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2 mplete responses occurred in 4 patients with extramedullary acute myeloid leukemia and 1 patient with
5 e loss of graft-versus-leukemia response and extramedullary AML relapse in tissue with reduced immuno
6 hypothesized that this mechanism applies to extramedullary AML relapse which occurs frequently after
7 best characterized in the mouse, where it is extramedullary and utilizes progenitors and signals that
8 review inflammation's effects on central and extramedullary B lymphopoiesis and discuss the potential
11 cells into BM, an in vivo model of humanized extramedullary BM (EXM-BM) was developed in NOD/SCID/IL-
13 ulation of the bone marrow microenvironment: Extramedullary bone marrow in which hypoxia-inducible fa
15 ctively; P < .001), and higher likelihood of extramedullary disease (16% v 5%, respectively; P = .013
17 ved EFS (P = .02), whereas grade 4 aGVHD and extramedullary disease at diagnosis led to inferior OS.
24 ty, with or without imaging-based absence of extramedullary disease, to allow uniform reporting withi
29 after bone marrow (BM) relapse and isolated extramedullary (EM) relapse for 347 patients with SR-ALL
30 cellular bone marrow (BM), splenomegaly with extramedullary erythropoiesis and erythropoietin-indepen
31 tosis that was partially compensated by avid extramedullary erythropoiesis at all erythroid stages in
33 y, elevated erythropoietin (EPO) levels, and extramedullary erythropoiesis in a process independent o
35 ocytes in the peripheral blood and extensive extramedullary erythropoiesis indicated that the Rb-/- e
36 roid and erythroid tissues, including during extramedullary erythropoiesis induced by n-acetylphenylh
38 emolytic anemia with compensatory marrow and extramedullary erythropoiesis, abundant circulating sick
39 fever with splenomegaly, microcytic anemia, extramedullary erythropoiesis, and increased hemophagocy
40 a, hemolytic anemia with reticulocytosis and extramedullary erythropoiesis, and, notably, the charact
41 R3K5A) mice were found to have splenomegaly, extramedullary erythropoiesis, granulocytosis and thromb
45 This disease, which was characterized by extramedullary erythropoietin-independent erythropoiesis
50 a link between the IL17 cytokine family and extramedullary haematopoiesis, and suggests a previously
52 ts and platelet counts, and markedly reduced extramedullary hematopoeisis and bone marrow fibrosis.
53 characterized by splenomegaly, leukocytosis, extramedullary hematopoiesis (EMH) in spleen and liver w
57 ere anemia (2-4 g/dL), massive splenomegaly, extramedullary hematopoiesis (EMH), and hepatic iron ove
58 oplasms (MPNs), including varying degrees of extramedullary hematopoiesis (myeloid metaplasia) and sp
59 , an increase in splenic megakaryocytes, and extramedullary hematopoiesis accompany the hematologic c
60 e capacity is sustained by expanded sites of extramedullary hematopoiesis and is accompanied by multi
62 thalassemia, with the potential of reversing extramedullary hematopoiesis and preventing splenectomy.
64 2 heterozygous mutant mice exhibit increased extramedullary hematopoiesis and susceptibility to lymph
66 rease in myeloid progenitor populations, and extramedullary hematopoiesis composed of maturing myeloi
67 der steady-state conditions and mobilize for extramedullary hematopoiesis during periods of stress su
68 aly, fibrotic and hypercellular bone marrow, extramedullary hematopoiesis in both spleen and liver, a
71 mplicate IL-25-elicited MPP(type2) cells and extramedullary hematopoiesis in the promotion of Th2 cyt
73 erative phenotype, which was associated with extramedullary hematopoiesis in the spleen and liver, wa
74 lls; myeloid hyperplasia in bone marrow; and extramedullary hematopoiesis in the spleen and liver.
