ライフサイエンスコーパス: extraocular muscle

1 ed to study the effect of Pitx2 depletion on extraocular muscle.

2 d receptor (PPAR)gamma were more abundant in extraocular muscle.

3 ase were only approximately 2-fold higher in extraocular muscle.

4 drug treatments to strengthen an underacting extraocular muscle.

5 as means of pharmacologically weakening the extraocular muscle.

6 gents that weaken and strengthen the treated extraocular muscle.

7 ated for patients with total paralysis of an extraocular muscle.

8 rhodamine-phalloidin, as does the zebrafish extraocular muscle.

9 system in association with the medial rectus extraocular muscle.

10 to all en plaque and en grappe endplates of extraocular muscle.

11 ismus, possibly by altering vergence tone in extraocular muscle.

12 f oculomotor axons to innervate their target extraocular muscles.

13 related to the pattern of innervation of the extraocular muscles.

14 iation of the myogenic regulatory cascade in extraocular muscles.

15 phogenesis and gene expression in developing extraocular muscles.

16 by an outer mechanism driven by the oblique extraocular muscles.

17 imum [Ca2+]i and force significantly more in extraocular muscles.

18 sis that mitochondria serve as Ca2+ sinks in extraocular muscles.

19 educed muscle fiber diameters within treated extraocular muscles.

20 ic response of oculomotor nuclei to abnormal extraocular muscles.

21 ients (22/28 orbits) had enlargement of some extraocular muscles.

22 motor nucleus, and contractility of isolated extraocular muscles.

23 in patients with total paralysis of multiple extraocular muscles.

24 portion of slow fibers at birth, such as the extraocular muscles.

25 orbital inflammation primarily involving the extraocular muscles.

26 nd their corresponding alpha motoneurons and extraocular muscles.

27 ar motor neurons and/or their innervation of extraocular muscles.

28 lities result from myopathic fibrosis of the extraocular muscles.

29 omosome 12-linked congenital fibrosis of the extraocular muscles.

30 at they determine functional origins for the extraocular muscles.

31 lmoplegia involving progressive paralysis of extraocular muscles.

32 plicating primary involvement of the oblique extraocular muscles.

33 issue biopsy for lesions not confined to the extraocular muscles.

34 ectivity between cranial motor axons and the extraocular muscles.

35 sessment of the pathophysiological status of extraocular muscles.

36 commonly affect the optic nerve, retina, and extraocular muscles.

37 related to the pattern of innervation of the extraocular muscles.

38 GLUT1 and GLUT4 were detectable in extraocular muscles.

39 velopmental decision regions close to target extraocular muscles.

40 ated upstream activator of myogenesis in the extraocular muscles.

41 lability of substrate for energy pathways in extraocular muscles.

42 ative image of the motor command sent to the extraocular muscles.

43 tly remodel the proximal segment of juvenile extraocular muscles.

44 regulates [Ca2+]i and production of force in extraocular muscle; (2) mitochondrial content correlates

45 ed by afferent signals from receptors in the extraocular muscles [3,4].

46 ated or syndromic congenital fibrosis of the extraocular muscles, a form of complex congenital strabi

47 uired at several steps in the development of extraocular muscles, acting first as an anti-apoptotic f

48 er candidates, including pulleys that affect extraocular-muscle action and the role of nasally biased

49 ults are consistent with the hypothesis that extraocular muscle afferent signals provide a feedback s

50 genetic locus for congenital fibrosis of the extraocular muscle, an autosomal dominant muscular dystr

51 All three Pitx2 isoforms were expressed by extraocular muscle and at higher levels than in other st

52 , slow-tonic MyHC and EOM-MyHC expression in extraocular muscle and its absence leads to increased ex

53 disorders such as congenital fibrosis of the extraocular muscles and blepharophimosis.

54 C are expressed in and around the developing extraocular muscles and cause growth cone collapse of oc

55 trophic factors strengthen juvenile maturing extraocular muscles and gain insight into mechanisms of

56 onance imaging revealed marked hypoplasia of extraocular muscles and intraorbital cranial nerves.

57 increases the dynamic response range of the extraocular muscles and matches metabolic demand to supp

58 can now directly demonstrate innervation to extraocular muscles and quantify optic nerve size.

