1 f the pancreas whose etiology is often multi-
factorial.
2 was not determined and is most likely multi-
factorial.
3 A
factorial (
2x2), double-blind, randomized clinical trial
4 This in vitro study comprised 2 parts (both
factorial 4 x 2), with 4 lesion types (erosion, abrasion
5 PSCs remains challenging given complex multi-
factorial actions at different stages.
6 as grown on a sandy loam soil while provided
factorial additions of N and CO2 .
7 Factorial analysis for the peer counselling intervention
8 articipants were determined by using two-way
factorial analysis of covariance with age adjustment.
9 regression, analysis of covariance, two-way
factorial analysis of variance, and continuity-adjusted
10 Data were compared by
factorial analysis of variance, post hoc Tukey, and Pear
11 The data were analyzed by using two-way
factorial analysis of variance.
12 A
factorial analysis was carried out to evaluate the influ
13 In addition, multiple
factorial analysis was performed to explore potential re
14 Considering the 2 x 2
factorial analysis, the 5-year CFS was 76.5% versus 75.0
15 es in the control group in a single flexible
factorial analysis.
16 solidification of organic drop: a fractional
factorial and a central composite design.
17 tion step was performed using two-level full
factorial and Box-Behnken designs, being that a new mult
18 Results from combined
factorial and conjunction analyses indicated that the po
19 isons, some that incorporate noninferiority,
factorial and crossover designs.
20 d by a multivariate approach (two-level full
factorial and Doehlert designs).
21 AD is multi-
factorial and is characterized by two histopathological
22 Statistical analyses were performed by
factorial ANOVA.
23 and protocols to test the SGH, take a multi-
factorial approach that considers variables such as plan
24 A 2 x 2
factorial approach was used to analyze main and interact
25 o) in a randomized, placebo-controlled, full-
factorial,
between-subjects design.
26 Glaucoma is a multi-
factorial blinding disease in which genetic factors play
27 ters were optimized by using a half-fraction
factorial central composite design (CCD).
28 tion were optimised by using a half-fraction
factorial central composite design (CCD).
29 ponse surface methodology, using a 2(3) full-
factorial central composite design.
30 We implemented a fully
factorial climate manipulation of warming (+2.5-3.0 degr
31 Randomized 2 x 2
factorial clinical trial in neonates (>/=36 weeks' gesta
32 We did a 2x2
factorial,
cluster-randomised trial in 185,888 people in
33 The study was a prospective 2 x 2
factorial,
cluster-randomized trial in 467 FT-LBW infant
34 SHINE is a proof-of-concept, 2 x 2
factorial,
cluster-randomized, community-based trial in
35 At each site we implemented a fully
factorial combination of 2.5-3 degrees C warming and 20%
36 Host plants were grown across a
factorial combination of N and P supply rates that creat
37 ns), and Cascades frogs (Rana cascadae) to a
factorial combination of two pathogen treatments (Bd(+),
38 Optimized
factorial combinations have been found to be 0.5mm layer
39 Here we manipulated
factorial combinations of CO2 concentration (two levels)
40 north-central United States were exposed to
factorial combinations of elevated carbon dioxide (CO2 )
41 ore and piscivore over depth and time across
factorial combinations of latitude (0-70 degrees ), turb
42 intended to allow users to search for multi-
factorial combinations of species' omics properties.
43 e cross-link set, we constructed 40,320 (= 8
factorial)
computational models of the TRiC particle, wh
44 A cluster-randomized
factorial controlled trial with two replications was con
45 In a 6-month cluster randomized 2 x 2
factorial controlled trial, with GP as unit of cluster,
46 We used
factorial correspondence analysis to describe categories
47 In a full
factorial crossed design with parental and offspring JA
48 extraction procedure was optimized by a 3(2)
factorial design (%HCl in methanol, temperature, and tim
49 A
factorial design (2(3)) was used to find the optimal QuE
50 A fractional
factorial design (2(7-2)) with a centre point was used t
51 mixtures using MALDI-TOF-MS with fractional
factorial design (FFD) and Pareto optimality.
52 A full
factorial design (FFD) consisting of four independent va
53 adiotherapy was reduced) in a partial 2-by-2
factorial design (results not reported here).
