ライフサイエンスコーパス: factor I

1 The p53 transcription factor is a critical barrier to pancreatic cancer progre

2 box 2 (Zeb2, also called Sip1) transcription factor is a critical intrinsic timer that controls the o

3 rest-like reprogramming achieved by a single factor is a critical process for melanoma progression.

4 he NRF2 (also known as NFE2L2) transcription factor is a critical regulator of genes involved in defe

5 The sigma factor is a functionally obligatory subunit of the bacte

6 We propose that the activity-stability factor is a key "metric" for determining the technologic

7 The E2F transcription factor is a key cell cycle regulator.

8 he activation of the NF-kappaB transcription factor is a major adaptive response induced upon treatme

9 We show that the Ikaros transcription factor is a major negative regulator of B1 cell developm

10 The ABORTED MICROSPORES (AMS) transcription factor is a master regulator of sporopollenin biosynthes

11 eedlings, suggesting that this transcription factor is a negative regulator of early root growth, pos

12 The Gata2 transcription factor is a pivotal regulator of hematopoietic cell deve

13 Granulocyte-macrophage colony-stimulating factor is a potential therapeutic target to reduce esoph

14 The p53 transcription factor is a regulator of key cellular processes includin

15 In some cases, the transcription factor is a small ubiquitin-like modifier conjugated dir

16 Angiopoietin-1 (Ang1) growth factor is a Tie2 agonist, whereas Ang2 functions as a co

17 ledge, intended aggregation of a termination factor is a way to overcome the bacterial translation qu

18 (repressor element-1 silencing transcription factor) is a key regulator in differentiation of pluripo

19 factor Y (NF-Y) CCAAT-binding transcription factor, is a central regulator that controls many aspect

20 Progranulin (PGRN), a secreted growth factor, is a key regulator of inflammation and is geneti

21 alpha), a nuclear receptor and transcription factor, is a novel transcriptional regulator of SEMA3E-m

22 ze that considering and addressing all these factors is a conditio sine qua non for appropriate treat

23 mes with genetic variation and environmental factors is a core pursuit in biology and biomedicine.

24 The coordinated activity of DNA replication factors is a highly dynamic process that involves ubiqui

25 riven biological processes and environmental factors is a key driver of research questions spanning m

26 Identifying specific context factors is a major challenge that requires new approache

27 Alzheimer's disease one of many contributing factors is a metabolic imbalance that leads to elevated

28 pounding effects of non-climate soil forming factors is a nontrivial challenge that must be overcome

29 The identification of addiction resilience factors is a potential strategy to identify new mechanis

30 Included among these developmental factors is a robust repertoire of signaling proteins, wh

31 etabolism and express regenerative paracrine factors is a strategy to treat vasculopathies and to pro

32 One of its most potent virulence factors is a type III secretion system (T3SS) that injec

33 similar functional demands or environmental factors, is a common phenomenon in the animal kingdom.

34 f the SIX family of homeobox transcriptional factors, is a novel repressor of senescence.

35 be initiated by physiological or atherogenic factors, is a pivotal process in atherogenesis, a disord

36 ear but may have involved three interrelated factors: (i) a Middle to Late Ordovician increase in ava

37 tiation-related transcription factor nuclear factor I-A (NFI-A) controls MDSC expansion during sepsis

38 ike EGF repeat containing (Dner) and nuclear factor I/A (Nfia), that are each heavily expressed in AI

39 We also found that no auxiliary factor is absolutely required for flavinylation, indicat

40 Re-compaction of Von Willebrand factor is accelerated by intramolecular interactions and

41 ming through loss of the FOG-1 transcription factor is accompanied by increased lymphoid output.

42 es reveal that aging, a significant AAA risk factor, is accompanied by segmental infrarenal aortic st

43 This separation factor is achieved within the first minute of contact an

44 ar how functional modulation of H-NS by such factors is achieved.

45 Here we report that NFkappaB transcription factor is activated by misincorporation of amino acid an

46 We show that Von Willebrand factor is activated through a two-step conformational tr

47 ce shows that the burden of behavioural risk factors is affected by socioeconomic position within LLM

48 ation with NAD+, but not with UDP-containing factors, is affected by amino acids of the Rifampicin-bi

49 e observed phenomena, suggesting that a host factor is also important in shaping the community.

