ライフサイエンスコーパス: factory

1 intly contribute to a local 'gene expression factory'.

2 rtment that we call the 'V(D)J recombination factory'.

3 ve genes to congregate in discrete 'NFkappaB factories'.

4 nt from, appropriate transcription sites or 'factories'.

5 in a VLS functioning as a virus replication factory.

6 organized for processing at each replication factory.

7 ong enough to allow re-initiation in another factory.

8 e enough to be present on the surface of one factory.

9 presents part of the core of a transcription factory.

10 he recently proposed mammalian transcription factory.

11 sister forks act within a fixed replication factory.

12 equired for the formation of the replication factory.

13 aryotic model and widely used microbial cell factory.

14 reventing formation of the viral replication factory.

15 ments for the formation of viral replication factories.

16 effect on established membranous replication factories.

17 ution to viral replication and transcription factories.

18 entirely replicate within cytoplasmic virion factories.

19 of bromodeoxyuridine into viral replication factories.

20 virions within assembly sites of cytoplasmic factories.

21 atial organization and composition of repair factories.

22 ATAD5 regulates the lifespan of replication factories.

23 er relatively stably to maintain replication factories.

24 the GpSGHV-induced colony collapse in tsetse factories.

25 vely recruit origins to emergent replication factories.

26 consistent with their sharing transcription factories.

27 nes are transcribed in analogous specialized factories.

28 hock treatment, which disrupts transcription factories.

29 calized with virion membrane proteins in the factories.

30 leus, genes are transcribed in transcription factories.

31 rescent membranes, occurs within cytoplasmic factories.

32 entiated rhizobia effectively become ammonia factories.

33 recursors of immature virions in cytoplasmic factories.

34 d function of organelle-like RNA replication factories.

35 gins to initiate within existing replication factories.

36 tion of beta-globin in nuclear transcription factories.

37 ories, thereby reducing the number of active factories.

38 d that viral RNA is synthesized within viral factories.

39 elf-synthesising and self-repairing chemical factories.

40 ear protein, and it localizes to replication factories.

41 limited number of specialized transcription factories.

42 ites, where the protein surrounded the virus factories.

43 e for the construction of microbial chemical factories.

44 ther than recruitment of DNA to pre-existing factories.

45 ns is restricted to pre-existing replication factories.

46 what others have described as transcription factories.

47 viral membranes form de novo in cytoplasmic factories.

48 give structures reminiscent of transcription factories.

49 s and thus represent specialized translation factories.

50 at appear to function as viral transcription factories.

51 th the viral E3 protein in cytoplasmic viral factories.

52 psid assembly, functioning as viral assembly factories.

53 itecture and biogenesis of viral replication factories.

54 ike structures, designated viral replication factories.

55 consistent with expression via transcription factories.

56 ould broadly facilitate design of novel cell factories.

57 ome occurs in cytoplasmic membrane-delimited factories.

58 x work (329 [32%]), fishing (275 [27%]), and factories (136 [13%]).

59 Infected MDMs formed VACV factories, actin tails, virion-associated branching stru

60 The inhibition of new factory activation by ATR/Chk1 therefore redirects repli

61 ifferentially effect replication initiation, factory activation, and progression through the timing p

62 Virus factories actively producing virus capsids on their surf

63 specific cellular protein complexes to these factories aids efficient and controlled viral replicatio

64 ifferent operational procedures in the dairy factories along the DL processing.

65 is concentrated into transcription foci or "factories," analogous to the eukaryotic nucleolus, indic

66 ways to synthesize products using microbial factories and can pinpoint the contributions of microorg

67 The meristems are the factories and cells that are left behind will expand and

68 L2 was detected in tubular membranes outside factories and inside factories near crescents and close

69 tes with the super-activation of replication factories and loss of temporal continuity in the replica

70 lular RNA polymerase II was trapped in these factories and served to transcribe viral genomes, which

71 that these foci represent viral replication factories and that a cellular DNA damage response is act

72 naling intermediate Syk to cytoplasmic viral factories and this recruitment requires the mu2 ITAM.

