ライフサイエンスコーパス: extraintestinal

1 ny of them predominantly or even exclusively extraintestinal.

2 t mucosal immunity, both intraintestinal and extraintestinal.

3 ry and soft tissues, as well as a variety of extraintestinal abdominopelvic IBD inflammatory bowel di

4 DC responses can promote both intestinal and extraintestinal adaptive immunity.

5 (malabsorption syndrome); 2) non-classical (extraintestinal and/or gastrointestinal symptoms other t

6 Salmonella disease was typically severe, extraintestinal, and caused by nontyphoidal serovars.

7 We describe key intestinal, extraintestinal, and laboratory features of 50 genetic v

8 uster and are produced by certain commensal, extraintestinal, and probiotic E. coli.

9 inal submucosa can cause both intestinal and extraintestinal autoimmune disorders in genetically susc

10 amely segmented filamentous bacteria, and an extraintestinal autoinflammatory disease.

11 lative whether the gut microbiota influences extraintestinal biological functions.

12 METHODS Extraintestinal C. difficile infections (CDIs) were sear

13 s of gastrointestinal cancer and 16 cases of extraintestinal cancer.

14 ic bacteria can influence the development of extraintestinal cancers, highlighting the opportunities

15 atory events that can suppress or accelerate extraintestinal cancers.

16 Extraintestinal CDI was found in 31 patients who compris

17 Extraintestinal CDIs in the abdominal area may result fr

18 Mortality in extraintestinal CDIs is associated with the severity of

19 Extraintestinal CDIs occur mainly in hospitalized patien

20 that infectious rotavirus has access to any extraintestinal cell within contact of blood.

21 interstitial fluid for transport of heme to extraintestinal cells, including oocytes.

22 duced reporter gene activity to the level of extraintestinal cells.

23 ia coli O157 causes severe enteritis and the extraintestinal complication hemolytic-uremic syndrome.

24 gainst amebic liver abscess, the most common extraintestinal complication of amebiasis.

25 f uncommon, but often severe, intestinal and extraintestinal complications can occur.

26 Extraintestinal complications from salmonella, shigella,

27 gic abnormalities are among the most serious extraintestinal complications of infection with Shiga to

28 rs during inflammation might account for the extraintestinal complications such as abnormalities in b

29 l for cardiometabolic, autoimmune, and other extraintestinal conditions that were not previously cons

30 xporter trafficking that is coordinated with extraintestinal copper levels in Caenorhabditis elegans

31 s sufficient to induce its own production by extraintestinal DC in vitro and in vivo.

32 Pretreatment of extraintestinal DC with a TLR1/2 agonist was sufficient

33 r fetus is a cause of enteritis and invasive extraintestinal disease in humans.

34 s hypothesis and explain the distribution of extraintestinal disease in inflammatory bowel disease.

35 e types and resemble E. coli associated with extraintestinal disease in phylogeny and virulence gene

36 o the intestine, recent reports suggest that extraintestinal disease occurs.

37 Yersinia enterocolitica rarely causes extraintestinal disease.

38 lly, and have potential links to enteric and extraintestinal disease.

39 but its breakdown can lead to intestinal and extraintestinal disease.

40 particularly in those strains that can cause extraintestinal disease.

41 vention in a variety of gastrointestinal and extraintestinal diseases including diseases of the colon

42 and birds, causing gastroenteritis and other extraintestinal diseases.

43 nd modulation of a variety of intestinal and extraintestinal diseases.

44 intestinal epithelial cells and facilitates extraintestinal dissemination in vivo.

45 This CD18-dependent pathway of extraintestinal dissemination may be important for the d

46 h nodes and kidneys were cultured to monitor extraintestinal dissemination of C. albicans.

47 Extraintestinal dissemination was greatest with HLC54, i

48 nity is confined to periods of high risk for extraintestinal dissemination.

49 ntitative data analysis to gain insight into extraintestinal dissemination.

50 fer between clones, the adhesive subunits of extraintestinal E. coli are under strong positive select

51 a strategy for the prevention and therapy of extraintestinal E. coli infection including bacteremia a

52 onal group that is both the leading cause of extraintestinal E. coli infections and the main source o

53 d-borne organisms are a significant cause of extraintestinal E. coli infections in humans.

