP is involvement of both the extrahepatic and intrahepatic bile ducts, with small duc
17 median age 58 years; median AMA titer 1:160; extrahepatic autoimmune disorders 46%; normal serum alka
18 HCV) infection is frequently associated with extrahepatic autoimmune disorders while interferon (IFN)
19 gkin lymphoma (P < .001) and gallbladder and extrahepatic bile duct cancer (P = .01) was observed.
20 higher: 100% for gallbladder cancer, 97% of extrahepatic bile duct cancer, 91% of ampula of Vater ca
21 ered or partially covered) for palliation of extrahepatic bile duct obstruction initially is more exp
25 h biliary tract cancer (237 gallbladder, 127 extrahepatic bile duct, and 47 ampulla of Vater), 895 wi
28 and active caspase-3 staining in livers and extrahepatic bile ducts from Balb/c mice infected with R
31 progressive fibroinflammatory obstruction of extrahepatic bile ducts that presents as neonatal choles
32 d cholangiocytes, that line intrahepatic and extrahepatic bile ducts, contribute substantially to bil
33 truction of segments or the entire length of extrahepatic bile ducts, the timely pursuit of hepatopor
34 epithelial and subepithelial compartments of extrahepatic bile ducts, with onset within 3 days and pe
40 h affect these loops and are associated with extrahepatic biliary atresia, lead to a loss of membrane
41 tire glandular stomach, rostral duodenum and extrahepatic biliary system to pancreas, with formation
42 resulting in inflammatory obstruction of the extrahepatic biliary tract and intrahepatic bile ducts.
44 at the upper, middle, and lower part of the extrahepatic biliary tree in 11, 4, and 4 patients (58%,
46 propagation of human cholangiocytes from the extrahepatic biliary tree in the form of extrahepatic ch
49 enitors are present in peribiliary glands of extrahepatic biliary trees from humans of all ages and i
50 ptoms of HCC and/or vascular invasion and/or extrahepatic cancer are considered to have advanced-stag
51 ses in 48 (47%; bacterial infection: n = 13; extrahepatic cancers: n = 10; cardiovascular events: n =
52 r cancer: n = 18; miscellaneous, n = 30) and extrahepatic causes in 48 (47%; bacterial infection: n =
53 stigated the relative role of hepatic versus extrahepatic CB1 receptors in the metabolic consequences
54 ies where the distinction between intra- and extrahepatic CC was used, some potential risk factors se
57 50 human CCA samples (25 intrahepatic and 25 extrahepatic CCA) as well as human KMCH-1, Mz-CHA-1, and
60 nclude endocrine effects, HCV replication in extrahepatic cells, or a heightened immune reaction with
61 e measured in the following intrahepatic and extrahepatic cholangiocarcinoma (CCA) cell lines, Mz-ChA
62 known about the association between HCV and extrahepatic cholangiocarcinoma (ECC) or pancreatic canc
65 = 3, intrahepatic cholangiocarcinoma: n = 2, extrahepatic cholangiocarcinoma: n = 2, malignant epithe
66 ct cancers (BTC), which encompass intra- and extrahepatic cholangiocarcinomas and gallbladder carcino
67 t cancers (BTCs), which encompass intra- and extrahepatic cholangiocarcinomas as well as gallbladder
68 the extrahepatic biliary tree in the form of extrahepatic cholangiocyte organoids (ECOs) for regenera
71 testinal FXR protected mice from obstructive extrahepatic cholestasis after bile duct ligation or adm
76 ajor clinical problem that leads to frequent extrahepatic complications including intestinal dysfunct
77 to develop a frailty index to capture these extrahepatic complications of cirrhosis and enhance mort
79 tion and to reduce the burden of hepatic and extrahepatic complications of HCV that are observed in k
80 oma, and end-stage liver disease, as well as extrahepatic complications such as cryoglobulinemia and
82 normal kidney function or do not have severe extrahepatic conditions, TIPS is an excellent option to
83 ic cytochrome b(5) deletion, suggesting that extrahepatic cytochrome b(5) plays a significant role in
84 ults demonstrate that hepatic and, possibly, extrahepatic cytochrome P450 (P450) enzymes play a role
87 r, in contrast to (99m)Tc-MAA, an unintended extrahepatic deposition of this beta-emitting scout dose
89 used for lung shunt analysis, evaluation of extrahepatic deposition, and sometimes for treatment pla
93 ectal liver metastases (CRLM) and concurrent extrahepatic disease (EHD), and to define prognostic fac
94 ectal liver metastases (CRLM) and concurrent extrahepatic disease (EHD), and to define prognostic fac
96 correlated with the severity of hepatic and extrahepatic disease and systemic inflammatory responses
98 onous presentation, primary node status, and extrahepatic disease as matching variables to compare ov
101 These studies concluded that the presence of extrahepatic disease should be a contraindication to res
102 al after resection is worse in patients with extrahepatic disease than in patients with liver-only di
105 , absence of postoperative chemotherapy, and extrahepatic disease were predictive of recurrence (HR=2
106 ighly selected patients with single sites of extrahepatic disease, although expectations should be di
107 performance status, macrovascular invasion, extrahepatic disease, and alpha-fetoprotein level to bes
108 or B, ECOG performance status of 0 to 2, no extrahepatic disease, and no prior radiation received 15
109 or and metastases, CRLM number and diameter, extrahepatic disease, and preoperative chemotherapy.
