ライフサイエンスコーパス: extrarenal

1 D has been broadened by the discovery of the extrarenal 1alpha-hydroxylase (CYP27B1) in various vitam

2 For example, although the identification of extrarenal 1alpha-hydroxylase activity suggests that aut

3 but also may be important for providing the extrarenal 1alpha-hydroxylase that is present in most ti

4 ies support the concept that the MR also has extrarenal actions and that defects in sodium handling a

5 ts (retransplants, highly sensitized, etc.), extrarenal allograft recipients, or alternative drug reg

6 have not discriminated between the roles of extrarenal and intrarenal dopamine in the overall regula

7 a (34%), systemic atherosclerosis (25%), and extrarenal aneurysms (6.5%).

8 first example of hypertonic induction of an extrarenal aquaporin, as well as the first association b

9 nstrate that regulation of blood pressure by extrarenal AT(1A) receptors cannot be explained by alter

10 kidney, the residual repertoire of systemic, extrarenal AT1 receptors is not sufficient to induce hyp

11 Overall, extrarenal cells did not substitute for any intrinsic EC

12 elative contribution of intrarenal cells and extrarenal cells to kidney regeneration is not clear.

13 ion (I/R) injury as well as the potential of extrarenal cells to substitute for injured local EC.

14 as smooth-muscle, epithelial, mesangial, and extrarenal cells.

15 ibutable to defective renal clearance and/or extrarenal clearance and metabolism, the latter possibly

16 te the specific contribution of renal versus extrarenal collectrin on BP regulation and salt sensitiv

17 disease seems to be a distinct and important extrarenal complication of ADPKD.

18 er characterized by renal cyst formation and extrarenal complications such as hypertension and vascul

19 management of the renal failure and serious extrarenal complications that may occur during the cours

20 e model induces more severe renal injury and extrarenal complications.

21 Basal renal and extrarenal CYP24 is usually low but is highly induced by

22 To determine the role of renal versus extrarenal D(5) receptors in BP regulation, we performed

23 but not with extrarenal disease activity or extrarenal damage.

24 injury underscores the reluctance to recover extrarenal DCD organs since lack of medical therapy to s

25 tations, such as R246Q, can have less severe extrarenal defects but still exhibit congenital nephroti

26 The extrarenal defects in this murine model include common b

27 ric kidney development and abrogated several extrarenal developmental defects.

28 lovesical fistula, and incidentally detected extrarenal disease (a liver mass, hepatic metastases, ly

29 < 0.0001 for both comparisons), but not with extrarenal disease activity or extrarenal damage.

30 I score (r = 0.452, P = 0.009), but not with extrarenal disease activity.

31 C57BL/6 mice were negative for BM-derived or extrarenal ECFCs.

32 vestigations reveal a range of unanticipated extrarenal effects of aldosterone, as well as a detailed

33 duction in peritubular cells and unwarranted extrarenal effects.

34 Hepatocytes are the primary source of extrarenal EPO in the adult and express HIF-1 and HIF-2,

35 The extrarenal etiology of systemic lupus is based on multip

36 The prevalence of death or serious extrarenal events was 18% and 20% in the experimental an

37 podocyte-specific transgenic expression when extrarenal expression of a transgene is problematic.

38 of mediators of epithelial Cl(-) flux whose extrarenal expression overlaps with WNK4.

39 sion of both, suggesting that both renal and extrarenal factors are important in the regulation of AT

40 However, in edematous disorders, extrarenal factors can override the 'innate wisdom' of t

41 s achieved by a dual mechanism that includes extrarenal factors such as insulin and beta-adrenergic a

42 cross-sectional study that aimed to evaluate extrarenal factors that may have influence on kidney gra

43 ependently associated with eGFR but not with extrarenal factors.

44 h autosomal dominant FSGS but without either extrarenal features or ultrastructural abnormalities of

45 lity is important to ensure compensation for extrarenal fluid losses.

46 Phenotype analysis of kidney and extrarenal function in knockout mice has been very infor

47 would be the definite proof of extrahepatic, extrarenal glucose production.

48 to systemic EPO homeostasis and the role of extrarenal HIF-2 in erythropoiesis, in the absence of ki

49 the associated uremia did not seem to affect extrarenal HO-1 gene activity assessed in the liver, lun

50 Anesthetic effects on extrarenal injury (plasma creatine phosphokinase, lactat

51 ted in all 8 patients with PTMA, and limited extrarenal involvement by PTMA was observed in 3 of thes

52 nsporters and channels involved in renal and extrarenal K(+) homeostasis.

53 (PCLD) and are recognized as the most common extrarenal manifestation in autosomal dominant polycysti

54 The principal extrarenal manifestation of autosomal dominant polycysti

55 racteristics of the liver disease, and other extrarenal manifestations in ADPKD.

