ライフサイエンスコーパス: extravascular

1 sensitivity, and imaging space (vascular and extravascular).

2 blood vessel and significantly increases its extravascular accumulation.

3 ionine gamma-lyase, activated caspase-3, and extravascular albumin), and immunoblotting (nuclear fact

4 =.003), backflow compartmental rate constant extravascular and extracellular to plasma (Kep) (-15% re

5 Currently, we compared the abilities of extravascular and intravascular cells to support fibrin

6 ional databases of ECs toward uncovering the extravascular and intrinsic signals that define EC heter

7 developed with a goal of inhibiting both the extravascular and the intravascular hemolysis of PNH.

8 e in regulating the biology of TF-expressing extravascular and vessel wall cells that are exposed to

9 therapeutic strategies aimed at controlling extravascular as well as intravascular hemolysis are als

10 mages the uptake of inhaled xenon gas to the extravascular brain tissue compartment across the intact

11 ession illness is caused by intravascular or extravascular bubbles that are formed as a result of red

12 ration either from the adventitia or from an extravascular, but nonhematopoietic source.

13 fragments were intravascular or immediately extravascular by using primarily endobronchial forceps f

14 Extravascular cells (fibroblasts, smooth muscle) support

15 This renders extravascular cells clearly distinct and allows tumor ce

16 Once TF on epithelial and other extravascular cells is exposed to plasma, sequential act

17 s acquire IgE and reveal a strategy by which extravascular cells monitor blood contents to capture mo

18 ty, and instead have supported the idea that extravascular cells sense O2 .

19 vasation assays, robust and rapid scoring of extravascular cells, combined with high-resolution imagi

20 actors, effects of various intravascular and extravascular cells, hydrodynamic flow, and some functio

21 ells throughout the vascular bundle and into extravascular cells, revealing a radial movement of jasm

22 of integrin alpha6beta1-dependent neutrophil extravascular chemotactic function in vivo, effective th

23 odulating the size and density of intra- and extravascular clots and thrombi.

24 ravascular proliferation, extravasation, and extravascular colony formation.

25 ith staining for fibrin(ogen) present in the extravascular compartment of tumors, but not in other ti

26 s in vivo to target the tumor vasculature or extravascular compartment with high specificity.

27 150 IU/kg, where they appear to saturate an extravascular compartment, because there is no additiona

28 40 to 50 IU/kg will, because of FIX's large extravascular compartment, efficiently prolong prophylac

29 s from the capillary lumen to the peripheral extravascular compartment, in the absence of vascular di

30 y effect of complement may be present in the extravascular compartment, in which many malignant lymph

31 ill require understanding its biology in the extravascular compartment, within the interstitium and l

32 at unbound Hb is oxidatively modified within extravascular compartments consistent with our in vitro

33 ype 1 (HIV-1) can replicate independently in extravascular compartments such as the central nervous s

34 As infected prMCs mature within extravascular compartments, they become both latently in

35 cal indices of coronary resistance (HMR) and extravascular compression (pressure at zero flow) obtain

36 Increased extravascular compression and reduced diastolic perfusio

37 repair inevitably initiates within or around extravascular deposits of a fibrin-rich matrix.

38 ated that alpha6beta1 integrins orchestrated extravascular directionality but not the speed of neutro

39 es neutrophil transendothelial migration and extravascular directionality without affecting the speed

40 e that the barrier layer effectively impedes extravascular drug loss.

41 During intrabronchial or intraperitoneal (extravascular) E. coli challenge, the pattern of effecti

42 erythropoiesis, with specific injury to the extravascular erythron, expansion and maturation of EPO-

43 ate between blood and tissue (K(trans)), and extravascular extracellular fractional volume values for

44 ADC (P = .021) and fractional volume of the extravascular extracellular space (v(e)) (P = .025) of o

45 : transfer constant (K(trans)) and volume of extravascular extracellular space per unit volume of tis

46 presents transfer of contrast agent from the extravascular extracellular space to the blood plasma),

47 nt (K(trans)), reflux rate (Kep), fractional extravascular extracellular space volume (Ve), fractiona

