ライフサイエンスコーパス: extrinsic factor

1 o deregulation of various cell intrinsic and extrinsic factors.

2 tly to those of other vertebrates to certain extrinsic factors.

3 interactions between cell intrinsic and cell extrinsic factors.

4 ein activities and is typically regulated by extrinsic factors.

5 the coordinated action of many intrinsic and extrinsic factors.

6 complex interplay between cell intrinsic and extrinsic factors.

7 e of an arbor is the result of intrinsic and extrinsic factors.

8 le requires regulation by many intrinsic and extrinsic factors.

9 been the inability to control intrinsic and extrinsic factors.

10 ate of primitive HPCs, might be modulated by extrinsic factors.

11 nder the influence of distinct intrinsic and extrinsic factors.

12 nce of hexokinase function in the absence of extrinsic factors.

13 a may mediate its lymphopoietic function via extrinsic factors.

14 ic cell fates can involve both intrinsic and extrinsic factors.

15 loss of peripheral NKT cells is due to cell-extrinsic factors.

16 t reactivity of the subject as well as other extrinsic factors.

17 ed by a variety of interacting intrinsic and extrinsic factors.

18 de that cancer risk is heavily influenced by extrinsic factors.

19 -layer and seven-layer MoS2 to exclude other extrinsic factors.

20 inguish between the effects of intrinsic and extrinsic factors.

21 an be predicted by a number of intrinsic and extrinsic factors.

22 uch of the leukemia signature is mediated by extrinsic factors.

23 in) by accounting for possible variations in extrinsic factors.

24 lgorithm to identify osteogenic cocktails of extrinsic factors.

25 ormation and its modulation by intrinsic and extrinsic factors.

26 on scheme that accounts for the variation in extrinsic factors.

27 hich this intrinsic dichotomy is enhanced by extrinsic factors.

28 is accomplished by a myriad of intrinsic and extrinsic factors.

29 In each case, these extrinsic factors act as molecular switches to facilitat

30 simple model in which transient exposure to extrinsic factors acting through known pathways initiate

31 Through the interplay of intrinsic and extrinsic factors, adult neurogenic niches ensure neuron

32 We examined intrinsic and extrinsic factors affecting phrenic motoneuron (PMN) exc

33 in epidemiological parameters; intrinsic and extrinsic factors affecting population dynamics; provide

34 genesis is regulated by interactions between extrinsic factors and intrinsic transcriptional cascades

35 Extrinsic factors and the interactions of neurons with s

36 Thus, T cell-extrinsic factors appear to promote the increased Th1, T

37 ctors in HC specification suggests that cell extrinsic factors are also crucial to their development.

38 Intrinsic rather than extrinsic factors are likely to play the critical roles

39 lly susceptible to failure, or whether other extrinsic factors are responsible that distort scientist

40 Chief among the extrinsic factors are the environmental cues of hematopo

41 pecies, the importance of species traits and extrinsic factors as determinants of establishment in ex

42 one formation was probably due to osteoblast-extrinsic factors, as Atp6v02 was not expressed in osteo

43 ect and illuminates the complex influence of extrinsic factors at the molecular level in breast cance

44 In aged subjects, the influence of extrinsic factors becomes increasingly more important.

45 le, in identifying hallmarks associated with extrinsic factors, biomarkers and therapeutics targets.

46 Here, we examined the effects of cell-extrinsic factors (buffer environment) and cell-intrinsi

47 test the relative roles of intrinsic versus extrinsic factors by challenging the developmental poten

48 mature infants and ameliorating the risks of extrinsic factors by the use of prophylactic antibiotics

49 e trauma in mice could be explained by these extrinsic factors, by utilizing an increasing severity o

50 thway activation, provide evidence that cell extrinsic factors can contribute to the development of m

51 or after the terminal cell division and that extrinsic factors can influence fate choices.

52 he available structural examples of how such extrinsic factors can modulate the way in which a DNA-bi

53 mples reveal a variety of ways in which such extrinsic factors can significantly extend the repertoir

54 and residual solvent molecules are the major extrinsic factors causing changes of charge-state distri

55 ures indicated that both cell-intrinsic and -extrinsic factors contribute to the aberrant migratory p

56 s alone cannot demonstrate that ecological ("extrinsic") factors contribute to such isolation.

