ライフサイエンスコーパス: fail

1 diately available to revise shunts when they fail.

2 o retrieval, where standard techniques often fail.

3 conditions when unfamiliar face recognition fails.

4 e., 217 degrees C) where pristine PEI almost fails.

5 the anterior-posterior body axis frequently fails.

6 lex process that can lead to disease when it fails.

7 reening programs and antibiotic therapy have failed.

8 ous attempts to explain this phenomenon have failed.

9 s in patients for whom prior AML therapy had failed.

10 rtunity to submit new data for scanners that failed.

11 When standard retrieval techniques failed, advanced techniques were used; this was necessar

12 The environment of the failing and infarcted myocardium drives resident and tra

13 was compromised, cytokinesis was delayed or failed, and 50% of embryos died during development.

14 k patients with degenerated bioprostheses or failed annuloplasty rings, but mitral ViR was associated

15 infected with HIV in whom first-line ART had failed (assessed by WHO criteria with virological confir

16 Prey that do not elicit takeoff generally fail at least one of the criterion, and the loss of prey

17 hom GRE examinations were considered to have failed because of low SNR, the SNR and confidence level

18 e mid-infrared and long-wavelength infrared, failing beyond, roughly 2.5 mum, our generalization of t

19 heter aortic valve replacement (TAVR) within failed bioprosthetic surgical aortic valves has shown th

20 r high-temperature application but generally fail by early cracking with limited plasticity at room t

21 ntaining adult FOXA2-deleted mice, pregnancy failed by day 10 in neonatal FOXA2-deleted mice lacking

22 ho are eligible for HSCT have typically been failed by most approved therapies, have undergone multip

23 e NaV1.5 proteins purified from adult WT and failing CaMKIIdeltac-overexpressing (CaMKIIdeltac-Tg) mo

24 ealthy cells undergo while transforming into failing cells.

25 and mice, while its absence in mice leads to failed chorioallantoic fusion and death at embryonic day

26 We propose that a combination of failed clearance and exaggerated release of glutamate by

27 However, a long history of failed clinical trials has demonstrated that broad-spect

28 Ps have reduced localization efficiencies or fail completely.

29 ment with reported fractographic analyses of failed crowns.

30 outine metabolic imaging with [(18)F]FDG-PET failed due to low standard uptake values and low contras

31 230 initiated dialysis with a catheter after failed fistula placement.

32 This shift was also observed in human failing heart biopsies in comparison with nonfailing con

33 A failing heart differs from healthy hearts by an array of

34 ocaine autoradiography to determine that the failing heart has 30% lower SCN5A levels - the first ev

35 a 30% loss in levels of NAD(+) in the murine failing heart of both DCM and transverse aorta constrict

36 SCs) is an emerging therapy for treating the failing heart.

37 stabilizing myocardial NAD(+) levels in the failing heart.

38 or lipoxygenases attenuated mPTP opening in failing hearts.

39 Explants from healthy and failing human hearts were compared using radiocaine auto

40 ning OM-induced modulation of XB behavior in failing human myocardium are unclear.

41 ed the Ca(2+)-induced opening of the mPTP in failing human myocardium, and the highly selective pharm

42 a wide range of situations of successful and failed immune surveillance.

43 l one: They cause the Lindemann criterion to fail in 2D in the sense that the mean squared displaceme

44 effective against glioblastoma but generally fail in brain metastases of breast cancer.

45 Both mechanisms fail in CFTR(-/-) swine, suggesting that cystic fibrosis

46 o demonstrate why common textbook approaches fail in describing this important class of materials.

47 drug is a leading cause for the patients to fail in long term therapy post-surgery.

48 gation and that such an efficient system can fail in some circumstances and give rise to disease.

49 necrosis factor (TNF) antagonist (which had failed in 96 [79%]).

50 Two NDIs failed in one patient versus four SDIs in four patients

51 a long and difficult course with 3 compounds failing in phase III clinical trials.