48 trast agent from the arterial blood into the extravascular extracellular space), K(ep) (the rate cons

49 y-surface area product, extraction fraction, extravascular extracellular volume (v(e)), and volume tr

50 e constant (P = .003), 15.0% in the backflow extravascular- extracellular rate constant (P = .0007) a

51 lular rate constant (P = .0007) and 14.3% in extravascular-extracellular volume fraction (P = .002) w

52 = 2), idiopathic T-cell lymphopenia (n = 2), extravascular extravasation of lymphocytes (n = 3), and

53 Extravascular factor activity and joint-directed gene tr

54 a novel fibrin endocytic pathway engaged in extravascular fibrin clearance and shows that interstiti

55 revealing a novel intracellular pathway for extravascular fibrin degradation.

56 Extravascular fibrin deposition accompanies many human d

57 tissue becomes permeable to blood proteins, extravascular fibrin deposition correlates with sites of

58 ion of the blood clotting system, leading to extravascular fibrin deposition to limit the spread of i

59 work, immunohistochemical studies identified extravascular fibrin deposits within white adipose tissu

60 el and unexpected mechanism for clearance of extravascular fibrin that is accomplished by a specific

61 eness may be associated with accumulation of extravascular fibrin, plasma exudates, and inflammatory

62 al interventions to modify intravascular and extravascular fibrinogenesis, neutrophil activation and

63 A robust pool of extravascular FIX is clearly observed surrounding blood

64 There is also credible evidence of extravascular FIX.

65 days postinfusion, presumably because of the extravascular FIX.

66 If diuresis occurs at a rate greater than extravascular fluid can refill the intravascular space,

67 n has renal effects that could contribute to extravascular fluid collection characterizing anthrax in

68 n this early would not indicate euvolemia if extravascular fluid has not yet equilibrated.

69 of nanoparticles from tumor vessels into the extravascular fluid space.

70 867), but there was greater expansion of the extravascular fluid volume after saline (P = 0.029).

71 Changes in body water, blood volume, and extravascular fluid volume were calculated.

72 ays of least resistance for the transport of extravascular fluid, as well as tumor cells.

73 malignant ascites was used as surrogates for extravascular fluid, suggesting the inhibitory effect of

74 Because extravascular fragments are not readily accessible for r

75 All extravascular fragments except one were retained.

76 afts and selectively disseminated throughout extravascular glioma parenchyma, causing reduced tumor b

77 Extravascular granulomatous inflammation may be initiate

78 c stem cells through the blood, entering the extravascular hematopoietic cords, lodging in the proper

79 Extravascular hemolysis after transfusion progressively

80 e, we provide experimental evidence for such extravascular hemolysis and demonstrate that PNH erythro

81 nt on the surface of red cells, resulting in extravascular hemolysis by the reticuloendothelial syste

82 NH treatment in which both intravascular and extravascular hemolysis can be inhibited while preservin

83 deposition of complement opsonins that drive extravascular hemolysis in the liver.

84 y prevent both intravascular and C3-mediated extravascular hemolysis of PNH erythrocytes and warrants

85 e disease appears to be more associated with extravascular hemolysis than with intravascular hemolysi

86 uding disruption in iron handling, increased extravascular hemolysis, and the formation of circulatin

87 cells to healthy human volunteers increased extravascular hemolysis, saturated serum transferrin, an

88 y observed in iron parameters and markers of extravascular hemolysis.

89 to be susceptible to AP complement-mediated extravascular hemolysis.

90 RBC destruction in these patients occurs via extravascular hemolysis.

91 s, possibly leading to clinically meaningful extravascular hemolysis.

92 for intravascular infection and downward for extravascular infection.

93 ir emigration from the circulation toward an extravascular inflammatory insult.

94 y has demonstrated the application of MEs as extravascular injectable drug delivery systems for susta

95 e through in-situ phase transition following extravascular injection.

