ライフサイエンスコーパス: extranuclear

1 Recent evidence suggests that extranuclear action of retinoid receptors is involved in

2 binding protein (CREB), or c-Jun/c-Fos by an extranuclear action of the ER or AR, resulting in activa

3 ascades, referred to as the "nongenomic," or extranuclear, action.

4 d in vivo xenograft assays, we found that ER extranuclear actions contribute to cell migration.

5 s PELP1 serves as a critical component of ER extranuclear actions leading to cell motility/invasion a

6 or that plays a role in both the genomic and extranuclear actions of estrogen receptors (ER) in hormo

7 Collectively, our results suggest that ER extranuclear actions play a role in cell motility/metast

8 LP1 is required for optimal activation of ER extranuclear actions.

9 creatic islet survival in mice through rapid extranuclear actions.

10 ear inclusions and, in select brain regions, extranuclear aggregates localized to neuritic processes.

11 s can survive nearly a year with nuclear and extranuclear aggregates of mutant huntingtin, such lengt

12 und to co-localize with nuclear but not with extranuclear aggregates.

13 MxB seems to be exclusively extranuclear and is concentrated at the cytoplasmic face

14 Most neuronal PR labeling is extranuclear and is divided between pre- and postsynapti

15 the notion that the cell death machinery is extranuclear and is likely to be comprised of one or mor

16 and that E(2) favors islet survival through extranuclear and membrane estrogen receptor signaling.

17 We concluded that extranuclear and nuclear ER-alpha collaborate to suppres

18 whereas G(s) and G(o) are found in both the extranuclear and the nuclear compartments.

19 id raft membranes of an androgen-responsive, extranuclear AR/Akt1 complex.

20 Furthermore, Tpo treatment induced an extranuclear buildup and greatly weakened the DNA bindin

21 ies revealed that most tankyrase is actually extranuclear, but a discordant pattern of cytoplasmic ta

22 on, ERK dimerize, which is essential for ERK extranuclear, but not for nuclear, signaling.

23 , (iii) TPRs couple to G(q) and G(13) in the extranuclear compartment and to G(s) only in the nucleus

24 at TPRs couple to both G(q) and G(13) in the extranuclear compartment but only to G(s) in the nuclear

25 uesters wild-type TFE3 as well as p53 in the extranuclear compartment leading to functionally null p5

26 cent observations of its distribution in the extranuclear compartment raised the possibility that it

27 (q), G(13), and G(i) are present only in the extranuclear compartment, whereas G(s) and G(o) are foun

28 ascade while confining ERK1/2 activity to an extranuclear compartment.

29 The FABPs appear to be involved in the extranuclear compartments of the cell by trafficking the

30 downstream signaling in both the nuclear and extranuclear compartments, thereby contributing to thyro

31 transcription and is present in nuclear and extranuclear compartments.

32 teinase 2 pathway was detected mainly in the extranuclear compartments.

33 Wolbachia impair the male pronucleus but no extranuclear component of the sperm.

34 alization that progressed outward toward the extranuclear, cortical region.

35 The E2-induced DDR required extranuclear cyclin D1, which bound ERalpha at the cytop

36 In contrast, GPKA targeted to the extranuclear cytoplasm by addition of a nuclear export s

37 demonstrated that Rta is sequestered to the extranuclear cytoskeleton in the presence of LF2.

38 In addition, these findings demonstrate that extranuclear dendrites are an important termination site

39 Extranuclear dendrites in all pericoerulear regions rece

40 from neurons in the ventrolateral PAG to the extranuclear dendrites of noradrenergic LC neurons.

41 Locus coeruleus extranuclear dendrites were never presynaptic to other s

42 encountered in the "core" of the LC vs. its extranuclear dendritic zone, which included the medial p

43 sera indicated a predominant nonhomogeneous, extranuclear distribution within the cell following expr

44 ment with chloroquine led to accumulation of extranuclear DNA in human monocyte-derived macrophages.

45 Consistent with an extranuclear effect of CSK on RAR signaling and neurite

46 lates the functions of MTA1s, and that these extranuclear effects of estrogen might have important im

47 ar, influencing cell differentiation through extranuclear effects on Delta-Notch signaling.

48 recent ultrastructural studies have revealed extranuclear ERalpha immunoreactivity (IR) within select

49 h extranuclear ERbeta, or indirectly through extranuclear ERalpha in selected afferents.