52 odendrocytes to (re)generate myelin and that failed interactions with neighboring cells or factors in

53 nary disease: OR 1.65; cancer: OR 1.23; weak/failing kidneys: OR 2.29; diabetes: OR 1.56; hepatitis:

54 as inhibitors for clinical use have thus far failed, largely because of a lack of adequate small-mole

55 eater knowledge of why CMV infection usually fails may provide insight into how to prevent it from su

56 ntriguingly, formation of giant cells due to failed mitosis/cytokinesis is common in the blastomere s

57 Low SES individuals' plans fail more frequently because they operate close to budge

58 NOD1 was examined in human failing myocardium and in a post-myocardial infarction (

59 In failing myocardium, confocal laser microscopy revealed a

60 If treatment fails, notable changes occur in the DSC profile of NSCLC

61 s and third-line treatments for patients who fail or who do not tolerate the sequence of sorafenib an

62 BLAST jobs that hitherto failed or slogged inefficiently to completion now finish

63 rst, a catheter after a fistula placed first failed, or a catheter placed first (n=90,517; reference

64 patients with recalcitrant chronic itch that failed other immunosuppressive therapies markedly improv

65 Patients with functional kidney but failed pancreas allografts after 90 days were included.

66 complex anatomy, hemodynamic instability, or failed percutaneous coronary intervention.

67 e (GAA)n repeat expansions in vivo, implying failed phosphate-steering promotes an unanticipated lagg

68 Treatment options for patients who failed previous DAA-containing regimens, particularly th

69 are of the potential risks of CE including a failed procedure, capsule retention, or a missed lesion.

70 ed the literature based on whether normal or failing rat heart models were used.

71 empirical findings, which includes multiple failed replications of classic expectancy studies, meta-

72 ulates LCRs and Ca transient decay to insure fail-safe pacemaker cell operation within a wide range o

73 hese coordinated signaling pathways ensure a fail-safe system to prepare the oocyte for fertilization

74 86 patients failed screening and 313 remaining patients were randoml

75 te 13-O-desmethyl tacrolimus for AUC, but it failed the EMA criterion.

76 ified in NS3 from GT1a-infected patients who failed therapy with grazoprevir (in combination with elb

77 a patient, highly effective chemotherapy can fail, threatening patient health and lifespan.

78 fer an explanation as to why EGFR inhibitors failed TNBC patients and support how combining a select

79 ding coral health into the future, but often fail to account for the complex ecological and biogeoche

80 ce and assemble new species' genomes de novo fail to achieve the ultimate endpoint to produce contigs

81 Aged CPCs fail to activate mitochondrial biogenesis and increase p

82 MuSh and the CWI pathways are deleted, cells fail to adapt to compressive stress, and all cells lyse

83 ppress inflammation and symptoms of ACD, but fail to address the underlying immune dysfunction.

84 Traditional treatments for breast cancer fail to address therapy-resistant cancer stem-like cells

85 nsmission, such loss-of-function experiments fail to adequately distinguish between the roles played

86 hrenia, current treatment strategies largely fail to ameliorate these impairments.

87 omplete absence of liver invasion as mutants fail to attach to host cells.

88 one-third of newly diagnosed epilepsy cases fail to become seizure-free in response to antiseizure d

89 However, most monitoring systems fail to capture these small scale variations.

90 the latest replicating regions occasionally fail to complete endoreplication, resulting in underrepl

91 Folr1-deficient neural plate cells fail to constrict, resulting in widening of the neural p

92 vent the progression of liver diseases, they fail to cure the viral infection.

93 Such cements remain in the tooth and fail to degrade and thus normal mineral volume is never

94 ter significant injury has already occurred, fail to detect chronic subclinical inflammation that can

95 t methods commonly employed in the field may fail to detect or else conflate generalization that mani

96 EIC peaks that they do and in what ways they fail to detect real compounds.

97 Standard proteomics protocols fail to detect them as d/l substitutions do not affect t

98 c (HbA1c)/fasting plasma glucose (FPG) alone fail to diagnose or miscategorize up to 40% of individua

99 nic stem cells with deletion of EZH1 or EZH2 fail to differentiate into ectoderm lineages.

100 Pre-osteoblasts fail to differentiate leading to severe intramembranous

101 sion bottleneck sizes, whereas other methods fail to do so.