96 date, published research has used presession extravascular injections to examine nicotine as a contex

97 These results suggest a novel, critical extravascular iNKT cell immune surveillance in joints th

98 e joint tissue was met by a lethal attack by extravascular iNKT cells through a granzyme-dependent pa

99 Increases in cortical tissue damage, extravascular iron and glial activation assessed by hist

100 129X1Sv/J mice was accompanied by increased extravascular laminin in the lesion core and a reduced e

101 Extravascular leak in nonspecific organs appears to be a

102 s despite their respective intravascular and extravascular locations.

103 s in the disease course in intravascular and extravascular locations.

104 y in the disease-course in intravascular and extravascular locations.

105 these enzymes are dispensable for neutrophil extravascular locomotion.

106 tep 2-bypass pathway' of cell migration, and extravascular lodgment, in absence of chemokine receptor

107 atio were lower in patients with a change in extravascular lung water >/= 10% than in patients with a

108 A change in extravascular lung water >/= 10% was predicted by baseli

109 Predictive values for change in extravascular lung water >/= 10% were evaluated.

110 lly contributed to prediction of a change in extravascular lung water >/= 10%, independent of the pre

111 ung water <10% and patients with a change in extravascular lung water >/= 10%.

112 e compared between patients with a change in extravascular lung water <10% and patients with a change

113 er >/= 10% than in patients with a change in extravascular lung water <10%.

114 ding upper limits for fluid resuscitation of extravascular lung water (<10 mL/kg) and global end-dias

115 erval, 0.65-0.94) was larger than for actual extravascular lung water (0.72; confidence interval, 0.5

116 hough the area under the curve for predicted extravascular lung water (0.8; confidence interval, 0.65

117 l showed a pattern consistent with increased extravascular lung water (diffuse, bilateral, symmetrica

118 nd we quantified lung injury in terms of the extravascular lung water (EVLW) content, filtration coef

119 Measurements of extravascular lung water (EVLW) correlate to the degree

120 hypothesized that it could be improved using extravascular lung water (EVLWi) and plasma biomarkers o

121 ve analysis indicated that EVLWp, Vd/Vt, and extravascular lung water (p = .0005, .009, and .013, res

122 for lung edema and has been shown to reduce extravascular lung water and improve lung function in mo

123 Recruitment maneuvers reduced extravascular lung water and lung endothelial injury as

124 Extravascular lung water and other markers of lung injur

125 drome, to determine the relationship between extravascular lung water and other markers of lung injur

126 respiratory distress syndrome (ARDS) reduced extravascular lung water and plateau airway pressure.

127 iple logistic regression analysis, predicted extravascular lung water but not actual extravascular lu

128 The change in extravascular lung water correlated to baseline cardiac

129 predicted or actual body weight for indexing extravascular lung water does not lead to independence o

130 o abrogate significantly the accumulation of extravascular lung water evoked by 6-hour exposure to en

131 ody weight, improves the predictive value of extravascular lung water for survival and correlation wi

132 Traditionally, extravascular lung water has been indexed to actual body

133 Extravascular lung water increase during fluid loading i

134 Extravascular lung water increased in 17 of 22 liberally

135 Extravascular lung water increased to only 180 +/- 30 mi

136 Extravascular lung water increased with positive periope

137 was 70% in patients with a maximum value of extravascular lung water index >21 mL/kg and 43% in the

138 A maximum value of extravascular lung water index >21 mL/kg predicted day-2

139 distress syndrome episode (maximum value of extravascular lung water index and maximum value of pulm

140 ght, p < 0.001 [t-test] for maximum value of extravascular lung water index and median [interquartile

141 rome might be associated with an increase in extravascular lung water index and pulmonary vascular pe

142 The maximum values of extravascular lung water index and pulmonary vascular pe

143 Extravascular lung water index and pulmonary vascular pe

144 Extravascular lung water index and pulmonary vascular pe

145 We tested whether extravascular lung water index and pulmonary vascular pe

146 There was no difference in extravascular lung water index between those who progres

147 An extravascular lung water index cutoff value on day 1 of

148 Extravascular lung water index had a moderate sensitivit

149 Elevated extravascular lung water index is a feature of early acu

150 The mean extravascular lung water index on day 1 for patients who

151 In multivariate analyses, maximum value of extravascular lung water index or maximum value of pulmo

152 Furthermore, extravascular lung water index predicts progression to a

153 Extravascular lung water index, dead space fraction, PaO

154 We tested whether the changes in extravascular lung water indexed for ideal body weight c

155 An increase in extravascular lung water indexed for ideal body weight g

156 During spontaneous breathing trial, extravascular lung water indexed for ideal body weight i

157 ded pulmonary artery occlusion pressure, the extravascular lung water indexed for ideal body weight,