73 ing to reveal the relationship between virus factories and viroplasm and the cellular structures that

74 d male smelter workers from an Mn-iron alloy factory and 23 gender- and age-matched controls were rec

75 anspoviron replicates within the giant virus factory and accumulates in high copy numbers inside gian

76 gated all workers (9) employed by a cosmetic factory and exposed to argan powder to identify possible

77 oteins that are synthesized within the virus factory and lack COPII or other binding sites that enabl

78 ATAD5-mediated regulation of the replication factory and PCNA required an intact ATAD5 ATPase domain.

79 e extruded promoter is tethered close to the factory and so likely to re-initiate; later, the tether

80 enes with nuclear speckles or transcription "factories", and association of transcriptionally repress

81 lizes to ER-associated inclusions, the viral factories, and along microtubules before it is finally d

82 ructures, engineering the metabolism of cell factories, and analyzing human diseases is discussed.

83 of such optimally scheduled self-replicating factories, and find it has a universal form-log-Frechet,

84 Reovirus replicates in cytoplasmic viral factories, and there is no evidence that reovirus genomi

85 stant DNA segments to a common transcription factory, and the data provide a model for long-range all

86 ious work showed that at least some of these factories are tethered to nuclear pores.

87 Instead, factory areas of the cytoplasm contained large, electron

88 lities for designing complex micrometer-size factories as well as new biomimetic systems.

89 ere we show that H5 localizes to replication factories, as visualized by immunofluorescence and immun

90 Modern-day factory assembly lines often feature robots that pick up

91 rocess utilized by CVB for viral replication factory assembly, and depletion of RIP3 inhibits autopha

92 structures which surround the VV replication factories at an early stage of the nonproductive infecti

93 me active by moving to contact transcription factories at nuclear substructures; our previous work sh

94 addition, MVs were shown to move from viral factories at speeds consistent with microtubular transpo

95 oximity through sharing the same replication factory at a similar time.

96 transcription within a common transcription factory become stabilized by antitopoisomerase II drugs

97 3, A14, D8, and H3 did not localize to viral factories but instead accumulated in the secretory compa

98 nor colocalization to one tiny transcription factory but arises as a result of the known clustering o

99 f ATAD5 extended the lifespan of replication factories by retaining proliferating cell nuclear antige

100 a, we isolate and analyse the RNA content of factories by sequencing.

101 mone, using Nicotiana benthamiana as a plant factory, by transient expression of up to four genes cod

102 that it is carried out in fixed "replication factories." By tracking the progression of sister replic

103 nsistent with a polymerase immobilized in a 'factory' capturing a promoter and reeling in the templat

104 In factory cells, the accumulation of misfolded protein pro

105 delayed until early S phase and occurred in factories characterized by the absence of cellular DNA a

106 ents from an inspection database of Shanghai factories collected between 1954 and 2000.

107 e of the reported diameter of "transcription factories." Colocalization measurements of RNAP II molec

108 aspase treatment to release multi-megadalton factory complexes.

109 ganized at discrete sites called replication factories, consisting of DNA polymerases and other repli

110 sis to assemble morphologically normal viral factories containing functional replicase complexes.

111 PWS-IC and its target genes to transcription factories containing NRF's and YY1.

112 ther transcription occurs in discrete sites (factories) containing the required machinery and whether

113 e oven workers), medium PAH exposures (steel factory control workers), and low PAH exposures (volunte

114 hese studies indicate that viral replication factories could end up in the phloem and the xylem.

115 ountries each having one known solid cyanide factory: Czech Republic, Germany, and United States.

116 ith erythroid differentiation: Transcription factories decrease in number and contract toward the nuc

117 Focal assembly of "viral transcriptional factories" decreased the pool of cellular RNA polymerase

118 g new carbon capture technology or as a cell factory dedicated to formic acid production, which is a

119 e validation process revealed that autoclave factory default settings are potentially ineffective for

120 Cellular DNA replication factories depend on ring-shaped hexameric helicases to a

121 ORF29p in nuclear transcription/replication factories during lytic replication of VZV.

122 irion membrane proteins in viral replication factories during normal VACV replication.

123 Yeast cell factories encounter physical and chemical stresses when

124 Factories exchange components with the soluble nucleopla

125 Experts identify more affordable unit cost, factory fabrication, and shorter construction schedules

126 tein, its large-scale production by means of factory farming is a major driver of biodiversity loss,

127 ers who had worked in metal mines or pottery factories for at least 1 year from January 1, 1960, to D

128 is now clear that they are more than simply factories for Ig production, and they also play key role

129 xification) organelles or as artificial cell factories for in situ biocatalysis.

130 0% of the cells differentiate into anaerobic factories for nitrogen fixation (heterocysts), requires

131 developed genetic variants of microbial cell factories for production of biochemicals has been rapidl

132 th the objective to construct efficient cell factories for protein secretion.

