ライフサイエンスコーパス: extravasation

1 latures permit tumour cell intravasation and extravasation.

2 in endothelial cell activation and leukocyte extravasation.

3 rometastatic effects by enhancing tumor cell extravasation.

4 on to endothelial cells and transendothelial extravasation.

5 suggesting a role for adenosine in reducing extravasation.

6 to achieve particle adhesion and subsequent extravasation.

7 th endothelial cells (ECs) followed by their extravasation.

8 he joint diminished CXCL8-induced neutrophil extravasation.

9 but had no effect on tumor cell invasion or extravasation.

10 ells can regulate permeability and leukocyte extravasation.

11 ading to their arrest on the endothelium and extravasation.

12 nisms of dissemination, including intra- and extravasation.

13 nse, be it platelet aggregation or leukocyte extravasation.

14 field of endogenous inhibitors of leukocyte extravasation.

15 because the former merely counteracts fluid extravasation.

16 elial cells to mediate vascular adhesion and extravasation.

17 min effects that are inhibitory to leukocyte extravasation.

18 by the diffusion penetration distance after extravasation.

19 but not on myeloid cells affects neutrophil extravasation.

20 hich are crucial for tumor cell survival and extravasation.

21 e vasculature to avert tumor cell intra- and extravasation.

22 aLbeta2 integrin for subsequent crawling and extravasation.

23 creased vascular permeability and neutrophil extravasation.

24 the molecular mechanism facilitating T cell extravasation.

25 ponses via enhanced leukocyte activation and extravasation.

26 within vessels, and markedly inhibited their extravasation.

27 morigenesis and tumor progression, including extravasation.

28 he LERs in the vascular BM, facilitating PMN extravasation.

29 sepsis, associated with increased neutrophil extravasation.

30 lecule-1 (VCAM-1), which regulates leukocyte extravasation.

31 ed demyelination, and impaired CD4(+) T-cell extravasation.

32 hanism to limit the rate of Ag-driven T cell extravasation.

33 e-expressed oxidase that regulates leukocyte extravasation.

34 uitment in mouse lung but delayed neutrophil extravasation.

35 ty treatments, with somewhat improved tissue extravasation.

36 adhesion molecule actively involved in cell extravasation.

37 acilitate tumor angiogenesis and cancer cell extravasation.

38 ssion of ICAM-1, intravascular crawling, and extravasation.

39 adherens junctions and a block in molecular extravasation.

40 at prevent vascular leakage during leukocyte extravasation.

41 eutic interventions aimed at blocking cancer extravasation.

42 In areas of gadolinium extravasation, (123)I-CLINDE binding parameters were not

43 mechanisms have been suggested, including Hb extravasation across the blood vessel wall, scavenging o

44 ammatory protein 2, which favored neutrophil extravasation and adhesion in liver.

45 g in endothelial processes such as leukocyte extravasation and angiogenesis.

46 entify the vascular and/or enteric origin of extravasation and assess their level of diagnostic confi

47 rounding tissues which mediates nucleic acid extravasation and cellular uptake.

48 ty in neutrophils, thereby controlling their extravasation and chemotaxis.

49 tory response, cell proliferation, leukocyte extravasation and cholesterol biosynthesis.

50 ation of beta1 integrins promotes tumor cell extravasation and colonization, suggesting diagnostic an

51 ngiogenesis in these organs, allowing tumour extravasation and colonization.

52 robubble oscillations, for enhanced OV tumor extravasation and delivery has not been previously repor

53 mputational modeling evaluates drug vascular extravasation and diffusive transport as key RF-modulate

54 uced cavitation at 0.5 MHz could improve the extravasation and distribution of a potent breast cancer

55 in the metastatic process, platelets promote extravasation and establishment of metastatic cells in d

56 oro-Jade C staining, brain edema, Evans blue extravasation and fluorescence, western blot, RhoA activ

57 of the TRCs at the secondary sites show that extravasation and formation of micrometastases by TRCs a

58 ant beta1 integrins revealed that tumor cell extravasation and hepatic colonization required extracel

59 Selectins are involved in extravasation and homing of leukocytes to target organs.

60 , a process that is important for lymphocyte extravasation and homing.