59 uria, or fixed weakness, which often affects extraocular muscles and results in droopy eyelids (ptosi

60 amps, or fixed weakness, which often affects extraocular muscles and results in droopy eyelids (ptosi

61 ere detected in the posterior regions of the extraocular muscles and the connective tissues of the ex

62 cts of ocular motility are properties of the extraocular muscles and their associated connective tiss

63 The study of the oculomotor periphery, the extraocular muscles and their orbital attachments, is un

64 ive anatomic sites: eye, orbit, optic nerve, extraocular muscle, and lacrimal drainage system.

65 tion, and survival, leading to craniofacial, extraocular muscle, and ocular developmental abnormaliti

66 Thus, the retinal image and functional extraocular muscles appeared nearly simultaneously with

67 Motoneurons of extraocular muscles are controlled by different premotor

68 Second, extraocular muscles are divided into two layers; the inn

69 The extraocular muscles assumed their adult configuration be

70 fied five parameters of the superior oblique extraocular muscle at 2 weeks of age: contractile force,

71 This mechanism may not apply to extraocular muscles because their constant activity may

72 Morphogenesis of all extraocular muscle bundles correlated highly with Pitx2

73 sorder caused by aberrant innervation of the extraocular muscles by axons of brainstem motor neurons.

74 reported to cause congenital fibrosis of the extraocular muscles, c.1228G>A results in a TUBB3 E410K

75 (CN3) and applied to congenital fibrosis of extraocular muscles (CFEOM) and congenital oculomotor pa

76 ing of two CCDDs, congenital fibrosis of the extraocular muscles (CFEOM) and Duane retraction syndrom

77 egia, and include congenital fibrosis of the extraocular muscles (CFEOM) and Duane syndrome (DURS).

78 ly who segregates congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria.

79 e classic form of congenital fibrosis of the extraocular muscles (CFEOM1) are born with bilateral pto

80 all three age groups in the Pitx2-deficient extraocular muscle compared with littermate controls.

81 lternative subunit isoform expression in the extraocular muscles compared with limb muscles.

82 ar muscles and the connective tissues of the extraocular muscle cones in the normal mouse.

83 Mammalian extraocular muscles contain singly innervated twitch mus

84 Imaging of the orbit and extraocular muscles continues to be recommended as helpf

85 Extraocular muscle contractility was impaired by dark re

86 Pitx2) is known to regulate the formation of extraocular muscle development and in this report we sho

87 comparable upstream factors required during extraocular muscle development have not been identified.

88 s, the ectopic nerves were seen to innervate extraocular muscle directly.

89 nd additional proteomic data, establish that extraocular muscle does not constitute a distinctive mus

90 Exogenous IGF1 and CT1 strengthen extraocular muscles during maturation.

91 Enophthalmos, diplopia resulting from extraocular muscle dysfunction, and infraorbital nerve h

92 e, especially in the presence of ipsilateral extraocular muscle enlargement, sinus disease, or focal

93 mably is the basis for the broad spectrum of extraocular muscle (EOM) contractile properties in drivi

94 branched to enter the LR and arborized among extraocular muscle (EOM) fibers.

95 Extraocular muscle (EOM) has a distinct skeletal muscle

96 graphy (AS-OCT) in measuring the distance of extraocular muscle (EOM) insertion to the limbus to impr

97 The orbital layer of each rectus extraocular muscle (EOM) inserts on connective tissue, a

98 Although extraocular muscle (EOM) is skeletal muscle, aspects of

99 Extraocular muscle (EOM) is spared in Duchenne muscular

100 e quantitative measures of horizontal rectus extraocular muscle (EOM) morphology to determine the mag

101 t of recessions and resections on horizontal extraocular muscle (EOM) paths and globe position.

102 Extraocular muscle (EOM) paths are constrained by connec

103 Surgical recession of an extraocular muscle (EOM) posterior to its original inser

104 ic resonance imaging (MRI) was used to study extraocular muscle (EOM) responses to head tilt in HTDHT

105 direct injection of ricin-mAb 35 into rabbit extraocular muscle (EOM) results in significant muscle l

106 re correlated with MRI studies demonstrating extraocular muscle (EOM) size, location, contractility,

107 mutation and MRI findings that demonstrated extraocular muscle (EOM) size, location, contractility,

108 ated that prolonged exposure of adult rabbit extraocular muscle (EOM) to insulin-like growth factor-1

109 es were analyzed quantitatively to determine extraocular muscle (EOM) volume, maximum diameter, and l

110 In myasthenia gravis (MG), extraocular muscle (EOM) weakness is often an initial an

111 ative muscle classes, limb, masticatory, and extraocular muscle (EOM), in adult mice by high-density

112 Extraocular muscle (EOM)-specific MyHC expressing fibres

113 r (IGF)-II in increasing force generation in extraocular muscle (EOM).