111 nvasion (HR = 2.2; P = 0.03), but not pre-LT extrahepatic disease, were significant risk factors for
119 AFLD may be a new, and added risk factor for extrahepatic diseases such as CVD, chronic kidney diseas
120 nificantly higher mortality from hepatic and extrahepatic diseases than anti-HCV seropositives with u
121 s had higher mortality from both hepatic and extrahepatic diseases, showing multivariate-adjusted haz
122 ) for hepatic diseases; 1.35 (1.15-1.57) for extrahepatic diseases; 1.50 (1.10-2.03) for circulatory
125 s, with type 3 being the most common type of extrahepatic duct involvement and detected in 16 (35.5%)
127 were involved in 11 (24.4%) patients and the extrahepatic ducts were involved in 14 (31.1%), with 17
130 s of insulin on HGP and utilization, and (2) extrahepatic effects of insulin are sufficient to mainta
131 ribavirin was shown to improve some of these extrahepatic effects; sustained virological response is
133 FT505 concentrated in the liver with limited extrahepatic exposure and underwent extensive enterohepa
134 7 cm), and solitary (ISS) and those that had extrahepatic extension and were large (>/=7 cm) and mult
136 zards model demonstrated that multifocality, extrahepatic extension, grade, node positivity, and age
137 ithout metastatic disease, nodal metastasis, extrahepatic extension, or major vascular invasion).
143 to the liver in 1 patient (4%), exclusively extrahepatic in 18 patients (72%), and were both intra a
145 ssion pattern was divided into: intrahepatic/extrahepatic increase in tumor size, new intrahepatic le
147 ce test (FSIGT), we estimated hepatic versus extrahepatic insulin clearance in 29 EA and 18 AA health
148 el-based method to estimate both hepatic and extrahepatic insulin clearance using plasma insulin and
149 epatic extraction was 25.8% [32.7%], and for extrahepatic insulin clearance was 20.7 mL/kg/min [11.7
151 cterizes the contributions of hepatic versus extrahepatic insulin degradation related to ethnic diffe
153 ic insulin sensitivity; sitagliptin enhanced extrahepatic insulin sensitivity with a synergistic effe
154 trapancreatic bile duct in 51%; the proximal extrahepatic/intrahepatic ducts were involved in 49%.
162 umor diameter, number of nodules, intra- and extrahepatic macroscopic vascular invasion, extrahepatic
163 ents at risk for HCC but without established extrahepatic malignancy from August 2012 through August
165 2.9), and 5.2 (95% CI 3.3-7.8), and SIRs for extrahepatic malignancy were 2.7 (95% CI 1.8-3.9), 1.6 (
166 xed cryoglobulinemia (MC) is the most common extrahepatic manifestation of chronic hepatitis C virus
167 h clinical data, this description of a novel extrahepatic manifestation of NASH should sensitize derm
169 is the burden of HCV disease associated with extrahepatic manifestations (diabetes, B-cell proliferat
171 meta-analysis to determine the prevalence of extrahepatic manifestations in patients with HCV infecti
174 h condition to determine prevalence rates of extrahepatic manifestations of HCV infection and their e
178 r 2014, to identify studies of the following extrahepatic manifestations of HCV infection: mixed cryo
179 ic conditions associated with HCV infection, extrahepatic manifestations of HCV may become a major in
181 a from 102 studies, we found the most common extrahepatic manifestations to be diabetes (in 15% of pa
182 itis C virus (HCV) infection has hepatic and extrahepatic manifestations with various costs and impai
190 OC PET/CT detected additional hepatic and/or extrahepatic metastases in 22 of the 33 patients diagnos
191 LSF did not correlate with the presence of extrahepatic metastases or prior administration of bevac
192 Histologic examination demonstrated that no extrahepatic metastases were detectable during primary t
193 with liver metastases plus or minus limited extrahepatic metastases were randomly assigned to receiv
195 ce status, no more than 25% tumor burden, no extrahepatic metastases, albumin greater than 3 g/dL, an
196 ts in the absence of macrovascular invasion, extrahepatic metastases, and deteriorated PS predicts th
198 ocoregional therapies die without developing extrahepatic metastases, the notion of HCC as a systemic
199 minimisation with four factors: presence of extrahepatic metastases, tumour involvement of the liver
206 tus of 1-2, and/or macrovascular invasion or extrahepatic metastasis) were included in the study (n =
