ライフサイエンスコーパス: factor

1 opathy due to mutated BCS1L, a CIII assembly factor.

2 TG initiated by low concentrations of tissue factor.

3 any single individual- or neighborhood-level factor.

4 rylation of cofilin, an actin-depolymerizing factor.

5 and demographic, clinical, and socioeconomic factors.

6 of the FOXA1, FOXA2 and HNF4A transcription factors.

7 inear and nonlinear losses, and the coupling factors.

8 , independently of the robust antenatal risk factors.

9 G protein activation mediated by cytoplasmic factors.

10 liferation/differentiation switch of ID-bHLH factors.

11 progression, such as the insulin-like growth factors.

12 y, calcineurin inhibitors (CNI), and genetic factors.

13 t as well as responses to biotic and abiotic factors.

14 nfluenced by metabolic, genetic, and dietary factors.

15 t was partly mitigated by the organisational factors.

16 tural, psychosocial, or transplant knowledge factors.

17 nt after adjustment for contemporaneous risk factors.

18 r air toxics after adjustment for major risk factors.

19 celerator of traditional cardiovascular risk factors.

20 1), respectively, with high preconcentration factors.

21 terine mechanisms, or due to shared familial factors.

22 d involve multiple genetic and environmental factors.

23 rding their oral health status and OSCC risk factors.

24 ) is one of the strongest breast cancer risk factors.

25 ious adverse birth outcomes, and demographic factors.

26 chlamydia and gonorrhea prevalence and risk factors.

27 Chromatin assembly factor 1 (CAF-1) is the histone chaperone responsible fo

28 ng levels of insulin and insulin-like growth factor 1 (IGF-1).

29 the angiogenic factors stromal cell-derived factor 1 (SDF-1alpha), vascular endothelial growth facto

30 eterogeneity, response to colony-stimulating factor 1 receptor (CSF-1R) blockade and nanoparticle-bas

31 lial growth factor (VEGF), hypoxia-inducible factor 1-alpha (HIF-1alpha) and erythropoietin (EPO) wer

32 ng for standard clinicopathologic prognostic factors (10-year biochemical recurrence-free survival [b

33 ve mode of action for growth-differentiation factor 11 (GDF11) and an unusual mechanism of its inacti

34 amed tissue and allows binding of complement factor 1q (C1q) and activation of the classical compleme

35 ELL-associated factor 2 (EAF2) is an androgen-regulated tumor suppresso

36 of tumor necrosis factor receptor-associated factor 2 (Traf2) in regulating myocardial necroptosis an

37 und that GCH1 was regulated by NF-E2-related factor 2, a key mediator of the cellular antioxidant res

38 lammation, serum levels of fibroblast growth factor 21 (FGF21), and activation of signaling pathways

39 ich phosphorylates the eukaryotic initiation factor 2alpha to inhibit global protein translation.

40 In this study, we report that IFN regulatory factor 4 (Irf4) is highly expressed in murine thymic epi

41 mutant that binds to translation initiation factor 4A (eIF4A), sufficiently inhibited Sin1 translati

42 phorylated eukaryotic translation initiation factor 4E, phosphorylated 4E-binding protein 1, and p-S6

43 lpha) and its ligand platelet-derived growth factor A (PDGF-A) are co-expressed in migrating cranial

44 integrin are the best-studied von Willebrand factor A domains undergoing significant conformational c

45 ed fat and cholesterol were significant risk factors across ethnic/racial populations (p-trends < 0.0

46 We administered lentiviral transcription factor activated luciferase/eGFP reporter (TFAR) cassett

47 studies are needed to further define program factors affecting attrition.

48 However, potential limitations and factors affecting the accuracy of preoperative 4D-CTs re

49 Factors affecting the sensitivity and selectivity of thi

50 ng enzymes as well as relevant transcription factors, allowing us to better understand cell-type-spec

51 1) virus induce expression of tumor necrosis factor alpha, interleukin-6, and interleukin-8 in the re

52 produced elevated amounts of tumor necrosis factor-alpha (TNFalpha) that contributed to the increase

53 ucible nitric oxide synthase, tumor necrosis factor-alpha, and interleukin 6).

