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1 pic anchors for in vitro to in vivo toxicity extrapolation.
2 sound, but not the post hoc ergo procter hoc extrapolation.
3 dose rabbit data and then conduct a low-dose extrapolation.
4 herefore, they were well suited for regional extrapolation.
5 extrapolation and 5.53 dl/g using the Kramer extrapolation.
6 llowed us to approximate the missing data by extrapolation.
7 tions for diarrhea, and associated costs, by extrapolation.
8 We did intention-to-treat analyses with no extrapolation.
9 d in vitro to in vivo biotransformation rate extrapolation.
10 l responses proposed to contribute to motion extrapolation.
11 stic of Earth's core is higher than previous extrapolations.
12 --unlike previous estimates, which relied on extrapolations.
13 derived from toxicology-based, interspecies extrapolations.
14 nding model reduces the uncertainty in these extrapolations.
15 least in the order of 10(15) M(-1) (based on extrapolation), 3 orders of magnitude larger than that o
16 rns of variability can lead to more rational extrapolations across species and improved protectivenes
18 rogeneity of some HIV-1 Env proteins and, by extrapolation, also vaccine immunogens from other pathog
19 ic viscosity was 5.84 dl/g using the Huggins extrapolation and 5.53 dl/g using the Kramer extrapolati
20 effective framework to test in vitro-in vivo extrapolation and holds great promise for predicting tox
25 r demand on visual-spatial memory for motion extrapolation, and thus participants did not experience
27 (EIAV) as an example, demonstrates a linear extrapolation approach to obtain backbone (15)N spin rel
30 ed mice needs to be viewed with caution when extrapolations are made to the function of the human ner
31 in uses the fast-OFF cell circuit for target extrapolation as we suggest, the circuit dynamics should
32 nceptually reversing these expansions allows extrapolation backward in time to generate models of pri
37 terpreting field data and the constraints of extrapolations between species, particularly in terms of
39 ing subsets of the data, we demonstrate that extrapolation beyond a known part of the landscape is di
41 5.15, in the range 185.8-153.8 degrees C, on extrapolation by the derived Arrhenius equation, lead to
44 Recent advances, including the CO-eXpression ExtrapolatioN (COXEN) algorithm, suggest that developmen
46 1 FMNs to axotomy-induced cell death and, by extrapolation, disease progression, is not intrinsic to
47 e methods used and the taxa considered, such extrapolations, especially from small percentages of kno
51 on can be reconstructed via interpolation or extrapolation from adjacent contextual cues by what is n
52 endering management decisions to be based on extrapolation from adult data and the experience of the
55 of low dose radiation has been estimated by extrapolation from data at higher doses according to the
56 in patients with obesity or IBD are based on extrapolation from general guidelines for antithrombotic
59 of similarities is nearly exhausted and that extrapolation from one receptor to another is as likely
62 and daily everolimus administration allowed extrapolation from preclinical studies and first clinica
67 sease is based largely on expert opinion and extrapolation from studies in older children given the r
69 for dyslipidemia in this population requires extrapolation from studies performed in older adults.