114 Because the extraocular muscles (EOM) are preferentially affected in

115 Human extraocular muscles (EOM) are preferentially susceptible

116 Extraocular muscles (EOM) represent a unique muscle grou

117 le, only 56 genes were altered in the spared extraocular muscles (EOM).

118 erve as functional mechanical origins of the extraocular muscles (EOMs) and are normally stable relat

119 onance imaging (MRI) was used to demonstrate extraocular muscles (EOMs) and associated motor nerves i

120 ed magnetic resonance imaging (MRI) to study extraocular muscles (EOMs) and nerves in Duane-radial ra

121 Connective tissue pulleys inflect the extraocular muscles (EOMs) and receive insertions from s

122 n freshly dissected and cryosectioned rectus extraocular muscles (EOMs) and tibialis anterior (TA) mu

123 Orbital and global layers of rectus extraocular muscles (EOMs) are believed to serve differe

124 Mammalian extraocular muscles (EOMs) are both physiologically and

125 The paths of the rectus extraocular muscles (EOMs) are constrained by pulleys, c

126 Extraocular muscles (EOMs) are highly specialized skelet

127 Extraocular muscles (EOMs) are specialized skeletal musc

128 ial DNA (mtDNA) defects were investigated in extraocular muscles (EOMs) collected from individuals co

129 Rectus extraocular muscles (EOMs) consist of orbital (OL) and g

130 Rectus and the inferior oblique extraocular muscles (EOMs) consist of orbital layers (OL

131 Strabismic extraocular muscles (EOMs) differ from normal EOMs in st

132 hy after intramuscular injection with Botox, extraocular muscles (EOMs) do not.

133 The phenotypically novel extraocular muscles (EOMs) exhibit fundamental differenc

134 e lateral rectus (LR) and medial rectus (MR) extraocular muscles (EOMs) have largely nonoverlapping s

135 mmon treatment for motility disorders of the extraocular muscles (EOMs) is a resection procedure in w

136 tramuscular innervation of horizontal rectus extraocular muscles (EOMs) is segregated into superior a

137 nective tissues that surround the horizontal extraocular muscles (EOMs) of humans.

138 dings are nerve specializations found in the extraocular muscles (EOMs) of mammals, including primate

139 Structural abnormalities of extraocular muscles (EOMs) or their pulleys are associat

140 toxin-treated normal adult rabbit and monkey extraocular muscles (EOMs) were analyzed.

141 studies have shown that direct injection of extraocular muscles (EOMs) with insulin growth factor or

142 ry nerve terminal elimination at synapses in extraocular muscles (EOMs), a specialized set of muscles

143 sue structures constrain paths of the rectus extraocular muscles (EOMs), acting as pulleys and servin

144 l of compartmentalization in all four rectus extraocular muscles (EOMs), evidence was sought of possi

145 inear viscoelastic stress-strain behavior of extraocular muscles (EOMs).

146 ayer (OL) and global layer (GL) of adult rat extraocular muscles (EOMs).

147 as the functional mechanical origins of the extraocular muscles (EOMs).

148 aths and determine pulling directions of the extraocular muscles (EOMs).

149 rbital tissues--retina, choroid, sclera, and extraocular muscles--exists.

150 Extraocular muscles express a number of characteristics

151 Populations of mature myofibers from all six extraocular muscles express N-CAM homogeneously on their

152 reported to have congenital fibrosis of the extraocular muscles, facial weakness, developmental dela

153 pothesis that there is greater complexity to extraocular muscle fiber types than the traditional desc

154 ous trophic factors regulate and/or maintain extraocular muscle force through a rapid mechanism that

155 fibers may either provide resistance against extraocular muscle forces or limit globe axial elongatio

156 We show Pax7 is dispensable for extraocular muscle formation, whereas Pitx2 is cell-auto

157 Extraocular muscles from adult male Sprague-Dawley rats

158 h sensory-induced strabismus, innervation to extraocular muscles from motor nuclei produce the inappr