54 A full
factorial design 2(2) (two factors at two levels) with d
55 adding the vectors at two levels (fractional
factorial design 2(VI)) to a de-aromatised aged red wine
56 A
factorial design analysis was carried out to reduce the
57 The method was optimized using a full
factorial design and Doehlert Matrix.
58 3 g/L of drinking water) was determined by a
factorial design and preneoplastic endpoints in chemical
59 ember 2011) in stage III NSCLC using a 2 x 2
factorial design and stratified by histology, positron e
60 The full
factorial design applied to the microwave-assisted extra
61 olives, were investigated by applying a full
factorial design approach (4 oxygen levels x 4 storage t
62 06, and July 31, 2009, and assessed in a 2x2
factorial design between Jan 9, 2010, and Dec 6, 2010.
63 A randomized, 2 x 2
factorial design clinical trial performed in 18 US cente
64 al (RCT) with a completely crossed 2 x 2 x 2
factorial design comprising daily oral 400 mug FA + 100
65 control trial, 3 groupsx4 time points mixed
factorial design conducted from July 2015 to March 2016.
66 Response variables in the full
factorial design consisted of absorption intensity, sign
67 Factorial design directly measures the energetic couplin
68 A
factorial design experiment was conducted and the effect
69 A full
factorial design experiment was defined to develop aqueo
70 multivitamins with selenium vs placebo in a
factorial design for 24 months.
71 d quality and density were varied in a fully
factorial design for a total of eight treatment combinat
72 ure was done in two steps: using a two-level
factorial design for preliminary evaluation of the contr
73 AND PARTICIPANTS: A randomized trial with a
factorial design in Matlab, Bangladesh, of 4436 pregnant
74 HR-CS FAAS) was optimized by applying a full
factorial design in two levels and the response surface
75 A full
factorial design in two levels was applied to evaluate t
76 bo-controlled, multicenter trial using a 2x2
factorial design in which HIV-infected subjects with abd
77 ed, randomized controlled trial with a 2 x 2
factorial design including iron supplements (42 mg eleme
78 ation were determined using a full two-level
factorial design involving the following factors: nitric
79 on step was performed using a two-level full
factorial design involving the following factors: pH of
80 The 2 x 2
factorial design led to 547 patients receiving prednisol
81 Therefore, this 2 x 2 x 2
factorial design manipulated: (1) auditory motion inform
82 ed with 100 mum PDMS fibres according to the
factorial design matrix and desorbed into a gas chromato
83 ibitor and a statin with the use of a 2-by-2
factorial design minimizing differences in baseline char
84 orm was used to implement a three-level full
factorial design of experiments (DOE) optimization for t
85 To this end we used a two-level fractional
factorial design of resolution IV (2(IV)(7-3)).
86 nt, participants were randomly assigned in a
factorial design to 1 of the following 4 groups: placebo
87 ed a blinded, randomized trial with a 2-by-2
factorial design to allow separate evaluation of low-dos
88 We conducted a trial with a 2-by-2
factorial design to assess the benefits of early antiret
89 models with and without eyespots in a 2 x 2
factorial design to avian predators in the field.
90 din anticoagulation were randomized in a 2x2
factorial design to bolus abciximab delivered locally at
91 tion were randomized in an open-label, 2 x 2
factorial design to bolus intracoronary abciximab delive
92 trial 40101 was conducted using a phase III
factorial design to define whether six cycles of a chemo
93 double-blind, randomized trial with a 2-by-2
factorial design to evaluate the effect of treatment wit
94 soluble and ionizable drugs and a 3 x 3 full
factorial design to prepare nine formulations.