54 the E. coli hemolysin (Hly) associated with extraintestinal E. coli infections.

55 A total of 1,679 extraintestinal E. coli isolates (collected from 2010 to

56 We examined here extraintestinal E. coli strain CFT073 by differential fl

57 lineage of E. coli ST131 distinct from other extraintestinal E. coli strains within the B2 phylogroup

58 The rapid identification of major extraintestinal E. coli STs will benefit future epidemio

59 m sewage using strain 536, a highly virulent extraintestinal E. coli.

60 l as well as pathogenic (both intestinal and extraintestinal) E. coli strains and in Salmonella strai

61 expression; since Stx is responsible for the extraintestinal effects of STEC infection, such as hemol

62 ncrease in mucosal permeability and that the extraintestinal endocytotic uptake of transferred partic

63 Extraintestinal Escherichia coli (ExPEC), a heterogeneou

64 gested to play a role in the pathogenesis of extraintestinal Escherichia coli infection.

65 Extraintestinal Escherichia coli infections are associat

66 Most human extraintestinal Escherichia coli infections, including t

67 Extraintestinal Escherichia coli strains cause meningiti

68 there is evidence that a proportion of human extraintestinal ESCR-EC infections originate from FPAs.

69 ood-producing animals (FPAs) are a source of extraintestinal expanded-spectrum cephalosporin-resistan

70 sease related symptoms (gastrointestinal and extraintestinal), family history, co-morbid diseases and

71 l hamartomatous polyps in the absence of the extraintestinal features that are classic for other hama

72 CT enterography and SBFT depicted extraintestinal findings (eg, mesenteric adenopathy in t

73 Extraintestinal findings were recorded.

74 Fine-needle aspiration, the presence of extraintestinal gas on computed tomography, or both were

75 BALB/c.D2 mice and was severely impaired in extraintestinal growth but not in growth in the cecum.

76 s propagated in the rat tissue cage model of extraintestinal growth, and that this ability provides a

77 STa (5--18) to selectively target and image extraintestinal human colon cancer xenografts in vivo in

78 tive interaction to target imaging agents to extraintestinal human colon tumors in nude mice.

79 ndicated that APEC resembles E. coli causing extraintestinal human diseases.

80 stratified by host group (104 predominantly extraintestinal human isolates and 100 predominantly int

81 Here we show that heme homeostasis in the extraintestinal hypodermal tissue was facilitated by the

82 In IFN-alpha/beta receptor KO mice the extraintestinal infection and systemic disease were only

83 also important in order for E. coli to cause extraintestinal infection in mice.

84 We report an unusual case of extraintestinal infection with adult Enterobius vermicul

85 inary tract infection (UTI) is a very common extraintestinal infection, and Escherichia coli is by fa

86 also are discussed, including information on extraintestinal infection, viral antagonists of the inte

87 phoP significantly attenuated E. coli during extraintestinal infection.

88 90 E. coli strains (18 fecal isolates and 72 extraintestinal-infection isolates) were characterized f

89 ts with serious, invasive, non-urinary tract extraintestinal infections (pneumonia, deep surgical wou

90 isolated almost exclusively from humans with extraintestinal infections and accounted for 50% of all

91 gs for the pathophysiology of B. fragilis in extraintestinal infections and competition in ecological

92 luence of systemic disorders, intestinal and extraintestinal infections and enteric bacteria on diges

93 i strains that originally were isolated from extraintestinal infections and represented 5 multilocus

94 with other E. coli types in causing invasive extraintestinal infections and suggest instead that ST13

95 desirable to prevent the millions of annual extraintestinal infections and the thousands of associat

96 targets for preventive interventions against extraintestinal infections due to E. coli.

97 onas hydrophila leads to both intestinal and extraintestinal infections in animals and humans, and th

98 morrhagic septicemia in fish and gastro- and extraintestinal infections in humans.

99 diversity, and contributes significantly to extraintestinal infections in humans.

100 icemia in fish and both gastrointestinal and extraintestinal infections in humans.

101 but also contributes to gastrointestinal and extraintestinal infections in humans.

