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1 elB on cDC development is cell-intrinsic or -extrinsic.
3 /-) bone marrow showed that RelB exerts cell-extrinsic actions on some lineages, but it has remained
6 artilage; in the absence of tenogenic cells, extrinsic alphaSMA-expressing cells persist to form a pe
7 ly, these results highlight the role of cell-extrinsic and cell-intrinsic factors in regulating the e
9 o best understood pathways of apoptosis, the extrinsic and intrinsic (mitochondrial) pathways, the fo
11 roved understanding of the interplay between extrinsic and intrinsic factors at the molecular level i
13 ern goshawk) to quantify the extent to which extrinsic and intrinsic factors interact to influence ow
14 rk should explore the interactive effects of extrinsic and intrinsic factors on tool production and d
15 tributions results from interactions between extrinsic and intrinsic factors, with important implicat
18 cell identity depends on the integration of extrinsic and intrinsic signals, which directly influenc
19 ism monitors spatial position in response to extrinsic and intrinsic stress and modulates the respons
22 g protein (RIP) kinase RIP 3 (RIPK3) driving extrinsic apoptosis and necroptosis is not fully underst
24 rom cancer cells in response to induction of extrinsic apoptosis by death receptors or intrinsic apop
25 s the role of caspase-8 in the initiation of extrinsic apoptosis execution and the mechanism by which
28 herapy because it mediates activation of the extrinsic apoptosis pathway in a tumor-specific manner b
29 inactivates components of the intrinsic and extrinsic apoptosis pathways and was recently found to b
32 hyperglycemia was specific to necroptosis as extrinsic apoptosis was inhibited by exposure to high le
33 progression, and induced both intrinsic and extrinsic apoptotic pathway in vitro with a dose-depende
34 pendent anti-tumor effects by activating the extrinsic apoptotic pathway which could overcome the cyt
35 th factor-beta processing, activation of the extrinsic apoptotic pathway, and regulation of Hedgehog
36 ties through the activation of intrinsic and extrinsic apoptotic pathways in ovarian cancer but only
37 chanism underlying this impaired response to extrinsic apoptotic stimuli has not been identified.
40 environment and highlight the need to target extrinsic as well as intrinsic mechanisms of drug resist
41 assembly is coordinated by at least thirteen extrinsic assembly factor proteins that are not part of
42 ses or chronically inflamed, pointing toward extrinsic causes for transformation that are potentially
43 D4(+) T cells to determine (1) intrinsic and extrinsic CD4(+) T-cell defects and (2) how defects acco
47 cell-intrinsic (telomere attrition) and cell-extrinsic (chemical- or metabolism-induced genotoxic str
49 that inhibit components of the intrinsic and extrinsic coagulation cascades upstream of thrombin and
50 es, with the aim of separating intrinsic and extrinsic components of resistance in BRAF-mutated melan
51 and independent control of the intrinsic and extrinsic components of the photon's angular momentum at
52 udy aimed to evaluate the prevalence of LMCA extrinsic compression from a dilated pulmonary artery (P
55 intervention does not address the underlying extrinsic compression resulting in symptoms, although an
56 could potentially lead to alleviation of the extrinsic compression, the associated significant risk o
57 ian Mixture Models (GMMs) to address natural extrinsic (condition-specific) variation during network
59 erall, our results suggested that changes in extrinsic conditions (predominantly food availability, b
60 s because of pre-existing differences in the extrinsic connectivity of that region to the rest of the
61 promising route to identifying the limits on extrinsic control of tumor initiation, which is highly r
64 and left arm movements to identical targets (extrinsic coordinates) in visual cortices, and across mo
65 asticity occurs in response to intrinsic and extrinsic cues and is a key step in the formation of mat
70 r of neurons generated is also influenced by extrinsic cues, representing a potential avenue to direc
72 transistors (G-FETs) were demonstrated, with extrinsic cutoff frequency and maximum oscillation frequ