61 rnalization was suggested, based on the fast extravasation and internalization rates of copolymer uni

62 A new mechanism of micelle extravasation and internalization was suggested, based o

63 activity of iRGD in inducing macromolecular extravasation and leads to greater drug accumulation in

64 ty and adherens junctions disassembly during extravasation and may aid in identification of therapeut

65 hibition prevented VEGF-dependent tumor cell extravasation and melanoma dermal to lung metastasis wit

66 IL-35 has critical roles in PDAC cell extravasation and metastasis by facilitating the adhesio

67 th or anoikis in vitro, and it also impaired extravasation and metastasis formation in vivo.

68 rin on endothelial cells to mediate vascular extravasation and metastasis in zebrafish and murine xen

69 Xenograft models showed that the lung extravasation and metastasis of FOXC1-overexpressing TNB

70 FMN2 in mouse melanoma cells inhibits their extravasation and metastasis to the lung.

71 eta/Smad pathway that promotes lung ADC cell extravasation and metastasis.

72 Metastatic progression, including extravasation and micrometastatic outgrowth, is the main

73 was associated with significantly increased extravasation and overall adverse event rates for iopami

74 s associated with a significant reduction in extravasation and overall adverse event rates for the mo

75 lly significant role of NRP-2 in cancer cell extravasation and promotion of metastasis.

76 re detailed understanding for the continuing extravasation and recruitment of Th1 lymphocytes into si

77 djacent stroma, intravasation and ultimately extravasation and seeding.

78 icular, we study the effect of IFP on oxygen extravasation and show that small blood/lymphatic vessel

79 , including genes involved in immune escape, extravasation and small GTPase signal transduction.

80 oduction to inhibit late-stage melanoma cell extravasation and subsequent metastasis development.

81 cellular processes involved in driving fluid extravasation and the severe anaphylactic phenotype are

82 tion of monocytes that facilitate tumor cell extravasation and thereby metastasis.

83 We report a case of vasopressor extravasation and threatened limb perfusion related to i

84 in the processes of micelle and nanodroplet extravasation and tissue accumulation was possible.

85 eal an unexpected role for CtsB in leukocyte extravasation and transmigration, which advances our und

86 Intravital imaging of nanoparticle extravasation and tumor accumulation has revealed, for t

87 The extravasation and tumor cell internalization occurred mu

88 term high-fat-diet feeding decrease molecule extravasation and uptake rates in vivo in islets, indepe

89 rule out a role for NO in bradykinin-induced extravasation and/or angioedema.

90 ocytes and perivascular edema, 4) Evans blue extravasation, and 5) appearance of parenchymal astrogli

91 Similarly, leukocyte adhesion, extravasation, and bacterial clearance were diminished.

92 processes, which include rolling, adhesion, extravasation, and chemotaxis.

93 , interactions with components of the blood, extravasation, and colonization of distant organs.

94 ic tumor vaccine model, inhibited neutrophil extravasation, and delayed the outgrowth of tumor xenogr

95 nt adhesion to endothelial cells, supporting extravasation, and directing specific intratissue locali

96 Evans blue (bound to macromolecule albumin) extravasation, and hematoxylin-eosin staining helped det

97 induced strong leukocyte adhesion, enhanced extravasation, and interrupted blood flow, whereas pCS c

98 se effect of diabetes on SCI, reduced EB dye extravasation, and limited the loss of endothelial cells

99 s that enable efficient tumor cell survival, extravasation, and metastasis.

100 lymphocytes and neutrophils, red blood cell extravasation, and plumping endothelium were the main hi

101 that includes local invasion, intravasation, extravasation, and proliferation at distant sites.

102 he premetastatic niche, intravasation and/or extravasation, and resistance to apoptosis.

103 and histamine-induced VE dysfunction, fluid extravasation, and the severity of anaphylaxis through a

104 the most critical events for limiting plasma extravasation are the stable accumulation of platelets,

105 ocesses, which are fundamental to tumor cell extravasation, are driven by DOCK4-mediated Rac1 activat

106 racterized by marked neutrophil adhesion and extravasation as visualized by intravital microscopy.

