ライフサイエンスコーパス: extraocular

1 some patients with coloboma had evidence of extraocular abnormalities, the majority of findings on r

2 th oMG had serum autoantibodies to the mouse extraocular AChR, pathologic deposits of IgG, C3, and C5

3 Extraocular and extensor digitorum longus (EDL) muscles

4 Recordings of extraocular and limb motor nerves during spontaneous "fi

5 gic deposits of IgG, C3, and C5b-C9 in their extraocular and limb neuromuscular junctions, and droopi

6 Thus, Porcn is required in both extraocular and neuroectodermal tissues to regulate dist

7 eleration signals to control the activity of extraocular and postural neurons, thus completing a fund

8 he tumor but loss of the 3q arm only for the extraocular area.

9 8p was observed between the intraocular and extraocular areas of the tumor.

10 or screening of the entire body and directed extraocular biopsy.

11 The percentage of extraocular cases was also higher in counties with the f

12 ndingly, the neural pathways mediating spino-extraocular coupling have switched from contralateral to

13 Hispanic children had a higher percentage of extraocular disease (86 of 261 [33.0%] vs. 102 of 510 no

14 al invasive procedures caused the subsequent extraocular disease or if growth of the tumor into the e

15 tive biopsies compared to those who also had extraocular disease.

16 ic and genomic analyses with minimal risk of extraocular dissemination.

17 to the fovea are essential for the design of extraocular drug delivery systems.

18 contrast to its basolateral localization in extraocular epithelia.

19 led RPE-specific cre activity in the eye and extraocular expression limited to the testes.

20 tation (48%, 53%, 69%, 78%) (P < 0.001), and extraocular extension (0%, 1%, 11%, 22%) (P < 0.001).

21 mbrane (9%, 24%, 40%, and 40%; P<0.001), and extraocular extension (1%, <1%, 4%, and 12%; P<0.001).

22 esence of ciliary body involvement (CBI) and extraocular extension (EXE) was analyzed among 5,403 pat

23 51%), intratumoral cysts (n = 25, 61%), and extraocular extension (n = 4, 10%).

24 phatic signal between cases with and without extraocular extension (P > 0.05).

25 malignant melanomas of the ciliary body with extraocular extension (two of these developed a regional

26 ent-naive medium choroidal melanomas without extraocular extension from July 2012 through September 2

27 Four cases of extraocular extension of melanoma are documented followi

28 e aspiration biopsy (FNAB) or open biopsy is extraocular extension of the tumor.

29 globes with a ciliary body melanoma without extraocular extension regarding tumor size, cell type, m

30 Malignant melanomas of the ciliary body with extraocular extension show intraocular lymphatic vessels

31 malignant melanoma of the ciliary body with extraocular extension were matched with 10 globes with a

32 ary body in uveal melanomas with and without extraocular extension, and as such, the presence of peri

33 These results suggest that for UM with extraocular extension, both the intraocular and the extr

34 cidence of subretinal fluid, hemorrhage, and extraocular extension.

35 tic metastasis in ciliary body melanoma with extraocular extension.

36 avior such as intraocular tissue invasion or extraocular extension.

37 ed families differed in that one included no extraocular features and the other manifested with highl

38 Ocular and extraocular features were recorded using Human Phenotype

39 response to rapid (<0.2 seconds) changes in extraocular fluid osmolarity.

40 conjunctival erosion or dehiscence over the extraocular implant and was treated successfully in all

41 ssive retinitis pigmentosa (RP), but without extraocular involvement.

42 the next few weeks, the area occupied by the extraocular isoform increased to include the entire cent

43 At 11 days postpartum, the extraocular isoform was detected in the orbital fibers a

44 adult-fast MyHC-IIa and the specialized MyHC-Extraocular isoform, that was predicted to be the fastes

45 sthenia gravis clinically involving only the extraocular, levator palpebrae superioris, and orbicular

46 fibrillar PEX aggregates in both intra- and extraocular locations and to co-localize with various el

47 AQP1 expression was also studied in extraocular microvessels and in primary endothelial cell

48 choroidal and hyaloid vessels and in various extraocular microvessels in neonatal and prenatal mice.