50 An adaptive speed factor is also introduced to improve its convergence spe

51 e demonstrated that Esc8, a Sir2-interacting factor, is also required for silent chromatin cohesion.

52 ntial expression of MMP-9 and its regulatory factors is also examined.

53 modeled in animals wherein a single genetic factor is altered, our work provides a biological basis

54 The Escherichia coli Rho factor is an exemplar hexameric RNA translocase that ter

55 The PacC transcription factor is an important component of the fungal ambient p

56 The PacC/Rim101 pH-responsive transcription factor is an important pathogenicity element for many pl

57 RESPONSE FACTOR VII (ERF-VII) transcription factor is an important regulator of osmotic and hypoxic

58 Unexpectedly, the transcription factor is an ortholog of the stomatal regulator AtMUTE,

59 ptors, signal transducers, and transcription factors is an essential regulatory mechanism for immune

60 r endothelial growth factor (VEGF) and other factors is an important cause of diabetic macular edema.

61 pression of key islet-enriched transcription factors is an important mediator of glucotoxicity and li

62 the predictive capacity of traditional risk factors is an understudied area.

63 We find that gene regulation by these two factors is analogous to logic gate systems.

64 tically with the human complement regulators factor I and factor H, promoting inactivation of C3b.

65 tor receptor 1 and lower insulin-like growth factor I and leptin.

66 Insulin and insulin-like growth factors I and II are closely related protein hormones.

67 arely collected for SAM, and so a correction factor is applied instead.

68 PAX7-FOXO1A chimeric oncogenic transcription factor, is associated with poor prognosis and a strong r

69 f RUNX1, a major hematopoietic transcription factor, is associated with thrombocytopenia and impaired

70 ons and Relevance: A range of perinatal risk factors is associated with a higher risk for OCD indepen

71 nce.Deregulation of E2F family transcription factors is associated with cancer progression and metast

72 This 'master regulator' transcription factor is at the top of the hierarchy of the transcripto

73 and phylogenetically conserved transcription factor is both necessary and sufficient to determine sex

74 iscovery of the unique role of Nfic (nuclear factor I C; a transcriptional factor) in controlling roo

75 differentiation with upregulation of nuclear factor I/C (Nfic).

76 nd diacylglycerol-regulated guanine exchange factor I (CalDAG-GEFI), have been reported previously in

77 ndocrine progenitors, demonstrated that this factor is central to the control of the fate through a n

78 mediated proteolysis of Ci/Gli transcription factors is central to Hh signaling, but whether deubiqui

79 n subunit (CfaE) tip adhesin or colonization factor I (CFA/I) fimbraie (positive control) or placebo.

80 1 x 109 colony-forming units of colonization factor I (CFA/I)-ETEC strain H10407 with buffer.

81 CPA factor expression, we see that cleavage factor I (CFI) expression is actually elevated in the la

82 in the complement factor H (CFH), complement factor I (CFI), complement C9 (C9), and complement C3 (C

83 and CPSF7 are known subunits of the cleavage factor I (CFIm) 3' end processing complex; however, CPSF

84 lele-specific manner by binding the Cleavage Factor I (CFIm) complex with distinct affinities for the

85 diseases, assessing the risk due to genetic factors is challenging because it requires knowledge of

86 selective alteration of mobility separation factors is closely linked to existing chemical functiona

87 C3bBb decay-accelerating activity (DAA) and factor I cofactor activity (CA).

88 close linkage between compensatory cis-trans factors is common in spruce.

89 s onto the modeled structure of C3b-Kaposica-factor I complex supported the mutagenesis data.

90 e auxotroph, the production of key virulence factors is compromised, and the ability to infect nemato

91 lasticity accommodated by certain regulatory factors is conserved, despite substantial change in the

92 with Fe(II)aq using published fractionation factors, is consistent with our resulting delta(56)FeNaA

93 The Pet-1 ETS (E26 transformation-specific) factor is continuously expressed in serotonin (5-HT) neu

94 ith combined deficiency of FH and complement factor I, CR2-FH prevented de novo C3 deposition along t

95 body repertoires and genetic and environment factors is critical for basic research and clinical appl

96 ollaborative functions of genome maintenance factors is critical for understanding how genome duplica

97 gh AUXIN RESPONSE FACTOR (ARF) transcription factors, is critical for embryo patterning.

