ライフサイエンスコーパス: extrathymic

1 y of T cell maturation previously defined as extrathymic.

2 Recently, extrathymic Aire-expressing cells (eTACs) have been desc

3 The origin and function of extrathymic Aire-expressing cells (eTACs) is incompletel

4 f expression, with only mTECs and peripheral extrathymic Aire-expressing cells (eTACs) known to expre

5 Here we report the identification of extrathymic Aire-expressing cells (eTACs) resident withi

6 As a model of extrathymic alloantigen expression, pancreatic islet all

7 ased the number of gammadelta and thymic and extrathymic alphabeta T cells in gastrointestinal mucosa

8 S1P(1) inhibited the generation of extrathymic and natural T(reg) cells while driving T(H)1

9 asis by a variety of immunologic (thymic and extrathymic) and nonimmunologic mechanisms in this model

10 served non-coding sequence 1), essential for extrathymic but dispensable for thymic Treg-cell differe

11 ly partially overcome by the addition of the extrathymic chemoattractant S1P and was not associated w

12 the timing of development of intrathymic and extrathymic chimerism, and for clonal deletion of host-t

13 the factors controlling both intrathymic and extrathymic clonal deletion or inactivation of T cells,

14 These efforts indicate that extrathymic dendritic cells control autoimmunity by indu

15 rment resulted in a proportional increase in extrathymic-derived T cell progenitors.

16 Extrathymic development in athymic recipients generated

17 Extrathymic development of intestinal intraepithelial ly

18 This demonstrated that extrathymic development of TCR gamma delta IEL required

19 expression by enterocytes was sufficient for extrathymic development of TCR-gammadelta cells in situ

20 patches (CP) are the major anatomic site for extrathymic differentiation by precursors destined to be

21 se some CD8alphaalpha+ IEL can arise through extrathymic differentiation in CP, we investigated CCR6

22 ession by T lymphocyte precursors undergoing extrathymic differentiation in intestinal CP.

23 receptor (TCR) ligation is required for the extrathymic differentiation of forkhead box p3(+) (Foxp3

24 f systemic and tissue-specific autoimmunity, extrathymic differentiation of T(reg) cells affects comm

25 ing evolution, a CNS1-dependent mechanism of extrathymic differentiation of Treg cells emerged in pla

26 ision of butyrate was due to potentiation of extrathymic differentiation of Treg cells, as the observ

27 llowed to escape negative selection, undergo extrathymic differentiation, and find sanctuary in the i

28 induce recipient tolerance toward subsequent extrathymic donor strain islet allografts.

29 cursors of dermal Vgamma4T cells may require extrathymic environment for imprinting skin-homing prope

30 tains differentiated T cells en route to the extrathymic environment.

31 tern of promiscuous gene expression in these extrathymic epithelia is consistent with developmental r

32 ession of genes characteristic of particular extrathymic epithelial cell lineages.

33 c epithelial cells express these TRAs, as do extrathymic epithelial tissues that are not usually cons

34 We also document that extrathymic epithelial tissues that originate from phary

35 n of Vgamma2+/Vdelta7+ T cells are postnatal extrathymic events that do not require microbial antigen

36 counterparts, supporting the possibility of extrathymic expansion as well.

37 The extrathymic generation and proliferation of regulatory T

38 The molecular mechanism of the extrathymic generation of adaptive, or inducible, CD4(+)

39 isms during starch fermentation, facilitated extrathymic generation of Treg cells.

40 iesis provides a unique opportunity to study extrathymic human T lymphocyte development in an in vivo

41 cryptopatches, expressed transiently during extrathymic IEL development, and is required for homeost

42 gamma delta cells occurred, indicating that extrathymic IL-7 did not support TCR gamma delta IEL gen

43 development of TCR gamma delta IEL required extrathymic IL-7 production.

44 Extrathymic induction of regulatory T (T reg) cells is e

45 Mechanisms of extrathymic induction require further scrutiny, especial

46 up-regulating Bcl-2 expression and promoting extrathymic iNKT cell ex-pansion and their homeostatic p

47 In addition, extrathymic inoculation of donor Ag in similarly immunos

48 betic rats, indicating that extrapancreatic, extrathymic insulin production occurs in more than one s

49 led to a selective and dramatic decrease in extrathymic intestinal intraepithelial lymphocytes (IELs

50 d in the development of intrathymic, but not extrathymic, intestinal intraepithelial T lymphocytes (i

51 T cells are indifferent to Ags expressed by extrathymic islet allografts when presented in the absen

52 scure, especially since it became known that extrathymic lineage-negative, Sca-1-positive, c-kit high

53 ears that in MRL/lpr mice there is defective extrathymic lymphoid apoptosis, permitting a relatively

54 t in the thymus, but is not required for the extrathymic maturation of CD8 alpha alpha+ IEL.