158 taneous breathing trial-induced increases in extravascular lung water indexed for ideal body weight,

159 nary edema were 0.89 (95% CI, 0.78-0.99) for extravascular lung water indexed for ideal body weight,

160 Associations between extravascular lung water indexed to predicted body weigh

161 50 eligible patients, 132 patients (88%) had extravascular lung water indexed to predicted body weigh

162 Peak values for extravascular lung water indexed to predicted body weigh

163 Extravascular lung water indexed to predicted body weigh

164 Perioperative extravascular lung water indexed to predicted body weigh

165 We assessed the accuracy of peak extravascular lung water indexed to predicted body weigh

166 Extravascular lung water indexed to predicted body weigh

167 Extravascular lung water indexed to predicted body weigh

168 Extravascular lung water indexed to predicted body weigh

169 We aimed to evaluate whether extravascular lung water indexed to predicted body weigh

170 Early measurement of predicted extravascular lung water is a better predictor than actu

171 Increased extravascular lung water is a feature of early acute res

172 Extravascular lung water is a quantitative marker of the

173 Increasing extravascular lung water is further reflected by a decre

174 It is largely unknown why extravascular lung water may increase during fluid loadi

175 Extravascular lung water may prove valuable for diagnosi

176 Here, we tested the prognostic value of extravascular lung water measured by a simple, well vali

177 We explored extravascular lung water measured by single-indicator tr

178 The primary endpoint was extravascular lung water measured by thermodilution (PiC

179 Extravascular lung water measurement may be valuable for

180 Accurate extravascular lung water measurements were obtained afte

181 to predicted body weight, females had a mean extravascular lung water of 9.1 (SD=3.1, range: 5-23) mL

182 To determine whether extravascular lung water predicts survival in patients w

183 o detect small short-term changes of indexed extravascular lung water secondary to bronchoalveolar la

184 iately after bronchoalveolar lavage, indexed extravascular lung water significantly increased from 12

185 Our data suggest that indexing extravascular lung water to height is superior to weight

186 lung water is a better predictor than actual extravascular lung water to identify patients at risk fo

187 Indexing extravascular lung water to predicted body weight, inste

188 A baseline predicted extravascular lung water value of 16 mL/kg predicted int

189 Extravascular lung water values were significantly highe

190 ribe and assess the clinical significance of extravascular lung water variations after pulmonary enda

191 cted extravascular lung water but not actual extravascular lung water was a predictor of mortality wi

192 Extravascular lung water was indexed to predicted body w

193 Extravascular lung water was measured using the PiCCO sy

194 bronchoalveolar lavage, the value of indexed extravascular lung water was significantly different fro

195 s of lung injury, and to examine if indexing extravascular lung water with predicted body weight (EVL

196 lial and epithelial permeability to protein, extravascular lung water, and airway tone.

197 , PaO2/Fio2 ratio, oxygenation index, actual extravascular lung water, and predicted extravascular lu

198 lowing endotoxin-induced lung injury reduced extravascular lung water, improved lung endothelial barr

199 ting a 169 +/- 166 mL increase in nonindexed extravascular lung water.

200 was performed to record the value of indexed extravascular lung water.

201 iac index, pulmonary blood volume index, and extravascular lung water.

202 ema, which can be assessed by measurement of extravascular lung water.

203 tual extravascular lung water, and predicted extravascular lung water.

204 tment with intravenous beta-agonists reduces extravascular lung water.

205 By contrast, the extravascular migration of T cells was insensitive to th

206 ration along abluminal vascular surfaces, or extravascular migratory metastasis (EVMM).

207 ating the molecular interactions involved in extravascular migratory metastasis.

