ライフサイエンスコーパス: extravasate

1 etween 7 and 100 nm (e.g., liposomes did not extravasate).

2 the walls through which fluid and cells can extravasate.

3 CF-7 cells are deficient in their ability to extravasate.

4 herical circulating T cells must polarize to extravasate.

5 seemed to strongly vary in their ability to extravasate.

6 Edema was estimated by measuring extravasated 125 I-labeled albumin in the various tissue

7 based contrast agent with high propensity to extravasate across a permeable capillary endothelial bar

8 locally increase vascular permeability, and extravasate across inflamed endothelium.

9 lial cells (VECs), leukocytes preferentially extravasate across junctional gaps in the endothelial mo

10 d survive the vascular system can eventually extravasate across the endothelium to metastasize at a s

11 cells contact blood vessels either when they extravasate across the walls of microvessels into inflam

12 ng the ability of circulating tumor cells to extravasate and colonize, leading to inhibition of metas

13 ould also assist the drug and/or carriers to extravasate and enter the tumor cells.

14 their way to distant organ sites where they extravasate and establish metastatic lesions.

15 ting tumor cells to distant sites where they extravasate and establish metastatic lesions.

16 lls lacking the integrin activator Kindlin-3 extravasate and induce experimental autoimmune encephalo

17 than 50% of all accumulated neutrophils were extravasated and colocalized with foci of oncotic hepato

18 (ii) liposome material in these tissues has extravasated and is found extracellularly near a variety

19 pothesis that, in addition to hyperglycemia, extravasated and oxidized LDL is an important insult to

20 nment, serum coagulation factors are readily extravasated and therefore lead to continuous TF-mediate

21 e capacity of these cells to adhere, arrest, extravasate, and survive in the murine lung over a 24-h

22 er i.v. inoculation, both variants arrested, extravasated, and proliferated in host tissues with simi

23 this issue by examining the distribution of extravasated antibodies in islet cell tumors of RIP-Tag2

24 tumour cells to survive in the circulation, extravasate at distant sites, then proliferate; it invol

25 the primary tumor and then adhere to ECs and extravasate at the metastatic site.

26 Thrombin, an important clotting factor, extravasates at sites of blood-retina barrier breakdown

27 argeted CT could depict CEB as low as 111 HU extravasating at a rate of 0.3 mL/min.

28 r perfusion with lactated Ringer's solution, extravasated bBSA was detected with immunoprecipitation

29 clodronate-ablated macrophages, neutrophils extravasate, but have limited ability to reach the perit

30 nd, as predicted by our hypothesis, ferritin extravasated by way of VVOs, just as in hyperpermeable t

31 cyte activation in the immediate vicinity of extravasating cancer cells might support their progressi

32 However, once extravasated, CD18(-/-) leukocytes transmigrated more ra

33 is allowed quantification of the dilution of extravasated CEB as a function of time that was then mod

34 The extravasated cells had a near absence of neutrophil phag

35 ted with a significant delay in apoptosis of extravasated cells.

36 study of cancer cells, neutrophils, or other extravasating cells.

37 in the diagnosis of vascular versus enteric extravasated contrast material.

38 mmunogens expressing PF3 elicited activated, extravasating CS-specific T cells that protected against

39 Extravasated dye was detected at 620 nm and was normaliz

40 inal muscularis identified the phagocytes as extravasating ED1+ monocytes.

41 The extravasated erythrocytes that surround the brain contai

42 cular and interstitial spindle-shaped cells, extravasated erythrocytes, and an inflammatory mononucle

43 had, in addition, tumor cell-lined lakes of extravasated erythrocytes.

44 y was determined by fluorescent detection of extravasated Evans blue.

45 forts to define the physiologic functions of extravasated fibrin(ogen) have led to the discovery, rep

46 city of the surrounding tissue to absorb the extravasated fluid, edema (with its associated increased

47 Plasma fibronectin (pFN) extravasates for days from intact hyperpermeable vessels

48 g, suggesting that memory cells can directly extravasate from blood into Peyer's Patches and lymph no

49 rious extracellular matrix molecules as they extravasate from blood vessels and accumulate within can

50 Mst1-/- neutrophils also failed to extravasate from gastric submucosal vessels in a murine

51 avital microscopy we showed that neutrophils extravasate from inflamed dermal venules in close proxim

52 s "shrink" to 10-nm nanoparticles after they extravasate from leaky regions of the tumor vasculature

53 Leukocytes extravasate from the blood in response to physiologic or

54 Leukocytes extravasate from the blood into inflammatory sites throu

55 by increasing the ability of tumor cells to extravasate from the blood vessels into surrounding tiss

56 ve the primary tumor and circulate, they may extravasate from the vasculature and colonize tissues to

57 in nanomedicine depends on their ability to extravasate from vasculature towards the target tissue.