55 iated by IL-7 and due to both the thymic and extrathymic mechanisms.

56 microbiota-specific CD4 T cells in a form of extrathymic negative selection.

57 entrally induced, nondeletional tolerance to extrathymic nonself Ags.

58 stinal sites, new insights into the possible extrathymic origin of mucosal T cells in the intestine,

59 f Vbeta5(-)CD4(+) T cells all point to their extrathymic origin.

60 arrow can generate functional T cells via an extrathymic pathway in athymic nu/nu mice.

61 reconstitution predominantly by means of an extrathymic pathway.

62 thymic NK1.1+ cells mature in a thymic or an extrathymic pathway.

63 CD3(+) (NK-T) cells can also develop through extrathymic pathways, we have investigated the role of C

64 SMG had T cells with characteristics of extrathymic populations, expressing TCRgammadelta(+) (28

65 es were compared with other conventional and extrathymic populations.

66 The hCD25 reporter marked intra- and extrathymic precursors of lymphocytes but not myeloid ce

67 Clonogenic assays showed that the extrathymic precursors were common lymphoid progenitors

68 he intestinal epithelial environment and the extrathymic presence of the self-Ag.

69 itively determine whether TCR revision is an extrathymic process that occurs in mature peripheral T c

70 on of antigen-specific tolerance mediated by extrathymic regulatory T (Treg) cells remains incomplete

71 also antigen-specific tolerance mediated by extrathymic regulatory T (Treg) cells, yet it remains un

72 ctin-1 signaling pathway, indicating a novel extrathymic role for AIRE and a defect that likely contr

73 The addition of extrathymic SDF-1 inhibited emigration of wild-type SP c

74 rous T cells that are specific for innocuous extrathymic self antigens.

75 gastrointestinal epithelium may be an early extrathymic site for the increased prevalence of both pr

76 tivity of the thymus, arguing in favor of an extrathymic site of gammadelta T cell production in huma

77 age-restricted progenitors were generated at extrathymic sites, both in the spleen and in peripheral

78 that immature salivary gland T cells had an extrathymic source.

79 ice, suggesting that expansion was driven by extrathymic stimuli.

80 These findings demonstrate the potential of extrathymic T cell development for T cell reconstitution

81 ally, many researchers remain skeptical that extrathymic T cell development has an important role in

82 e in mice that mesenteric LNs (MLNs) support extrathymic T cell development in euthymic and athymic r

83 he intestinal mucosa is suggested to support extrathymic T cell development, particularly for T cell

84 e human tonsil in a comprehensive program of extrathymic T cell development.

85 itive selection of gammadelta T cells and on extrathymic T cell development.

86 been viewed as evidence for the existence of extrathymic T cell generation.

87 Extrathymic T cell precursors can be detected in many ti

88 re the first strong evidence that thymic and extrathymic T cells participate in mucosal immunity to C

89 t, we assessed the ability of ICN1 to induce extrathymic T lineage commitment in BM progenitors from

90 marrow progenitors efficiently gave rise to extrathymic T lineage-committed cells, whereas common ly

91 the gut environment preferentially supports extrathymic T reg cell development.

92 lts treated for HD, an increased activity of extrathymic T-cell differentiation may partially compens

93 heral IL-7 was sufficient for development of extrathymic TCR gamma delta IEL.

94 ough TCR revision, RAG reexpression mediates extrathymic TCRbeta rearrangement and results in a popul

95 ese two model systems, we determined whether extrathymic tissue allografts could induce a development

96 maintenance of transplantation tolerance to extrathymic tissue allografts remains unclear.

97 to Ags expressed exclusively on peripheral (extrathymic) tissues is less clear.

98 T environment and indicate that Notch-driven extrathymic Tlineage commitment from multipotent progeni

99 ntigens can contribute to either peripheral (extrathymic) tolerance or the differentiation of autorea

100 Therefore CD5 instructs extrathymic Treg cell development in response to self an

101 tigens in the thymus and periphery, governed extrathymic Treg cell development.

102 lineage-committed T cell precursors linking extrathymic with intrathymic lymphopoiesis in adult mice