49 tients requiring surgery had higher rates of extraocular motility (EOM) restriction (78.6% vs 38.8% P

50 l nucleus neurons project contralaterally to extraocular motoneurons and in addition to multiple site

51 We show that BT neurons, like extraocular motoneurons but different from the evoked ey

52 We propose that the temporal development of extraocular motoneurons plays a key role in assembling a

53 cologically distinct functional subgroups of extraocular motoneurons that act in concert to mediate t

54 nces that ensure a coactivation of bilateral extraocular motoneurons with synchronous left-right limb

55 showed, for the first time, that they, like extraocular motoneurons, are also immunoreactive for cal

56 ellar output into the sustained discharge of extraocular motoneurons.

57 locomotory CPG output that produce rhythmic extraocular motor activity appropriate for minimizing mo

58 ring metamorphosis enables spinal CPG-driven extraocular motor activity to match the changing require

59 oncert to mediate the large dynamic range of extraocular motor commands during gaze stabilization.SIG

60 ific CNS lesions, we have investigated spino-extraocular motor coupling in the juvenile frog and the

61 se amplitude and peak velocity revealed that extraocular motor function was unchanged, and immunohist

62 e timing yielded unique activity patterns in extraocular motor nerves, compatible with a spatially an

63 t of nontargeted effects at the level of the extraocular motor neurons and/or their innervation of ex

64 This study examined the development of two extraocular motor nuclei (nIII and nIV), structures in w

65 uron pools: SIF motoneurons found within the extraocular motor nuclei, and MIF motoneurons found alon

66 g change in spinal efference copy control of extraocular motor output.

67 Decrease in proptosis and improvement in extraocular movements were also significantly better wit

68 mably is the basis for the broad spectrum of extraocular muscle (EOM) contractile properties in drivi

69 branched to enter the LR and arborized among extraocular muscle (EOM) fibers.

70 Extraocular muscle (EOM) has a distinct skeletal muscle

71 graphy (AS-OCT) in measuring the distance of extraocular muscle (EOM) insertion to the limbus to impr

72 e quantitative measures of horizontal rectus extraocular muscle (EOM) morphology to determine the mag

73 t of recessions and resections on horizontal extraocular muscle (EOM) paths and globe position.

74 Surgical recession of an extraocular muscle (EOM) posterior to its original inser

75 ic resonance imaging (MRI) was used to study extraocular muscle (EOM) responses to head tilt in HTDHT

76 mutation and MRI findings that demonstrated extraocular muscle (EOM) size, location, contractility,

77 re correlated with MRI studies demonstrating extraocular muscle (EOM) size, location, contractility,

78 ated that prolonged exposure of adult rabbit extraocular muscle (EOM) to insulin-like growth factor-1

79 Extraocular muscle (EOM)-specific MyHC expressing fibres

80 r (IGF)-II in increasing force generation in extraocular muscle (EOM).

81 sex (P = .01) and inflammation extending to extraocular muscle (P = .01).

82 All three Pitx2 isoforms were expressed by extraocular muscle and at higher levels than in other st

83 , slow-tonic MyHC and EOM-MyHC expression in extraocular muscle and its absence leads to increased ex

84 fied five parameters of the superior oblique extraocular muscle at 2 weeks of age: contractile force,

85 Morphogenesis of all extraocular muscle bundles correlated highly with Pitx2

86 all three age groups in the Pitx2-deficient extraocular muscle compared with littermate controls.

87 ar muscles and the connective tissues of the extraocular muscle cones in the normal mouse.

88 Extraocular muscle contractility was impaired by dark re

89 Pitx2) is known to regulate the formation of extraocular muscle development and in this report we sho

90 comparable upstream factors required during extraocular muscle development have not been identified.

91 s, the ectopic nerves were seen to innervate extraocular muscle directly.

92 Enophthalmos, diplopia resulting from extraocular muscle dysfunction, and infraorbital nerve h

93 e, especially in the presence of ipsilateral extraocular muscle enlargement, sinus disease, or focal

94 ous trophic factors regulate and/or maintain extraocular muscle force through a rapid mechanism that

95 fibers may either provide resistance against extraocular muscle forces or limit globe axial elongatio

96 We show Pax7 is dispensable for extraocular muscle formation, whereas Pitx2 is cell-auto

97 Modulation of Pitx2 expression can influence extraocular muscle function with long-term therapeutic i

98 The mutant extraocular muscle had no obvious pathology but had alte

99 Extraocular muscle inner mitochondrial membrane density

100 mage, and ptosis and ocular dysmotility from extraocular muscle involvement.

