ライフサイエンスコーパス: failing

1 failure or shock in whom medical therapy is failing.

2 se findings may not mean that peer review is failing.

3 munity, although fundamental, is fragile and failing.

4 type of infertility treatment in relation to failing a developmental domain.

5 moderate to severe hidradenitis suppurativa failing adalimumab therapy, or those ineligible to recei

6 Immune aging manifests with a combination of failing adaptive immunity and insufficiently restrained

7 erns," DAMPs), as they die in the context of failing adaptive responses to stress.

8 To determine the role of SPEG in healthy and failing adult hearts.

9 n cardiac progenitor cell [FhCPC]) and adult failing (adult human cardiac progenitor cell [AhCPC]) he

10 linical Trials Group 5230 evaluated patients failing an initial nonnucleoside reverse-transcriptase i

11 The environment of the failing and infarcted myocardium drives resident and tra

12 chanism of adenosine-induced AF in explanted failing and nonfailing human hearts (n=37).

13 ector control field studies, highlight major failings and strengths of published studies, and provide

14 such models, along with their successes and failings, and finish with an outlook on the future.

15 s not associated with risk of their children failing any developmental domain (aOR, 1.33; 95% CI, 0.9

16 ology was associated with increased risk for failing any developmental domain but only when singleton

17 t also was not significantly associated with failing any developmental domain for ovulation induction

18 Cohort 1 patients failing any target escalated to imatinib 800 mg/day, and

19 Cohort 2 patients failing any target switched to nilotinib directly, as di

20 phoma for whom treatment was at high risk of failing appear to benefit from early treatment intensifi

21 (subcohort), and 218 additional participants failing ART (case group).

22 Adaptive VL monitoring reduces time on failing ART, is cost-effective, and should become standa

23 Cases failing azithromycin were treated with moxifloxacin, and

24 ive in 53(88% [95% CI, 78%-94%]) of 60 cases failing azithromycin; all failures had gyrA and parC mut

25 The number of subjects failing because of inadequately controlled IOP or reoper

26 ere we isolate and functionally characterize failing beta cells from various experimental models of d

27 e mid-infrared and long-wavelength infrared, failing beyond, roughly 2.5 mum, our generalization of t

28 human health and well-being, increasingly, a failing brain is the arbiter of a death preceded by a gr

29 ed substrates for ventricular tachycardia in failing, but not in donor, hearts.

30 e NaV1.5 proteins purified from adult WT and failing CaMKIIdeltac-overexpressing (CaMKIIdeltac-Tg) mo

31 atively modified and desensitized by GRK2 in failing cardiomyocytes, contributing to post-MI remodeli

32 sion patterns are pivotal characteristics of failing cardiomyocytes, with several excitation-transcri

33 The failing cell model was first validated by reproducing th

34 ion in one dimensional cables of healthy and failing cells.

35 ealthy cells undergo while transforming into failing cells.

36 A strains lacking STK1 become susceptible to failing cephalosporins, such as Ceftriaxone and Cefotaxi

37 f severe acute respiratory distress syndrome failing conventional measures.

38 h drug-resistant and refractory tuberculosis failing conventional therapy.

39 nderwent successful open-chest surgery after failing epicardial/endocardial ablation.

40 Patients failing ERP therapy are candidates for deep brain stimul

41 n make the difference between succeeding and failing, even between life and death.

42 it from identifying patients immunologically failing first-line ART at 48 weeks.

43 T failures; (2) second-line LA-ART for those failing first-line therapy; and (3) first-line LA-ART fo

44 of NAD(+) biosynthetic enzymes in the human failing heart and in the heart of a mouse model of dilat

45 GRK2 and GRK5 are overexpressed in the failing heart and thus have become therapeutic targets.

46 er abnormal calcium-handling proteins in the failing heart are candidates for gene therapy; many shor

47 rial dysfunction and energy depletion in the failing heart are innovative therapeutic targets in hear

48 This shift was also observed in human failing heart biopsies in comparison with nonfailing con

49 ied to probe TATS electrical conductivity in failing heart cells.

