ライフサイエンスコーパス: failed to

1 We found that lower-level, absolute judgments failed to account for higher-level, relative/ordinal judgment

2 g LKB1, a serine/threonine protein kinase upstream of AMPK, failed to activate AMPK and sustain energy homeostasis and re

3 As a consequence, HVEM-deficient recipients failed to afford protection against respiratory reinfection w

4 In contrast, treatment with dynasore failed to alter the surface membrane expression of SK2 channe

5 ighly up-regulated, unassembled alpha-globin molecules that failed to assemble with beta-globin were selectively ubiquiti

6 Previously identified putative de novo mutations failed to complement yeast strains lacking the EEF1A ortholog

7 In the absence of endogenous Treg, IVIg failed to confer protection against AHR and airway inflammati

8 Traditional graphs and charts failed to convey the complex shapes of brain structures which

9 Pre-treatment with ABT-627 failed to decrease renal ER stress and apoptosis in ETB def r

10 the genetic cause of FE is unknown, and prior studies have failed to demonstrate a primary abnormality in the eosinophil

11 assay performed at 3 h of the in vitro antifungal exposure failed to detect C. glabrata isolates with echinocandin resis

12 s of PD-1 blockade, whereas FMT from nonresponding patients failed to do so.

13 trimeric and monomeric Env immunogens designed to date have failed to elicit such antibodies.

14 the B lymphocyte-directed T1D interventions tested to date failed to halt beta cell demise.

15 Whole-exome sequencing in 997 subjects failed to identify any large-effect coding alleles of lower f

16 es (1 & 2 & 3) improved WHO compliance less (P < 0.001) and failed to improve technical performance.

17 ment associated in the atria, and truncated MyBP-HL protein failed to incorporate into the myofilament.

18 mRNA levels of key ISR gene targets such as Atf5 and Trib3 failed to increase.

19 Analysis of these cells revealed that CDK4/6 inhibition failed to induce cell-cycle arrest or senescence.

20 ve strains attained high levels of mucosal colonization but failed to induce robust vaginal immunopathology (neutrophil r

21 57-469)(D253A,D418A), a mutant that does not bind to eIF4A, failed to inhibit Sin1 translation, and consequently failed t

22 he graft, no axons exited, and Schwann cells and astrocytes failed to integrate.

23 Previous studies have failed to investigate the role of natural regulatory T cells

24 tive, clean contaminated colorectal surgery, the use of IPA failed to meet criterion for noninferiority for overall SSI p

25 eurons electroporated with a shRNA targeting IGF-1 receptor failed to migrate to the upper cortical layers and accumulate

26 btained two anti-A(H1N1)pdm09 HA monoclonal antibodies that failed to neutralize viruses isolated after 2013 from a vacci

27 d betaine in vitro in the presence of choline, whereas this failed to occur in Chdh(-/-) oocytes, directly demonstrating

28 ine CXCL10 in a TLR3-, TRIF-, and IRF3-dependent manner but failed to produce IFNbeta.

29 FEN1 also failed to provide excision of the 5'-adenylated BER intermedi

30 (99% and 83% for dry and wet food, respectively), but many failed to provide nutritional minimum (e.g. Cu, 20% of wet fo

31 euro-typical group, for ASD participants a smaller response failed to reach statistical significance.

32 In contrast, cardiomyocytes failed to reactivate the neonatal proliferative network follo

33 ls from patients with sPE, which dedifferentiated in vitro, failed to redecidualize in culture.

34 mazonensis metacyclic promastigotes lacking one SODA allele failed to replicate in macrophages and were severely attenuat

35 eIF4A, failed to inhibit Sin1 translation, and consequently failed to repress mTORC2 activity and invasion.

36 However, all past models tested failed to reproduce the most salient property of an intermedi

37 ha-SYN expression; while exogenous promoter-reporter assays failed to reproduce the similar outcomes.

38 constructs defective in Ca(2+) binding in either C2A or C2C failed to rescue two defects in PM lipid homeostasis observed

39 ons by PND22, the SHS-exposed Scnn1b-Tg(+) (SHS-Tg(+)) mice failed to resolve these infections.

40 movement prevented BTP, whereas nerve block after movement failed to reverse BTP.

41 d abilities to bind the PP2A-C subunit or activate PP2A and failed to reverse the tumorigenic phenotype induced by PTPA s

42 and 17/44 (39%) lacked a NAP6-defined extended panel; many failed to screen all cases for chlorhexidine 19/44 (43%) or l

43 n oocytes during meiotic resumption, homologous chromosomes failed to segregate accurately during meiosis I.

44 nfirmatory analysis using the per-protocol sample (n = 153) failed to show noninferiority of GSH-I (adjusted effect, 1.47

45 ciated alterations in dopamine signals for reward magnitude failed to subsequently discriminate between reward options.

46 Conditioned medium from these cells failed to support CTB invasion.

47 The epimerized hexaketide failed to undergo cyclization and was exclusively hydrolyzed,

48 orroborated by showing that MEFs lacking AMPK activity also failed to up-regulate IFN-beta and TNF-alpha after treatment

49 We found that PRMT1 knock-out macrophages failed to up-regulate PPARgamma expression in response to IL4

50 on in N-poor and more productive environments respectively, failed to vary with delta(15) N.