95 drome were randomly assigned in a two-by-two
factorial design to receive 600 mg aspirin or aspirin pl
96 f 156 patients were randomized using a 2 x 2
factorial design to receive either a 600-mg (n = 78) or
97 igated MRD in subjects randomized in a 2 x 2
factorial design to receive either high-dose methotrexat
98 6 years) were randomly assigned (1:1:1) in a
factorial design to receive lay counsellor clinic linkag
99 chemotherapy were randomly assigned using a
factorial design to rituximab purging (P+; 375 mg/m(2) o
100 Participants were randomized using a 2 x 2
factorial design to sertraline/placebo and active/sham t
101 lacunar infarcts were randomly assigned in a
factorial design to target levels of systolic blood pres
102 The UK TACT2 trial used a 2x2
factorial design to test two hypotheses: whether use of
103 The study used a
factorial design to test whether erythropoietin would fa
104 ts), placebo-controlled, double-blind, 2 x 2
factorial design trial in which adults with persistent s
105 severe CKD through a pilot, randomized, 2x2
factorial design trial.
106 A fractional
factorial design was employed, and the number of statist
107 A
factorial design was implemented to determine optimal th
108 , placebo-controlled trial that used a 2 x 2
factorial design was undertaken at 2 teaching hospitals
109 A full
factorial design was used to assess the single and inter
110 A two level
factorial design was used to determine the effect of key
111 A 2 x 2
factorial design was used to randomly assign subjects to
112 A 2 x 2
factorial design was used to test two hypotheses: (1) th
113 A quasi-experimental, 3x4
factorial design was used.
114 cesses and eXchanges (LPX) DGVM was run in a
factorial design with fire 'off' or 'on', CO2 at LGM (18
115 We used a 2 x 2
factorial design with the following factors: (i) the pre
116 Microcosms were subjected to a
factorial design with two levels of nutrient-induced div
117 ) were developed and characterized in a full
factorial design with varying levels of montmorillonite
118 ssigned to one of four daily regimens (2 x 2
factorial design) for 12 weeks: milk protein powder and
119 l warming and altered precipitation (in full-
factorial design) on biocrust communities and compared t
120 By using a 2 x 2
factorial design, 2,914 participants were randomly assig
121 According to a 2 x 2
factorial design, 86 overweight/obese individuals with a
122 particulate air filters (n = 2) and, using a
factorial design, acaricide and HDM impermeable bedding
123 f two patch-level resource levels in a 2 x 2
factorial design, allowing us to assay colonization at b
124 ess vs. 12:12 h light:dark cycle) in a 2 x 2
factorial design, allowing us to elucidate potential pat
125 irst question was investigated using a 2 x 2
factorial design, and by spatial overlap analyses of the
126 y reproduction assay to Zn following a 5 x 2
factorial design, comprising five waterborne concentrati
127 In this study with a 2-by-3
factorial design, conducted at 41 clinical centers, we r
128 lacebo-controlled phase 3 study with a 2 x 2
factorial design, conducted in 2006-2012 and enrolling 4
129 As a 2 x 2
factorial design, duration of therapy was also addressed
130 A full
factorial design, including different cycles, probe size
131 A 2 x 2
factorial design, including subliminal/supraliminal expo
132 AN ( 5 lux) for 9 weeks, then paired in full
factorial design, mated, and thereafter housed under dar
133 In a 2 x 2
factorial design, patients were randomized to genotype-g
134 In study 3, with the use of a 2 x 2
factorial design, subjects consumed a maize meal fortifi
135 0 y were randomly assigned, by using a 2 x 2
factorial design, to receive 0.56 mg 5-methyl-tetrahydro
136 pain were randomly assigned, in a two-by-two
factorial design, to target levels of systolic blood pre
137 vestigated such an influence through a 2 x 2
factorial design, using attractiveness (high/low) of the
138 In a 2 x 2
factorial design, visual and auditory feedback on one's
139 Using a
factorial design, we compared gray (GMV) and white (WMV)
140 randomized, double-blind trial with a 2-by-2
factorial design, we compared inhaled racemic adrenaline
141 Applying a
factorial design, we investigated 4 groups of children a
142 In this double-blind study with a 2-by-2
factorial design, we randomly assigned 12,536 patients w
143 In a trial with 2-by-2
factorial design, we randomly assigned 12,705 participan
144 Using a 2-by-2
factorial design, we randomly assigned 1400 adults with
145 Using a 2-by-2
factorial design, we randomly assigned 452 patients to c
146 Using a 2-by-2
factorial design, we randomly assigned 5177 patients at
147 Using a 2-by-2
factorial design, we randomly assigned infants born betw
148 In a trial with a 2-by-2
factorial design, we randomly assigned patients who were
149 For this purpose, two level half
factorial design, which involves 16 experiments, was ado
150 In a
factorial design, with or without adaptation, a single T
151 functionally relevant context using a fully
factorial design.