54 Serum tumor necrosis factor-alpha, interleukins, hemogram, and liver and rena

55 cross-sectional associations with lifestyle factors among participants of the Danish Health Examinat

56 The results, together with the large g-factor and Rashba spin-orbit coupling in In0.75 Ga0.25 A

57 of hypoxia are the three main clinical risk factors and are more predictive of poor outcomes than th

58 nding sites for the identified transcription factors and are necessary and sufficient for PRE activit

59 ed reduced levels of B-lineage transcription factors and B cell receptor (BCR)/pre-BCR-signaling gene

60 substrates, most paxillin binds to endocytic factors and facilitates vesicle invagination, elevating

61 wn to interact with diverse transcription co-factors and integrate signals from multiple pathways to

62 Nonlaboratory-based risk factors and lipids measured in adolescence independently

63 functional validation of known genetic risk factors and potentially pathogenic alleles identified in

64 netic assays revealed that Abl allows growth factors and Semaphorin/Plexin repellents to combinatoria

65 Understanding the relationship between known factors and spending increases over time could inform po

66 d on genetic risk, established clinical risk factors, and diagnostic biomarkers.

67 were correlated with clinical and molecular factors, and patterns of postprotocol therapies were enu

68 both its RING E3 ligase and ADP-ribosylation factor (ARF) GTPase activity.

69 nhibited the expression of immunosuppressive factors arginase I and iNOS.

70 the Atonal family of proneural transcription factors as a model.

71 allowed the implementation of high dilution factors as high as 100:1.

72 The only factor associated with increased risk of IC within 6 mon

73 0 genes, including novel and known virulence factors associated with adherence and autoaggregation.

74 Factors associated with dysfunction were analyzed with u

75 urgent and urgent ocular conditions and risk factors associated with ED use for nonurgent and urgent

76 In 2014, factors associated with filling high-intensity statin pr

77 mal ascending aorta, we sought to assess (1) factors associated with increased longer-term cardiovasc

78 The PMF analysis revealed four resolved factors at each site.

79 een decreasing number of cardiovascular risk factors at target and major adverse cardiovascular outco

80 -) LSCs was activated by transforming growth factor beta (TGFbeta)-activated kinase 1 (TAK1; MAP3K7),

81 ndrogenic induction with transforming growth factor beta to set up a dual-compartment culture.

82 urprisingly, more active transforming growth factor beta.

83 ded expression of the maternal transcription factor Bicoid (Bcd) provides positional information to a

84 based method for prediction of transcription factor binding sites using an integrative energy functio

85 nt by promoting serum response transcription factor binding to a cryptic cis-element.

86 Finally, analysis of transcription factor-binding site motifs of differentially dysregulate

87 anding of pathophysiology and important risk factors both for the development of ARDS and for importa

88 transduced with the neurogenic transcription factors Brn2, Ascl1, Myt1l and NeuroD.

89 utcome in these patients and what modifiable factors can be targeted for preventive intervention.

90 A number of factors can increase the risk of FGR, one of which is po

91 maintained under subsaturating neurotrophic factor conditions operates under cholinergic constraint

92 Only 4.4% had all 5 risk factors controlled and 42.4% had >/=3 risk factors contr

93 k factors controlled and 42.4% had >/=3 risk factors controlled.

94 revealed molecular insights about molecular factors controlling the antiparallel-to-parallel equilib

95 ediated mechanism by which a transcriptional factor conveys a general chromatin modifier to specific

96 1)/DNA-dependent activator of IFN-regulatory factors (DAI) that contain receptor-interacting protein

97 Risk factor differences between the cohorts were measured usi

98 rmine whether, after controlling for medical factors, differences in time to acceptance for transplan

99 Analysis of enriched transcription factor DNA-binding sites in the promoters of differentia

100 which at least six (35%) alter transcription factor-DNA binding in neuroblastoma cells.

101 Soluble klotho down-regulates growth factor-driven PI3K signaling, contributing to extension

102 Aroma perception is an important factor driving food acceptance.

103 hose bound by the S-phase gene transcription factor E2F1.

104 kinases phosphorylate eukaryotic initiation factor eIF2alpha, enabling the translation of stress res

105 Depletion of the assembly factor Erb1 prevents stable assembly of seven other inte

106 consensus binding site for the transcription factor ETS within an enhancer region.