101 Ca2+ sinks; and (3) mitochondrial content in extraocular muscle is determined by the transcription fa

102 Extraocular muscle is fundamentally distinct from other

103 pmental disorder in which the lateral rectus extraocular muscle is not properly innervated.

104 Extraocular muscle is unusually fast with a far weaker K

105 specific isoform alpha, and the specialized extraocular muscle isoform).

106 th the different loads and usage patterns of extraocular muscle layers, as proposed in the active pul

107 of the structure-function characteristics of extraocular muscle layers.

108 transcripts) was identified between the two extraocular muscle layers.

109 nition of the regulation of MyHC isoforms in extraocular muscle may allow their rational manipulation

110 Activity of complexes I and IV was lower in extraocular muscle mitochondria (approximately 50% the a

111 The results demonstrate that extraocular muscle mitochondria respire at slower rates

112 The authors tested the hypothesis that extraocular muscle mitochondria respire faster than do m

113 States 3, 4, and 5 respiration rates in extraocular muscle mitochondria were 40% to 60% lower th

114 Finally, complex V was less abundant in extraocular muscle mitochondria.

115 ntains premotor neurons supplying horizontal extraocular muscle motoneurons.

116 demonstrated the presence of Pitx2 mainly in extraocular muscle myonuclei.

117 Alan Scott initially investigated extraocular muscle paralysis by botulinum injection in 1

118 bulbar anesthesia for cataract extraction is extraocular muscle paresis/restriction and is unique to

119 Pitx2 is important in maintaining the mature extraocular muscle phenotype and regulating the expressi

120 omously required to prevent apoptosis of the extraocular muscle primordia.

121 iplopia, enophthalmos, orbital dystopia, and extraocular muscle restriction.

122 endogenous and exogenous trophic factors on extraocular muscle strength and mass were examined in th

123 Extraocular muscle strengthening is a common treatment f

124 Extraocular muscle surgery frequently is required for pl

125 ing may provide an adjunct or alternative to extraocular muscle surgery in selected cases.

126 ium 103 plaque brachytherapy with or without extraocular muscle surgery.

127 Imaging studies disclosed extraocular muscle swelling (8 cases), most frequently o

128 rengthening of eye muscles in the developing extraocular muscle system.

129 expression in adulthood also defines certain extraocular muscle traits.

130 Peak tetanic [Ca2+]i increased in extraocular muscle with caffeine and CEP.

131 ive anatomic sites: eye, orbit, optic nerve, extraocular muscle, and lacrimal drainage system.

132 tion, and survival, leading to craniofacial, extraocular muscle, and ocular developmental abnormaliti

133 identified in the Pitx2(Deltaflox/Deltaflox) extraocular muscle, suggesting that altered innervation

134 ismus, possibly by altering vergence tone in extraocular muscle.

135 ed to study the effect of Pitx2 depletion on extraocular muscle.

136 d receptor (PPAR)gamma were more abundant in extraocular muscle.

137 ase were only approximately 2-fold higher in extraocular muscle.

138 regulates [Ca2+]i and production of force in extraocular muscle; (2) mitochondrial content correlates

139 (CN3) and applied to congenital fibrosis of extraocular muscles (CFEOM) and congenital oculomotor pa

140 ing of two CCDDs, congenital fibrosis of the extraocular muscles (CFEOM) and Duane retraction syndrom

141 ly who segregates congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria.

142 Because the extraocular muscles (EOM) are preferentially affected in

143 Human extraocular muscles (EOM) are preferentially susceptible

144 Extraocular muscles (EOM) represent a unique muscle grou

145 onance imaging (MRI) was used to demonstrate extraocular muscles (EOMs) and associated motor nerves i

146 ed magnetic resonance imaging (MRI) to study extraocular muscles (EOMs) and nerves in Duane-radial ra

147 Connective tissue pulleys inflect the extraocular muscles (EOMs) and receive insertions from s

148 n freshly dissected and cryosectioned rectus extraocular muscles (EOMs) and tibialis anterior (TA) mu

149 Extraocular muscles (EOMs) are highly specialized skelet

150 ial DNA (mtDNA) defects were investigated in extraocular muscles (EOMs) collected from individuals co

151 Rectus and the inferior oblique extraocular muscles (EOMs) consist of orbital layers (OL

152 Strabismic extraocular muscles (EOMs) differ from normal EOMs in st

153 hy after intramuscular injection with Botox, extraocular muscles (EOMs) do not.

