ライフサイエンスコーパス: exuberant

1 f striatal inhibitory neurons were much more exuberant.

2 concentration of rhBMP-2, bone formation was exuberant.

3 ay represent a mechanism to prevent the over-exuberant activation of macrophages during infection and

4 kin-6) induces systemic inflammation with an exuberant acute-phase response.

5 ls following a lymphopenic event can prevent exuberant Ag-stimulated CD4(+) cell cycle progression an

6 uses increased mortality by promoting overly exuberant airway inflammation and cumulative lung damage

7 s, P2Y(6) receptors protect the lung against exuberant allergen-induced pulmonary inflammation by inh

8 nvironmental irritants but that also trigger exuberant allergic reactions in patients with allergies.

9 Exuberant and expansive myelination/remyelination is det

10 atients suffer from recurrent infections and exuberant and persistent tissue granuloma formation.

11 dysregulation of FasL could further enhance exuberant and prolonged cytokine production by DCs follo

12 lial-mesenchymal transition (EMT) along with exuberant angiogenesis that together changed the microen

13 microvilli, whereas high density cells have exuberant apical surface infolding and microvilli.

14 Electron microscopy revealed exuberant apoptosis and necrosis as the mechanisms of Pr

15 to dissociate PrV patterning anomalies from exuberant apoptosis in DRG11(-/-) mice.

16 e are not the result of refinement of richly exuberant arbors but rather the elaboration of arbors pr

17 The IRP in normal mice is also more exuberant at early ages, and the process of refinement m

18 y promoting either the corrective pruning of exuberant axon branches or the specific ingrowth and ela

19 in JNK-interacting protein 3 (JIP3) triggers exuberant axon branching and self-contact in primary gra

20 ate the cerebellar cortex, where they sprout exuberant axon collaterals.

21 pecific projections emerge by elimination of exuberant axonal branches and suggest that they may use

22 Axon pruning by degeneration remodels exuberant axonal connections and is widely required for

23 The widespread developmental phenomena of exuberant axonal projections and synaptic connections re

24 active ErbB2 (CAErbB2) led to synaptic loss, exuberant axonal sprouting, and lethality at birth.

25 There was no indication of exuberant bipolar cell projections.

26 We hypothesize that exuberant branches and synapses are eliminated to achiev

27 lop precisely from the outset without making exuberant branches in incorrect cortical layers.

28 ns that are later refined through pruning of exuberant branches.

29 has been hypothesized that normal pruning of exuberant branching of afferent neurons in the developin

30 pment, dendrites acquire their morphology by exuberant branching.

31 n epithelial repair - both too little or too exuberant - can render mice susceptible to tumorigenesis

32 aorta, enhanced yolk sac hematopoiesis, and exuberant cardiac blood island formation.

33 versible cartilage and bone destruction, and exuberant coagulation system activity within joint tissu

34 sponsive neurons could be the consequence of exuberant connections formed during development that wer

35 Exuberant corneal fibrin(ogen) deposition was noted in P

36 ulation of whole T cell subsets leads to the exuberant cytokine production that in turn causes the sh

37 A dysregulated innate immune response and exuberant cytokine/chemokine expression are believed to

38 s were enhanced, and this was accompanied by exuberant dendritogenesis of bSCs by 24 h.

39 ion increases connectivity by stabilizing an exuberant developmental projection, we examined the norm

40 erns do not result from anomalous pruning of exuberant distributions of 17-18a fibers in gray matter.

41 iacaran and earliest Cambrian, heralding the exuberant diversification of body forms that account for

42 the prepatterning of a biological system of exuberant diversity and illustrate how shifts in the dep

43 To study the dependence of exuberant endothelial cell proliferation on initial apop

44 The exuberant expression of GC-C by nonparenchymal cells and

45 ry sensory projections are established in an exuberant fashion.

46 n tdc2-Gal4 neurons was sufficient to induce exuberant feeding of liquid food in fed animals, whereas

47 Exuberant fibroproliferation is a common complication af

48 stimulated microvascular rarefaction with an exuberant fibrotic response.

49 In contrast, the exuberant functional connectivity between extrastriate a

50 circuit maturation culminates in a period of exuberant GABAergic transmission.

51 Exuberant generation of nitric oxide (NO) by inducible n

52 These results suggest that exuberant granulomatous inflammation in CGD is probably

53 lling branches during a subsequent period of exuberant growth and refinement.

54 endritic growth, having an initial period of exuberant growth followed by a period of retraction to m

55 than littermate controls but exhibited more exuberant growth in response to chronic phenylephrine in

56 onversely, Dscam gain of function results in exuberant growth into the dorsal thalamus.

57 Exuberant growth of connective tissue within the periodo

58 A pyogenic granuloma is an exuberant growth of granulation tissue secondary to irri

59 The exuberant growth of neurites during development becomes

60 ic development is characterized by stages of exuberant growth, pruning, and stabilization during adul

61 In development, 'exuberant' growth of neurons is often followed by prunin

62 , vascular ectasia, intravascular hemolysis, exuberant hematopoiesis, cardiomegaly, glomerulosclerosi

63 Lungs of control mice manifested exuberant histiocytic inflammation with visible C. neofo

64 s of the organism on the lung parenchyma and exuberant host immune responses.