73 try into one environment according to linear extrapolation from the time-dependent shifts observed du
76 iatric psychosis are urgently needed because extrapolations from adult studies might not be implement
77 ng and treating P-NETs in MEN1 patients, and extrapolations from approaches used in patients with non
79 timates are derived from large spatial-scale extrapolations from highly heterogeneous and often poorl
85 This estimation of J0 does not involve an extrapolation in length, because it was possible to meas
87 of allosteric binding sites in AChBP and, by extrapolation, in the human alpha7 nAChR as determined b
90 We also evaluate how the method chosen for extrapolation into nonanalog conditions affects the pred
94 rces based on published estimates as well as extrapolations made using these estimates, and lay out p
96 amilial hemiplegic migraine and possibly, by extrapolation, may reflect on the pathophysiology of mor
97 ly, we have developed and validated a double extrapolation method for predicting retention factors at
102 Two computational methodologies-a vinylogue extrapolation methodology and a block localized wave fun
104 methods to fill data gaps and on identifying extrapolation methods to derive suitable values for the
105 reaction (qPCR) analysis, the threshold and extrapolation methods, either make assumptions about PCR
107 ction accuracy were consistent with a linear extrapolation model that predicted prey position at the
110 xplicit forest disturbance maps coupled with extrapolation models predicted mortality and severe stru
115 ount of binding molecules allows the precise extrapolation of adhesion rates, from which the concentr
120 he issues surrounding interchangeability and extrapolation of biosimilars to other disease and patien
121 en real-life patient populations, which make extrapolation of clinical trial data to actual clinical
122 tial for the correct data interpretation and extrapolation of conclusions applicable to the human bra
123 cate a necessary caution with respect to the extrapolation of crystal structures to the study of fibr
127 hildren with mild and moderate asthma and on extrapolation of data from studies in adults with severe
131 nsitive analytical determination allowed the extrapolation of diagnostic information from the minor c
132 rformed and that have been licensed based on extrapolation of efficacy and safety data from other ind
133 al burden of disease, other factors, such as extrapolation of environmental sampling to the entire ex
135 diators might have been overstated, owing to extrapolation of experimental findings from young animal
136 rs and exhibits unique properties which make extrapolation of findings from the other two subtypes di
139 ts could serve as supportive information for extrapolation of hepatobiliary elimination from preclini
140 on the association kinetics, justifying the extrapolation of in vitro data to processes in the cell.
141 n squared error for MD forecasts with linear extrapolation of indices were 3.58 dB and 31.91 dB(2), a
143 onductivity of C60, obtained from the linear extrapolation of inverse conductivity vs. inverse length
145 rstand the functioning of the system and for extrapolation of laboratory findings of stressor impacts
146 fety regulations in structural design or the extrapolation of laboratory results to geophysical field
149 index (VFI) forecasts were calculated by (1) extrapolation of linear regression of MD and VFI, and (2
150 ere we use bottom-up (inventory, statistical extrapolation of local flux measurements, and process-ba
151 ent instead, a modification of the method by extrapolation of logarithmic selectivity coefficients ap
153 he stability is much lower than predicted by extrapolation of measurements made at high denaturant co
154 discussed seven independent approaches: (i) extrapolation of mobility to the zero power, (ii) initia
156 The calculated effective dose, based on extrapolation of mouse data, was 0.0218 mSv/MBq, which w
157 uss the challenges specific to cross-species extrapolation of neutrophil function during mouse versus
158 inear prediction motion task that emphasized extrapolation of occluded accelerative object motion.
162 nterfacial free energy of 29(3) mN/m from an extrapolation of our results to the melting temperature.
164 e oxygen levels have largely been limited to extrapolation of paleoredox conditions reconstructed fro
167 eatment design of complex diseases; (ii) the extrapolation of phenotype profiles beyond provided clas
170 estimated to live 4.4 years on average from extrapolation of recent constant hazard rates beyond the
171 f biological organization and facilitate the extrapolation of results across routes of exposure, dosi
172 he mobile-phase density, complicating linear extrapolation of retention over longer or shorter column
173 subtypes, particularly in humans; this makes extrapolation of rodent findings to the human situation
174 , such hypotheses have largely relied on the extrapolation of single-cell responses to population res
175 obal mass balance estimates for GICs rely on extrapolation of sparse mass balance measurements repres
178 n higher numbers than expected from a simple extrapolation of the bulk solubility to the low growth t
179 ublet levels is not consistent with a simple extrapolation of the calculated relative reaction cross
180 nal program, which is in large part a direct extrapolation of the changes that occur during slow grow
181 ced the understanding of its photochemistry, extrapolation of the conclusions to the real system requ
182 ncogene in the majority of melanomas, and in extrapolation of the correlation data, interference with
185 6 ms, which corresponds to 1 +/- 0.6 ms upon extrapolation of the data to zero SDS concentration.