75 y high white blood cell counts and extensive extramedullary hematopoiesis in the spleen, liver, bone
78 marrow, and spleen; significantly increased extramedullary hematopoiesis in the spleen; and a 2-fold
82 it, leukocytosis, megakaryocyte hyperplasia, extramedullary hematopoiesis resulting in splenomegaly,
85 ecrease in bone marrow hematopoiesis, active extramedullary hematopoiesis was observed in the spleen
88 Instead, these animals exhibit extensive extramedullary hematopoiesis with progressive splenomega
89 e blood cells, bone marrow hypercellularity, extramedullary hematopoiesis, a tendency for thrombosis,
90 f Hmga2 enhanced megakaryopoiesis, increased extramedullary hematopoiesis, and accelerated the develo
91 enlargement of the spleen, increased splenic extramedullary hematopoiesis, and altered clinicopatholo
92 mune manifestations, including splenomegaly, extramedullary hematopoiesis, and autoantibody productio
93 loproliferation, ineffective erythropoiesis, extramedullary hematopoiesis, and bone marrow fibrosis a
94 acterized by erythrocytosis, granulocytosis, extramedullary hematopoiesis, and bone marrow fibrosis,
95 1(+) granulocytes, splenomegaly, evidence of extramedullary hematopoiesis, and bone marrow fibrosis,
96 enlarged spleen due to lymphoid hyperplasia, extramedullary hematopoiesis, and bone marrow hypoplasia
97 atopoietic stem and progenitor cell cycling, extramedullary hematopoiesis, and differentiation defect
98 gh incidence of premature death, age-related extramedullary hematopoiesis, and lack of early degenera
99 ymph nodes, splenomegaly due to erythrocytic extramedullary hematopoiesis, and lymphoid hyperplasia w
100 ave important implications for understanding extramedullary hematopoiesis, and may be relevant to cur
101 icrovesicular fatty metamorphosis, prolonged extramedullary hematopoiesis, and portal hypercellularit
102 poietic defects develop without compensatory extramedullary hematopoiesis, and the loss of HSCs occur
103 osis, resulting in extreme levels of splenic extramedullary hematopoiesis, anemia, and leukopenia.
104 gic malignancy characterized by BM fibrosis, extramedullary hematopoiesis, circulating CD34+ cells, s
105 e develop severe neutrophilia, splenomegaly, extramedullary hematopoiesis, decreased body weight, and
106 ient mice have a peripheral leukocytosis and extramedullary hematopoiesis, demonstrating that Lsc is
107 sease phenotype-bone marrow stromal changes, extramedullary hematopoiesis, ineffective erythropoiesis
108 d circulating MIP-1alpha and ameliorated the extramedullary hematopoiesis, inflammation, and osteopen
109 tipotential progenitor cell mobilization and extramedullary hematopoiesis, leading to decreased produ
110 , lead to autoinflammatory disease involving extramedullary hematopoiesis, skin and bone lesions.
111 by bone marrow fibrosis, myeloproliferation, extramedullary hematopoiesis, splenomegaly and leukemic
112 opoietic stem cell function, contributing to extramedullary hematopoiesis, splenomegaly, BM failure,
113 n the P-loop of Gimap5, lymphopenia, hepatic extramedullary hematopoiesis, weight loss, and intestina
114 -old IRP1(-/-) mice exhibit splenomegaly and extramedullary hematopoiesis, which is corrected in olde
137 on in the splenic red pulp of typically rare extramedullary hematopoietic stem and progenitor cells,
139 ype I IFN signaling resulted in compensatory extramedullary hemopoiesis in the liver and spleen.