152 ty of food for Tree Swallow chicks in a full
factorial design.
153 eaxanthin (2 mg) vs placebo were tested in a
factorial design.
154 r doses or weekly for 12 doses using a 2 x 2
factorial design.
155 e we describe a novel generalized fractional
factorial design.
156 f each the factor were assessed using a full
factorial design.
157 roximately 50 mg l(-1) NO3 (-) -N) in a full
factorial design.
158 domly allocated to one of 4 diets in a 2 x 2
factorial design.
159 (1200 mg), both, or neither in a partial 2x2
factorial design.
160 ure or standard dialysate using a two-by-two
factorial design.
161 zed, controlled phase III trial with a 2 x 2
factorial design.
162 nt sex x diagnosis interactions in the 2 x 2
factorial design.
163 3, randomised, open-label study with a 2 x 2
factorial design.
164 a randomized, controlled trial with a 2 x 2
factorial design.
165 A supplementation or placebo in a two-by-two
factorial design.
166 halonil and chlorpyrifos) using a randomised
factorial design.
167 ty acids or placebo with the use of a 2-by-2
factorial design.
168 , infant-nevirapine prophylaxis, or neither)
factorial design.
169 erceived size/distance in these regions in a
factorial design.
170 ntration was determined using a two variable
factorial design.
171 city of extracts were investigated by a full
factorial design.
172 eness, cluster-randomised trial with a 2 x 2
factorial design.
173 Randomized clinical trial with 2 x 2
factorial design.
174 polydextrose or placebo for 50 d in a 2 x 2
factorial design.
175 igated as independent variables in two level
factorial design.
176 nd gradations of natural sunlight in a fully
factorial design.
177 interleukin 15 (IL-15) priming using a 2 x 2
factorial design.
178 Prospective, randomized, 2 x 2
factorial-
design trial with explicit methods (July 1, 20
179 We conducted duplicated
factorial designed experiments producing tangerine tomat
180 Two-level fractional
factorial designs remain the preferred approach due to h
181 ates the potential of generalized fractional
factorial designs to be applied in many other areas of a
182 issues: noninferiority trials, the value of
factorial designs, the importance and challenges of stra
183 on and phase separation were optimized using
factorial designs.
184 pesticide residues were evaluated using 2(3)
factorial designs.
185 on of which employed a sequence of different
factorial designs.
186 nalogous to a fold-over in two-level reduced
factorial designs.
187 urrence of fetal microchimerism to the multi-
factorial development of disease.
188 In this 2 x 2
factorial,
double-blind placebo-controlled trial, 457 le
189 In this randomized, 2 x 2
factorial,
double-blind trial, 2400 infants were randoml
190 , SETTING, AND PATIENTS: A randomized, 2 x 2
factorial,
double-blind, placebo-controlled trial, Timin
191 odian women screened as anemic.In this 2 x 2
factorial,
double-blind, randomized trial, nonpregnant w
192 The randomized two-way
factorial Dressing Study (1,636 patients, 28,931 cathete
193 an interaction effect on growth responses in
factorial eCa x temperature experiments.
194 (2+), Al(3+), Cr(3+), Fe(3+), and Ga(3+)) in
factorial excesses to anthocyanin concentration (0-500x)
195 difficult to combine these approaches due to
factorial expansion in experiments when networks are exa
196 ll-length enzyme (fragments A-D), comprise a
factorial experiment from which we deduce individual and
197 We used a
factorial experiment in mesocosms wherein we crossed hig
198 ape pomace was extracted in hot water, and a
factorial experiment was used to evaluate polysaccharide
199 l exposure system was then applied in a full
factorial experiment with seven exposure levels (7(2)),
200 We show, using a long-term
factorial experiment, that plant diversity loss alters t
201 In a
factorial experiment, the responses of the insect and it
202 olysis period and temperature), three-level,
factorial experimental design (3(2)) was adopted.