74 oherently strained film structure suppresses extrinsic damping, enables soft magnetic behavior, and g
77 tal axon pruning relies on receptor-mediated extrinsic degeneration mechanisms to determine which axo
78 tion of the same risk as either intrinsic or extrinsic, depending on people's socioeconomic status (S
79 ith CML also provided new insights into cell-extrinsic disruption of hematopoiesis in CML associated
84 es to employ different intrinsic domains and extrinsic effectors to ultimately mediate a common outpu
86 he measurements of the intrinsic SFD and the extrinsic effects of magnetostatic and exchange interact
87 As the MPN clone expands, it exerts cell-extrinsic effects on components of the bone marrow niche
88 f information with focus on the role of cell-extrinsic effects on innate and adaptive immunity, sugge
91 electronic structure and does not arise from extrinsic effects such as residual ensemble size distrib
92 activation of NFkappaB elicited cancer cell-extrinsic effects, impacting endothelial cells of the tu
93 wing that the UPR is also the source of cell-extrinsic effects, particularly directed at those immune
95 acts as a tumor suppressor, and identify the extrinsic environmental and molecular factors required f
96 temperate walnut species were not driven by extrinsic environmental changes alone, and a key role wa
97 and diversification are driven primarily by extrinsic environmental changes such as climatic oscilla
98 This is mediated by interactions between extrinsic environmental cues and the intrinsic oscillato
99 d (independent of blood cell counts) and the extrinsic epigenetic aging rates of blood (dependent on
102 eport good performance in both intrinsic and extrinsic evaluations, demonstrating both the accuracy o
105 t of intrinsic traits (e.g. weaning age) and extrinsic factors (e.g. precipitation seasonality within
106 in epidemiological parameters; intrinsic and extrinsic factors affecting population dynamics; provide
107 ect and illuminates the complex influence of extrinsic factors at the molecular level in breast cance
108 n a cell autonomous manner, after quiescence extrinsic factors control the reactivation of neuroblast
110 ed in evolutionary biology, gives primacy to extrinsic factors in producing morphological variation,
111 e the mechanistic influence of intrinsic and extrinsic factors on the Abeta aggregation network.
112 ain immune competence, but the intrinsic and extrinsic factors regulating survival of transitional st
114 ave provided insights into the intrinsic and extrinsic factors that control stomatal development.
116 t a combination of stem cell mutagenesis and extrinsic factors that enhance the proliferation of thes
117 tative evaluation of potential intrinsic and extrinsic factors that impact vitamin C degradation in a
119 e, we outline the cancer-cell-intrinsic and -extrinsic factors that regulate metastasis, discuss the
120 ce, we found that both ILC-intrinsic and ILC-extrinsic factors were responsible for this ILC dysregul
121 n individuals is thought to be influenced by extrinsic factors which modulate this rate of stem cell
122 It is particularly unclear how multiple extrinsic factors with contrasting effects among seasons
123 le, in identifying hallmarks associated with extrinsic factors, biomarkers and therapeutics targets.
125 ddition, miRNAs can modulate tumor-modifying extrinsic factors, such as cancer-immune system interact
126 viability, the tissue microenvironment, and extrinsic factors, such as microbial products and cytoki
136 they are affected by changes in intrinsic or extrinsic factors.SIGNIFICANCE STATEMENT Multisensory in
137 cell cycle at G2/M phase and activating the extrinsic Fas-mediated membrane receptor pathway to indu
138 eutrophil recruitment and function in a cell-extrinsic fashion, highlighting the importance of the en
143 d evolution holds that the environment is an extrinsic force that is not, in turn, shaped by the adap
144 s blood-lymph separation and integrates both extrinsic forces and intrinsic cues to regulate lymphati
146 in the interannual distribution of rainfall (extrinsic forcing), and asymmetry in the response of gro
147 lammatory conditions, the prevalence of this extrinsic glycosylation pathway in vivo remains unknown.