98 Activation of NF-kappaB transcription factors is critically required for Treg cell development

99 The Sox6 transcription factor is crucial for terminal maturation of definitive

100 atory factor X (RFX) family of transcription factors is crucial for ciliogenesis throughout evolution

101 hat of topoisomerase 1, an R-loop preventing factor, is decreased at R-loop-enriched regions of IFNG

102 mbinant human granulocyte colony stimulating factor is demonstrated.

103 The factor is described by a simple linear combination of bu

104 d nongenetic factors but disentangling these factors is difficult.

105 n of NFATc2 with several other transcription factors is DNA-dependent, indicating cooperative DNA bin

106 of the Kruppel-like family of transcription factors, is downregulated in lung cancer cell lines that

107 onsmokers, suggesting that a tobacco-derived factor is driving metastatic progression.

108 n by limiting the diffusion of transcription factors (i.e. removing the unstable intermediate states)

109 also determined the effects of environmental factors (i.e. soil nutrients, moisture, and phenolics) a

110 whether elevation, rather than other spatial factors (i.e. volcanoes, watersheds) structures both spe

111 The influence of two controlling factors (i.e. water content (11%, 35-50%, wet basis) and

112 his study was to identify additional genetic factors (i.e., "second hits") that may contribute to sch

113 ned may reflect differences in physiological factors (i.e., BSA) as well as use of personal care prod

114 and outperforms acclimation of other single factors (i.e., Ea or DeltaS alone); (2) multifactor scen

115 tically in recent years, with driver-related factors (i.e., error, impairment, fatigue, and distracti

116 iate analyses, while adjusted for known risk factors (i.e., gestational age [GA] at delivery, small f

117 d via nuclear reprogramming by transcription factors (i.e., induced pluripotent stem cells, iPSCs) or

118 ed hypermethylation of retinal transcription factors (i.e., PAX6, RAX, SIX6) in a tissue-dependent ma

119 ll interfering RNA, well-studied age-related factors (i.e., rapamycin, resveratrol, TNF-alpha, and st

120 ), adjusting for other potential confounding factors (i.e., socio-demographic factors and medical ins

121 addition, and propagule input) and climatic factors (i.e., temperature) into one seed-addition exper

122 formance is predicted by four person-related factors, i.e. self-efficacy to perform self-management s

123 gate any potential influences of confounding factors, i.e., platform switching design, cement-/screw-

124 Sensing performance factors, i.e., sensitivity, a detection limit and respon

125 that Seb1 associates with 3' end processing factors, is enriched at the 3' end of genes, and binds R

126 d entirely of adult nonlaboratory-based risk factors is equivalent to an approach that additionally i

127 The RpoE sigma factor is essential for the viability of Escherichia col

128 Snail1 transcriptional factor is essential for triggering epithelial-to-mesench

129 lator 1 (Mxr1p), a zinc finger transcription factor, is essential for growth in these media.

130 that Bcl11b, known as a T-lineage commitment factor, is essential for proper expression of ThPOK and

131 ohawk (Mkx), a tendon-specific transcription factor, is essential in mechanoresponsive tenogenesis th

132 ted intimate partner violence (IPV) and risk factors is essential for building evidence-based prevent

133 that deacetylates histones and transcription factors is essential for the rewarding effects of long-t

134 29, the combination of steric and electronic factors is exploited to orient substituents toward S1, S

135 scl3, a basic helix-loop-helix transcription factor, is expressed in the developing OE.

136 nductor lasers, and the linewidth broadening factor is extracted from the residual side-modes, which

137 of Zeeman splitting, from which the Lande g-factor is extracted.

138 activated C3b (iC3b), in a step catalyzed by factor I (FI) and its cofactor, factor H (FH), with or w

139 Serum concentrations of factor H (FH), factor I (FI), C9, and C3 were measured, and C3b degrada

140 The impact of these two factors is further enhanced by high levels of RBM39, who

141 enal tubular dysfunction as a potential risk factor is growing also.

142 re the incidence of perinatal and early risk factors is high.