208 face of the endothelium, a mechanism termed "extravascular migratory metastasis." In the present stud

209 ng of cancer through imaging of vascular and extravascular molecular targets.

210 ese proteins not only drive the formation of extravascular networks but also ensure their perfusion b

211 y be initiated by ANCA-induced activation of extravascular neutrophils, causing tissue necrosis and f

212 nstable oxygen levels in tumor interstitium, extravascular oxygenation of R3230Ac mammary tumors grow

213 Importantly, we demonstrate the presence of extravascular parasites in human skin biopsies from undi

214 stration only" (CM1) and "sequestration with extravascular pathology" (CM2), CM1 was associated with

215 onstrated that IgD(hi) B cells can occupy an extravascular perisinusoidal niche in the bone marrow in

216 ion, but supported optimal intravascular and extravascular phagocytosis of zymosan particles.

217 tein permeability (217 +/- 28 vs. 314 +/- 70 extravascular plasma equivalents [microL], p < .05).

218 Lung endothelial permeability, expressed as extravascular plasma equivalents, was reduced to 64 +/-

219 olyps from subjects with AERD contained many extravascular platelets that colocalized with leukocytes

220 r, tissue nitrite can serve as a significant extravascular pool of NO during brief periods of hypoxia

221 se activity may benefit from evaluating this extravascular pool.

222 topenia caused by both formation of aberrant extravascular PPs and defective intravascular PP sheddin

223 Furthermore, the extravascular presence of platelets in lungs of patients

224 udy clearly indicate that acute increases in extravascular pressure (200 mmHg for 2 s) elicit a signi

225 lation was found between graded increases in extravascular pressure and both the immediate and peak r

226 forearm blood vessels via acute increases in extravascular pressure elicits rapid vasodilatation in h

227 tagonist delays vessel sealing and increases extravascular protein accumulation, as does either inhib

228 ute fibrinolysis, is a critical component of extravascular proteolytic damage in immature brains, rep

229 n of whole-plant hydraulics, in general, and extravascular, radial hydraulic conductance in leaves (K

230 Extravascular RBCs were found to associate with placenta

231 % within 2 hr, but reduction rates slowed as extravascular re-equilibration occurred.

232 ls (RBCs) can lead to both intravascular and extravascular red cell destruction.

233 Thus, VEGF is a mediator of vascular and extravascular remodeling and inflammation that enhances

234 oxide (NO), inflammation, and vascular- and extravascular remodeling coexist in asthma and other dis

235 major inflammatory stimulus occurs in local extravascular sites of infection and circulating bacteri

236 Neutrophil recruitment from blood to extravascular sites of sterile or infectious tissue dama

237 a critical role in fibrin clot formation at extravascular sites, the expression and role of coagulat

238 to accumulate in allergic airways and other extravascular sites.

239 leukocytes, carcinoma cells, and at various extravascular sites.

240 aRIIIB-mediated neutrophil interactions with extravascular soluble ICs results in the formation of ne

241 Classical Ly6c(hi) monocytes patrol the extravascular space in resting organs, and Ly6c(lo) nonc

242 migration and cell-cell interactions in the extravascular space in three dimensions.

243 of plasma proteins that have leaked into the extravascular space in tumors and other lesions.

244 hat contribute to neutrophil swarming in the extravascular space of a damaged tissue.

245 tant, or K(trans), fraction of extracellular extravascular space, or ve, and blood normalized initial

246 r Hb, translocation of the molecule into the extravascular space, oxidative and nitric oxide reaction

247 intraluminal crawling and diapedesis to the extravascular space, remains elusive.

248 escaped from the intravascular space to the extravascular space.

249 py to investigate how fibrin is removed from extravascular space.

250 ssels, and to a lesser extent throughout the extravascular space.

251 s migrated through the endothelium into the "extravascular" space (mean migration, 1.37% +/- 2.14%; n

252 along with haematopoietic progenitors in the extravascular spaces of the lungs.