65 f parasites, suggesting three possibilities: exuberant host reactions to the few remaining parasites,

66 oresolving agent, possibly in the context of exuberant host responses to damaging respirable agents s

67 dy that ectopic FGF-3 expression resulted in exuberant hyperplasia of all bigenic prostatic lobes typ

68 is achieved by first establishing an initial exuberant immature pattern of connectivity that is then

69 e intensity of an immune response; an overly exuberant immune response can cause collateral damage th

70 mechanisms that limit damage from an overly exuberant immune response have evolved.

71 t phenotypic outcomes, an aberrant or overly exuberant immune response may be an additional requireme

72 st defense mechanisms against pathogens, the exuberant immune response resulting from inflammasome ac

73 nknown, the vulvar ulcers may result from an exuberant immune response to infection.

74 A dysregulated overly exuberant immune response, termed a "cytokine storm," ac

75 despite aggressive antibiotic therapy and an exuberant immune response.

76 ify a mechanism by which Treg cells suppress exuberant immune responses, highlighting a key role for

77 lf-tolerance and function to suppress overly exuberant immune responses.

78 T (T(reg)) cells capable of suppressing over-exuberant immune responses.

79 Despite providing the interface between an exuberant immune system and a highly antigenic lumenal e

80 observed at P15, with the pathway being more exuberant in CCKO mice.

81 , and somatostatin-immunoreactive axons were exuberant in the dentate gyrus despite loss of immunopos

82 owed hemophagocytic lymphohistiocytosis with exuberant infiltrates of CD8+ T cells that lacked perfor

83 asthma/chronic sinusitis in large part by an exuberant infiltration of eosinophils that are character

84 In conjunction, there was exuberant inflammasome-mediated caspase-1 activation in

85 c kidney disease (ADPKD) is characterized by exuberant inflammation and fibrosis, a process believed

86 sepsis, this response is dysregulated, with exuberant inflammation being followed by a state of prof

87 ought to be predominantly a syndrome of over exuberant inflammation, sepsis is now recognized as a sy

88 unoregulatory circuits will help to mitigate exuberant inflammation.

89 adenocarcinoma (PDAC) is characterized by an exuberant inflammatory desmoplastic response.

90 Adult wound healing is characterized by an exuberant inflammatory response and scar formation.

91 cterial replication while preventing an over-exuberant inflammatory response.

92 cause acute lethal disease characterized by exuberant inflammatory responses and lung damage.

93 Filarial infections evoke exuberant inflammatory responses in the peritoneal cavit

94 An exuberant innate response, postulated to diminish as the

95 , neural circuits are initially generated by exuberant innervation and are rapidly refined by selecti

96 of neural circuit development include early exuberant innervation followed by competition and prunin

97 During the development of other systems, exuberant innervation is followed by activity-dependent

98 lack of IL-1alpha and not IL-1beta led to an exuberant intracellular pathogen replication and progres

99 cytogenetic abnormalities in lymphocytes are exuberant: juxtacentromeric heterochromatin is greatly e

100 The exuberant liver injury phenotypes in syndecan-1 null (Sd

101 efects in neural patterning and wiring, with exuberant local and short-distance cortical interactions

102 vely active v-abl construct (CA-Abl) show an exuberant microtubule-associated protein 2-positive (MAP

103 ts show expression of stress response genes, exuberant mitochondrial gene transcription, and increase

104 of alveolar walls and spaces, followed by an exuberant mononuclear cell infiltration that correlated

105 inhibition may be a strategy for modulating exuberant mucosal airway inflammation.

106 rcholesterolemia, vascular injury induced an exuberant myointimal lesion that was augmented by the ac

107 APP expression is required for exuberant neurite outgrowth and hippocampal axonal sprou

108 ollowed by refinement through elimination of exuberant neurons and synapses.

109 ve in neutrophil efferocytosis, resulting in exuberant neutrophil accumulation and delayed healing.

110 ies P. aeruginosa infections is caused by an exuberant neutrophil response stimulated by 3-O-C12-HSL-

111 bally NADPH oxidase-deficient mice developed exuberant neutrophilic lung inflammation and proinflamma

112 by Jag1) in PCECs, which in turn stimulates exuberant Notch signaling in perivascular fibroblasts an

113 cal work suggests that the evolution of such exuberant offspring behavior reflects parent-offspring c

114 at human diseases characterized by an overly exuberant or chronic immune response to LPS.

115 To avoid damaging exuberant or chronic inflammation, the inflammatory proc

116 Regressive events that refine exuberant or inaccurate connections are critical in neur

117 Indeed, bone particles cause exuberant osteoclastogenesis in the presence of RANKL, a

118 posure to high-dose cytokine ex vivo induces exuberant osteoclastogenesis irrespective of in vivo TNF

119 that, during early postnatal life, there is exuberant outgrowth of local CA3 recurrent axons, and wi

120 Previous studies have shown that an exuberant outgrowth of local recurrent excitatory axons

121 lular migration, amacrine cells exhibited an exuberant outgrowth of neurites that was undirected.