188 ension of supercooled water follows a smooth extrapolation of the IAPWS equation in the supercooled r
189 o be corrected for equilibrium, typically by extrapolation of the loss kinetics of performance refere
192 odiversity results not just from large-scale extrapolation of the process of adaptive radiation in a
195 ncrease was less than expected from a linear extrapolation of the trend observed at lower concentrati
198 cle oxidative phosphorylation cascade, while extrapolation of these data to the exercising muscle pre
201 among household contacts may also limit the extrapolation of these findings to the community setting
203 s been demonstrated in bioassay experiments, extrapolation of these laboratory results to natural con
210 iacetylene oligomers and provide an accurate extrapolation of these values to the polymer limit.
214 ialized properties, to the three-dimensional extrapolation of this technique to more complex structur
215 rences in organ dosimetry, thus complicating extrapolations of dose-response relationships to human p
216 t research groups, leading to the paucity of extrapolations of experimental findings into understandi
217 se biases should temper the use of plots for extrapolations of forest dynamics to larger scales, and
221 much of the current controversy to premature extrapolations of the effects of acidification on neuron
222 ing to the obtained results and regardingthe extrapolations of the maximum residue limits existing fo
223 han would be expected on the basis of linear extrapolations of the relative risks from active smoking
227 higher pressure phase boundaries are either extrapolations or inferred based on indirect evidence.
228 laims concerning selectivity are based on an extrapolation over four orders of magnitude to low Ca(2+
230 nd European emission inventories using three extrapolation proxies, namely the gross domestic product
232 of assessment and the challenges of species extrapolation require the development of alternative app
236 ropose a novel application of the simulation-extrapolation (SIMEX) procedure to address measurement e
239 62800 (32000-118000) averted infections, and extrapolation suggested that 202000 (98300-407000) infec
241 othesis, we trained subjects on a moving dot extrapolation task that makes distinct predictions for t
242 pts at solving this problem involve delicate extrapolations that are highly nonunique and that lack a
244 e, and congenital fibrosis syndrome) and, by extrapolation, the hypoplasia or dysgenesis of noncephal
246 he electrodes in a pi system is an immediate extrapolation; the theory then predicts that for some sp
247 he vicinity of the replication forks, and by extrapolation, this is also likely to be the case for th
248 energy of stable phases, without relying on extrapolation, thus enabling a formal assessment of wide
251 ative rodent bioassay dose-response data for extrapolation to a single cancer potency estimate for hu
255 that salamanders aim their tongues by using extrapolation to estimate future prey position, thereby
263 r crater chronology and an updated dynamical extrapolation to Mercury, we find that the oldest surfac
265 impact local malaria dynamics is complex and extrapolation to other settings or future times is contr
269 re conducted under controlled conditions for extrapolation to real situations, we evaluate exposure r
273 xicity is preferably performed in vitro, but extrapolation to the in vivo outcome remains very challe
274 tration alters its speciation, rendering the extrapolation to the low dose exposure chemically incons
275 he nonthermostated capillary part, (v) inter/extrapolation to the nominal temperature, (vi) internal
276 he reliance on a rough figure of 400,000 for extrapolation to the total Yazidi population of Sinjar a
278 e-based studies with an expectation of valid extrapolation to the understanding and treatment of pati
284 ant plant trait distributions will not allow extrapolations to novel community assemblages in future
285 chanism-dependent isotope effects precluding extrapolations to other organic micropollutants reacting
286 nt gradient profiles, by simple mathematical extrapolation using a known equation, thus offering very
287 D absent PCV7 introduction were estimated by extrapolation using either Poisson regression modeling o
291 as estimated using actual survival data with extrapolation using proportional hazard models adjusting
292 vation efforts must estimate connectivity by extrapolation using taxonomy, adult distribution, life h
297 e was poor extrapolation between species and extrapolation was limited to geographic scales smaller t
299 mens for 1- and 2-d protocols based on those extrapolations will result in the expected radiation dos
300 es lower than previously inferred from model extrapolations, with implications for the evolution of t
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