107 We find that platelet-derived growth factor evokes transient oxidation on or close to RAB5+/

108 The factors explaining such similarities are still debated,

109 Despite the potential importance of these factors, few studies have directly tested their effects

110 ytic enzymes downstream of fibroblast growth factor (FGF) signaling.

111 ells depleted for the Forkhead transcription factors, Fkh1 and Fkh2, previously associated with repli

112 n deficiency is a common and consistent risk factor for anemia globally and that anemia control must

113 sis is now recognized as an independent risk factor for coronary heart disease and cardiovascular mor

114 sive disorder (MDD) in the elderly is a risk factor for dementia, but the precise biological basis re

115 s have shown that sarcopenia is a novel risk factor for developing NAFLD.

116 a hepatic secretory protein and a novel risk factor for diabetes.

117 e importance of biliary strictures as a risk factor for graft failure, and does not validate other ri

118 -kinase IIIbeta (PI4KB) is an essential host factor for many positive-sense single-stranded RNA (+RNA

119 group, were a strong, independent prognostic factor for recurrence (hazard ratio, 1.78; P=0.005).

120 Antibiotic therapy is a major risk factor for the development of diarrhea and colitis with

121 dentification of immune-related genetic risk factors for AD, including coding variants in the gene TR

122 aluate clinicopathological and perioperative factors for associations with major complications and fa

123 nal sodium channel NaV1.2 are important risk factors for autism spectrum disorder (ASD), developmenta

124 To identify incidence of and risk factors for calcifications of intraocular lenses (IOLs)

125 These traits are risk factors for cardiovascular disease even below the diabet

126 rospective case-control study to assess risk factors for carriage of MCRPEC in rectal swabs from inpa

127 gitis, two cholangiopathies regarded as risk factors for CCA.

128 We examined potential risk factors for changes in objectively assessed sleep durati

129 oncentration are independent and causal risk factors for coronary heart disease.

130 Without trend data or correction factors for dolphin availability, the impact of bycatch

131 abolic COMT capacity for methylation are key factors for high HVAL concentrations.

132 rtunistic infections; and lifestyle are risk factors for HIV-associated atherosclerosis.

133 ft failure, and does not validate other risk factors for IC found in smaller studies.

134 Future studies should explore risk factors for increased AL in Chinese Americans and potent

135 Cox regression analysis explored risk factors for interim death or cardiac transplantation.

136 Among patients without known risk factors for iron deficiency, gastric acid inhibitor use

137 ity and type 2 diabetes are significant risk factors for malignancies, being associated with chronic

138 and genetic abnormalities are important risk factors for outcome in acute lymphoblastic leukemia.

139 Risk factors for RVAD implantation and the combined end point

140 assess pooled survival rates and prognostic factors for survival in patients with HCM.

141 detected a direct effect of these intrinsic factors for the majority of immune genes.

142 e expression of the promitotic transcription factor FOXM1 (Forkhead box protein M1).

143 etabolic network, the forkhead transcription factor FOXO has been shown to interact with diverse tran

144 induction of expression of the transcription factor Foxp3 in T cells, trans-presentation of IL-6 by D

145 tivity in the presence of common interfering factors from biological matrixes.

146 regulation of granulocyte-colony stimulating factor (G-CSF); these effects are reversed following adm

147 hermore, SRC-2 coactivated the transcription factors GATA-binding protein 4 (GATA-4) and hypoxia-indu

148 ectopic glial cell line-derived neurotrophic factor (GDNF) promotes the function, plasticity, and sur

149 In humans, mutations in the NMD factor gene, UPF3B, cause intellectual disability (ID) a

150 ly greater mRNA levels of select restriction factor genes than CSF-1-Mphis.

151 long-sought-after nephrin and tumor necrosis factor genes.