203 LDV and SOF were evaluated using a fully
factorial experimental design in the BelloCell system.
204 For this approach we applied a semi
factorial experimental design to identify and quantify t
205 Using a multi-
factorial experimental design we found that growth phase
206 use of growth curve assays with a fractional
factorial experimental design.
207 me, pH and temperature) were optimized using
factorial experimental design.
208 ically important olive varieties with a full
factorial experimental design.
209 o identify the significant factors, two full
factorial experimental designs were built, each containi
210 A fully
factorial experimental manipulation of predator and para
211 Using null-models and meta-analyses of 22
factorial experiments in herbaceous plant communities ac
212 study of grassland species, we used two full
factorial experiments to independently vary SR (one or f
213 nction and highlight the need for long-term,
factorial experiments.
214 A 2 x 2
factorial intention-to-treat analysis with the use of a
215 will help to avoid incorrect conclusions in
factorial interaction studies (genotype x genotype, geno
216 A 32-member fraction
factorial library is designed that simultaneously pertur
217 This is compared to a 64-member full
factorial library just varying expression (0.64 Mb of DN
218 Factorial life-history experiments and reproductive assa
219 were estimated in 2000 participants by using
factorial logistic regression.
220 d simulated predation threat in a two-by-two
factorial long-term experiment.
221 A
factorial MANCOVA was used to detect interactions betwee
222 ommunities of wood-decomposing fungi using a
factorial manipulation of fungivore (Folsomia candida) p
223 Here we use a large-scale
factorial manipulation to assess the extent to which bir
224 cebo and nateglinide versus placebo in a 2x2
factorial manner, with a median follow-up of 6.5 years.
225 In the other matriline, a separate
factorial mating assay of cured and infected spiders dem
226 l infarction) among each group using a 2 x 2
factorial mendelian randomization study design.
227 We used a
factorial mesocosm experiment to investigate how increas
228 In a
factorial model adjusted only for clustering and the vol
229 We performed a
factorial model comparison across a large set of Bayesia
230 pared to a fixation baseline contrast, and a
factorial model with Group as between-subject and Drug a
231 , bidirectional MR, network MR, two-step MR,
factorial MR and multiphenotype MR, are outlined in this
232 although the study also highlights the multi-
factorial nature of changes in exploration and the signi
233 However, the multi-
factorial nature of non-adherent behaviour may explain t
234 In a multicentre, 2x2
factorial,
non-inferiority randomised trial, we enrolled
235 Here, we report results from a standardized
factorial nutrient addition experiment, in which we adde
236 Here we present the results of full-
factorial nutrient amendment experiments conducted at th
237 r seedlings nested within a replicated 15-yr
factorial nutrient enrichment experiment (nitrogen, N; p
238 In this
factorial open-label trial conducted in Uganda, Zimbabwe
239 CALGB 40603 (Alliance), a 2 x 2
factorial,
open-label, randomized phase II trial, evalua
240 the results obtained using traditional full
factorial optimization technique and a TEG configuration
241 l etiologic factor involved in common, multi-
factorial osteoporosis.
242 Thermodynamic cycles use
factorial perturbations to measure coupling energies bet
243 A 2x2
factorial phase 3 randomized clinical trial among 320 pa
244 In this open-label randomised, two-by-two
factorial phase 3 study in 185 institutions in the USA a
245 In our randomised, open-label, 2x2
factorial phase 3 trial (Neo-tAnGo), we enrolled women (
246 Our results support that MPOD is a multi-
factorial phenotype associated with variation in genes r
247 +1.414 refer to axial values, -1 and +1 mean
factorial points and 0 refers to centre point of the des
248 Factorial pragmatic randomised trial, analysed by treatm
249 oil macrofauna, in an experiment with a full
factorial,
random block design.
250 We did this
factorial randomised controlled study at Mulago Hospital
251 MORE CARE was a multicentre, single-blind,
factorial,
randomised controlled trial in urban, semi-ur
252 elease Controlled Evaluation (ADVANCE) was a
factorial randomized controlled trial of blood pressure
253 aneous assessment of several treatments in a
factorial randomized trial.