133 haromyces cerevisiae is among preferred cell factories for recombinant protein production, and there

134 a glandular trichomes and their potential as factories for the production of novel alternate sesquite

135 etabolic engineering of pathways in cells as factories for the production of simple compounds such as

136 e a generalized approach to engineering cell factories for valuable metabolites production.

137 ls the interior of infected cells to build a factory for assembling new infectious particles (virions

138 suggests that KSHV assembles an "all-in-one" factory for both gene transcription and DNA replication.

139 ty to use this model organism as a microbial factory for production of selenium nanoparticles.

140 symbiont with a tiny genome that serves as a factory for the production of tyrosine.

141 of A. flavus gradually evolved into a "cell factory" for enzymes and metabolites involved in the sac

142 ize into functionally defined aggregates or 'factories' for transcription and DNA replication.

143 Virally induced structures called viral factories form throughout the cytoplasm of cells infecte

144 as normal at viral gene expression and viral factory formation, but it was defective for proteolytic

145 HPV replication factories formed in the nucleus are locations where vira

146 scribe a protocol for the isolation of large factory fragments under isotonic salt concentrations in

147 ion gratings, and a dynamic surface template/factory from which various static micropatterns can be m

148 the conceptual ideas of how marine carbonate factories function both today and in the past.

149 Some factories further specialize in transcribing responsive

150 ng of cyanobacteria to create efficient cell factories has been impaired by the cumbersome genetic to

151 Microbial factories have been engineered to produce lipids from ca

152 Transcription factories have been proposed as one mechanism by which g

153 of the hGH locus with polymerase II (Pol II) factories, histone acetylation at the hGH-N promoter, an

154 andful of genes have evolved into sequencing factories identifying thousands of variants of known and

155 Pase, SLIP-GC, that localizes to replication factories in B cells and that, when reduced, induces DNA

156 and E3 colocalized within cytoplasmic viral factories in cells infected with a decapping enzyme muta

157 of a cohort of 14,008 chemical workers at 6 factories in England and Wales, covering the period 1941

158 tion is restricted to poxvirus or alphavirus factories in infected cells.

159 kers at two melamine tableware manufacturing factories in Taiwan (16 manufacturers, eight grinders, t

160 aintain a large number of unique biochemical factories in the form of singular plastids might be a ke

161 ic enzymes and are used as protein-producing factories in the industrial biotechnology sector.

162 , we re-evaluate the models of transcription factories in the light of recent and older data.

163 ainst a prevalent existence of transcription factories in the mammalian nucleus as previously propose

164 d localization of gene loci to transcription factories in the nucleus.

165 lication and, thus, the possibility of virus factories in this region.

166 regated RNA polymerases termed transcription factories in three-dimensional nuclear space.

167 Indeed, by up-grading treatment plants to factories in which the incoming materials are first deco

168 lymerases (pols) co-localize in 'replication factories' in vivo after cells are exposed to ultraviole

169 e thought of as a highly sophisticated micro factory: in a pool of billions of molecules - metabolite

170 Intriguingly, the CaMV-induced virus factory inclusions seem to protect against autophagic de

171 n of the membranous web, the HCV replication factory, independent of RNA replication.

172 nelles and highlight research on perinuclear factories induced by the nucleocytoplasmic large DNA vir

173 d interactions, most likely at transcription factories, initially compact the Igh locus, bringing dis

174 eins around the peripheries of virus-encoded factories, interrupting the normal formation of SGs.

175 nucleic acid from the interior of the virus factory into the nearly completed capsids.

176 We show that the formation of replication factories is a consequence of DNA replication itself.

177 mation of viral membranes within cytoplasmic factories is a mysterious, poorly understood first step

178 However, making cells into efficient factories is challenging because cells have evolved robu

179 e show that the grouping of replicons within factories is highly variable from cell to cell.

180 doption in more complex environments outside factories is their fragility.

181 Water used in a food factory is frequently disinfected with chlorine, which o

182 al and spatial regulation of the replication factory is important for efficient DNA replication.

183 y of starch to solubilise across a sugarcane factory is largely limited by increased Brix values.