102 ith diarrheal illness in patients with AIDS, extraintestinal infections involving various organs have

103 -resistant epidemic clonal group A can cause extraintestinal infections other than uncomplicated urin

104 herichia coli isolates from four adults with extraintestinal infections underwent molecular phylotypi

105 ibrio cholerae can cause gastroenteritis and extraintestinal infections, but, unlike O1 and O139 stra

106 a, and we show its frequent association with extraintestinal infections, compared to other NTS serova

107 h urinary tract infection, sepsis, and other extraintestinal infections, especially the most extensiv

108 Pic-related protease Tsh/Hbp, implicated in extraintestinal infections, exhibited a spectrum of subs

109 cases of Campylobacter fetus intestinal and extraintestinal infections, including 2 patients with an

110 esin of E. coli, papG-II, also implicated in extraintestinal infections.

111 genesis of gram-negative pneumonia and other extraintestinal infections.

112 similar serotypes from patients with diverse extraintestinal infections.

113 ribute to the pathogenesis of B. fragilis in extraintestinal infections.

114 ce types are shared between the two forms of extraintestinal infections.

115 ridium difficile has rarely been isolated in extraintestinal infections.

116 Extraintestinal infectious rotavirus, but not diarrhea,

117 vestigated in experimental enterocolitis and extraintestinal inflammation induced by bacterial polyme

118 tion significantly attenuated intestinal and extraintestinal inflammation, with even more pronounced

119 bacteria may provide therapeutic targets for extraintestinal inflammatory diseases such as MS.

120 in Buffalo rats resolved by 24 days without extraintestinal involvement.

121 Our laboratory is studying an extraintestinal isolate of Escherichia coli as a model p

122 t unique to J96 but is present in a group of extraintestinal isolates of E. coli O4:H5 that represent

123 e regarded as important virulence factors in extraintestinal isolates of Escherichia coli, but their

124 Our knowledge of the traits possessed by extraintestinal isolates of Escherichia coli, necessary

125 III capsular polysaccharides (e.g., K54) of extraintestinal isolates of Escherichia coli, similar to

126 of dsdX present at the argW-dsdCXA island of extraintestinal isolates.

127 Four patients had associated extraintestinal location (biliary tract [n = 3] and lung

128 virus antigen and/or nucleic acid in various extraintestinal locations such as serum, liver, kidney,

129 l Ags are not responsible for the anemia and extraintestinal lymphoid hyperplasia that occur in IL-2(

130 ma (ETL) and B-cell lymphoma of the gut, but extraintestinal lymphomas can also be seen.

131 Myositis can be considered to be a rare extraintestinal manifestation of Crohn's disease and can

132 The current case demonstrates a rare extraintestinal manifestation of Crohn's disease, orbita

133 f neurologic syndromes may be the presenting extraintestinal manifestation of gluten sensitivity with

134 mise in treating this rare, but devastating, extraintestinal manifestation.

135 eportedly more common in patients with other extraintestinal manifestations (EIMs), particularly arth

136 g the gastrointestinal tract with associated extraintestinal manifestations and immune disorders.

137 visualize the lumen, transmural involvement, extraintestinal manifestations and may facilitate decisi

138 o thrive, and abdominal distention; however, extraintestinal manifestations are becoming increasingly

139 gical management of intestinal polyposis and extraintestinal manifestations are reviewed.

140 gastroenteritis and are also associated with extraintestinal manifestations in humans and many animal

141 Extraintestinal manifestations included osteopenia/osteo

142 Extraintestinal manifestations of C. difficile are uncom

143 The response of extraintestinal manifestations of CD should be investiga

144 d T cells migrating into the liver can cause extraintestinal manifestations of inflammatory bowel dis

145 disease, although its effect on some of the extraintestinal manifestations of the disease remains to

146 D) is associated with osteoporosis and other extraintestinal manifestations that might be mediated by

147 for JPS in a child is controversial because extraintestinal manifestations that would exclude JPS co

148 behavior, disease course, age at onset, and extraintestinal manifestations).

149 he indication for colectomy, the presence of extraintestinal manifestations, and an elevated platelet

150 y, celiac disease is associated with various extraintestinal manifestations, including neurologic com

151 is not confined only to the gut but can have extraintestinal manifestations, including viremia.