58 nstrate that soluble and particulate tracers extravasate from venules by apparently different transce

59 gents, particulates circulating in the blood extravasate from venules through endothelial cell openin

60 Circulating leukocytes are thought to extravasate from venules through open interendothelial j

61 Wild-type (WT) leukocytes extravasated from limbal vessels, angiogenic stalks, and

62 enous particulates (erythrocytes, platelets) extravasated from plasma through transendothelial openin

63 Both tracers extravasated from venules in response to all three perme

64 cleic acid cargo from enzymatic degradation, extravasates from the vasculature, traverses the cell me

65 Chyle extravasates from these plexuses and enters the thoracic

66 t-TBI is decompartmentalization of iron from extravasated hemoglobin (Hb).

67 The overall area density of extravasated IgG/antibodies decreased after treatment bu

68 Long-circulating liposomes extravasate in tumors such as the rat 9L gliosarcoma and

69 mmunodetection confirmed that TTR was indeed extravasated in its monomeric form when CNS barriers wer

70 circulation, arrest in the microcirculation, extravasate into a tissue compartment, and grow.

71 nto the lymphatic system or vasculature, and extravasate into and colonize secondary sites.

72 lation, indicating an inherent propensity to extravasate into inflamed and barrier sites.

73 While classical monocytes extravasate into inflamed tissue and give rise to macrop

74 a critical role in stimulation of T cells to extravasate into inflammatory tissue.

75 Furthermore, CTLs were able to extravasate into islets in vivo, and no evidence for ind

76 when defects in angiogenesis permit blood to extravasate into many tissues.

77 w cancer cells bind to vascular surfaces and extravasate into target organs is an underappreciated, y

78 ls must dock at the bone marrow endothelium, extravasate into the bone microenvironment, and destroy

79 Since serum proteins are known to extravasate into the brain parenchyma in AD due to blood

80 after naive T cells are activated they must extravasate into the ECM to function effectively.

81 Neutrophils did not extravasate into the lungs of tryptase alpha-treated mic

82 istics in vitro and for tumorigenic cells to extravasate into the mouse lung.

83 cells from Kindlin-3-deficient mice fail to extravasate into the naive CNS.

84 ed to the endothelium of venules but did not extravasate into the tissue.

85 t 39 degrees C, nanoparticles were unable to extravasate into the tumor interstitium.

86 (at 34 degrees C), no liposomes were able to extravasate into the tumor interstitium.

87 nzymatic up-regulation, or hypoxia once they extravasate into the tumor microenvironment.

88 somes to escape from the blood stream and to extravasate into tissues that have appropriate receptors

89 reted by HIV-infected cells, causing them to extravasate into underlying tissues and ultimately contr

90 ype lymphocyte counterparts and successfully extravasated into inflamed lymph nodes.

91 usly injected into mice and followed as they extravasated into lung tissue.

92 ere complication (18 mL of contrast material extravasated into the arm, causing brachial plexopathy).

93 ere complication (75 mL of contrast material extravasated into the hand, causing compartment syndrome

94 e vessels but was not detectable on PMN that extravasated into the infected cornea.

95 About 60% of these neutrophils had extravasated into the parenchyma.

96 plex class I expression on PMN that recently extravasated into the peritoneal cavity when compared wi

97 have marginated on activated endothelium or extravasated into the tissue.

98 ally recognizes angiogenic blood vessels and extravasates into sites of injury, fused with a therapeu

99 tatic cancer cells cease proliferating after extravasating into the parenchyma of the lungs; this res

100 Diffusible molecules extravasate, intravasate, are removed from the healthy t

101 CD18(-/-) leukocytes extravasated later than WT leukocytes.

102 h refers to the ability of macromolecules to extravasate leaky tumor vessels and accumulate in the tu

103 n a higher number in angiogenic vessels, but extravasated less toward the implanted cytokine.

104 out of corneal stroma, we showed reentry of extravasated leukocytes from angiogenic vessels into new

105 on in the retinal vessels, and the number of extravasated leukocytes into the vitreous.