143 after controlling for g This spatial ability factor is highly heritable (69%).

144 ead-like 2 (GRHL2), a CP2-type transcription factor, is highly expressed in chorionic trophoblast cel

145 tors and show that interaction between those factors is highly polymorphic between species.

146 oreceptor for class 3 semaphorins and growth factors, is highly expressed in vascular cells and myelo

147 -induced epithelial secretion of profibrotic factors is hypothesized to underlie this link, but the i

148 " perforation in CC, in which no instigating factor is identified, is even less common, with only fiv

149 Insulin and insulin-like growth factor I (IGF-I) signal through the scaffold protein ins

150 Disruption of insulin-like growth factor I (IGF-I) signaling is a key step in the developm

151 positively to decreased insulin-like growth factor I (IGF-I) signaling, a pathway also implicated in

152 etal growth by modifying insulin-like growth factor-I (IGF-I) bioavailability.

153 ical recovery, and serum insulin-like growth factor-I (IGF-I) may mediate this effect.

154 In the total population, insulin-like growth factor-I (IGF-I)-enhanced cell cycle entry by >5-fold co

155 en ovalbumin upstream promoter transcription factor I/II.

156 r, recruitment of all TFs, including pioneer factors, is impeded by condensed H3K27me3-containing chr

157 udy further suggests that this transcription factor is implicated in actively restraining the specifi

158 gulfment, and determined that serum response factor is important for MFG-E8 production in myofibrobla

159 However, a systematic exploration of these factors is important for more confident integration of t

160 nderstanding the most important contributing factors is important to improving prediction of and redu

161 ut mutant C3 was less efficiently cleaved by factor I in the presence of factor H, leading to enhance

162 Expression of the Runx1 transcription factor is increased in adult cardiomyocytes after MI; ho

163 Id2, an inhibitor of E protein transcription factors, is indispensable for ILC differentiation.

164 hat DeltaFosB, a highly stable transcription factor, is induced in the hippocampus in mouse models of

165 C-repeat-binding factor (CBF) transcription factors is induced by cold stress, which in turn activat

166 t on an autonomous pathway in which a growth factor is internalized, has its localization regulated b

167 ible by ATRA, this zinc finger transcription factor is involved in modulating other ATRA-inducible ge

168 The Forkhead box C1 (FOXC1) transcription factor is involved in normal embryonic development and r

169 with histone modifications and transcription factors is key to understanding their regulatory and dev

170 Progranulin (PGRN), a pleiotrophic growth factor, is known to play an important role in the mainte

171 p A2 (HMGA2), an architectural transcription factor, is known to regulate mesenchymal differentiation

172 Cooperative binding of transcription factors is known to be important in the regulation of ge

173 NA occupancy of a polymerizing transcription factor is lacking, and such a description would have bro

174 rvation is mirrored by specific postsynaptic factors is largely unexplored.

175 ytic lesions; however, the identity of these factors is largely unknown.

176 , modulation of uptake by microenvironmental factors is largely unstudied.

177 of diseases, the importance of anthropogenic factors is less commonly evaluated.

178 e absence of even a single Fox transcription factor is lethal.

179 tebrates, whereas its role as an adipostatic factor is likely to be a secondary role acquired during

180 daptive immunity together with environmental factors is likely to play major roles.

181 al mechanisms, like allosteric transcription factors, is limited; expanding the set of detectable com

182 , wavefront curvature, and complex coherence factor is measured in the far-field by the SCIMITAR tech

183 ible mechanisms, because this potential risk factor is modifiable.

184 nd degree to which expression of restriction factors is modulated by conditions such as CD4(+) T cell

185 The gene encoding the RUNX1 transcription factor is mutated in a subset of T-cell acute lymphoblas

186 e significantly altered when the controlling factor is mutated.

187 scription factor and the expression of these factors is mutually exclusive because of cross-regulatio

188 nding respiration responses to environmental factors is necessary for improved projections.

189 Identification of early and modifiable risk factors is necessary to advance the screening and interv

190 eath (SCD) in athletes and its precipitating factors is necessary to establish preventative strategie

191 RBBP5 activates core stem cell transcription factors, is necessary and sufficient for self-renewal, a

192 sociocultural, behavioral, and environmental factors is needed to determine their roles in this regar

193 ffects of, cardiovascular disease (CVD) risk factors is needed to develop effective strategies to pre

194 standing of the long-term influence of these factors is needed to prioritise public health investment

195 current temozolomide treatment and molecular factors is needed.