152 trix-bound chemokines, cytokines, and growth factors (GFs) influence functional properties of key cel

153 ty of the nitrite reductase gene (aniA), the factor H-binding protein gene (fHbp), and the capsule bi

154 ing protein 4 (GATA-4) and hypoxia-inducible factor (HIF)-1alpha and -2alpha in response to angiotens

155 xpression, including other AP2 transcription factors, histone-modifying enzymes, and regulators of nu

156 ombination with an additional metabolic risk factor (hypertension, dyslipidemia, or diabetes) (aOR, 6

157 g the role of female sex hormones as a major factor in determining migraine risk and characteristics,

158 vitamin D has been proposed as a modifiable factor in multiple disorders, could explain any of these

159 events in AM but not IM may be an important factor in the reduction of cancer incidence.

160 A major factor in the variation of SUMO-target function is the b

161 toimmune regulator (AIRE) protein is the key factor in thymic negative selection of autoreactive T ce

162 n vivo indication of a role for postsynaptic factors in amphetamine-induced psychosis in SCH.

163 might be considered in individuals with risk factors in early adulthood to inform discussions about p

164 d motifs, suggesting interplay between these factors in gene regulation.

165 bial dysregulation, induced by environmental factors in genetically susceptible individuals.

166 nderstanding the role of multiple regulatory factors in modulating Fshb gene activity.

167 ion of 45 confirmed and putative restriction factors in primary CD4(+) T cells from rhesus macaques u

168 cognize the additional role of environmental factors in regulating birth and mortality rates can lead

169 ld increase the availability of neurotrophic factors in the lesion site, thereby promoting axonal reg

170 xperimental conditions, the preconcentration factors in the range of 90-121were obtained for the anal

171 mad4, Hif1a, and Rora, all key transcription factors in the Th17 cell gene-expression program.

172 ed participants according to their lifestyle factors including body mass index, healthy diet, sedenta

173 A number of factors, including age, sex, and genotype, may affect th

174 The number of early life risk factors, including high levels (extreme 75th percentile

175 We identify five factors, including the HIV co-receptors CD4 and CCR5, th

176 , PPAR agonism is sufficient to drive growth-factor-independent growth in the context of concurrent t

177 as bile salts and alkaline pH, but how these factors influence ToxR is not yet understood.

178 ancers integrate combinatorial transcription factor input, feedback and redundancy to generate cell t

179 Critical factors involved in invasion have been identified using

180 The p53 transcription factor is a critical barrier to pancreatic cancer progre

181 d entirely of adult nonlaboratory-based risk factors is equivalent to an approach that additionally i

182 Our findings indicate that a combination of factors is required to sensitize these regions.

183 arked by expression of antiviral restriction factors, it was intuitive to find that IL-34-Mphis posse

184 pecific antibody recognizing both the enzyme factor IXa and the substrate factor X.

185 enuated the HS-induced activation of nuclear factor kappa B and reduced the expression of proinflamma

186 pressor of the receptor activator of nuclear factor-kappaB ligand-mediated osteoclastogenesis.

187 validation and propensity score matching of factors known to affect recurrence to assess independent

188 4-dependent het-siRNAs also requires several factors known to participate in the effector portion of

189 In general, clinicopathological factors known to predict and drive allograft fibrosis in

190 may occur and what genetic or environmental factors may hinder it.

191 Other factors may need to be considered in deciding the optima

192 DHD is independent of, or explained by, risk factors may provide etiological insight.

193 findings provide evidence for EAF2 as a key factor mediating androgen protection of DNA damage via K

194 tions in the gene encoding the transcription factor Methyl CpG Binding Protein 2 (MECP2).

195 ownregulated macrophage migration inhibitory factor (MIF) to be the most pertinent mediator of increa

196 sis thaliana SG2-type R2R3-MYB transcription factor MYB15 as a regulator of defense-induced lignifica

197 stablish a new link between the pluripotency factor NANOG and autophagy involved in resistance to CTL

198 Together, this work identifies Actr10 as a factor necessary for dynactin-mitochondria interaction,

199 expression is repressed by the transcription factor Nkx2-1, a well-established suppressor of metastat

200 The efficiency is improved by a factor of 6 compared with previous demonstrations.

201 age of approximately 1 V and a striking fill factor of approximately 80%.

202 lly, SNP rs11265269 was identified as a risk factor of BPD (OR 1.8, p = 5.3 x 10(-5)), independently

203 ties (RSDs13.53%, n=3) with preconcentration factors of 4 and 72 for PHE and PYR, respectively.