107 We include fluid/oxygen extravasation as well as a continuous lymphatic field, a

108 Contrary to most in vivo and in vitro extravasation assays, robust and rapid scoring of extrav

109 Neutrophil recruitment and extravasation at sites of inflammation provide a mechani

110 eterogeneous, and in vitro analysis of their extravasation behavior is often impeded by the inability

111 EGF-A exposure of muscle increased leukocyte extravasation but not the levels of SDF-1alpha.

112 myosin, or alpha-actinin, regulate leukocyte extravasation by controlling actin dynamics, biomechanic

113 demonstrates that pericytes can regulate PMN extravasation by controlling the size of pericyte gaps a

114 f tumor cells and also to observe tumor cell extravasation by having a suitable tumor seeding density

115 a sequence of steps, including circulation, extravasation by the enhanced permeability and retention

116 to mediate leukocyte rolling, adhesion, and extravasation by up-regulation of leukocyte adhesion mol

117 The leukocyte extravasation cascade is a complex multistep process tha

118 elongation is a final step in the leukocyte extravasation cascade, which may be important for precis

119 Ab before i.v. injection into mice inhibited extravasation/colonization of circulating tumor cells an

120 sion of LZTFL1 in lung tumor cells inhibited extravasation/colonization of circulating tumor cells to

121 Following vascular arrest and extravasation, CTLs adopted a random motility pattern th

122 conventional multistep paradigm of leukocyte extravasation depends on CD18 integrin-mediated events s

123 al fluorescent microscopy, the extent of the extravasation, diffusion in the tissue, internalization

124 are critical prerequisites for efficient PMN extravasation during inflammation.

125 t MST1 is a critical regulator of neutrophil extravasation during inflammation.

126 C-A/cGMP signaling and facilitate neutrophil extravasation during the early phase after MI.

127 deformability is a key factor in controlling extravasation dynamics during metastasis.

128 (SCID-bg) mice, should be attributed to the extravasation effect, leading to the lipoproteinated NC

129 Furthermore, neutrophil extravasation elicited by CCL3 was almost completely abo

130 d, after which the tumor can be perfused and extravasation events are easily tracked over 72 h via st

131 ation between separate doses implies dynamic extravasation events on the scale of microns.

132 capability for live tracking of single-cell extravasation events, allowing both tumor and endothelia

133 er breakdown characterized by plasma protein extravasation following fibrinogen and IgG immunohistoch

134 n a breast cancer xenograft model as well as extravasation following injection of carcinoma cells int

135 cruitment of neutrophils to the heart, their extravasation from coronary veins, and infiltration of t

136 analysis of mutant mouse eyes showed protein extravasation from dilated vessels into the anterior cha

137 etal blood neutrophil rolling, adhesion, and extravasation from inflamed yolk sac vessels is apparent

138 bone marrow but a central role in eosinophil extravasation from the blood into the lungs.

139 regulated by "inside-out" signals leading to extravasation from the circulation into tissues.

140 Extravasation from the proximal sites of both of the cav

141 atic seeding, including: tumor cell arrival; extravasation; growth and progression to micrometastases

142 of receptor-ligand interactions to leukocyte extravasation has been studied extensively, the contribu

143 Although the mechanisms of extravasation have been vastly studied in vitro and in v

144 Mechanisms controlling PMN extravasation have been well characterized, but the mole

145 th and metastasis, but its specific roles in extravasation have not yet been clearly elucidated.

146 cells is involved with regulating tumor cell extravasation, homing, disease progression, and drug res

147 cruitment and we show a failure of leukocyte extravasation in a peritonitis model.

148 nted neutrophil adherence to endothelium and extravasation in heart grafts.

149 nce of Coro1A impairs leukocyte adhesion and extravasation in inflamed cremaster muscle venules in co

150 s), specialized blood vessels for lymphocyte extravasation in lymphoid organs.

151 severely compromised leukocyte adhesion and extravasation in MK(-/-) mice compared with MK(+/+) anim

152 t a role for MST1 in vesicle trafficking and extravasation in neutrophils, providing an additional me

153 m1 to 3 days after tumor seeding, indicating extravasation in our system generally occurs within the

154 ural hemorrhage characterized by erythrocyte extravasation in outer lamellar layers of the media.

155 d as increased leukocyte adhesion and plasma extravasation in response to oxidative stress inducers P

156 with Cy5-Fab-PAS200 confirmed better tracer extravasation in the Granta-519 tumors.