196 The nuclear factor I (NFI) family of transcription factors plays an

197 eficiency virus type 1 (HIV-1), on host cell factors is no more apparent than when the endosomal sort

198 Furthermore, the FoxA1 factor is not associated with detectable footprints at i

199 ssing adverse events beyond traditional risk factors is not clear.

200 inactivation independent of the levels of co-factors is not understood.

201 ic dermatitis (AD) and cardio-metabolic risk factors is not yet established.

202 ed, and the causal relevance of several risk factors is now well established (including, but not limi

203 Enhanced expression of the MYC transcription factor is observed in the majority of tumors.

204 essment (P = 0.003), and insulin-like growth factor I (P = 0.002), and lowered C-reactive protein (P

205 lustering effects revealed that, when impact factor is partialed out, the positive correlation betwee

206 wth factor, insulin, and insulin-like growth factor I, particularly at the parasite surface.

207 /EBPbeta, a key pro-adipogenic transcription factor, is PARylated by PARP-1 on three amino acids in a

208 One of the major factors is phase transformation, with change to more sta

209 The contribution of surgeon-specific factors is poorly defined.

210 transduced to cause the release of relaxing factors is poorly understood.

211 VP35 function is regulated by host cellular factors is poorly understood.

212 nancy, and identification of modifiable risk factors is potentially of great importance for public he

213 evealed that CIA1, but none of the other CIA factors, is predominantly required for (55)Fe/S cluster

214 evaluated in addition to information on risk factors is presented by Risch et al. in this issue of th

215 cal analysis of the most promising virulence factors is presented, highlighting their potential as ta

216 on studies that did not differentiate these factors, ID prevalence was 4-18%.

217 The desired dilution factor is programmed by setting the duration of sample a

218 cally measured and typically unmeasured risk factors, is progressive in its course, and is associated

219 Von Willebrand factor is proposed to be mechanically activated by flow,

220 Inhibition of the insulin-like growth factor I receptor (IGF-IR) is a new therapeutic strategy

221 ceptor beta (Pdgfrb) and insulin-like growth factor I receptor (Igf1r) on T-ALL cells, with concomita

222 l dysfunction induced by cardiovascular risk factors is reduced bioavailable endothelial nitric oxide

223 c regions for activation by lineage-specific factors is regulated in part through dynamic chromatin-n

224 Epidermal growth factor is released from stressed cells and signals to ac

225 rtion losses with a limited degradation of Q-factors is reported.

226 The Escherichia coli sigma70 initiation factor is required for a post-initiation, promoter-proxi

227 The E2f1 transcription factor is required for and sufficient to drive EC endore

228 on expression by the Fork head transcription factor is required for apicomedial accumulation of Rho k

229 The BCL11A transcription factor is required for B cell and plasmacytoid dendritic

230 GATA1 transcription factor is required for murine DC development, and data s

231 costs, and a functional WRKY70 transcription factor is required for the induction of low-cost resista

232 Finally, the pathogen's anthrax lethal factor is required to establish lethal infection, wherea

233 a kidney-enriched zinc finger transcription factor, is required for restoring podocyte differentiati

234 imultaneous and cooperative binding of these factors is required to regulate RNAPII recruitment, the

235 e indicates that the binding of trans-acting factors is required to remodel the tertiary organization

236 Our findings indicate that a combination of factors is required to sensitize these regions.

237 ciological, psychological, and environmental factors is required.

238 ciological, psychological, and environmental factors is required.

239 ase with no structural homology to known MMR factors, is required for mutation avoidance and anti-rec

240 hat the subtle interplay between these three factors is responsible for (i) the formation of non-IPR

241 other pluripotency-associated transcription factors is responsible for maintaining the balance betwe

242 with the hypothesis that a new set of local factors is secreted by the oocyte during ovulation.

243 assays that at least one auxiliary cytosolic factor is specifically required for the efficient packag

244 However, targeting a transcription factor is still challenging.

245 wever, the readable code for recruiting such factors is still not fully defined and how CTD modificat

246 terbalanced by the activity of antisilencing factors is still unclear.