102 found that known membrane insertion pathways fail to effectively engage tail-anchored membrane protei

103 ecruit PI3K activity like the wild type, but fail to elevate the cellular level of PIP3, the product

104 Standard accretion models fail to explain its luminosity, even assuming beamed emi

105 ns why wild population studies may generally fail to find strong support for interactions between inb

106 ER-Golgi contacts fail to form during ER stress in cells lacking Nvj2p.

107 o WT muscles, suggesting that dyW-/- muscles fail to generate enough muscle cells to sustain fetal my

108 ver, many subunit vaccines under development fail to generate robust LLPC responses, and therefore a

109 Recent studies fail to identify a causative organism in more than 50% o

110 Furthermore, IgE autoantibodies fail to induce BP in eosinophil-deficient mice, confirmi

111 phils with a genetic defect in NADPH oxidase fail to induce either actin and tubulin polymerization o

112 These embryos fail to initiate timely MZT, undergo cell-cycle pause, a

113 We show that early AnkG-deficient nodes fail to mature and undergo rapid destabilization.

114 ent with these findings, viral glycoproteins fail to mature in SPCA1-deficient cells preventing viral

115 intervention if other therapeutic modalities fail to prevent progression.

116 Here, we demonstrate that bdMphi fail to produce nitric oxide (NO) or upregulate inducibl

117 Cells lacking this activation mechanism fail to proliferate after hyperosmotic stress.

118 Sin3B-deleted HSCs accumulate and fail to properly differentiate following transplantation

119 ifferent immunodominant vaccine antigens can fail to protect for opposite reasons, highlighting a maj

120 rticles in 4 ophthalmology clinical journals fail to provide a Snellen equivalent when visual acuity

121 ptical, X-ray and photoelectron probes often fail to provide interface-specific information in such s

122 ever, current downstream computational tools fail to reliably determine regulatory region accessibili

123 SC depletion, E(z) knockdown germ cells also fail to replenish lost GSCs.

124 is study, we show that CX3CR1-deficient mice fail to resolve gut inflammation despite high production

125 in lung and other cancers, but some patients fail to respond and in those that do resistance inevitab

126 at patients with 11q22.1-q22.2 amplification fail to respond to radiotherapy.

127 approved for MIBC, the majority of patients fail to respond, suggesting existence of complementary i

128 proportion of patients with many tumor types fail to respond.

129 AnkB variants that fail to restore normal lipid accumulation and GLUT4 loca

130 orrespond to the postimplantation embryo and fail to resume development in chimaeric assays.

131 remains controversial because ROS scavengers fail to retard mitophagy.

132 zymatic liberation only if mechanical forces fail to retrieve antigen.

133 mber when extent is controlled, that infants fail to track extent cues with precision, and that infan

134 teromers in which the ATD of GluA1 is absent fail to translocate, establishing a critical role of the

135 Two routes that failed to access eupalinilide E were triaged either as a

136 e found that lower-level, absolute judgments failed to account for higher-level, relative/ordinal jud

137 oduction with deuterated carbon sources have failed to account for roughly half of NADPH's redox acti

138 cient CD8(+) tumour-infiltrating lymphocytes failed to accumulate in tumours, resulting in greater ra

139 e/threonine protein kinase upstream of AMPK, failed to activate AMPK and sustain energy homeostasis a

140 mate concentrations that exceeded 250 microM failed to activate cell signaling.

141 Loss of either protein alone failed to affect Wnt signaling levels or tissue homeosta

142 As a consequence, HVEM-deficient recipients failed to afford protection against respiratory reinfect

143 In contrast, treatment with dynasore failed to alter the surface membrane expression of SK2 c

144 ted, unassembled alpha-globin molecules that failed to assemble with beta-globin were selectively ubi

145 f under-sampled glycoforms and of those that failed to be identified by searching against a predefine

146 ed that two E.coli enzymes, EcTSR and EcGCL, failed to be targeted into rice chloroplasts by the comm

147 mutants were defective in PI3K because they failed to bind the enzyme and bring the activity to the

148 ing, repetitively displayed allergen on VLPs failed to cause mast cell activation.

149 ting common alleles found in cancer patients failed to complement in these assays.

150 iously identified putative de novo mutations failed to complement yeast strains lacking the EEF1A ort

151 In the absence of endogenous Treg, IVIg failed to confer protection against AHR and airway infla

152 In contrast, a null mutant in gamma34.5 failed to control IRF3 phosphorylation due to an inabili

153 Traditional graphs and charts failed to convey the complex shapes of brain structures

154 Compared with control cells, they failed to decidualize in vitro as demonstrated by morpho

155 Pre-treatment with ABT-627 failed to decrease renal ER stress and apoptosis in ETB

156 use of FE is unknown, and prior studies have failed to demonstrate a primary abnormality in the eosin

157 anconi anemia (FA) gene therapy studies have failed to demonstrate engraftment of gene-corrected hema

158 Till date, studies have failed to demonstrate that preventing gastroesophageal r

159 recision on the proteins for which threading failed to detect any DCDs.