157 im KO mice have markedly decreased bacterial extravasation in the setting of DSS-induced acute coliti

158 y 1 (ABL1)-mediated VE dysfunction and fluid extravasation in the severity of IgE-mediated anaphylact

159 mors shared the similar systemic PK, but DOX extravasation in the tumor extravascular tissue was subs

160 ma cell-induced gap formation, melanoma cell extravasation in vitro and subsequent lung metastasis de

161 cient to induce EMT, stimulate migration and extravasation in vitro.

162 bly, transendothelial migration in vitro and extravasation in vivo impaired by singly alternating miR

163 n in vitro and metastasis via attenuation of extravasation in vivo.

164 f endothelial cell contacts during leukocyte extravasation in vivo.

165 ortant in regulating leukocyte migration and extravasation, including the CXCR1/2 ligand, KC.

166 rall accuracy of identification of source of extravasation increased from 78% with conventional CT to

167 lyze organ-specific human breast cancer cell extravasation into bone- and muscle-mimicking microenvir

168 ood brain barrier (BBB) and dampen leukocyte extravasation into CNS during AHI.

169 erivascular basement membrane for successful extravasation into inflamed tissue, but this process is

170 s after inflammatory stimulation, neutrophil extravasation into lung, peritoneum, and skin wounds was

171 adhesion to endothelial cells and lymphocyte extravasation into neoplastic tissues, limiting the ther

172 ir arrest at the endothelium, supporting CTC extravasation into secondary sites.

173 DTC extravasation into the bone marrow may be encouraged by

174 stically, Src activation promoted tumor cell extravasation into the brain parenchyma via permeabiliza

175 sing peripheral inflammatory cells and their extravasation into the brain.

176 Hydroxyurea treatment decreased neutrophil extravasation into the infected lung coincident with sig

177 bility sufficient to cause protein and fluid extravasation into the interstitium to reduce the vascul

178 om the skin via dermal lymphatic vessels and extravasation into the LN parenchyma from lymph in the s

179 over, Ccl5-triggered neutrophil and monocyte extravasation into the peritoneal cavity was severely re

180 sed net fluid production via enhanced plasma extravasation into the pleural space.

181 ites of infection or inflammation and enable extravasation into tissues.

182 cells within capillaries, resulting in their extravasation into tissues.

183 mor cells (CTC) and endothelial cells during extravasation is a critical process during metastatic co

184 Tumor cell extravasation is a critical step in the metastatic casca

185 Tumor cell extravasation is a multistep process preceded by cell ro

186 Extravasation is observed for 38.8% of the tumor cells i

187 ed in inflammation and at sites of leukocyte extravasation, its role in leukocyte trafficking is unkn

188 ole of the tumor extravascular tissue in the extravasation kinetics of doxorubicin (DOX), delivered b

189 The extravasation kinetics were different for nanodroplets a

190 a several targeting mechanisms, particularly extravasation (leakage into tumour).

191 Zebrafish imaging demonstrates that after extravasation, melanoma cells become pigmented and enact

192 ely, our findings in this novel model of the extravasation microenvironment revealed a critical requi

193 No blood extravasation occurred.

194 Neutrophil extravasation occurs across postcapillary venules, struc

195 tLyP-1 furthermore improves extravasation of a co-injected nanoparticle into the tum

196 tion of alpha4beta1 is sufficient to prevent extravasation of activated T cells and is successfully u

197 hered to CD44 on CNS ECs is critical for the extravasation of activated T cells into the CNS providin

198 R3 in stabilizing intravascular adhesion and extravasation of adoptively transferred CD8(+) effectors

199 a physical barrier that may hinder vascular extravasation of agents through transvascular fluid flux

200 and decreased vascular leak, as measured by extravasation of an I-labeled intravascular tracer.

201 ure, loss of vascular integrity resulting in extravasation of blood cells, stromal inflammation, and

202 ensin II-infused rats, minocycline prevented extravasation of BM-derived cells to the hypothalamic pa

203 cells after injection into the yolk sac and extravasation of cancer cells into tissues from the vasc

204 nd extracellular matrix invasion, as well as extravasation of cancer cells into tissues in zebrafish

205 44 mimics CNL-induced anoikis and diminished extravasation of cancer cells.