247 regulated by limited availability of growth factors is still unknown.

248 Instead, the CAF-1(chromatin assembly factor I) subunit Cac2 level decreased in the H3K14R mut

249 at the combinatorial activity of these three factors is sufficient to reprogramme developing ectoderm

250 of the fluid, and hence of the mobile repair factors, is sufficient to account for the extent of DNA

251 provide evidence that 1 of the 2 prognostic factors is superior.

252 ains, suggesting that at least 1 stimulatory factor is susceptible to SpeB proteolytic degradation.

253 One example of a system-level factor is the allocation of resources (eg, hospital beds

254 osed mediator, the direct effect of the risk factor is the change in the outcome resulting from a cha

255 The total causal effect of a risk factor is the change in the outcome resulting from inter

256 A critical factor is the correlation of clinical symptoms with magn

257 Another factor is the dearth of standardized laboratory tasks th

258 Here, it is revealed that the limiting factor is the different perovskite film deposition condi

259 In Europe, a key factor is the geography and history of climate change th

260 One such accessory factor is the GTPase EFL1 involved in the cytoplasmic ma

261 A major contributing factor is the lack of biomarkers that can accurately qua

262 However, one major limiting factor is the lack of robust sensors to quantitatively t

263 One factor is the low sensitivity of present-day aerosol to

264 A likely factor is the phylogeographic movement of peoples from t

265 One potential contributing factor is the presence of maternal antenatal helminth in

266 One such factor is the sirtuin (SIRT) family of nicotinamide aden

267 ing of the second-order non-linear structure factor is the source of this contrast and develop a mode

268 A determining factor is the tumor ECM, which strongly influences the e

269 A potentially important confounding factor is the variation in mutation rates between lineag

270 is, for which hyperlipidemia is a major risk factor, is the leading cause of morbidity and mortality

271 ls of circulating PPi, an antimineralization factor, is the sole mechanism of PXE.

272 e, minimizing patient exposure to known risk factors is the best available approach to prevent CRT.

273 Understanding the shape-determining factors is the key for tailoring nanoparticles with desi

274 put a hypothesis that one of the responsible factors is the presence of gastrointestinal inflammatory

275 nt observed with mismatches results from two factors: (i) the complex possesses a 26-fold higher bind

276 the genetic absence or in vitro depletion of Factor I, the enzyme that is essential for the breakdown

277 protein binding partners and other cellular factors is thought to play a major role in defining the

278 known how a 50% reduction of a transcription factor is translated at the cis-regulatory level into a

279 luding glucose, insulin, insulin-like growth factor I, triglycerides, cholesterol, cortisol, and lept

280 The BEL1-like family of transcription factors is ubiquitous in plants and plays important role

281 s and functions of effector fate-determining factors is ubiquitylation.

282 y penetrant obesity, a major additional risk factor, is unclear.

283 lesi cases, but the role of individual-level factors is unclear.

284 ince the last screening, and individual risk factors is unclear.

285 nate with key fate-determining transcription factors is unclear.

286 expression of T helper (TH) lineage-defining factors is unknown.

287 portion of breast cancers explained by these factors is unknown.

288 ssel formation), even if the identity of the factors is unknown.

289 en of SAM with a common incidence correction factor is unlikely to be adequate.

290 hich encodes an elastin-microfibril bridging factor, is upregulated in Fgfr3;4 mutants.

291 e of the most important of such translocated factors is VirF, an F-box protein produced by octopine s

292 in relation to environmental and biological factors is vital for developing management tools for mit

293 ve contributions of cardiac output and other factors is warranted to further elucidate the pathophysi

294 Without regard to these factors, ID was reported in 3-48% of children aged >/=12

295 The Nrf2 transcription factor is well conserved throughout metazoan evolution a

296 The Nrf2 transcription factor is well known for its cytoprotective functions th

297 The Sox2 transcription factor is well known for its roles in the development an

298 nd non-communicable disease behavioural risk factors is well established in high-income countries, bu

299 One frequently mentioned factor is whether duty hours' restrictions (DHR) impleme

300 ice lacking the transcription factor nuclear factor I/X (Nfix).