148 (GST) proteins and could particularly detect extrinsic GST proteins added in crude Escherichia coli o
149 dered superhard (Hv > 40 GPa), likely due to extrinsic hardening that plays a key role in these super
150 gether, these findings reveal roles for cell-extrinsic HLA in driving NK cell reactivity upward, and
153 rticular we focus on the distribution of the extrinsic incubation period (EIP) which determines the t
154 NV) transmission potential and have a longer extrinsic incubation period than their wild-type counter
155 be largest and mosquito mortality rates and extrinsic incubation periods to be smallest in 2015.
156 Recent evidence suggests that motor neuron extrinsic influences, such as those arising from astrocy
160 1, a transcription factor known to integrate extrinsic input in order to specify survival, DNA repair
161 ain homeostasis in the face of intrinsic and extrinsic insults, cells have evolved elaborate quality
162 The conductivities are stable in air without extrinsic ion contributions associated with PEDOT:PSS th
164 d human RPE cell line ARPE-19, expression of extrinsic JN up-regulated formation of actin cytoskeleto
165 ells before injection) and at the tumor-cell-extrinsic level (such as the tissue microenvironment, vi
166 We devised a genetic mouse model to study extrinsic long bone growth modulation, in which injury i
167 ranching morphogenesis in an epithelial cell extrinsic manner by controlling the organisation of the
168 dy, we report that IL-10 functions in a cell-extrinsic manner early following acute lymphocytic chori
172 omeostasis involves both cell-intrinsic and -extrinsic mechanisms and relies upon context-dependent i
173 focused on intrinsic mechanisms rather than extrinsic mechanisms based in the tumor microenvironment
174 ional properties of CSCs, what intrinsic and extrinsic mechanisms regulate CSC functions, how plastic
175 n APC/C degrons, and we describe some of the extrinsic mechanisms that control APC/C-substrate recogn
176 n NSCLC can act by tumor cell-intrinsic and -extrinsic mechanisms to suppress tumor cell growth, most
177 s through distinct tumor cell-intrinsic and -extrinsic mechanisms, and may represent a novel and ther
183 munoglobulin class, both cell-autonomous and extrinsic metabolic programming have emerged as modulato
185 poral problem that implicates inequities and extrinsic mortality risk - documenting more future-orien
187 trate this idea using the specific factor of extrinsic mortality risk, an important factor in evoluti
189 joint and full active range of motion of the extrinsic muscles of the hand, but with diminished prote
190 nctions, the central nervous system provides extrinsic neural inputs that modulate, regulate, and int
191 the relative glomerular distribution of two extrinsic neuromodulators associated with distinct physi
193 n mathematical modeling, we hypothesize that extrinsic noise from fluctuations in transcription facto
194 ysis of the relative impact of intrinsic and extrinsic noise in invertebrate phototransduction using
197 mness of both the photon inputs (regarded as extrinsic noise) and the conversion process (intrinsic n
201 s own synthesis - and assess its response to extrinsic noises perturbing gene deactivation in a varie
203 ysis from healthy controls and patients with extrinsic or intrinsic atopic dermatitis (AD) and psoria
204 ry disease that can be initiated by numerous extrinsic or intrinsic factors that promote an unstable
207 Ultradian rhythms are thought to have an extrinsic origin because of a perceived absence of ultra
208 es DR6, suggesting a link between this novel extrinsic pathway and the axon autonomous, intrinsic pat
210 in is robustly generated within clots by the extrinsic pathway followed by late-stage FXIa contributi
212 t lead to neoplasia and inflammation, and an extrinsic pathway, driven by inflammatory conditions tha
214 cent results, however, have revealed several extrinsic pathways that regulate Drosophila neuroblast t
215 nductivity as proton conduction dominated by extrinsic pathways would be enabled by small particles (
218 erves in health, adaptations to intrinsic or extrinsic perturbations and alterations that may result
219 and remain modular, seemingly insulated from extrinsic perturbations-an intriguing possibility for na
220 ely tunable BP photodetector exhibits a peak extrinsic photo-responsivity of 518, 30, and 2.2 mA W(-1
225 rmonic generation circular dichroism in such extrinsic/pseudo-chiral materials can be understood in t
226 graphitic carbon has yet to be coupled with extrinsic redox reactions to develop rechargeable batter
229 iews, we wish to bring attention to the cell-extrinsic regulation of tumor growth, including tumor UP
234 decrease in CD80 and CD86, supporting a cell-extrinsic role for CTLA-4 in downregulating B7 ligand ex
237 ation, and increasing overall sialylation by extrinsic sialic acid intake reduced ROS and protein S-n
241 sialylation in resting mice, suggesting that extrinsic sialylation is not a constitutive process.