204 em cell tools to identify microenvironmental factors of importance to the development of improved reg

205 Burkart et al. present a paradox - general factors of intelligence exist among individual differenc

206 The etiologic factors of late-life depression are still poorly underst

207 ion of GRF1 and possibly other transcription factors of the GRF family.

208 hanisms with the need to identify predictive factors of therapy response.

209 The Experimental Factor Ontology (EFO) is an application ontology driven

210 Importantly, genetic factors operating at 8 years explained only approximatel

211 earning (-0.140 standard deviations per risk factor, p < 0.0001) and remained significant after adjus

212 PARAllel FACtor (PARAFAC) analysis supported a two-component mode

213 ression levels within the pigment dispersing factor (PDF) cell-pacemaker neurons; only mir-92a peaks

214 SCT and that the presence of fibrotic growth factor, PDGF-AA, results in increased proliferation of P

215 of the mRNA surveillance and ribosome rescue factor Pelota.

216 levels of leukocytes, platelets, and tissue factor-positive (TF(+)) microvesicles (MVs) are all pote

217 Pathogenicity-related factor prediction, orthology and multigene family classi

218 ocus, we hypothesized that the transcription factor PRRX1 could be a strong candidate gene as it is e

219 Here, we show that platelet-derived growth factor receptor alpha (PDGFRalpha) and its ligand platel

220 Here we report that platelet-derived growth factor receptor alpha (PDGFRalpha) positive ( + ) cells

221 e increase independently of epidermal growth factor receptor transactivation.

222 Epidermal growth factor receptor tyrosine kinase inhibitors, including ge

223 We examined the role of tumor necrosis factor receptor-associated factor 2 (Traf2) in regulatin

224 y receptor systems, notably including growth factor receptors and G protein-coupled receptors, contro

225 Several transcription factors regulating pancreas lineage specification have b

226 However, the interplay of factors regulating target selectivity is not well unders

227 Factors related to laminar depth were determined with mi

228 trition, a confirmed independent cancer risk factor, remain poorly understood.

229 ough the role of individual and neighborhood factors remains prevailing in explaining black-white dif

230 es the DNA occupancy of YY1, a transcription factor required for OL maturation.

231 ock protein 60, was identified as one of the factors responsible for inducing the expression of PTX3

232 or CXCR7 and its ligand stromal cell-derived factor (SDF)-1 are known to be involved in inflammation.

233 n this study, we tested current paradigms on factors setting thermal limits by investigating the acut

234 tus and various patient- and implant-related factors (sex, patient age, smoking, number of remaining

235 ith the hypothesis that oxygen is a limiting factor shaping the temperature-size rule in fishes.

236 ed processes such as neurogenesis and growth factor signaling.

237 n analyses revealed that this combination of factors significantly accounted for variability in memor

238 The high-mobility group box transcription factor SOX4 is the most highly expressed SOX family prot

239 is antagonized by the MADS box transcription factor SQUAMOSA (SQUA).

240 duced expression and binding of the splicing factor SRSF3, and increased binding of total and phospho

241 ciated with conventional cardiovascular risk factors, stroke, and chronic kidney disease.

242 In addition, the angiogenic factors stromal cell-derived factor 1 (SDF-1alpha), vasc

243 if protein 25 (RBM25) is a putative splicing factor strongly conserved across eukaryotic lineages.

244 l fit to the data compared with a non-nested factor structure model.

245 Importantly, this nested factor structure provided better overall fit to the data

246 sults and SUVs were compared with prognostic factors such as histologic grade (G1, G2, or G3, for low

247 tterning might involve modulatory regulatory factors such as R-spondin 1 (Rspo1), an extracellular pr

248 atty liver disease) or is a significant risk factor, such as reflux esophagitis and gallstones.