159 Extraocular muscles from rabbits, monkeys, and humans we

160 Modulation of Pitx2 expression can influence extraocular muscle function with long-term therapeutic i

161 nd in the multiply innervated slow fibers of extraocular muscle, gamma subunit expression persists in

162 The mutant extraocular muscle had no obvious pathology but had alte

163 stablished several years ago that the rectus extraocular muscles have connective tissue pulleys, rece

164 (CT1) are known to increase the strength of extraocular muscles in adult and embryonic animals, but

165 Because of the exclusive involvement of the extraocular muscles in Graves' ophthalmopathy, the absen

166 elation was found between IS and T2-time for extraocular muscles in healthy volunteers.

167 s established the normal paths of the rectus extraocular muscles in primary gaze.

168 s in estimation of inflammatory processes of extraocular muscles in the clinical practice.

169 ng group in whom greater manipulation of the extraocular muscles inevitably occurs, are consistent wi

170 Extraocular muscle inner mitochondrial membrane density

171 Compartmentalization of the extraocular muscles into well-defined orbital and global

172 alterations in the dynamic properties of the extraocular muscles involved in eye torsion.

173 are likely to underlie the low threshold for extraocular muscle involvement in this disease?

174 mage, and ptosis and ocular dysmotility from extraocular muscle involvement.

175 in retinal pigment epithelium, optic nerve, extraocular muscle, iris, ciliary body, cornea, and seve

176 Ca2+ sinks; and (3) mitochondrial content in extraocular muscle is determined by the transcription fa

177 Extraocular muscle is fundamentally distinct from other

178 pmental disorder in which the lateral rectus extraocular muscle is not properly innervated.

179 Extraocular muscle is unusually fast with a far weaker K

180 Extraocular muscle is very responsive to direct injectio

181 Congenital fibrosis of the extraocular muscles is an autosomal dominant congenital

182 amount of residual function of the affected extraocular muscles is essential to determine which surg

183 tested the hypothesis that glucose uptake by extraocular muscles is not regulated by insulin or contr

184 Glucose uptake in extraocular muscles is regulated by insulin and contract

185 y-induced strabismus, central innervation to extraocular muscles is responsible for setting the state

186 The constant activity of the extraocular muscles is supported by abundant mitochondri

187 specific isoform alpha, and the specialized extraocular muscle isoform).

188 th the different loads and usage patterns of extraocular muscle layers, as proposed in the active pul

189 of the structure-function characteristics of extraocular muscle layers.

190 transcripts) was identified between the two extraocular muscle layers.

191 rom an abnormality in the development of the extraocular muscle lower motor neuron system.

192 nversus syndrome, congenital fibrosis of the extraocular muscles, lymphedema-distichiasis syndrome, n

193 nition of the regulation of MyHC isoforms in extraocular muscle may allow their rational manipulation

194 The presence of N-CAM in normal mature extraocular muscles may play a role in the etiology and

195 risk factors for congenital fibrosis of the extraocular muscles, may play a role in SOP and conseque

196 Activity of complexes I and IV was lower in extraocular muscle mitochondria (approximately 50% the a

197 The results demonstrate that extraocular muscle mitochondria respire at slower rates

198 The authors tested the hypothesis that extraocular muscle mitochondria respire faster than do m

199 States 3, 4, and 5 respiration rates in extraocular muscle mitochondria were 40% to 60% lower th

200 Finally, complex V was less abundant in extraocular muscle mitochondria.

201 of insulin-like growth factor II (IGF-II) on extraocular muscle morphometry and force generation were

202 ntains premotor neurons supplying horizontal extraocular muscle motoneurons.

203 demonstrated the presence of Pitx2 mainly in extraocular muscle myonuclei.

204 The ultrafast extraocular muscles necessitate tight regulation of free

205 t animals' (16 and 20 to 21 days) RPE and in extraocular muscle of a 16-day-old untreated mutant.

206 nalysis of triceps surae (a limb muscle) and extraocular muscles of adult male Sprague-Dawley rats.

207 Mouse extraocular muscles of different ages were examined for

208 Direct injection of ricin-mAb 35 into the extraocular muscles of rabbits results in a dose-related

209 M, was assessed immunohistochemically in the extraocular muscles of rabbits, monkeys, and humans to e

210 rough the oculomotor nucleus that innervates extraocular muscles of the eye.