253 ing this process, neutrophils migrate in the extravascular spaces, directed to the site of injury by

254 e, whereas targeted nanoparticle delivery to extravascular structures is often limited and difficult

255 in intravascular and transvascular, but not extravascular, T-cell migration in LNs.

256 induced BBB opening technology for potential extravascular targeted drug delivery in the brain, exten

257 ar imaging can be extended to the imaging of extravascular targets through use of nanoscale, phase-ch

258 actor II (HCII) has been proposed to inhibit extravascular thrombin.

259 Here, we have studied the role of the tumor extravascular tissue in the extravasation kinetics of do

260 ar functions; and 3), inhomogeneities in the extravascular tissue lead to sprout branching and anasto

261 ngiogenesis factor reactive-diffusion in the extravascular tissue matrix.

262 f concentration levels and exposure times in extravascular tissue of tumors.

263 te inflammation, neutrophil recruitment into extravascular tissue requires neutrophil tethering and r

264 We hypothesized that VEGF-induces extravascular tissue responses via NO-dependent mechanis

265 temic PK, but DOX extravasation in the tumor extravascular tissue was substantially different.

266 g was detected by HPLC/MS/MS in any examined extravascular tissue whereas high levels of drug were de

267 of leukocytes from the vascular lumen to the extravascular tissue, but fundamental aspects of this re

268 nitude more efficient drug delivery into the extravascular tissue, compared to non-internalized local

269 of network geometry, endothelialization and extravascular tissue, it is compatible with a wide varie

270 es within the same lobe was used to identify extravascular tissue-resident mononuclear phagocytes and

271 ugs to both the vascular wall and non-target extravascular tissue.

272 up to the nanoparticle size scale deep into extravascular tissue.

273 onsiveness and behavior of leukocytes in the extravascular tissue.

274 regulate several biological functions in the extravascular tissue.

275 rect high-resolution measurement of cortical extravascular (tissue) pO(2), opening many possibilities

276 argeted nanoparticles that can interact with extravascular tissues at the receptor level.

277 of cholesterol on HDL particles (HDL-C) from extravascular tissues to plasma, ultimately for fecal ex

278 he trafficking of leukocytes into and out of extravascular tissues.

279 ylaxis due to rapid clearance, bleeding, and extravascular toxicity.

280 Extravascular translocation of cell-free Hb into interst

281 However, how targeting ligands affect extravascular transport of nanoparticles in solid tumors

282 mechanical and chemical stimuli; intra- and extravascular transport of nutrients, growth factors and

283 Significant differences in vascular and extravascular transport variables as well as in lymphati

284 Intravascular and extravascular triggers may warrant different approaches

285 by the intact quantum dots remaining in the extravascular tumor cells and fibroblasts.

286 Such extravascular tumor spread may represent another form of

287 Poor penetration of antitumor drugs into the extravascular tumor tissue is often a major factor limit

288 The accessibility of extravascular tumor tissue to drugs is critical for ther

289 owing coadministered drugs to penetrate into extravascular tumor tissue.

290 rs by promoting transport of the drug to the extravascular tumour tissue, but the number of available

291 vascular VCD (0.5 minute [IQR, 0.2-1.0]), vs extravascular VCD (2.0 minutes [IQR, 1.0-2.0]; P <.001)

292 ntly lower among those with intravascular vs extravascular VCD (80 patients [5.3%], vs 184 patients [

293 received intravascular VCD and 1506 received extravascular VCD) and 1509 patients were randomly assig

294 zed to hemostasis with an intravascular VCD, extravascular VCD, or manual compression in a 1:1:1 rati

295 4.2 +/- 2 mL/kg; p < 0.001), plasma volume, extravascular volume (bolus resuscitation: 17 +/- 4 mL/k

296 ansfer constant (P < .001) and extracellular extravascular volume (P < .001).

297 e transfer constant, K(trans); extracellular extravascular volume fraction, v(e); and blood plasma fr

298 fer constant [K(trans)], v(e) [extracellular extravascular volume fraction], k(ep)[K(trans)/v(e)], an

299 ther important features include papilledema, extravascular volume overload, sclerotic bone lesions, t

300 Extravascular zeta-globin(+) primitive erythroid cells w