50 We find that the extranuclear ERalpha interacts with the tyrosine kinase

51 ural analysis additionally revealed discrete extranuclear ERalpha-, ERbeta-, and PR-ir in neuronal an

52 We previously reported that extranuclear ERbeta immunoreactivity (ir) in adult rats

53 Thus, we sought to determine if extranuclear ERbeta is in newly generated cells in adult

54 bulbospinal neurons either directly, through extranuclear ERbeta, or indirectly through extranuclear

55 ERbeta-EGFP colocalize with both nuclear and extranuclear ERbeta-immunoreactivity.

56 Except for very low levels of extranuclear ERbeta-ir in mossy fiber terminals in mice,

57 nfocal imaging revealed punctate staining of extranuclear ERs along dendrites of hippocampal neurons

58 These data suggest that extranuclear ERs may be promising therapeutic targets to

59 neurons after stroke, an effect mediated by extranuclear estrogen receptor alpha (ERalpha)-mediated

60 Previously, we found that extranuclear estrogen receptor-alpha (ERalpha) immunorea

61 We also found a high degree of extranuclear estrogen receptor-alpha colocalization with

62 e rapid effects are likely to be mediated by extranuclear estrogen receptors associated with the plas

63 igenicity, presumably via the stimulation of extranuclear estrogen responses, such as the activation

64 We conclude that extranuclear EWS is a previously unrecognized target of

65 pears to be consistent, direct proof of such extranuclear/extracellular effects are limited.

66 umulated over the past decade suggested that extranuclear/extracellular targets and events may also p

67 s (e.g., DNA or pronuclear proteins) or some extranuclear factor from the sperm required for embryoni

68 (2) also activates nongenomic signals via an extranuclear form of ERalpha and the G protein-coupled e

69 the oncogenic potential of both nuclear and extranuclear forms of truncated TAN1 in hematopoietic ce

70 mitochondrial PTP and suggest an additional extranuclear function for Elk-1 in neurons.

71 Our studies reveal an unforeseen extranuclear function for Ezh2 in regulating adhesion dy

72 t the molecular mechanisms underpinning this extranuclear function have remained unclear.

73 r enhancement of DNA repair uncovers a novel extranuclear function of cyclin D1 that may contribute t

74 ever, whereas estrogens activate ERKs via an extranuclear function of the estrogen receptor, bisphosp

75 E2-dependent DNA damage response via a novel extranuclear function.

76 protein (HMGB1) that has been shown to have extranuclear functions and can be secreted from some cel

77 possibility that Elk-1 may have alternative extranuclear functions in neurons.

78 that mediate the transcriptional effects of extranuclear G-kinase II are not regulated by G-kinase I

79 that nearly all SCN neurons receive local or extranuclear GABAergic inputs operating via GABAA recept

80 Ultrastructural analysis revealed discrete extranuclear GPER1-IR affiliated with the plasma membran

81 on lipid droplets allows embryos to build up extranuclear histone stores and provides histones for ch

82 es, early Drosophila embryos contain massive extranuclear histone stores, thought to be essential for

83 AW264.7 cells by 10 min postinfection and is extranuclear in its cellular location.

84 In this study we show that the extranuclear localization of AHNAK in epithelial cells d

85 that also plays a major role in determining extranuclear localization of AHNAK.

86 The extranuclear localization of MEF2A suggests novel roles

87 ctivate RhoA, but mechanisms controlling the extranuclear localization of Net1 isoforms have not been

88 irst physiological mechanism controlling the extranuclear localization of Net1 isoforms.

89 effects, we have developed a novel class of extranuclear-localizing 14-O-acylanthracyclines that bin

90 Despite a predominantly extranuclear location, Hdj1, Hdj2, Hsc70, alphaSGT and b

91 oth disease models, Nmnat1 overexpression in extranuclear locations significantly enhanced the surviv

92 in select interneuron nuclei and in several extranuclear locations, including dendritic spines and a

93 Thus, paxillin is a liaison between extranuclear MAPK signaling and nuclear transcription in

94 de production following X-rays represents an extranuclear mechanism for the development of radioresis

95 delays the DNA damage response (DDR) via an extranuclear mechanism.

96 on in vivo of both intranuclear spindles and extranuclear microtubules in otherwise wild-type cells.