152 auses gastrointestinal disorders, as well as extraintestinal manifestations.

153 ecognized range of associated conditions and extraintestinal manifestations.

154 ms of isolated poor growth, anemia, or other extraintestinal manifestations.

155 an inflammatory bowel disease and associated extraintestinal manifestations.

156 and penetrating complications, and diagnose extraintestinal manifestations.

157 nce, their role in intestinal absorption and extraintestinal metabolism of dietary fat is less clear.

158 ficant associated morbidity and mortality of extraintestinal microsporidiosis.

159 mice and humans in vitro, and intestinal and extraintestinal mouse DC activation and mobilization to

160 acquires amino acid replacements adaptive in extraintestinal niches (the genitourinary tract) but det

161 to disseminate from the bowel and establish extraintestinal niches is promoted by the spv locus.

162 paration of pathotypes on the basis of their extraintestinal or diarrheagenic nature is not supported

163 ppaB decoy ODNs did not inhibit NF-kappaB in extraintestinal organs and resulted in CD4+ T cell apopt

164 mice harbored high numbers of pathobionts in extraintestinal organs despite comparable pathogen load

165 in any of the six gastrointestinal and five extraintestinal organs examined.

166 distinctive replication capacities in mouse extraintestinal organs such as the biliary tract.

167 he intestine and control bacterial spread to extraintestinal organs.

168 remia, spread, and pathology of rotavirus in extraintestinal organs.

169 Escherichia coli O15:K52:H1 is a significant extraintestinal pathogen in Europe.

170 y emerged, disseminated, multidrug-resistant extraintestinal pathogen, after presumably having acquir

171 epidemiological relevance of J96 as a model extraintestinal pathogen, provide further evidence of th

172 ), a widely disseminated multidrug-resistant extraintestinal pathogen, typically exhibits serotype O2

173 mplicate sigma(E) and its regulon in E. coli extraintestinal pathogenesis.

174 y of 312 blood- or urine-derived isolates of extraintestinal pathogenic (ExPEC) Escherichia coli, a c

175 69 ecpA+ strains representing intestinal and extraintestinal pathogenic as well as normal flora E. co

176 The pks genomic island, which is harbored by extraintestinal pathogenic E. coli (ExPEC) and encodes t

177 e disease outside the intestine are known as extraintestinal pathogenic E. coli (ExPEC) and include h

178 e disease outside the intestine are known as extraintestinal pathogenic E. coli (ExPEC) and include p

179 t among phylogenetically diverse lineages of extraintestinal pathogenic E. coli (ExPEC) and supersede

180 ge of BALB/c mice with a clinical isolate of extraintestinal pathogenic E. coli (ExPEC) leads to stab

181 and susceptible, plus isolates from classic extraintestinal pathogenic E. coli (ExPEC) sequence type

182 An isogenic ksl(k2)ABCDE mutant of extraintestinal pathogenic E. coli (ExPEC) strain CFT073

183 i infections are associated with specialized extraintestinal pathogenic E. coli (ExPEC) strains and,

184 (ECOR) collection, and other collections of extraintestinal pathogenic E. coli (ExPEC) was assessed.

185 % of control isolates (P<.001), qualified as extraintestinal pathogenic E. coli (ExPEC), and even the

186 mber of distinctive E. coli lineages, termed extraintestinal pathogenic E. coli (ExPEC), that have a

187 stic of specific familiar virulent clones of extraintestinal pathogenic E. coli (ExPEC), which tradit

188 ns, and septicemia are collectively known as extraintestinal pathogenic E. coli (ExPEC).

189 lence genes that are characteristic of human extraintestinal pathogenic E. coli (ExPEC).