154 e lateral rectus (LR) and medial rectus (MR) extraocular muscles (EOMs) have largely nonoverlapping s

155 mmon treatment for motility disorders of the extraocular muscles (EOMs) is a resection procedure in w

156 tramuscular innervation of horizontal rectus extraocular muscles (EOMs) is segregated into superior a

157 nective tissues that surround the horizontal extraocular muscles (EOMs) of humans.

158 dings are nerve specializations found in the extraocular muscles (EOMs) of mammals, including primate

159 Structural abnormalities of extraocular muscles (EOMs) or their pulleys are associat

160 toxin-treated normal adult rabbit and monkey extraocular muscles (EOMs) were analyzed.

161 studies have shown that direct injection of extraocular muscles (EOMs) with insulin growth factor or

162 ry nerve terminal elimination at synapses in extraocular muscles (EOMs), a specialized set of muscles

163 l of compartmentalization in all four rectus extraocular muscles (EOMs), evidence was sought of possi

164 inear viscoelastic stress-strain behavior of extraocular muscles (EOMs).

165 ayer (OL) and global layer (GL) of adult rat extraocular muscles (EOMs).

166 rst time that neuromuscular junctions of the extraocular muscles (responsible for the control of eye

167 C are expressed in and around the developing extraocular muscles and cause growth cone collapse of oc

168 trophic factors strengthen juvenile maturing extraocular muscles and gain insight into mechanisms of

169 onance imaging revealed marked hypoplasia of extraocular muscles and intraorbital cranial nerves.

170 increases the dynamic response range of the extraocular muscles and matches metabolic demand to supp

171 can now directly demonstrate innervation to extraocular muscles and quantify optic nerve size.

172 uria, or fixed weakness, which often affects extraocular muscles and results in droopy eyelids (ptosi

173 amps, or fixed weakness, which often affects extraocular muscles and results in droopy eyelids (ptosi

174 ere detected in the posterior regions of the extraocular muscles and the connective tissues of the ex

175 cts of ocular motility are properties of the extraocular muscles and their associated connective tiss

176 Motoneurons of extraocular muscles are controlled by different premotor

177 Second, extraocular muscles are divided into two layers; the inn

178 This mechanism may not apply to extraocular muscles because their constant activity may

179 sorder caused by aberrant innervation of the extraocular muscles by axons of brainstem motor neurons.

180 lternative subunit isoform expression in the extraocular muscles compared with limb muscles.

181 Mammalian extraocular muscles contain singly innervated twitch mus

182 Imaging of the orbit and extraocular muscles continues to be recommended as helpf

183 Exogenous IGF1 and CT1 strengthen extraocular muscles during maturation.

184 Extraocular muscles from adult male Sprague-Dawley rats

185 h sensory-induced strabismus, innervation to extraocular muscles from motor nuclei produce the inappr

186 stablished several years ago that the rectus extraocular muscles have connective tissue pulleys, rece

187 (CT1) are known to increase the strength of extraocular muscles in adult and embryonic animals, but

188 elation was found between IS and T2-time for extraocular muscles in healthy volunteers.

189 s in estimation of inflammatory processes of extraocular muscles in the clinical practice.

190 Compartmentalization of the extraocular muscles into well-defined orbital and global

191 alterations in the dynamic properties of the extraocular muscles involved in eye torsion.

192 tested the hypothesis that glucose uptake by extraocular muscles is not regulated by insulin or contr

193 Glucose uptake in extraocular muscles is regulated by insulin and contract

194 y-induced strabismus, central innervation to extraocular muscles is responsible for setting the state

195 The constant activity of the extraocular muscles is supported by abundant mitochondri

196 The ultrafast extraocular muscles necessitate tight regulation of free

197 nalysis of triceps surae (a limb muscle) and extraocular muscles of adult male Sprague-Dawley rats.