211 CAM-positive myofibers were found in all six extraocular muscles of the three species examined.

212 Although polyNCAM was present in the extraocular muscles, only a few small diameter cells wer

213 ll musculature, as well as the diaphragm and extraocular muscles, originate from MyoD+ progenitors.

214 sex (P = .01) and inflammation extending to extraocular muscle (P = .01).

215 Alan Scott initially investigated extraocular muscle paralysis by botulinum injection in 1

216 bulbar anesthesia for cataract extraction is extraocular muscle paresis/restriction and is unique to

217 The rectus extraocular muscles pass through fibromuscular connectiv

218 Pitx2 is important in maintaining the mature extraocular muscle phenotype and regulating the expressi

219 Data show that the extraocular muscle phenotype results from the combinatio

220 Three congenital fibrosis of the extraocular muscles phenotypes (CFEOM1-3) have been iden

221 omously required to prevent apoptosis of the extraocular muscle primordia.

222 al eye position information (efference copy, extraocular muscle proprioception, or both) that is used

223 onsequence of modified efference copy and/or extraocular muscle proprioception.

224 Topographic relationships of the extraocular muscles relative to the fovea are essential

225 rst time that neuromuscular junctions of the extraocular muscles (responsible for the control of eye

226 iplopia, enophthalmos, orbital dystopia, and extraocular muscle restriction.

227 nts evidence that congenital fibrosis of the extraocular muscles results from an abnormality in the d

228 Extraocular muscles show specific adaptations to fulfill

229 disorder is genetically distinct from other extraocular muscle-specific disorders such as congenital

230 endogenous and exogenous trophic factors on extraocular muscle strength and mass were examined in th

231 Extraocular muscle strengthening is a common treatment f

232 In vitro, Pitx2 loss made the extraocular muscles stronger, faster, and more fatigable

233 identified in the Pitx2(Deltaflox/Deltaflox) extraocular muscle, suggesting that altered innervation

234 al mitochondrial clumping are found in other extraocular muscles, suggesting that the muscle patholog

235 Extraocular muscle surgery frequently is required for pl

236 ing may provide an adjunct or alternative to extraocular muscle surgery in selected cases.

237 ium 103 plaque brachytherapy with or without extraocular muscle surgery.

238 ouplings facilitate implementation by rectus extraocular muscle suspensions of a commutative ocular m

239 Imaging studies disclosed extraocular muscle swelling (8 cases), most frequently o

240 rengthening of eye muscles in the developing extraocular muscle system.

241 oscopic study of the enthesis site-where the extraocular muscle tendon inserts onto the sclera-in nor

242 All 6 patients had enlarged extraocular muscles that caused restrictive strabismus.

243 There are two muscle fiber types in extraocular muscles: those receiving a single motor endp

244 , from the genetics of disorders that affect extraocular muscles to the way in which the cerebral cor

245 fugal projection, the retinal image, and the extraocular muscles, to obtain an integrated picture of

246 expression in adulthood also defines certain extraocular muscle traits.

247 Current concepts regarding extraocular muscle transposition and the use of autogeno

248 es in humans with congenital fibrosis of the extraocular muscles type 1 (CFEOM1) due to missense muta

249 ve been linked to congenital fibrosis of the extraocular muscles type 1 (CFEOM1), a dominant disorder

250 Congenital fibrosis of the extraocular muscles type 1 (CFEOM1; OMIM #135700) is an

251 otility disorder "Congenital fibrosis of the extraocular muscles type 1" (CFEOM1) results from hetero

252 abnormalities in congenital fibrosis of the extraocular muscles type 3 (CFEOM3), a disorder resultin

253 s consistent with congenital fibrosis of the extraocular muscles type 3 (CFEOM3); 1 patient harbored

254 or movements, and Congenital fibrosis of the extraocular muscles, Type III.

255 ng-term myopathic effects of ricin-mAb 35 on extraocular muscle were investigated.

256 We also analyzed the expression profile of extraocular muscle, which is divergent from other skelet

257 Peak tetanic [Ca2+]i increased in extraocular muscle with caffeine and CEP.

258 are effective for patients who have paretic extraocular muscles with residual function.

259 position and pulling direction of the recti extraocular muscles within the orbit.