160 d at 3 h of the in vitro antifungal exposure failed to detect C. glabrata isolates with echinocandin

161 erformed automated segmentation of songs but failed to detect the proposed rhythm.

162 V600E) expression induced by the same method failed to develop LCH-like neoplasms, suggesting that ea

163 DLC and SB algorithms failed to diagnose 4 (44%) and 3 (33%) patients with gen

164 Unlike intact SAA1alpha, these SAA fragments failed to directly chemoattract neutrophils and monocyte

165 eward and no-reward levers; however, KO mice failed to discriminate based on relative quantity-reward

166 the case of S. cerevisiae, the OD600 method failed to distinguish between cytotoxic and cytostatic d

167 using oligonucleotide microarrays have often failed to distinguish these two phenotypes.

168 ted with DNA from neoplastic cells, but they failed to do so in 80 to 90% of the transfections.

169 ade, whereas FMT from nonresponding patients failed to do so.

170 impairing MC accumulation within the CNS and failed to drive clinical improvement.

171 nomeric Env immunogens designed to date have failed to elicit such antibodies.

172 ervations further suggested that Afh mutants failed to exhibit the necessary phenotypic plasticity fo

173 tested NSAIs, LMEs activity and biosorption failed to explain the observed removal.

174 adients, likely due to disorganized MTs that failed to extend into the peripheral domain and enter fi

175 Furthermore, stm6 failed to fully activate chlororespiration and cyclic el

176 te-directed T1D interventions tested to date failed to halt beta cell demise.

177 regulated exocytosis, but previous work has failed to identify a clear physiological defect in mice

178 Interestingly, two different shRNA screens failed to identify a single TP53 target gene required fo

179 Whole-exome sequencing in 997 subjects failed to identify any large-effect coding alleles of lo

180 ethicillin-resistant S. aureus (MRSA), which failed to identify from 0 to 41% of tested mecC-harborin

181 g in two prospective randomized DLBCL trials failed to identify prognostic subgroups, whereas dual ex

182 nclusion The addition of palifosfamide to CE failed to improve survival in ES SCLC.

183 improved WHO compliance less (P < 0.001) and failed to improve technical performance.

184 was not observed in patients whose epiphora failed to improve.

185 in the atria, and truncated MyBP-HL protein failed to incorporate into the myofilament.

186 so increased basal mROS expression, but they failed to increase production after pneumococcal challen

187 key ISR gene targets such as Atf5 and Trib3 failed to increase.

188 59, 290 and 569R) abolished JNK1 binding and failed to induce apoptosis.

189 esponses in rabbits and macaques, but so far failed to induce broadly neutralizing antibodies.

190 these cells revealed that CDK4/6 inhibition failed to induce cell-cycle arrest or senescence.

191 tained in BAC transgenic Foxp3.LuciDTR4 mice failed to induce complete rejection of HCmel12 melanomas

192 (EMT) of ovarian cancer cells in vivo, STAT4 failed to induce EMT directly in vitro, suggesting that

193 ued to exhibit low liver Hamp at 8 weeks and failed to induce Hamp in response to Bmp6 in primary hep

194 s had high expression of SIRT1 and SIRT7 and failed to induce p-FOXO3 and apoptosis in response to LP

195 However, several studies failed to induce performance deficit implementing this a

196 ined high levels of mucosal colonization but failed to induce robust vaginal immunopathology (neutrop

197 veral EGFR-mediated cancer models, cetuximab failed to inhibit downstream signaling or to kill cells

198 In in vitro studies, Nogo-A-Fc failed to inhibit growth of lizard RGC axons.

199 418A), a mutant that does not bind to eIF4A, failed to inhibit Sin1 translation, and consequently fai

200 t docked poorly in the GtfC catalytic domain failed to inhibit the activity of Gtfs and S. mutans bio

201 ited all three mutants by as much as 80% but failed to inhibit WT-GC-B.

202 ons exited, and Schwann cells and astrocytes failed to integrate.