146 romosome 13 deletion, advanced bone disease, extramedullary involvement, and patients with renal impa
147 tiple myeloma, pPCL presents more often with extramedullary involvement, anemia, thrombocytopenia, hy
148 D56 expression has been associated with both extramedullary leukemia and multidrug resistance, we sou
149 g the same hydrogels to a xenograft model of extramedullary leukemias, we confirm the pathological re
155 d patients with intramedullary and extensive extramedullary manifestations of multiple myeloma underg
156 ated in 15, and blastic in 8 (7 medullary, 1 extramedullary); median time from transplantation to rel
158 stly, KO animals exhibited excessive splenic extramedullary megakaryocytopoiesis, which likely compen
159 hyperdiploid D1 group is virtually absent in extramedullary MM and MM cell lines, suggesting a partic
161 rves as the primary niche for hematopoiesis, extramedullary mobilization and differentiation of HSPCs
162 Our data implicate inflammation-induced extramedullary monocytopoiesis as a peripheral source of
163 tained need of newly made Mo was fostered by extramedullary monocytopoiesis in the spleen; d) splenic
165 megaly, myeloid bone marrow hyperplasia, and extramedullary myeloid cell infiltration of multiple org
166 th, but soon manifested marked medullary and extramedullary myeloid hyperplasia associated with cache
167 dependent expansion of functionally enhanced extramedullary myeloid progenitors that correlated with
168 revealed a partial loss of chromosome 6p in extramedullary myeloid sarcoma relapse of AML after sust
170 R T cells led to resolution of medullary and extramedullary myeloma manifestations in a murine xenogr
171 on B cells or plasma cells, more than 90% of extramedullary myelomas (a late stage B-cell neoplasm) e
172 e 1 (VCAM-1)(+) macrophages are essential to extramedullary myelopoiesis because these macrophages us
173 3(+) T cells can negatively regulate splenic extramedullary myelopoiesis by suppressing the naive T c
174 e demonstrate that Kit(W-sh) causes aberrant extramedullary myelopoiesis characterized by the expansi
181 ssociated with worse prognosis than isolated extramedullary or late relapse (> 30 months from diagnos
182 ant tumor proliferation and dissemination to extramedullary organs, leading to disease progression an
184 These findings provide a unique model of extramedullary PCT for studies on pathogenesis and treat
186 solitary bone plasmacytoma (SBP; n = 35) and extramedullary plasmacytoma (EMP; n = 29) through multip
187 ic insult, these cells are replenished by an extramedullary radio-resistant and UV-sensitive Bmi1(+)
189 8 patients transplanted in CR2 for isolated extramedullary relapse (all MRD-), MRD was detected at h
192 We use both systemic and local treatment for extramedullary relapse, mainly represented by radiothera
193 posed to marrow involvement only or isolated extramedullary relapse, was associated with impaired out
196 eukemic blasts in blood, bone marrow, or any extramedullary site after 4 to 6 weeks of remission-indu
197 for early versus late relapse, marrow versus extramedullary site, adolescent versus younger age and T
198 Ns, and positions the spleen as an important extramedullary site, which can continuously supply growi
200 ematopoiesis in marrow, and hematopoiesis in extramedullary sites and is associated with abnormal meg
201 ection work-up revealing increased uptake at extramedullary sites and/or bones and joints that would
203 igh sensitivity and specificity, and detects extramedullary sites of proliferating clonal plasma cell
204 as decreased in bone marrow and increased in extramedullary sites of Prx1-Cre;Has2(flox/flox);Has1(-/
207 tic plasma cells in the bone marrow or other extramedullary sites, along with evidence of disease-rel
208 in the skeleton significantly differed from extramedullary sites, showing similar numbers but differ
214 onstrated a role for ST6Gal-1, possibly from extramedullary sources (eg, produced in liver) in regula
215 mours can be divided into intramedullary and extramedullary spinal-cord tumours on the basis of their
217 In phenylhydrazine-treated Lyn-/- mice, extramedullary splenic erythropoiesis was hyperactivated
219 CD26 expression may explain the abnormal extramedullary spread of CML LSC, and inhibition of CD26
221 esses within the bone marrow, and then to an extramedullary stage from which MM cell lines are genera
222 vironment until progressing to very advanced extramedullary stages of the disease such as plasma cell
223 epended on S1P(1) signaling, and allowed the extramedullary tissue to supply new tumor-associated mac
225 egulate hematopoietic stem cell migration to extramedullary tissues and the metastasis of cancer stem
228 retazine has significant activity and modest extramedullary toxicity in elderly patients with AML or
235 h intramedullary tumors versus 16 (59%) with extramedullary tumors had undergone surgery for the resp
237 tramedullary tumors, 27 (55%) had intradural extramedullary tumors, and 22 (45%) had at least one tum
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