249 ical resonators with relatively high quality factors, such as cantilevers vibrating in vacuum, can sh

250 Genetic and environmental factors, such as metals, interact to determine neurologi

251 tion of honey is also affected by many other factors, such as overfeeding of bees with sucrose, harve

252 n treatment with medications and confounding factors, such as substance use, previous adverse birth o

253 with Wnt-responsive enhancers through T cell factors (TCF) and kept silent by Groucho/TLE co-represso

254 Plants have significantly more transcription factor (TF) families than animals and fungi, and plant T

255 regulation induced by aberrant transcription factors (TF) is a key feature of cancer, but its global

256 Transcription factors (TFs) are proteins that bind to specific DNA seq

257 g the binding specificities of transcription factors (TFs) is crucial to the study of gene expression

258 In the 25 related transcription factors (TFs), our analysis of The Cancer Genome Atlas d

259 r Y (NF-Y) is a heterotrimeric transcription factor that binds CCAAT elements.

260 role of MAC and facility and organizational factors that affect choice of endoscopic sedation.

261 TF(+)) microvesicles (MVs) are all potential factors that alone or in combination increase cancer-ass

262 ructural elements, small molecules, and host factors that alter these relatively conserved splicing p

263 e troubleshooting tips and identification of factors that contribute to experimental variability.

264 d range of influence, of the physicochemical factors that control the retention profile shape.

265 lators of EIF2B5 splicing identified several factors that influence intron retention in EIF2B5: a wea

266 ation-based studies have identified numerous factors that modify the atrial substrate and increase AF

267 ted forms of early-onset AD and genetic risk factors that provide insights about molecular pathophysi

268 ther variation in binding of a transcription factor, the vitamin D receptor (VDR), whose activating l

269 The Rac1 guanine nucleotide exchange factor Tiam1 mediates an OGD-induced increase in Rac1 ac

270 Little is known about how donor factors, timing of procurement, and geographic location

271 Dysregulation of tumor necrosis factor (TNF) receptor signaling is a key feature of vari

272 munosorbent assays quantified tumor necrosis factor (TNF), interleukin (IL)-12, and IL-10 in gingival

273 ning the light environment by a single sigma factor to regulate chloroplast transcription.

274 ility and shared and nonshared environmental factors to AF susceptibility.

275 ution of social, biologic, and clinical risk factors to RSV mortality in low-income regions is unclea

276 gic modulation, and the potential of genetic factors to stratify patients.

277 eostasis and delivering antigens and soluble factors to the lymph node for immune surveillance.

278 cted by a mix of baseline and periprocedural factors translating into poorer clinical outcomes.

279 e highly cancer relevant insulin-like growth factor type 1 receptor (IGF-1R).

280 Insulin-like growth factor type 2 (IGF2) receptor (IGF2R) recognizes mannose

281 se and patient mortality, adjusting for risk factors typically associated with poor treatment outcome

282 al that we understand better the immunologic factors underlying both original antigenic sin and negat

283 morbidity in observational studies, but the factors underlying this association are uncertain.

284 Vascular endothelial growth factor (VEGF) is implicated in the peritoneal membrane r

285 We also show how vascular endothelial growth factor (VEGF) regulates PRKCB promoter function in CLL c

286 he importance of Vascular Endothelial Growth Factor (VEGF) secretion for this pathway of hypoxia-medi

287 1 (SDF-1alpha), vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1-alpha (HIF-1al

288 in the exon-8 of vascular endothelial growth factor (VEGF)-A results in production of proangiogenic V

289 factor (vWF) and vascular endothelial growth factor (VEGF)-C expression were measured.

290 To evaluate vascular cells, von Willebrand factor (vWF) and vascular endothelial growth factor (VEG

291 Thirteen independent risk factors were identified in the derivation cohort and wer

292 and dosing regimen, and baseline prognostic factors were requested from the leaders of the 6 trials.

293 pecific terminal selector-type transcription factors, whereas the sex specificity of dmd-3 action is

294 abilization of helical structures is a major factor, which determines sequence-dependent behavior of

295 te GWAS meta-analysis to demonstrate genetic factors with pleiotropic effects on bone mineral density

296 embly of seven other interdependent assembly factors with pre-60S subunits, resulting in turnover of

297 Herein, we review the factors within the cellular and the extracellular microe

298 Deficiency of factor X (F10) in humans is a rare bleeding disorder wit

299 both the enzyme factor IXa and the substrate factor X.

300 Nuclear Factor Y (NF-Y) is a heterotrimeric transcription factor