190 dings provide novel insights into the VFs of extraintestinal pathogenic E. coli and demonstrate the n

191 vide novel insights into the papA alleles of extraintestinal pathogenic E. coli and indicate that the

192 Comparisons indicate that extraintestinal pathogenic E. coli arose independently f

193 Avian pathogenic Escherichia coli (APEC), an extraintestinal pathogenic E. coli causing colibacillosi

194 In contrast, the clade of extraintestinal pathogenic E. coli strains apparently un

195 s associated with human infections caused by extraintestinal pathogenic E. coli strains such as K1 in

196 an biologic fluids, and its prevalence among extraintestinal pathogenic E. coli strains, support furt

197 s required for the full in vivo virulence of extraintestinal pathogenic E. coli This is the first rep

198 o one of the most prominent clonal groups of extraintestinal pathogenic E. coli, comprised of O1:K1-,

199 using urinary infection and/or sepsis, i.e., extraintestinal pathogenic E. coli.

200 , and all had virulence genotypes typical of extraintestinal pathogenic E. coli.

201 ColV plasmids of extraintestinal pathogenic Escherichia coli (ExPEC) enco

202 Extraintestinal pathogenic Escherichia coli (ExPEC) is t

203 Extraintestinal pathogenic Escherichia coli (ExPEC) resi

204 A heterogeneous subset of extraintestinal pathogenic Escherichia coli (ExPEC) stra

205 Extraintestinal pathogenic Escherichia coli (ExPEC) stra

206 hough dogs have been proposed as carriers of extraintestinal pathogenic Escherichia coli (ExPEC) with

207 To test the canine reservoir hypothesis of extraintestinal pathogenic Escherichia coli (ExPEC), 63

208 Extraintestinal pathogenic Escherichia coli (ExPEC), so

209 iple large plasmids is a defining feature of extraintestinal pathogenic Escherichia coli (ExPEC), suc

210 ic associations of the pks genomic island of extraintestinal pathogenic Escherichia coli (ExPEC), whi

211 Extraintestinal pathogenic Escherichia coli can successf

212 P fimbriae of extraintestinal pathogenic Escherichia coli mediate diga

213 t unintended secondary mutations occurred in extraintestinal pathogenic Escherichia coli strains CP9,

214 aboratory had previously used for studies of extraintestinal pathogenic Escherichia coli were clinica

215 t and antigenic determinant of P fimbriae of extraintestinal pathogenic Escherichia coli, are of cons

216 produced by certain strains of commensal and extraintestinal pathogenic Escherichia coli.

217 Our laboratory is studying an extraintestinal pathogenic isolate of Escherichia coli (

218 These findings demonstrate the extraintestinal pathogenic versatility of ExPEC clones,

219 n and extent of disease, and the presence of extraintestinal pathologic changes.

220 n and extent of disease, and the presence of extraintestinal pathologic conditions.

221 f1, and cvaC) associated with intestinal and extraintestinal pathotypes.

222 ii) intestinal polyp distribution, and (iii) extraintestinal phenotypes.

223 Patients with extraintestinal presentation at diagnosis had fewer curr

224 Extraintestinal presentations are not uncommon in the li

225 Furthermore, the concept of extraintestinal presentations without enteropathy has on

226 nce of mucosal immunity, both intestinal and extraintestinal, primarily through immunoglobulin A (IgA

227 ccur in several leukocytes subsets; and that extraintestinal replication is likely a part of the norm

228 stemic sites; that the level and location of extraintestinal replication varies between strains; that

229 Extraintestinal replication, as measured by ssQRT-PCR, w

230 s systemic, with an acute active viremia and extraintestinal replication.

231 utside the intestine and the consequences of extraintestinal reservoirs of infection are beginning to

232 Recent studies demonstrated that viremia and extraintestinal rotavirus infection are common in acutel

233 e but well-documented reports of findings of extraintestinal rotavirus.

234 ic examination of tissues from patients with extraintestinal sequelae suggested that Stxs damage endo

235 ent with gastrointestinal signs or symptoms, extraintestinal signs or symptoms, or both, suggesting t

236 e the cellular interactions that occur at an extraintestinal site of nematode infection in which the

237 r proliferation in intestinal tissues and at extraintestinal sites in the natural host.

238 within the mammalian gut but can disperse to extraintestinal sites to cause diseases like urinary tra

239 via M cells and independently disseminate to extraintestinal sites via CD18-expressing phagocytes.

240 t have a special ability to cause disease at extraintestinal sites when they exit their usual reservo

241 h have the ability to infect a wide range of extraintestinal sites.