106 ewly developed knockin mouse, we report that extravasating leukocytes (neutrophils, monocytes, and T

107 euronal nuclei, diminished the appearance of extravasated macrophages, and diminished the loss of dop

108 e among the first brain cells encountered by extravasating melanoma cells, they may play important ro

109 Recently extravasated metastatic cancer cells use the Rif/mDia2 a

110 ngs suggest a potentially important role for extravasated, modified LDL in promoting DR by promoting

111 We previously showed that extravasated, modified LDL is implicated in pericyte los

112 Our data suggest that extravasated, modified lipoproteins may be implicated in

113 d be avoided as it may result in the flow of extravasated nanoparticles from the tumor to normal orga

114 14-fold, and the median penetration depth of extravasated nanoparticles was increased from 1.3-fold t

115 After accounting for tumor blood volume, the extravasated nanoparticles were quantified from the PET

116 Taken together, our data suggest that extravasated neutrophils acquire APC function within the

117 Although it had been assumed that extravasated neutrophils disintegrated (undergo necrosis

118 neutrophils at inflammatory sites, but that extravasated neutrophils displayed decreased surface exp

119 In addition, the presence of activated/extravasated neutrophils in intact intestines was determ

120 Because the host response of extravasated neutrophils to mycotic infections within ti

121 In addition, a substantial number of extravasated neutrophils were found in the portal tract.

122 y accelerating the programmed elimination of extravasated neutrophils.

123 ulocytes significantly reduced the number of extravasating neutrophils and improved survival in septi

124 Extravasated nonspecific immunoglobulin G (IgG) and anti

125 d intravascular tumor cells rather than from extravasated ones.

126 The ability of antibodies to extravasate out of blood vessels is critical for therape

127 trast, leukocytes expressing active MMPs and extravasating parenchymal vessels were not observed unti

128 age, catheter gauge, injection site, volume extravasated, patient symptoms, severity of injury, trea

129 d trafficking were most severe in regions of extravasated perivascular inflammatory cells.

130 several MMPs were identified in immune cells extravasating pial vessels as early as 1 day post infect

131 Immunohistochemical analyses revealed extravasated plasma components, including Abeta42 in 19

132 that interstitial flow, such as produced by extravasating plasma, directs endothelial morphogenesis

133 Secondary to epithelial abrasion, extravasated PMNs within the paralimbus developed close

134 The soluble plasma protein ferritin extravasated primarily by way of vesiculo-vacuolar organ

135 extremely high levels of vascular slits and extravasated red blood cells, making neoangiogenesis a k

136 The percent of tumor cells extravasated remained nearly constant from1 to 3 days af

137 welling), extent of the cellular infiltrate, extravasated serum albumin labeled by immunogold (for bl

138 mphatics to act as exchange vessels, able to extravasate solute and filter fluid.

139 ndings imply that activation of LFA-1 on the extravasating T cell will decrease the binding to VCAM-1

140 mammary duct) through the blood vessels and extravasating they initiate metastasis.

141 sues during development and is not simply an extravasated thrombin clearance mechanism as previously

142 In latter stages, myeloma cells extravasate through blood vessels and may seed a variety

143 h monocytes leave the circulatory system and extravasate through the endothelial lining of the blood

144 rculation time and made them small enough to extravasate through the openings of the bone's sinusoida

145 rne exposure to lipid antigen, they promptly extravasate to orchestrate the formation of peribronchio

146 ically, neutrophils in 24p3(-/-) mice do not extravasate to sites of infection and are defective for

147 irculating mononuclear phagocytes, poised to extravasate to sites of inflammation and differentiate i

148 t the ability of circulating cancer cells to extravasate to surrounding lung tissues was linked to th

149 ls or will migrate to tight junctions before extravasating to the site of injury or infection.

150 at the interface of blood and skin, ready to extravasate upon induction of inflammation, and we showe

151 rventions, which reversed the effects of the extravasated vasopressors: intraosseous phentolamine, to

152 (iii) An intravascular clot evolved when an extravasated vessel was further irradiated.

153 Extravasated volumes ranged from 3 to 150 mL.

154 nd perivascular spaces while albumin and IgG extravasates were parenchymal.

155 tically, autoreactive Kindlin-3-null T cells extravasate when the CNS is inflamed and the brain micro

156 ion in blood of brain-specific proteins that extravasate when these endothelial junctions are breache

157 phocytes bound at endothelial cell junctions extravasate within minutes.