203 Previous studies have failed to investigate the role of natural regulatory T c

204 gent showed why BCl3, in contrast to ClBcat, failed to mediate the complete the cyclization/demethyla

205 taminated colorectal surgery, the use of IPA failed to meet criterion for noninferiority for overall

206 Classic drug development strategies have failed to meet the urgent clinical needs in treating inf

207 orated with a shRNA targeting IGF-1 receptor failed to migrate to the upper cortical layers and accum

208 However, these same mutations failed to modify the toxicity of (GR)50, suggesting that

209 i-A(H1N1)pdm09 HA monoclonal antibodies that failed to neutralize viruses isolated after 2013 from a

210 tro in the presence of choline, whereas this failed to occur in Chdh(-/-) oocytes, directly demonstra

211 eories of demographic/family change, the SDT failed to predict many contemporary patterns of change/d

212 EC titers within the bladder, this treatment failed to prevent relapsing bacteriuria.

213 r spirochetemia induced by DeltaVlsE and yet failed to prevent WT-induced spirochetemia.

214 torsinA knockdown in the immature cerebellum failed to produce dystonia.

215 th target cells, Zap70(low)Syk(low) NK cells failed to produce IFN-gamma and lysed target cells at on

216 TLR3-, TRIF-, and IRF3-dependent manner but failed to produce IFNbeta.

217 sendothelial monocyte migration in vitro and failed to promote leukocyte recruitment when added to mu

218 ust levels of HA inhibition (HI) titers, but failed to protect against five different heterologous le

219 FEN1 also failed to provide excision of the 5'-adenylated BER inte

220 or dry and wet food, respectively), but many failed to provide nutritional minimum (e.g. Cu, 20% of w

221 apamycin did not trigger micro-lipophagy and failed to provide the needed substitute energy source fo

222 Corticosterone failed to re-establish extinguished preference alone but

223 oup, for ASD participants a smaller response failed to reach statistical significance.

224 ted in the circulation of the recipients and failed to reach the endocrine cells of grafted islets.

225 In contrast, cardiomyocytes failed to reactivate the neonatal proliferative network

226 s with sPE, which dedifferentiated in vitro, failed to redecidualize in culture.

227 ve THR-184 through a range of dose exposures failed to reduce the incidence, severity, or duration of

228 tly interact with an NACbs, and the proteins failed to regulate a promoter lacking a crucial NACbs.

229 cyclic promastigotes lacking one SODA allele failed to replicate in macrophages and were severely att

230 o inhibit Sin1 translation, and consequently failed to repress mTORC2 activity and invasion.

231 However, all past models tested failed to reproduce the most salient property of an inte

232 on; while exogenous promoter-reporter assays failed to reproduce the similar outcomes.

233 Unexpectedly, expression of mature HMR failed to rescue not only the plastidial but also the nu

234 Bone marrow transplantation failed to rescue outgrowth.

235 ctive in Ca(2+) binding in either C2A or C2C failed to rescue two defects in PM lipid homeostasis obs

236 CD300f-deficient mice failed to resolve dextran sulfate sodium-induced colonic

237 ction, SCD mice continued to deteriorate and failed to resolve the infection, resulting in increased

238 he SHS-exposed Scnn1b-Tg(+) (SHS-Tg(+)) mice failed to resolve these infections.

239 e closest invertebrate relatives of hagfish, failed to reveal evidence of an intact vwf gene.

240 However, in vivo studies have failed to reveal such a function, supporting instead a c

241 nted BTP, whereas nerve block after movement failed to reverse BTP.

242 bind the PP2A-C subunit or activate PP2A and failed to reverse the tumorigenic phenotype induced by P

243 When these neurons are ablated, fish failed to rotate their eyes following either nose-up or

244 bidirectional because Mecp2 KO neurons also failed to scale down mEPSC amplitudes and GluA1 synaptic

245 ) lacked a NAP6-defined extended panel; many failed to screen all cases for chlorhexidine 19/44 (43%)

246 g meiotic resumption, homologous chromosomes failed to segregate accurately during meiosis I.

247 rprisingly, patients with monophasic disease failed to show age-expected changes in diffusion paramet

248 ple integrin antagonist drug candidates have failed to show efficacy in cancer clinical trials.

249 ysis using the per-protocol sample (n = 153) failed to show noninferiority of GSH-I (adjusted effect,

250 es with CRISPR/Cas9-mediated knockout of C3G failed to show repression of histone marks and did not s

251 In contrast, VEGFR1/sVEGFR1 knockout EVs failed to show similar protection, thus indicating that

252 ons in dopamine signals for reward magnitude failed to subsequently discriminate between reward optio

253 fluenza virus infection or vaccination, they failed to support activation of naive CD8(+) T cells.

