ライフサイエンスコーパス: failed to

1 However, to date, pharmacological agents have failed to achieve significant target engagement in vivo, poss

2 the key PTM connectivity, which condensed-phase separations failed to achieve.

3 Interestingly, L1a and L5a failed to activate cellular DNA damage response.

4 CA4P failed to activate RhoA/ROCK/pMLC but its activity was restor

5 treatment failure (the proportion of women in which surgery failed to adequately resolve midline pain) and the frequency

6 acking Flvcr2 had altered expression of angiogenic factors, failed to adopt tip cell properties, and displayed reduced sp

7 enocarcinoma (HR, 0.18; 95% CI, 0.02-1.61), although the HR failed to attain statistical significance.

8 unately, proposed countermeasures against such attacks have failed to be effective, as they do not consider the utility o

9 These cellular mechanisms failed to be executed in regeneration-incompetent tadpoles.

10 her different degrees of severity in morbidity or mortality failed to be statistically significant because of survey desi

11 al ADPKD therapies with promising outcomes in animal models failed to be translated to human disease, our platform also i

12 directed medical therapies, imaging of myocardial viability failed to deliver effective guidance of coronary bypass surge

13 However, lesion of VTA GABA neurons failed to disrupt this effect.

14 mC-dependent depletion of local fumarate, the DeltahemB SCV failed to elicit trained immunity and protection from a secon

15 t depletion of host T(conv) and host T(regs), donor T(regs) failed to engraft even with interleukin-2 (IL-2) support.

16 , in both groups, eszopiclone increased spindle density but failed to enhance sleep-dependent procedural memory consolida

17 Gentamicin alone failed to eradicate Neisseria gonorrhoeae from the pharynx.

18 onstrate here that PLP(ECD)-immunized B cell-deficient mice failed to exhibit EAE.

19 We failed to find a difference between treatment training within

20 -proficient extension produced regular CLPs in bacteria but failed to form stable nucleocapsids in hepatoma cells.

21 the disruption of a C(32-)A(38) cross-loop interaction but failed to fully explain the means by which s(2)C(32) restrict

22 ashout of these chronically exposed cells for up to 1 month failed to fully reverse the transcriptional and phenotypic ef

23 However, SD-Foxo1 actively repressed CD127 expression and failed to generate memory precursors and long-lived memory T

24 Further imaging failed to identify a distant primary malignancy or metastatic

25 In alpha2delta-1 gene KO mice, treatment with FK506 failed to increase the frequency of NMDAR-mediated mEPSCs and

26 d that in insulin-resistant animals, portal vagal afferents failed to inhibit their spiking activity during glucose infus

27 MLAV VP24 differed from MARV VP24 in that it failed to interact with Keap1 or activate an antioxidant resp

28 high DFI (62.7 +/- 7.2% for IVF and 73.3 +/- 8.1% for ICSI) failed to litter after embryo transfer compared to embryos fr

29 capacity when cultured with FFA, whereas female macrophages failed to migrate.

30 xogenously provided competence stimulating peptide 1 (CSP1) failed to modulate the onset kinetics of competence developme

31 ite their intact cGAS sensing pathway, human CD4(+) T cells failed to mount a reverse transcriptase (RT) inhibitor-sensit

32 In the most extreme case, almost a third of observers failed to notice when less than 5% of the visual display was

33 entions targeting catabolic pathways have, however, largely failed to preserve muscle mass in cachexia, suggesting that o

34 thway that reduces synthesis of membrane proteins that have failed to properly assemble in the endoplasmic reticulum (ER)

35 strategies that have worked in rodent models of stroke have failed to provide protection in clinical trials.

36 r in PLDRH group than in the ODRH group (8% vs. 3%), but it failed to reach statistical significance (P = 0.167).

37 t gI could self-interact and that the rod-shaped structures failed to recognize glycoprotein E, the well-known binding pa

38 The avirulent strain failed to reduce CD40 relocation to the detergent-resistant m

39 typical CYP monomer structure, isavuconazole-bound AcCYP51 failed to refold 74 N-terminal residues.

40 whereas in betaA-Akt1WT/flx embryos, the capillary network failed to remodel.

41 Exploratory analyses of the microbiome failed to reveal possible responder compared with nonresponde

42 Ipilimumab (anti-CTLA-4) or anti-PD-1/PD-L1 monotherapy failed to show a significant benefit.

43 However, Smoothened (SMO) inhibitors have failed to show clinical benefit in patients with cancers disp

44 tional T lymphocytes or recombination-activating gene (Rag) failed to show rescue of mutant colonization.

45 Further, infection failed to stimulate the memory B cell compartment in preimmun

46 cytotoxicity and dendritic cell-induced proliferation, they failed to sufficiently regulate T cells stimulated by anti-CD

47 US failed to suggest metastases in 10 patients.

48 1) was largely excluded from the nucleus of CD8 T cells and failed to transactivate these genes.

49 MSU failed to trigger neutrophil and monocyte recruitment in Cd44

50 rA was highly expressed during pneumonia-derived sepsis but failed to turn off the competent state in mice.