122 es reminiscent of a mature retina, including exuberant outgrowth of outer segment-like structures and

123 during the first postnatal week, causing an exuberant outgrowth of thalamocortical axons (TCAs) in l

124 Immunofluorescence revealed exuberant overgrowth of auditory afferent neurites in th

125 oping more severe acute pancreatitis with an exuberant pancreatic inflammatory response.

126 iol by 95% and induced the development of an exuberant papillomatous enlargement of the gingiva by ge

127 ding domain protein-2-deficient mice exhibit exuberant patterns of cytokine expression despite approp

128 Most clearly, exuberant placodal fibers grew in 10-day OPE cocultures,

129 S), and overexpression of Kv2.1 induces more exuberant PM:ER MCS in neurons and in certain heterologo

130 this regulation of Dscam translation lead to exuberant presynaptic arbor growth in Drosophila somatos

131 At rest, however, these exuberant process movements do not result in overt cellu

132 influenza A viruses is characterized by the exuberant production of cytokines and chemokines and the

133 Deaths were due to exuberant proinflammatory responses, not increased bacte

134 Initially diffuse and exuberant projections in the VPM at P1 coalesce into row

135 misperception that their collaterals extend exuberant projections into pain-specific regions of the

136 der the control of the NT-3 promoter develop exuberant projections of vestibular sensory neurons to t

137 crossing of axon projections, elimination of exuberant projections, and myelination of established tr

138 ice are defective in the refinement of these exuberant projections, suggesting that Otx1 is required

139 specificity by the elimination of initially exuberant projections.

140 The exuberant proliferation of cortical precursors during fe

141 These deranged processes culminate in an exuberant proliferative response that occludes the pulmo

142 tration, loss of capillary barrier function, exuberant pulmonary inflammation, and extensive microthr

143 sponses: pathologies that are elicited by an exuberant reaction to antigens that do not pose any inhe

144 siological range (10-50 Hz), in spite of the exuberant recurrent excitation.

145 logy owing to self-reactivity or potentially exuberant responses to pathogens, but it may also limit

146 in the fresh JRA tissues correlated with the exuberant revascularization of JRA minced tissue fragmen

147 ng a secretory phenotype characterized by an exuberant secretion of inflammatory mediators and cytoki

148 By 8 weeks after SmT challenge, exuberant splenic granulomata developed in p47(phox-/-)

149 d induction of ATF4 and BiP, and (c) exhibit exuberant splice activation of XBP1 and robust cleavage

150 These connections undergo rapid and exuberant sprouting and pruning in response to removal o

151 tissues, fibrillin-2 antibodies demonstrated exuberant staining in only one location: peripheral nerv

152 pletion, while protecting the host from over-exuberant stem-cell proliferation.

153 on is a noncell autonomous defect, caused by exuberant stimulation of osteoclastogenesis by Cx43-defi

154 eptor previously implicated in hunger-driven exuberant sugar intake.

155 This exuberant synaptic connectivity was lost over time in th

156 development is characterized by a period of exuberant synaptic growth that is well studied.

157 which, in turn, was explainable by an overly exuberant systemic hypotensive response.

158 This is associated with an exuberant systemic IFN-gamma response.

159 ugmented disease are thought to be caused by exuberant T cell activation, attention has focused on th

160 perates primarily as a feedback inhibitor of exuberant T cell responses to microbial antigens.

161 (IFN-alpha2b), All biopsy samples showed an exuberant T-cell infiltrate with scattered atypical larg

162 egate into patches, and instead they develop exuberant terminal arbors spanning most of the PrV.

163 could be important to control the otherwise exuberant Th17 response.

164 he onset of hearing or whether refinement of exuberant thalamocortical connections occurs following h

165 roblast-specific Egr-1 overexpression showed exuberant tissue repair, with enhanced collagen accumula

166 ve-regulatory mechanism that prevents overly exuberant TLR2- and TLR4-driven inflammatory responses.

167 this hypothesis, arthritic disease driven by exuberant TNF-alpha expression was not impeded by fibrin

168 Our data suggest that exuberant TNF-induced osteoclastogensis is the result of

169 ed by cutaneous erosions, nail dystrophy and exuberant vascular granulation tissue in certain epithel

170 High-grade gliomas are characterized by exuberant vascularization, diffuse invasion, and signifi

171 BRD4 inhibition may be a strategy to reduce exuberant virus-induced mucosal airway inflammation.IMPO

172 tension and atherosclerosis characterized by exuberant VSM cell proliferation and vascular inflammati

173 , we show that increased activity results in exuberant VSN axonal projections and a delay in axonal c

174 e that olfactory sensory axons develop in an exuberant way, both in terms of branch growth and synapt

175 arge-scale overproduction and elimination of exuberant widespread axonal branches outside the target

176 oth tighter adhesion to wound matrix and the exuberant wound contraction observed in pathogenic scars