57 rs, such as patient severity of illness, and extrinsic factors contributing to the development of nos

58 n a cell autonomous manner, after quiescence extrinsic factors control the reactivation of neuroblast

59 s and MCF-7 indicate that both intrinsic and extrinsic factors cooperate to ultimately determine the

60 Here, we demonstrate that cell-extrinsic factors coordinate with the epigenetic regulat

61 hese findings suggest that IL-6 serves as an extrinsic factor counteracting CD4(+) T-cell-mediated im

62 Genes and orthologous intrinsic and extrinsic factors critical for embryonic pituitary gonad

63 supply, angiogenesis, and matrix turnover to extrinsic factors due to infection and continued trauma,

64 t intrinsic factors act synergistically with extrinsic factors during RGC genesis and development.

65 ies, or spurred on by some other large-scale extrinsic factor (e.g., climate change) remains to be de

66 t of intrinsic traits (e.g. weaning age) and extrinsic factors (e.g. precipitation seasonality within

67 sources, which may be further compounded by extrinsic factors (e.g., diet, psychosocial stressors, o

68 sic factors (eg, the tendency to sickle) and extrinsic factors (eg, the capacity of the reticuloendot

69 ver naive CD8+ T cells, suggesting that cell-extrinsic factors enhance memory CD8+ T cell proliferati

70 Our data suggest that RNA binding is the extrinsic factor essential for the assembly of HEV nativ

71 haematopoietic cells and bone cells could be extrinsic factors for each other.

72 study, we assessed the paracrine effects of extrinsic factors from haematopoietic cells on human mes

73 mply embryo-autonomous processes but require extrinsic factors from maternal tissues.

74 Both extrinsic factors from the neuronal environment and intr

75 etween intrinsic regional molecular cues and extrinsic factors from the thalamus shape multiple featu

76 How these intrinsic and extrinsic factors govern the activity of excitatory and

77 While certain extrinsic factors have been implicated, little is known

78 ical, a mixture of chemicals, and associated extrinsic factors (i.e., mechanical irritation) in the o

79 To test whether extrinsic factors impact development of Math1-null (Math

80 Intrinsic and extrinsic factors impact observed age-related changes an

81 cell precursor frequency as a possible cell-extrinsic factor impacting T cell programming in a model

82 The role of extrinsic factors in maintaining self-renewal of embryon

83 esting that they are short-lived and require extrinsic factors in order to persist.

84 le tools for studying the discrete action of extrinsic factors in organogenesis, and allow for the di

85 ed in evolutionary biology, gives primacy to extrinsic factors in producing morphological variation,

86 Together, these observations suggest that extrinsic factors in the bone marrow that decline with a

87 studying roles of cell-cell interactions and extrinsic factors in the development of the Drosophila n

88 actors within myeloid progenitors along with extrinsic factors in the microenvironment may foster clo

89 n-specific T cells can be compensated for by extrinsic factors in the presence of CTLA-4 expression b

90 lded an intriguing mix of both intrinsic and extrinsic factors in the readout of cell phenotype.

91 To determine if extrinsic factors in the retinal micro-environment are r

92 c clock-type mechanism; however, the role of extrinsic factors in the temporal control of cell-cycle

93 insic alterations of cellular metabolism and extrinsic factors in the tumor microenvironment, cancer

94 y which it resists injury from intrinsic and extrinsic factors, including gastric acid, nonsteroidal

95 otein components) or can be brought about by extrinsic factors, including the cytoskeleton.

96 s population age structure and mobility, and extrinsic factors, including weather systems and habitat

97 FL cell-intrinsic and cell-extrinsic factors influence FL biology and clinical outc

98 titioning reactions) appears to be the major extrinsic factor influencing the extent of protonation a

99 Intrinsic and extrinsic factors influencing succession and their healt

100 However, differentiation of hPSCs with extrinsic factors is a slow, step-wise process, mimickin

101 3 induction, but how the production of these extrinsic factors is controlled remains poorly understoo

102 The distribution of extrinsic factors is estimated using the maximum entropy

103 as well as relationships with intrinsic and extrinsic factors is important both for theoretical and

104 The evidence for a role of extrinsic factors is strongest for development of rodent

105 the disk surface, as well as surface-related extrinsic factors, is decisive for the asymmetric format

106 ynamics of a protein, induced by an array of extrinsic factors, is of central importance in producing

107 -LDH, thus stabilization due to intrinsic or extrinsic factors leads to decreased activity.

108 s is primarily driven by host genetics or by extrinsic factors like dietary intake.