56 Extrarenal manifestations include an increased level of

57 Imaging is also helpful in detecting extrarenal manifestations of ADPKD, most significant of

58 lmonary hemorrhage at onset; (3) presence of extrarenal manifestations versus renal limited disease;

59 to adult-onset FSGS in the absence of overt extrarenal manifestations.

60 sediment or the persistence or appearance of extrarenal manifestations.

61 ey injury (AKI) is frequently complicated by extrarenal multiorgan injury, including intestinal and h

62 alignant mesothelioma is one of the very few extrarenal neoplasms in which the Wilms tumor suppressor

63 med before EC injury to allow distinction of extrarenal or BM-derived cells from intrinsic renal cell

64 ) remains unacceptably high, likely owing to extrarenal organ dysfunction.

65 e supports extensive, yet indistinguishable, extrarenal organ manifestations.

66 these principles in recipients of renal and extrarenal organ transplants.

67 ng the role of facilitated urea transport in extrarenal organs expressing UT-B.

68 ICU extubation should not eliminate extrarenal organs from consideration and may be preferab

69 o increase the utilization of both renal and extrarenal organs from donors after cardiac death (DCD),

70 Circulating Angptl4 was secreted by extrarenal organs in response to an elevated plasma rati

71 red, 21 not transplanted, 8 en bloc, 23 with extrarenal organs, and 6 with missing records), 228 reci

72 has a significant effect on the function of extrarenal organs.

73 production of this steroid hormone in >/=10 extrarenal organs.

74 Furthermore, CAIX expression is apparent in extrarenal organs.

75 , we observed CAIX expression in a number of extrarenal organs.

76 diseases that are frequently associated with extrarenal pathologies such as retinal degeneration, obe

77 he present study characterizes the renal and extrarenal pathology in the BALB/c-cpk/cpk murine model

78 k/cpk murine model displays renal as well as extrarenal pathology similar to that found in human ARPK

79 time, in a local feedback loop, the elevated extrarenal pools of Angptl4 reduced tissue FFA uptake in

80 potassium and the neurohumoral mediators of extrarenal potassium disposal with maximal exercise.

81 levels may contribute to the maintenance of extrarenal potassium homeostasis in ESRD.

82 onal source of renin and constitute a unique extrarenal renin-angiotensin system.

83 oups provides evidence against any important extrarenal response to acute PO4 loads.

84 This pathway may explain renal and extrarenal responses to altered K(+) intake that occur i

85 abdoid tumors of the brain and 7 renal and 4 extrarenal rhabdoid tumors for mutations in the candidat

86 nvestigate the human placenta as a potential extrarenal site of EPO production.

87 press renin gene expression at inappropriate extrarenal sites where cellular proteases, to which pror

88 bdoid tumors of the brain, kidney, and other extrarenal sites.

89 ipants of developmental vascular assembly in extrarenal sites.

90 patients with moderately-to-severely active extrarenal SLE.

91 Associated renal or extrarenal symptoms should alert the nephrologist to HNF

92 Patients who exhibited extrarenal symptoms, had a familial history of the disea

93 l relevance, also with respect to additional extrarenal symptoms.

94 congenital nephrotic syndrome but only mild extrarenal symptoms; the mechanisms underlying the devel

95 Extrarenal thrombi were detected in the gastrointestinal

96 and may resemble those changes described for extrarenal tissues and (2) increased NHE-3 activity due

97 xpression in podocytes without expression in extrarenal tissues in adult or embryonic mice.

98 the kidney, is also expressed in many other extrarenal tissues including the pancreas.

99 ension, whereas the absence of RGS2 from all extrarenal tissues including the peripheral vasculature

100 AT(1) receptor actions in the kidney and in extrarenal tissues to determining the level of blood pre

101 e tested the ability of fibrotic kidneys and extrarenal tissues to produce EPO.

102 lore the relative contributions of renal and extrarenal tissues to the low blood pressure seen in the

103 of RGS2 actions in the kidney from those in extrarenal tissues with regard to BP regulation.

104 cts in renal epithelial cells directly or in extrarenal tissues, and whether inhibition of calcineuri

105 Prorenin is expressed in certain extrarenal tissues, but normally only the kidneys proces

106 Moreover, autoimmune injury in extrarenal tissues, including skin, heart, and joints, w

107 In extrarenal tissues, WNK4 is found almost exclusively in

108 e examined the distribution of WNK1 in these extrarenal tissues.

109 ents support our hypothesis that LPS acts on extrarenal TLR4, thereby leading to systemic TNF release

110 temic TNF release triggered by LPS acting on extrarenal TLR4.

111 l transplantation experiments confirmed that extrarenal transcription of transgenic albumin was unlik

112 stration compared with innervated kidneys in extrarenal transplantation.

113 Extrarenal tumors were also noted in the spleen and uter

114 e data support the hypothesis that increased extrarenal vascular ET-1 production in response to HS in

115 Extrarenal viral inclusions were documented in the gastr