242 icrobiota also regulates immune responses at extraintestinal sites.

243 reased dissemination of invasive bacteria to extraintestinal sites.

244 These data indicate that extraintestinal spread and replication occurs commonly d

245 estinal spread, rotavirus strains capable of extraintestinal spread at high frequency (rhesus rotavir

246 mouse model of rotavirus infection to study extraintestinal spread following oral inoculation.

247 t in the orally infected neonatal mouse, the extraintestinal spread of rotavirus occurs via a lymphat

248 avirus (RRV) to examine the mechanism of the extraintestinal spread of viruses following oral inocula

249 observations and compare the intestinal and extraintestinal spread of wild-type homologous murine ro

250 iters in the gut and liver revealed that the extraintestinal spread phenotype segregated with RRV gen

251 with initial enteric seeding and subsequent extraintestinal spread, and they provide mechanistic evi

252 on in the liver as a proxy determination for extraintestinal spread, rotavirus strains capable of ext

253 Extraintestinal symptoms included folliculitis (11 of 16

254 sent with a plethora of gastrointestinal and extraintestinal symptoms such as abdominal pain, diarrhe

255 ensitivity, which manifests as intestinal or extraintestinal symptoms that improve or disappear after

256 tic improvement in both gastrointestinal and extraintestinal symptoms was observed.

257 at allergy but who have intestinal symptoms, extraintestinal symptoms, or both, related to ingestion

258 enous sources, confer protection against the extraintestinal thrombosis that accompanies colonic infl

259 rotein C pathway contributes to the enhanced extraintestinal thrombosis that is associated with dextr

260 for the regulation of heme homeostasis in an extraintestinal tissue.

261 f C. jejuni translocation into the colon and extraintestinal tissues and by attenuation of neutrophil

262 has been demonstrated in the serum and many extraintestinal tissues in all experimental animal model

263 In cell culture, and probably in extraintestinal tissues in vivo, reovirus virions underg

264 addition, they suggest that MGAT activity in extraintestinal tissues may also modulate energy metabol

265 positive cells were observed in the colon or extraintestinal tissues of all inoculated pigs or in the

266 , and EGFP; C jejuni localized to colons and extraintestinal tissues of infected Il10(-/-); NF-kappaB

267 Enteric defensins were detected in extraintestinal tissues of patients with APECED, especia

268 lation of its target genes in intestinal and extraintestinal tissues of the digestive tract.

269 static colorectal adenocarcinomas but not by extraintestinal tissues or tumors.

270 tinal and colorectal cancer cells but not by extraintestinal tissues or tumors.

271 and metastatic colorectal tumors, but not in extraintestinal tissues or tumors.

272 d metastatic colorectal tumors, but not from extraintestinal tissues or tumors.

273 pression of GCC by colorectal tumor cells in extraintestinal tissues would permit this receptor to be

274 ng systemic autoimmunity and inflammation in extraintestinal tissues, whereas peripherally induced Tr

275 and metastatic colorectal tumors, but not in extraintestinal tissues.

276 tion in the intestine and, in certain cases, extraintestinal tissues.

277 inal obstruction, epithelial endocytosis and extraintestinal translocation of bacteria were observed

278 ng, which promotes CRC metastasis, increased extraintestinal tumor frequency by stimulating CCR9 prot

279 al CCL25+ microenvironment, while increasing extraintestinal tumor incidence.

280 ew insights into the phylogenetic origins of extraintestinal VFs in E. coli.

281 interferon system to inhibit intestinal and extraintestinal viral replication in suckling mice vary

282 were assessed as to genotype for 31 putative extraintestinal virulence factor (VF) genes and DNA sequ

283 ssociated phylogenetic group B2 and exhibits extraintestinal virulence factors.

284 ted that many different pathways can lead to extraintestinal virulence in E. coli and that the evolut

285 Extraintestinal virulence of several closely related mea

286 lar typing can estimate an E. coli isolate's extraintestinal virulence potential, regardless of sourc

287 ce) phylogenetic groups A and B1 and to lack extraintestinal virulence traits.

288 ckground, or ecological source best predicts extraintestinal virulence within Escherichia coli is und