198 Mouse extraocular muscles of different ages were examined for

199 Three congenital fibrosis of the extraocular muscles phenotypes (CFEOM1-3) have been iden

200 Topographic relationships of the extraocular muscles relative to the fovea are essential

201 Extraocular muscles show specific adaptations to fulfill

202 In vitro, Pitx2 loss made the extraocular muscles stronger, faster, and more fatigable

203 All 6 patients had enlarged extraocular muscles that caused restrictive strabismus.

204 es in humans with congenital fibrosis of the extraocular muscles type 1 (CFEOM1) due to missense muta

205 ve been linked to congenital fibrosis of the extraocular muscles type 1 (CFEOM1), a dominant disorder

206 otility disorder "Congenital fibrosis of the extraocular muscles type 1" (CFEOM1) results from hetero

207 abnormalities in congenital fibrosis of the extraocular muscles type 3 (CFEOM3), a disorder resultin

208 s consistent with congenital fibrosis of the extraocular muscles type 3 (CFEOM3); 1 patient harbored

209 ated or syndromic congenital fibrosis of the extraocular muscles, a form of complex congenital strabi

210 uired at several steps in the development of extraocular muscles, acting first as an anti-apoptotic f

211 reported to cause congenital fibrosis of the extraocular muscles, c.1228G>A results in a TUBB3 E410K

212 reported to have congenital fibrosis of the extraocular muscles, facial weakness, developmental dela

213 nversus syndrome, congenital fibrosis of the extraocular muscles, lymphedema-distichiasis syndrome, n

214 risk factors for congenital fibrosis of the extraocular muscles, may play a role in SOP and conseque

215 ll musculature, as well as the diaphragm and extraocular muscles, originate from MyoD+ progenitors.

216 or movements, and Congenital fibrosis of the extraocular muscles, Type III.

217 rbital tissues--retina, choroid, sclera, and extraocular muscles--exists.

218 issue biopsy for lesions not confined to the extraocular muscles.

219 plicating primary involvement of the oblique extraocular muscles.

220 related to the pattern of innervation of the extraocular muscles.

221 ectivity between cranial motor axons and the extraocular muscles.

222 sessment of the pathophysiological status of extraocular muscles.

223 commonly affect the optic nerve, retina, and extraocular muscles.

224 GLUT1 and GLUT4 were detectable in extraocular muscles.

225 ated upstream activator of myogenesis in the extraocular muscles.

226 lability of substrate for energy pathways in extraocular muscles.

227 ative image of the motor command sent to the extraocular muscles.

228 tly remodel the proximal segment of juvenile extraocular muscles.

229 f oculomotor axons to innervate their target extraocular muscles.

230 velopmental decision regions close to target extraocular muscles.

231 iation of the myogenic regulatory cascade in extraocular muscles.

232 phogenesis and gene expression in developing extraocular muscles.

233 by an outer mechanism driven by the oblique extraocular muscles.

234 imum [Ca2+]i and force significantly more in extraocular muscles.

235 sis that mitochondria serve as Ca2+ sinks in extraocular muscles.

236 educed muscle fiber diameters within treated extraocular muscles.

237 ic response of oculomotor nuclei to abnormal extraocular muscles.

238 related to the pattern of innervation of the extraocular muscles.

239 motor nucleus, and contractility of isolated extraocular muscles.

240 ients (22/28 orbits) had enlargement of some extraocular muscles.

241 portion of slow fibers at birth, such as the extraocular muscles.

242 ar motor neurons and/or their innervation of extraocular muscles.

243 lmoplegia involving progressive paralysis of extraocular muscles.

244 There are two muscle fiber types in extraocular muscles: those receiving a single motor endp

245 otection assays for the embryonic (Myh3) and extraocular (Myh13) MyHC isoform mRNAs were also perform

246 c monoclonal antibodies to the embryonic and extraocular MyHC isoforms and to neurofilaments, as well

247 s occur in bilateral antagonistic horizontal extraocular nerves, during adult fictive limb-kicking, t

248 s a dorsal initiation signal acting from the extraocular non-neural ectoderm during optic vesicle eva

249 However, neither extraocular nor cardiac muscle was affected in double-kn

250 MIF motoneurons are located outside the extraocular nuclei in primates, but are intermixed with

251 e intermixed with SIF motoneurons within rat extraocular nuclei.