242 ls deficient in ST6Gal-1, demonstrating that extrinsic sialylation is not mediated exclusively by ST6
243 ctivation was minimally sufficient to elicit extrinsic sialylation, as demonstrated with the FeCl3 mo
244 Although extracellular ST6Gal-1 supports extrinsic sialylation, other sialyltransferases are pres
245 that this apoptotic response provides a cell-extrinsic signal that promotes optimal innate immune cyt
246 ther, this work supports a model in which an extrinsic signal triggers an intrinsic transcription fac
248 Recent evidence points to the importance of extrinsic signaling cues in controlling the ability of T
250 age-matched allogeneic murine fetuses, cell-extrinsic signals appeared to dictate allospecific patte
252 endoplasmic reticulum (ER) stress, required extrinsic signals from innate lymphoid cells, and limite
253 Schwann cells in developing nerves depend on extrinsic signals from the axon and from the extracellul
254 s critical in integrating both intrinsic and extrinsic signals governing materno-fetal resource alloc
258 However, very little is known about the extrinsic signals that act on planarian stem cells to mo
259 been limited by fragmentary understanding of extrinsic signals that regulate the differentiation of h
260 mediates the adaptive responses of axons to extrinsic signals, but direct evidence that it occurs in
261 lear that plasma cell survival requires cell extrinsic signals, the nature and source of these signal
267 the mass transport of polymer molecules and extrinsic sites-charged polyelectrolyte repeat units bal
271 tion from melanoma-competent MCSCs following extrinsic stimuli, and they suggest that abrogation of H
272 s have been programmed to detect and process extrinsic stimuli, such as magnetic fields or light, or
273 and exiting shapes the cellular response to extrinsic stimuli, whereas prevalent disruption of the c
276 amond anvil cell to tailor the intrinsic and extrinsic strain in pyrochlore, Dy2Ti2O7 and Dy2Zr2O7.
277 lms, which are subject to both intrinsic and extrinsic strains, but also for developing flexible elec
280 d this was attributed to swift activation of extrinsic sympathetic neurons innervating the gut muscul
281 m (ENS), but it is additionally regulated by extrinsic (sympathetic and parasympathetic) innervation.
282 oduced from natural variation (intrinsic and extrinsic), systematic variation (caused by sample measu
284 lly inhibits factor X (FX) activation by the extrinsic tenase complex (ETC) and thus named as exactin
285 gest a novel cooperation between cancer cell-extrinsic TGFbeta signaling and cancer cell-intrinsic RU
286 ritional deficiency, fishery dependence, and extrinsic threats to biodiverse river ecosystems undersc
288 r, but the origin and molecular functions of extrinsic tissues in tendon repair are not fully underst
289 t the dominant noise source transitions from extrinsic to intrinsic as light intensity increases.
293 deling were performed using a broad range of extrinsic (to predict RI formation rates, RRI) and intri
294 e results suggest a deficit in intrinsic and extrinsic toughening mechanisms, which contribute to AFF
295 istors (OECTs) are transistors that can have extrinsic transconductances as high as 400 S m(-1) , but
296 uded that fluctuation induced tunnelling, an extrinsic transport model accounting for most of the ali
298 lts demonstrate that both local intra-V1 and extrinsic V1-to-V2 connections of L4B neurons preserve C
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