184 likely mediated by a stationary replication factory, is accompanied by rapid, directed migration of

185 mpartment long regarded as the cell ribosome factory, is emerging as an important player in the regul

186 lized the ultrastructure of DNA replication 'factories' labeled with GFP-proliferating cell nuclear a

187 f pedogenic clay minerals (the "clay mineral factory"), leading to increased marine burial of organic

188 of the TC-muNS fusion proteins to form virus factory-like (VFL) structures and colocalize with virus

189 M and RGG domains of G3BP1 for maximal viral-factory-like structure (VFL) localization and sigmaNS as

190 th VFs in infected cells and also with viral factory-like structures (VFLs) formed by ectopically exp

191 lls, MRV nonstructural protein microNS forms factory-like structures very similar in appearance to vi

192 tion of these viral proteins or particles at factory-like structures.

193 The viral transcriptional factories localized with replicating viral genomic DNAs.

194 sex, caste, standard of living, occupation, factory location, leisure time physical activity, daily

195 As such, they qualify as true cell factories, making them interesting targets for metabolic

196 Thermostable enzymes and thermophilic cell factories may afford economic advantages in the producti

197 that bacterial DNA replication occurs via a factory mechanism in which unreplicated DNA is spooled i

198 e results provide new support for the pol II factory model, in which an immobilized polymerase molecu

199 According to the transcription factory model, localized transcription sites composed of

200 gation occurs, consistent with a replication factory model.

201 Transcription or "replication factory" models [2], in which polymerases remain fixed w

202 protein clusters analogous to transcription factories, multiscale loops, and intrachromosomal contac

203 bular membranes outside factories and inside factories near crescents and close to the edge or rim of

204 This allowed us to visualize replication factories, nuclear foci consisting of replication protei

205 al distinctive nuclear bodies believed to be factories of DNA or RNA processing and sites of transcri

206 Ribosomes, the protein factories of living cells, translate genetic information

207 Ribosomes are the protein synthesizing factories of the cell, polymerizing polypeptide chains f

208 in biogenesis and maintenance of replication factories of this virus family.

209 Designing an optimal microbial cell factory often requires overexpression, knock-down, and k

210 pronounced colocalizations in transcription factories, often near the nuclear periphery, and display

211 elongation without disrupting transcription factories once they are established, but the looping is

212 e subcellular microenvironments called virus factories or 'viroplasm'.

213 ific intracellular compartments called virus factories or virioplasm.

214 le biomass grown from animal stem cells in a factory, or carnery.

215 fundamental principles promoting replication factory organization in budding yeast, but also provides

216 at defects in the disassembly of replication factories persist after S phase is complete.

217 were ascertained for all study subjects from factory personnel records or interviews.

218 Replication factories play important roles in coordinating replicati

219 ATAD5 regulates the cycle of DNA replication factories, probably through its PCNA-unloading activity.

220 The development of virus factories proceeded over 3 to 4 h postinfection and resu

221 tory-scale system were representative of the factory process.

222 Hence, we verify that transcription factories produce most nascent RNA and confer a regulato

223 among susceptible competitors, which become factories producing more phage.

224 ces of genomes are now produced in automated factories purified proteins are not, because their behav

225 DA Starch Research method as a reference and factory raw sugars, the impact of colourants on the accu

226 viruses, forms within a discrete cytoplasmic factory region.

227 as the distribution of origins within active factories remained relatively normal.

228 ith hyperphosphorylated Pol II transcription factories require the locus control region (LCR).

229 this analysis, we propose that transcription factories result from the aggregation of RNA polymerase

230 ractions reveals that sequencing of purified factory RNA maps the complete nascent transcriptome; it

231 cruited into RNA polymerase II transcription factories (RNAPII-Ser5) and that ETO and RUNX1 genes are

232 This method was validated using factory samples and found applicable to sugarcane and sw

233 Certain cell types function as factories, secreting large quantities of one or more pro

234 ontamination with M chimaera at the LivaNova factory seems a likely source for cardiothoracic surgery

235 the sort; however, iterative rounds of "cell factory" selection were required for the high-Env phenot

236 m climate conditions until the decarbonation factory shut down with the collision of Greater India wi

237 We conclude that factories specialize in producing a particular type of t

238 rise from membrane-enveloped RNA replication factories (spherules) containing VSV G protein that are

239 ructures very similar in appearance to viral factories, suggesting that it is involved in forming the

240 The first feature to appear on a virus factory surface when a new capsid is born is the center

241 These factories take the form of vesicles that contain viral R

242 N protein was detected in viral replication factories termed inclusion bodies (IBs).

243 he discrepancy between emissions observed in factory tests and 'real world' scenarios.

244 of hyperphosphorylated Pol II "transcription factories" (TFys).