109 In contrast, we show that if extrinsic factors maintain variation in behaviour, high

110 egulatory network of cell-intrinsic and cell-extrinsic factors maintains the epigenetic homeostasis o

111 We suggest that the variation in extrinsic factors may account for the observed wider-tha

112 t and raise the interesting possibility that extrinsic factors may instruct cortical progenitors to b

113 Cell intrinsic and cell extrinsic factors mediate asymmetric cell divisions duri

114 f Th17 cell lineage plasticity in which cell-extrinsic factors modulate Th17 cell fates through diffe

115 These data indicate that both intrinsic and extrinsic factors modulate the sensitivity of hippocampa

116 egulated by multiple cell-intrinsic and cell-extrinsic factors, most of which are not well defined.

117 We hypothesized that a tumor-extrinsic factor, notably tumor-associated macrophages,

118 phincteric muscle function, and as the first extrinsic factor of skeletal myogenesis in the murine es

119 n risk, yet while most studies (78%) include extrinsic factors of some kind (e.g., geographic or bioc

120 the relative contributions of intrinsic and extrinsic factors on observed tick burdens.

121 s illustrate the strong influence of epitope-extrinsic factors on TCD4+ responses and memory.

122 e the mechanistic influence of intrinsic and extrinsic factors on the Abeta aggregation network.

123 ata offer insight into the impact of epitope-extrinsic factors on the resulting TCD4+ responses.

124 ction sites, highlighting cell-intrinsic and extrinsic factors optimizing antigen surveillance at ste

125 posed to different environmental conditions (extrinsic factors), or inconsistencies in reporting (mea

126 We found that the extrinsic factors play a critical role in maintaining th

127 y between cell-intrinsic mechanisms and cell-extrinsic factors produced by the microenvironment.

128 e the bone marrow niche and/or influenced by extrinsic factors, promotes the stabilization of hypoxia

129 nd survival of plasma cells (PCs) depends on extrinsic factors provided in specialized niches.

130 Our results show that extrinsic factors qualitatively and quantitatively affec

131 -glial cell-fate segregation, especially how extrinsic factors regulate cell-fate changes, are poorly

132 Both intrinsic and extrinsic factors regulate each retinal cell type.

133 indicates that both cell-intrinsic and cell-extrinsic factors regulate memory T cell differentiation

134 he complex nature of the mechanisms by which extrinsic factors regulate signal transduction and cell-

135 Both cell-intrinsic and -extrinsic factors regulate the proliferation of progenit

136 ain immune competence, but the intrinsic and extrinsic factors regulating survival of transitional st

137 influenced by intrinsic neuronal factors and extrinsic factors related to myelination.

138 esolvated species; the ease of altering such extrinsic factors renders ESI-MS an appropriate method b

139 ibbean, I sought to reveal the intrinsic and extrinsic factors responsible for avian sensitivities to

140 However, the identity of CD8 T cell-extrinsic factor(s) and mechanism(s) that contribute to

141 X2 protein in neural crest is to regulate an extrinsic factor(s) required for development of the opti

142 they are affected by changes in intrinsic or extrinsic factors.SIGNIFICANCE STATEMENT Multisensory in

143 xplore the mechanism of cellular response to extrinsic factors, specific loss of function mutations w

144 gests that OA progression may be mediated by extrinsic factors such as altered joint loading.

145 e processes are highly regulated and require extrinsic factors such as chromatin remodelers and histo

146 stems locally and over short time spans, but extrinsic factors such as climate and oceanographic and

147 ammation and repair after activation by cell-extrinsic factors such as host-derived cytokines.

148 rmine if insulin resistance is the result of extrinsic factors such as hyperinsulinemia primary skele

149 at Ogn modifies the hypertrophic response to extrinsic factors such as hypertension and aortic stenos

150 NA contacts made by DNA recognition domains, extrinsic factors such as ligand binding, homo- and hete

151 ments is usually assumed to be determined by extrinsic factors such as limb biomechanics and feedback

152 Such biosensors can sense extrinsic factors such as nutrient or oxygen deprivation

153 In HCM patients, extrinsic factors such as obesity are independently asso

154 ion, we will describe how cell intrinsic and extrinsic factors such as oncogene mutations, nutrient a

155 ligand pairs points to a predominant role of extrinsic factors such as surface topography and accessi

156 the intrinsic properties of kinesin-13s and extrinsic factors such as their associated proteins resu

157 aving sufficient resolution to determine the extrinsic factors (such as perisynaptic astroglia) and t

158 ddition, miRNAs can modulate tumor-modifying extrinsic factors, such as cancer-immune system interact

159 sic factors, such as sequence variation, and extrinsic factors, such as crowding effects.