97 To dissect the impact of nuclear and extranuclear mutant htt on the initiation and progressio

98 ither as ligand-receptor or separately, play extranuclear, nongenomic roles that greatly expand the m

99 ts provide a mechanistic explanation for the extranuclear, nontargeted effects of ionizing radiation.

100 ires no male pronucleus but still depends on extranuclear paternal factors.

101 l comprises a nuclear nanoparticle within an extranuclear pegylated-lipid envelope, and is preferenti

102 hway is important for the fine modulation of extranuclear Pmk1 activity.

103 Here, we show that an extranuclear pool of BMI1 localizes to inner mitochondri

104 ellular locations, but it is unknown whether extranuclear pools are necessary for normal organ develo

105 hydroxylase- or tyrosine-hydroxylase-labeled extranuclear processes in the rat pericoerulear region.

106 t SUMO may also be a key determinant of many extranuclear processes.

107 ysis revealed that PR labeling is present in extranuclear profiles throughout the CA1 and CA3 regions

108 Although extranuclear profiles were detected in all animal groups

109 y be mediated by direct and rapid actions on extranuclear PRs and that PRs are well positioned to reg

110 The results reveal a novel extranuclear receptor-mediated antioxidant mechanism for

111 support a model in which Wld(S) protects by extranuclear redistribution of its nuclear NMNAT1 portio

112 ooth muscle-specific gene expression through extranuclear redistribution of SRF and consequent down-r

113 Furthermore, immunocytochemistry revealed extranuclear redistribution of SRF in serum-deprived myo

114 the dorsal root ganglia (DRG), suggesting an extranuclear role for this protein.

115 These findings not only establish a novel extranuclear role of BMI1 in the regulation of mitochond

116 We have elucidated a nongenomic extranuclear signal mediated by the RAR-SRC interaction

117 er conjugate (EDC) that uniquely activate ER extranuclear signaling and by using model cells that sta

118 Activation of extranuclear signaling by EDC uniquely enhanced E2-media

119 d-binding domain of ERalpha and initiated an extranuclear signaling cascade that requires ERalpha Ser

120 n shown to regulate both gene expression and extranuclear signaling events.

121 ng evidence suggests that ER participates in extranuclear signaling in addition to genomic functions.

122 rotein interactions that enable it to invoke extranuclear signaling in the endothelium and the conseq

123 nuate follicular atresia through nuclear and extranuclear signaling pathways by enhancing expression

124 ve reagents, we found that estrogen-mediated extranuclear signaling promotes cytoskeleton reorganizat

125 hanism and significance of ER-PELP1-mediated extranuclear signals in the cytoskeletal remodeling and

126 Modulation of extranuclear signals may increase tumor cell killing fol

127 the nucleus, is also present at two specific extranuclear sites as follows: around the microtubule or

128 tural analysis revealed ERbeta-ir at several extranuclear sites in all hippocampal subregions.

129 Notably, ERalpha seemed to redistribute to extranuclear sites in TAM-R cells.

130 us, to determine whether ERalpha is found in extranuclear sites in the hippocampal formation (HF), fo

131 tor (PR) immunoreactivities are localized to extranuclear sites in the rat hippocampal formation.

132 pt that ERbeta was more extensively found at extranuclear sites.

133 promotes LTC(4) formation at these specific extranuclear sites.

134 microscopy, suggesting that PR is present at extranuclear sites.

135 the WI-US fraction, whereas the five largest extranuclear species exhibited mixed solubility.

136 entified DLK and MKK7 in similar nuclear and extranuclear subcellular compartments.

137 These data indicate an extranuclear target of PKA for promotion of neuronal sur

138 Here, we utilize an extranuclear-targeted anthracycline N-benzyladriamycin-1

139 acer injections were made into the two major extranuclear targets of rNST, the parabrachial nucleus (

140 n, the data suggests that agents that modify extranuclear targets responsible for ceramide production

141 st for immune cells, progress in the role of extranuclear TDP-43 in causing cellular injury, and the

142 d morphological features of intranuclear and extranuclear virion trafficking have similarly been exam

143 rotein was also on cytoplasmic membranes and extranuclear virions.

144 he channels formed by the DMS throughout the extranuclear volume.

145 Moreover, we detect extranuclear Wld(S) for the first time in vivo, and high

146 tead of weakening the phenotype as expected, extranuclear Wld(S) significantly enhanced structural an

147 d to vesicular structures, colocalizing with extranuclear Wld(S), and was cotransported at least part