252 otor nuclei but not in the relatively spared extraocular nuclei.

253 known pathways of cholesterol elimination in extraocular organs are operative in the retina and that

254 ular extension, both the intraocular and the extraocular parts of the tumor should be sampled for acc

255 The intraocular and extraocular parts of the tumor were microdissected and a

256 most motor neurons die but those innervating extraocular, pelvic sphincter, and slow limb muscles exh

257 using siRNA in primary mouse myoblasts from extraocular, pharyngeal and limb muscles.

258 gan tissues harboring the symbionts serve as extraocular photoreceptors, with the potential to percei

259 ts show that TRPA1 is essential for a unique extraocular phototransduction pathway in human melanocyt

260 ge series of FNAB for uveal melanoma with no extraocular recurrence have been reported by multiple ex

261 relapse, no further episodes of intraocular/extraocular recurrence were recorded, and all patients w

262 hree groups on the basis of risk factors for extraocular relapse and metastasis assessed on centraliz

263 isease-free survival (DFS), considering only extraocular relapse as an event.

264 tion are at risk of developing late solitary extraocular relapse even more than 30 years after surger

265 e strongly suggestive of a diagnosis of late extraocular relapse from previously resected iris melano

266 To report on cases of late extraocular relapse of previously resected iris melanoma

267 grouping of patients with increasing risk of extraocular relapse.

268 The number of aqueous shunts to the extraocular reservoir increased 231% from 2356 in 1994 t

269 shunts (external approach), aqueous shunt to extraocular reservoir, and ECP.

270 Different staging systems for extraocular retinoblastoma have been published, but to d

271 e during needle withdrawal for prevention of extraocular seeding.

272 at induction of dorsal fate would require an extraocular signal arising from a neighboring tissue to

273 work has identified the nature and source of extraocular signals required to pattern the dorsal retin

274 inimal dissemination [MD]) of tumor cells in extraocular sites might be a tool for designing appropri

275 n of virus and not from spread of virus from extraocular sites via infected PBLs.

276 vered from the injected eye and from several extraocular sites, including liver, lungs, salivary glan

277 mRNA is a novel marker for retinoblastoma at extraocular sites.

278 r disease or if growth of the tumor into the extraocular space occurred independent of or prior to th

279 alous communications between intraocular and extraocular spaces.

280 alous communications between intraocular and extraocular spaces.

281 There has been no evidence of extraocular spread of tumor along the needle tract in an

282 nt correlated with ciliary body involvement, extraocular spread, largest basal tumor diameter, tumor

283 ckness, TNM stage, ciliary body involvement, extraocular spread, melanoma cytomorphological findings,

284 al tumor diameter, ciliary body involvement, extraocular spread, TNM stage, closed loops, and mitotic

285 ts showed a classic form of RP with variable extraocular symptoms, such as history of recurrent child

286 stem cell transplantation, conjunctival and extraocular tissue transplantation, multiagent immunosup

287 yes, peripheral blood leukocytes (PBLs), and extraocular tissues by plaque assay and by staining for

288 on, MCMV reactivates in the injected eye and extraocular tissues, and RPE cells are the initial site

289 ys of enzymatic cholesterol removal exist in extraocular tissues.

290 ls were not detected in the injected eyes or extraocular tissues.

291 aluation of studies of neovascularization in extraocular tissues.

292 permeability concentrations while minimizing extraocular toxicity.

293 T (P=0.019), tumor recurrence (P=0.002), and extraocular tumor extension (P=0.017) were predictive of

294 Biopsy of an extraocular tumor extension may not be representative of

295 The only factor predictive of extraocular tumor extension was intraocular tumor recurr

296 There was no case of extraocular tumor extension, hypotony, or phthisis bulbi

297 reased (18)F-FDG uptake was noted in primary extraocular tumor in all patients, except 5 with bilater

298 The implant consisted of an extraocular unit containing electronics for wireless dat

299 nd genetic analysis supported a diagnosis of extraocular uveal tumor spread rather than a primary con

300 neural tube and the branchial arches specify extraocular versus branchiomeric muscles.