160 alterations and the targeting of tumor-cell-extrinsic factors, such as growth factors.

161 A variety of extrinsic factors, such as in-utero and infant malnutrit

162 viability, the tissue microenvironment, and extrinsic factors, such as microbial products and cytoki

163 an incomplete understanding of the roles of extrinsic factors, such as non-radiative recombination a

164 ough this latter relationship may arise from extrinsic factors, such as resource heterogeneity, that

165 size and number might be influenced by local extrinsic factors, such as the availability of canal spa

166 Extrinsic factors, such as the Western diet and alcohol,

167 ntrinsic properties of the immune system and extrinsic factors, such as vaccination.

168 Regional sex differences suggest that extrinsic factors, such as water depth, contribute to be

169 Thus, TACE serves as a lymphocyte extrinsic factor that is essential for normal T developm

170 velopmentally regulated CaR, is an important extrinsic factor that modulates the intrinsic lung devel

171 Previously we identified IGFBP2 as an extrinsic factor that supports ex vivo expansion of hema

172 e is critically dependent upon intrinsic and extrinsic factors that act to regulate stem cell behavio

173 xplosion of information on the intrinsic and extrinsic factors that are responsible for the first pha

174 imarily supports T cell function by inducing extrinsic factors that can be shared by CD40L-deficient

175 n little synthesis of these effects with the extrinsic factors that can shape biodiversity over large

176 being invested in defining the intrinsic and extrinsic factors that control stem cell maintenance and

177 ave provided insights into the intrinsic and extrinsic factors that control stomatal development.

178 l location of sensors for both intrinsic and extrinsic factors that disrupt energy and/or nutrient ho

179 ta shed light on the cell-intrinsic and cell-extrinsic factors that drive CD8(+) ILL differentiation.

180 Our understanding of the intrinsic and extrinsic factors that enable PSCs to self-renew and to

181 t a combination of stem cell mutagenesis and extrinsic factors that enhance the proliferation of thes

182 ess has provided a framework for identifying extrinsic factors that establish proliferation rate and

183 fferentiation focusing on both intrinsic and extrinsic factors that govern the development of T cell

184 Extrinsic factors that impact iNKT cell development and

185 tative evaluation of potential intrinsic and extrinsic factors that impact vitamin C degradation in a

186 Identifying the intrinsic and extrinsic factors that make some species especially vuln

187 While various studies have identified extrinsic factors that modulate phagocytosis in health a

188 e, we outline the cancer-cell-intrinsic and -extrinsic factors that regulate metastasis, discuss the

189 However, extrinsic factors that regulate self-renewal of satellit

190 To identify the extrinsic factors that regulate the conversion from a no

191 lowing ORN injury, the precise intrinsic and extrinsic factors that regulate this dynamic process hav

192 Several extrinsic factors that stimulate ex-vivo expansion of he

193 s a solid understanding of the intrinsic and extrinsic factors that underlie purchase motivation.

194 , PTHrP provides an excellent example of the extrinsic factors that, through their network of activit

195 Because our system has reduced extrinsic factors, the changes we saw in the GABAergic n

196 Relative to other extrinsic factors, the effects of hydrodynamic flow fiel

197 Although influenced by both intrinsic and extrinsic factors, the genetic mechanisms coordinating t

198 rn of bristle curvature is a product of both extrinsic factors-the socket cell and the inner pupal ca

199 ponent of expression variability arises from extrinsic factors thought to influence multiple genes si

200 Angptl3, as an extrinsic factor, thus supports the stemness of HSCs in

201 The methodology using intrinsic and extrinsic factors to adjust for nosocomial infections sh

202 ive responses to a wide array of genetic and extrinsic factors to maintain contractile function.

203 the relative contributions of intrinsic and extrinsic factors to the functional specification of dif

204 nt to disentangle the relative importance of extrinsic factors vs. species characteristics for the es

205 ce, we found that both ILC-intrinsic and ILC-extrinsic factors were responsible for this ILC dysregul

206 n individuals is thought to be influenced by extrinsic factors which modulate this rate of stem cell

207 of the interplay of stem cell-intrinsic and extrinsic factors will set the stage for improving cell

208 It is particularly unclear how multiple extrinsic factors with contrasting effects among seasons

209 and activation of immune cells, the role of extrinsic factors within the microenvironment in immunos

210 reinitiating coagulation without input from extrinsic factor Xase activity.

211 ion is thought to require both intrinsic and extrinsic factors, yet few intrinsic gene products have