206 s play an essential part in the adhesion and extravasation of circulating leukocytes into inflamed ti

207 transport pathway and facilitating the local extravasation of circulating substances.

208 permeability, leading to a locally enhanced extravasation of components from the vascular compartmen

209 Notably, simple fluid without extravasation of contrast medium also correlated with ir

210 Of the remaining 30 patients, 17 had extravasation of contrast medium into the peritoneal cav

211 Presacral and free extravasation of contrast medium led to an increased nee

212 ee or simple pelvic fluid collection without extravasation of contrast medium, and 3 patients had an

213 an abscess near the anastomotic site without extravasation of contrast medium.

214 r phenotype, collagen content determined the extravasation of DOX-PLD to different tumor phenotypes.

215 The extravasation of Evan's Blue was observed in all tumors,

216 observed that diabetic rats showed increased extravasation of Evans Blue (EB) dye, and loss of endoth

217 nd structurally evaluated by determining the extravasation of Evans Blue and horseradish peroxidase t

218 nces in microvascular leakage (determined by extravasation of Evans Blue Dye) and in renal relative b

219 Increased extravasation of Evans Blue into the brain tissue of the

220 (TUNEL+ / NeuN+ cells) and BBB permeability (extravasation of Evans blue) at D1.

221 ed VEGF-induced permeability, as measured by extravasation of Evans blue, dextran, and microspheres i

222 which likely contributes to hypoxia-induced extravasation of fluid and leukocytes.

223 te-phase responses to histamine with reduced extravasation of fluid, SK-1 activity, proinflammatory c

224 application of SLC1 drastically reduced the extravasation of inflammatory cells.

225 eased vascular permeability, with subsequent extravasation of intravascular fluid into the surroundin

226 BBB damage was assessed by extravasation of intravascular fluorescein isothiocyanat

227 ukocyte migration but also can propagate the extravasation of leukocytes from the vascular space.

228 The extravasation of lymphocytes across central nervous syst

229 n binding, rolling, integrin activation, and extravasation of mature neutrophils, but only the combin

230 t junctions (TJ) between them, regulates the extravasation of molecules and cells into and out of the

231 The extravasation of monocytes across the brain endothelium

232 tochastic eruptions may explain the enhanced extravasation of nanoparticles from the tumour blood ves

233 r uptake and intratumoral distribution after extravasation of nanoparticles from tumor vessels into t

234 leukocytes and endothelial cells, leading to extravasation of neutrophils and monocytes.

235 or GDF-15 gene-deficient mice, we found that extravasation of neutrophils deficient for ALK-5 or TGF-

236 l and orchestrate the subsequent arrival and extravasation of neutrophils through the production of p

237 DC depletion did not influence extravasation of NK cells, inflammatory monocytes, or ne

238 n electron microscopy on brain tissue showed extravasation of plasma cells, neuronal degeneration and

239 of these findings demonstrated an attenuated extravasation of polymorphonuclear neutrophil granulocyt

240 jury to the alveolar capillary barrier, with extravasation of protein-rich edema fluid into the airsp

241 -eosin staining helped detect only scattered extravasation of red blood cells.

242 to drug delivery by only allowing selective extravasation of solutes and small molecules.

243 the sub-nanometre regime also slows down the extravasation of sub-nanometre AuNCs from normal blood v

244 In mice, loss of miR-155 reduced CNS extravasation of systemic tracers, both in EAE and in an

245 ack on the valve endothelium with subsequent extravasation of T cells through activated endothelium i

246 Extravasation of the contrast agent was defined as anast

247 The transfer coefficient Ktrans describing extravasation of the MRI contrast agent Gd-DTPA was sign

248 Remarkably, efficient extravasation of TRCs in vivo and transmigration in vitr

249 uction and aiding endothelial attachment and extravasation of tumor cells with platelet P-selectin be

250 We also show extravasation of tumour cells and the close association

251 Vascular permeability measured by Evans blue extravasation on days 1, 3, and 7 correlated with the T1

252 identified at CT angiography included active extravasation (ongoing hemorrhage) or hyperattenuating i

253 st that, although CD18 facilitates efficient extravasation, outside of the vessel CD18 interaction wi

254 en content may offer a biophysical marker of extravasation potential of liposomal drug formulations.