245 y, which comprises a highly organized virus "factory." TGB1 is both necessary and sufficient to remod

246 that these genomes accumulate in cytoplasmic factories that are delimited by membranes derived from t

247 hich occurs in clusters called transcription factories that are reminiscent of the dense phase charac

248 ing genes to be transcribed to protein-dense factories that contain all factors necessary for transcr

249 bly often occur in virus inclusions or virus factories that form at pericentriolar sites close to the

250 n expression and function act to produce the factories that power the viral replication cycle.

251 active templates concentrated in only a few factories that transcribe particular units depending on

252 t also needs an efficient and well-organized factory that is responsible for the fidelity and quality

253 interpretation of nuclear RFi as replication factories, that is, the complex entities that process mu

254 ic chaperone function for Hsc70 within viral factories, the sites of reovirus replication and assembl

255 to isolate RNA associated with transcription factories, the sites responsible for the majority of nuc

256 l machinery to establish a virion production factory, the cytoplasmic virion assembly complex (cVAC).

257 Much like a factory, the endoplasmic reticulum (ER) assembles simple

258 inhibiting the activation of new replication factories, thereby reducing the number of active factori

259 amolecular complexes known as 'transcription factories.' These complexes are difficult to isolate bec

260 rotein synthesized within these "translation factories." This mRNA clustering is dependent on MT, reg

261 ted: DNA or chromatin loops are tethered to "factories" through the transcription machinery-a polymer

262 desired membrane transport proteins in cell factories to achieve the export or import of substances

263 ability of recombinant vaccines to serve as factories to produce recombinant antigens to induce the

264 m the endoplasmic reticulum within the virus factory to nascent viral membranes and demonstrated that

265 ive pathway from ER domains within the virus factory to the viral membrane.

266 that revealed intranuclear sun-shaped capsid factories, tubules, various stages of capsid formation,

267 eplicons dynamically organized a replication factory using live-cell imaging and investigate how repl

268 urities for matching a cyanide sample to its factory using our current cyanide stocks.

269 large inclusion-like structures called viral factories (VFs) in which assembling viral particles can

270 encoded cytoplasmic structures, termed virus factories (VFs), where viral transcription, translation,

271 s, mammalian orthoreovirus (MRV) forms viral factories (VFs), which are sites of viral transcription,

272 Fusarium was not recovered from the factory, warehouse, solution filtrate, or unopened solut

273 sed in 2012 from three different fruit juice factories was investigated.

274 By 1992 the first 'sequencing factory' was established, and others soon followed.

275 n of higher-order structures or replication "factories." We show that the key replication enzyme of f

276 cell imaging and investigate how replication factories were structured using super-resolution microsc

277 Nuclear replication factories were visualized with confocal immunofluorescen

278 a wood-related industrial area, and a steel factory were 48, 160, and 1400 ng/g d.w., respectively,

279 herefore redirects replication toward active factories where forks are inhibited and away from region

280 rions (MVs) predominantly localized in viral factories where virions were assembled.

281 equipped anywhere such as a laboratory or a factory where the VOCs are either used or produced and o

282 ymerases become immobilized in transcription factories, where they reel in their templates.

283 tes located downstream from a pharmaceutical factory, where reproductive alterations in wild fish hav

284 a change in the number of active replication factories, whereas the distribution of origins within ac

285 tive polymerases cluster into transcription 'factories', which, inevitably, loops the intervening DNA

286 ssociated stochastically to form replication factories, which was validated by independent microscopy

287 n multiple puncta throughout the interior of factories, which were surrounded by endoplasmic reticulu

288 taneously aggregate to form transcriptional "factories," which recruited a significant fraction of ce

289 ociated with each other within a replication factory while the entire replicon is replicated.

290 Cancer cell line factories will facilitate the creation of a cancer depen

291 s led to an increase of inactive replication factories with an accumulation of replisome proteins.

292 rved colocalization of viral transcriptional factories with replicating viral genomic DNA suggests th

293 Glandular trichomes are metabolic cell factories with the capacity to produce large quantities

294 scovered that A11 colocalized in cytoplasmic factories with the endoplasmic reticulum (ER) and L2, an

295 usiness professionals had low mortality, and factory workers and garment trade workers had high rates

296 ng-pair design, the authors surveyed migrant factory workers and their spouses from 4 cities in India

297 mong professionals/administrators than among factory workers, with intermediate levels for other occu

298 ears [95% CI 593-809]), and housekeeping and factory workers.

299 nuclear cells (PBMC) of a population of shoe-factory workers.

300 Individual transcription factories would thus incorporate tissue-specific, co-reg