254 Multicenter, 2 x 2
factorial,
randomized trial of 374 women undergoing surg
255 DESIGN, SETTING, AND PATIENTS: A 2 x 2
factorial,
randomized, injection-blinded, placebo-contro
256 The RECORD was a
factorial RCT that compared vitamin D(3) (800 IU/d), cal
257 and common IBS medications in an exploratory
factorial RCT to test trial procedures and provide infor
258 er change to seasonal LAI increases based on
factorial simulations from 10 state-of-the-art ecosystem
259 Trend analysis, based on process-model
factorial simulations separating effects of climate, CO2
260 The BMA
factorial simulations suggest that eCO2 provides the gre
261 We here describe f-scLVM (
factorial single-cell latent variable model), a method b
262 or response were optimized using a 2(3) full-
factorial statistical design and response surface method
263 a human event-related fMRI study with a two-
factorial stimulus set with 54 images that explicitly di
264 earch could test the generalizability of its
factorial structure in other cultures.
265 This article aims to explore the
factorial structure of the Moral Distress Scale-Revised
266 Principal axis analysis revealed a four-
factorial structure of the RDF items, which mainly resem
267 to explore the Moral Distress Scale-Revised
factorial structure.
268 d to evaluate its psychometric qualities and
factorial structure.
269 We undertook a double-blind, randomised
factorial study at three UK hospitals, between Sept 6, 2
270 ated to have left lateral MIL ablation (2 x2
factorial study design).
271 r in combination, following a 2-factor, full-
factorial study design.
272 DESIGN Prospective, randomized,
factorial study design.
273 and copper (Cu) were assessed by applying a
factorial test design.
274 ponse surface methodology, coupled to a full
factorial three-level experimental design, was applied t
275 d, placebo-controlled, parallel group, 2 x 2
factorial trial (CEQUEL), patients with DSM-IV bipolar d
276 The TRAPEZE trial is a 2 x 2
factorial trial comparing docetaxel alone or with ZA, Sr
277 Randomized, attention-controlled, 2 x 2
factorial trial conducted from February 2009 through Nov
278 We used a 2-by-2
factorial trial design to randomly assign patients who w
279 Using a 2-by-2
factorial trial design, we randomly assigned 10,010 pati
280 We performed a 2x2
factorial trial of 104 patients with IBS (18-65 years ol
281 dy to CALGB40603, a randomized phase II, 2x2
factorial trial of neoadjuvant paclitaxel +/- carboplati
282 We conducted a 2-by-2
factorial trial of the effects of atorvastatin (80 mg da
283 and August 29, 2014, a randomised 2 x 2 x 3
factorial trial recruited 6- to 23-month-old children wi
284 NSABP B-40 was a 3 x 2
factorial trial testing whether adding capecitabine or g
285 A 2 x 2
factorial trial was performed to determine the efficacy
286 METHODS AND In the ARROW
factorial trial, 1,206 children initiating ART in Uganda
287 In a 2-by-2
factorial trial, children with iron deficiency (ID) (n =
288 a randomized and unblinded 2 x 2 sequential-
factorial trial, composed of an induction arm (part 1) c
289 In this randomised, 2 x 2
factorial trial, publicly available databases were used
290 fied Release Controlled Evaluation (ADVANCE)
factorial trial, the combination of perindopril and inda
291 In this 2 x 2
factorial trial, we enrolled patients with histologicall
292 In one comparison from a 2-by-2
factorial trial, we randomly assigned 12,705 participant
293 In one comparison from a 2-by-2
factorial trial, we randomly assigned 12,705 participant
294 In this blinded 2-by-2
factorial trial, we randomly assigned 1223 critically il
295 the covariance matrix was used to determine
factorial validity for the Timeline-acute/chronic, Conse
296 We tested this hypothesis in a full-
factorial warming (+4 degrees C above ambient) and alter
297 tudy of California grassland exposed to full-
factorial warming, added precipitation, elevated CO2, an
298 plex and persistence mechanisms likely multi-
factorial,
we previously observed associations between b
299 Genetically, SSc is multi-
factorial with many genetic risk loci for SSc generally
300 s of schizophrenia is considered to be multi-
factorial,
with likely gene-environment interactions (GE