208 Mice with loss-of-function mutation in the extrahepatic mitochondrial enzyme CoA transferase (succi
213 cutive patients with cirrhosis and untreated extrahepatic, nonmalignant partial PVT were followed up
214 currence site was intrahepatic only (43.2%), extrahepatic only (35.8%), intra- and extrahepatic (21.0
218 isting chronic liver disease and hepatic and extrahepatic organ failures, and is associated with subs
219 ay survival worsened with a higher number of extrahepatic organ failures, none (92%), one (72.6%), tw
220 mber of liver segments resected, concomitant extrahepatic organ resection, a diagnosis of primary liv
223 f (90)Y-microspheres to the lungs; to detect extrahepatic perfusion emerging from the injected vascul
226 ding indications for MesoRex bypass (MRB) in extrahepatic portal vein obstruction and the role of pri
229 ly more frequently in OPV than in cirrhosis: extrahepatic portal vein thrombosis (18 [43%] of 42 vs f
230 etric features of the liver in children with extrahepatic portal vein thrombosis (EHPVT), with surgic
233 95% CI: 1.544-2.975; P < 0.001), concomitant extrahepatic procedures (HR: 1.742, 95% CI: 1.103-2.750;
234 oss of ketone body oxidation, an exclusively extrahepatic process, disrupts hepatic intermediary meta
235 treated with exogenous PP-IX (mimicking XLP extrahepatic protoporphyria) or with the iron chelator d
239 CRBP1, and CD36 in retinoid mobilization and extrahepatic retinoid uptake, as well as a role for CYP2
240 retinoid dehydrogenase mRNAs and activities, extrahepatic retinol concentrations, and atRA catabolism
242 lective internal radiation therapy to detect extrahepatic shunting to the lung or the gastrointestina
246 is the first report on the identification of extrahepatic sites of HEV replication in animals after e
253 core (ECOG PS; 0 or 1), vascular invasion or extrahepatic spread (yes or no), and hepatitis B virus (
256 itions, indication and extent of hepatic (or extrahepatic) surgery and the hospital type, location, a
257 disease and is associated with a variety of extrahepatic syndromes, including central nervous system
259 rculating complement protein synthesis site, extrahepatic synthesis is known to optimize local tissue
260 ression-free survival (PFS) in the liver and extrahepatic (systemic) organs were retrospectively eval
261 is whether procarcinogen bioactivation in an extrahepatic target tissue (e.g., the lung) is essential
264 othyroidism-induced NAFLD is both intra- and extrahepatic; they also reveal key metabolic differences
265 expression, Bmp/Smad signaling, hepatic and extrahepatic tissue iron accumulation) with that of sing
267 f Foxo1, insulin signals via an intermediary extrahepatic tissue to regulate liver glucose production
268 t the poor distribution of PA-based drugs to extrahepatic tissues and thereby to improve the therapeu
270 The characterization of VKOR activity in extrahepatic tissues demonstrated that a part of the VKO
271 ining the supply of energy from the liver to extrahepatic tissues during periods of prolonged food de
273 by an initial phase of rapid mobilization to extrahepatic tissues followed by extensive catabolism wi
274 iched plasma HDL may serve to deliver S1P to extrahepatic tissues for atheroprotection and may have o
276 the vitamin K-dependent protein produced by extrahepatic tissues such as matrix Gla protein or osteo
278 aling molecules that act at both hepatic and extrahepatic tissues to regulate lipid and carbohydrate
279 rtly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists and the la
281 (RBP4) transports retinol from the liver to extrahepatic tissues, and RBP4 lowering is reported to i
284 ved in the breakdown of ketone bodies in the extrahepatic tissues, was identified in rat heart to und
288 ability thereby minimizing distribution into extrahepatic tissues; concurrently, they were also optim
291 pendently predicted by PS, prothrombin time, extrahepatic tumor spread, macrovascular invasion, and r
293 can readily be extended to a broad range of extrahepatic tumors, transgenic tumors with defined mech
294 ns (V) or portal bifurcation (P), contiguous extrahepatic tumour (E), multifocal tumour (F), and spon
298 The energy-intense nature of hepatic and extrahepatic urea osmolyte production for renal water co
300 ahepatic vascular invasion), and presence of extrahepatic vascular invasion or metastasis were includ
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