255 cell proliferation, migration, intravasation/extravasation potential, favors cell death, and suppress

256 s, and decreased migration and intravasation/extravasation potential, with a corresponding drastic su

257 ls have been reported thus far regarding the extravasation process or re-entry of circulating tumor c

258 of mature TAMs due to impaired recruitment, extravasation, proliferation, and maturation of their Ly

259 ent (interleukin-8 pathway, P = 1.41E-5) and extravasation proteins (P = 5.62E-4) were elevated durin

260 al requirement for beta1 in several steps of extravasation, providing new insights into the mechanism

261 Extravasation rates and microvasculature permeabilities

262 ll A3 adenosine receptors resulted in higher extravasation rates of cancer cells into the myoblast-co

263 erall adverse event rates for iopamidol 370 (extravasation rates: 0.27% [five of 1851] vs 0.87% [18 o

264 300 were not affected by extrinsic warming (extravasation rates: 0.30% [32 of 10,831] in period 1 vs

265 cess are relatively efficient, with the post-extravasation regulation of tumour growth ('colonization

266 Polymorphonuclear neutrophil (PMN) extravasation requires selectin-mediated tethering, inte

267 electron microscopy (EM) and Evans blue (EB) extravasation, respectively.

268 asthma, presumably due to greater eosinophil extravasation, specifically of activated or pre-activate

269 that they express molecular effectors of BM extravasation, such as the chemokine receptor CXCR4 and

270 rain-injured animals worsened Evans Blue dye extravasation, suggesting that systemic inflammation con

271 lex steps including transit, initial arrest, extravasation, survival and proliferation.

272 he premetastatic site and promote tumor cell extravasation, survival, and persistent growth.

273 ture to recapitulate the environment wherein extravasation takes place and assess the consequences of

274 RA-exposed mice increased TC1 migration and extravasation, TAMs from IH-exposed mice markedly enhanc

275 tissue is characterized by more intense drug extravasation than in contralateral mammary fat pad tiss

276 is a key evolutionary force driving parasite extravasation that could further result in tissue invasi

277 Our findings provide insights on how albumin extravasation that occurs upon BBB dysfunction in variou

278 We report an event of vasopressor extravasation that was potentially limb threatening.

279 dothelial barrier is critical for tumor cell extravasation through blood vessel walls and is mediated

280 aled that Nef potently impaired T-lymphocyte extravasation through high endothelial venules and reduc

281 bloodstream, arrest within capillaries, and extravasation to invade distant tissues.

282 In a separate step in leukocyte extravasation, transendothelial migration is regulated b

283 creases anoikis while preventing cancer cell extravasation under both static and physiological fluid

284 Contribution of liposomal extravasation was negligible in the case of TSL-i, but w

285 Histamine-induced extravasation was not affected by TSAd deficiency.

286 astomotic insufficiency was suspected but no extravasation was present, a computed tomography (CT) sc

287 Conversely, cell migration and extravasation was reduced in miR-214-overexpressing cell

288 The case of vasopressor extravasation was successfully treated with pharmacologi

289 s of rhodamine-6G-labeled leukocyte adhesion/extravasation, was used.

290 Using sodium fluorescein extravasation, we found that CD2AP(-/-) mice had reduced

291 tive T-lymphocyte clustering, and fibrinogen extravasation were demonstrated in the core of FCD-II le

292 s factor alpha (TNF-alpha), PMN adhesion and extravasation were severely compromised in HPK1-deficien

293 itro as well as increased BM trafficking and extravasation when transplanted into mice.

294 ed a microfluidic system to mimic tumor cell extravasation where cancer cells can transmigrate across

295 igration, indicating that the final steps of extravasation, where actin polymerization plays an impor

296 serine proteases are critical for neutrophil extravasation, whereas these enzymes are dispensable for

297 by pulmonary venous vasodilatation and fluid extravasation, which are thought to lead to the life-thr

298 is an essential endothelial Ag for leukocyte extravasation, which does not require homophilic interac

299 ze of the Hb:haptoglobin complex prevents Hb extravasation, which uncouples NO/Hb interaction and vas

300 treated tumors have detected red blood cell extravasation within tumors treated with temperature-sen