254 s a consequence, these cytoskeletal networks failed to support cell adhesion at the BTB.

255 Conditioned medium from these cells failed to support CTB invasion.

256 In contrast, additional coactivators failed to support robust HBV replication in the absence

257 lammasome activation as a TcpB(G158A) mutant failed to suppress pyroptotic cell death and inflammator

258 ular polysaccharide (EPS) locus consistently failed to transmit.

259 The epimerized hexaketide failed to undergo cyclization and was exclusively hydrol

260 showing that MEFs lacking AMPK activity also failed to up-regulate IFN-beta and TNF-alpha after treat

261 We found that PRMT1 knock-out macrophages failed to up-regulate PPARgamma expression in response t

262 Tfe3 knockout (Tfe3KO) mice in the fed state failed to upregulate Ppargamma and the adiponectin gene,

263 d more productive environments respectively, failed to vary with delta(15) N.

264 rweight risk paradox may result in part from failing to account for central adiposity, rather than re

265 Our results demonstrate that failing to account for nonbreeders in population studies

266 Failing to complete chemotherapy adversely affects survi

267 ents and had normal A11 localization despite failing to form immature virions.

268 However, failing to recognize the additional role of environmenta

269 g truncation of actin microfilament, thereby failing to support the Sertoli cell morphology and adhes

270 nd defect in lung development with lung buds failing to undergo branching morphogenesis and progressi

271 ate often applied in institutional settings, fails to account for complex factors that may influence

272 We report here that sulforaphane treatment fails to activate NRF2 and prevent PPK in female Krt16(-

273 ents are based on a level of generality that fails to appreciate the specific conditions of the Mongo

274 r efficient maturation, but recombinant Csm5 fails to cleave crRNAs in vitro.

275 or (A-P) symmetric stiffness gradient, which fails to develop in elongation-defective mutants.

276 lmonary embolism, physiological fibrinolysis fails to dissolve thrombi acutely and r-tPA (recombinant

277 We show that, in isolation, IL-12alpha fails to form its native structure but, instead, misfold

278 response maxima sites using the DR5 promoter fails to fully rescue lfs plants, suggesting that additi

279 mor resection and (neo)adjuvant chemotherapy fails to improve a poor prognosis.

280 pt, a decoy receptor that binds soluble TNF, fails to improve disease.

281 ) and dominant-negative rab5, ER cholesterol fails to increase when mTORC1 activity is low, and SREBP

282 volved in Fas-mediated cell death, and Erdr1 fails to induce apoptosis in Fas-deficient cells.

283 ics, which targets bacterial topoisomerases, fails to kill bacteria that have grown to high density;

284 es the effects of SCCRO on abscission, as it fails to localize to the midbody in SCCRO-deficient cell

285 Preclinical animal testing often fails to predict adverse outcomes arising from sequentia

286 lso associated with short-term mortality, it fails to predict development of RD, HRS, and ACLF.

287 cent research suggests that extinction often fails to reduce fear when administered soon after trauma

288 from a developmentally defective strain that fails to remove Pxr-mediated blockage of development and

289 In the absence of pUL31, CMV fails to reorganize nucleolin and UBF and exhibits a rep

290 nsive glycemic control (IGC) targeting HbA1c fails to show an unequivocal reduction of macrovascular

291 biosis associated with sensitization to food fails to stimulate protective tolerogenic pathways, lead

292 Recombinant FP E244K is monomeric, fails to support bacteriolysis, and binds weakly to C3 p

293 Importantly, while the peptide brHis2 fails to translocate across cell membranes on its own, a

294 entation challenges and should be considered failed trials that are largely uninformative and not eli

295 hrombocytopenia, preexisting kidney disease, failed ventilator liberation, and acute kidney injury +/

296 for whom gemcitabine-based chemotherapy had failed were randomized to selumetinib plus MK-2206 or mF

297 to Caenorhabditis elegans because they have failed when applied to animal parasites.

298 Despite its usual efficiency, this process fails when we encounter new problems in which past exper

299 lly rescue in vitro fertilization (IVF) that failed with epididymal spermatozoa alone.

300 to generate benzylic ethers, a reaction that failed with known ligands for Ni and designer phosphines