50 derstand why MyBP-C dephosphorylation in the failing heart contributes to contractile dysfunction and

51 cycle length decreases, both the normal and failing heart develop T-wave alternans, but only the fai

52 A failing heart differs from healthy hearts by an array of

53 The failing heart displays increased glycolytic flux that is

54 ocaine autoradiography to determine that the failing heart has 30% lower SCN5A levels - the first ev

55 Our findings indicate that the failing heart has a previously unrecognized reparative c

56 Thus, induction of Mg29 in the failing heart is a compensatory response that directly c

57 Significant evidence indicates that the failing heart is energy starved.

58 results suggest that IF1 upregulation in the failing heart may be a maladaptive response.

59 a 30% loss in levels of NAD(+) in the murine failing heart of both DCM and transverse aorta constrict

60 results indicate that the hypertrophied and failing heart shifts to ketone bodies as a significant f

61 trometry revealed that the hypertrophied and failing heart shifts to oxidizing ketone bodies as a fue

62 heart develop T-wave alternans, but only the failing heart shows QRS alternans (although moderate) at

63 METHODS AND Leukocytes infiltrating the failing heart were analyzed by a multistep enzymatic pro

64 process of deterioration from a healthy to a failing heart yet remains deficiently understood.

65 the cell and tissue level have increased the failing heart's susceptibility to dynamic instabilities

66 amage and DDR activation are observed in the failing heart, however, the type of DNA damage and its r

67 (GRKs), some of which are upregulated in the failing heart, making them desirable therapeutic targets

68 In the failing heart, oxidative stress occurs in the myocardium

69 ble alterations of NAD(+) homeostasis in the failing heart, we quantified the expression of NAD(+) bi

70 SCs) is an emerging therapy for treating the failing heart.

71 isms regulating homeostasis of NAD(+) in the failing heart.

72 ping new Ca(2+) buffering strategies for the failing heart.

73 downregulated in myocardial samples from the failing heart.

74 D maps show areas of conduction block in the failing heart.

75 ratures are appropriate for the resuscitated failing heart.

76 TPase (SERCA2a) activity is deficient in the failing heart.

77 ng initiated wave reentry and breakup in the failing heart.

78 gnaling within cardiomyocytes develop in the failing heart.

79 he dysfunctional substrate metabolism of the failing heart.

80 nans is significantly more pronounced in the failing heart.

81 NAD(+) ratio) and protein acetylation in the failing heart.

82 latory system occur in the hypertrophied and failing heart.

83 refore, PKG1alpha activation can benefit the failing heart.

84 inding protein, is up-regulated in the human failing heart.

85 buting to focal arrhythmia in the intact non-failing heart.

86 stabilizing myocardial NAD(+) levels in the failing heart.

87 a, thereby suppressing FA utilization in the failing heart.

88 e predominant GRK isoform upregulated in the failing heart.

89 FA metabolism and cardiac dysfunction in the failing heart.

90 e A signaling seems to be beneficial for the failing heart.

91 red SSB is observed in cardiomyocytes of the failing heart.

92 significantly increases the function of the failing heart.

93 Mg29 to model this observed induction in the failing heart.

94 ence in regional work between nonfailing and failing hearts after MI and offer novel insight into the

95 P2 in cardiomyocytes facilitated recovery of failing hearts after reversible transverse aortic constr

96 hondrial function, also are present in human failing hearts as well as in mouse hearts with pathologi

97 2 cm/s (95% CI, 27-37; P=0.001) in 12 native failing hearts at 1000 ms pacing cycle length (PCL).

98 reased conduction velocity in both donor and failing hearts but shortened action potential duration o

99 t studies also identified amylin deposits in failing hearts from patients with obesity or type 2 diab

100 Similarly, MeCP2 repression in human failing hearts resolved after unloading by a left ventri

101 achidonic acid (AA) in mitochondria from non-failing hearts was calcium-dependent phospholipase A2zet

102 a-actin isoforms in human healthy hearts and failing hearts with dilated cardiomyopathy (DCM).

103 Th1) and Th17 (versus Treg) predominance in failing hearts, and with expansion of memory T cells in

104 First described in failing hearts, autophagy within the cardiovascular syst

105 First described in failing hearts, autophagy within the cardiovascular syst

106 ransients duration (CaD) in donor but not in failing hearts, because of desensitization of beta1-adre

107 In human failing hearts, Drp1 phosphorylation at S616 is increase

108 In animal and human failing hearts, expression of JP2 is decreased markedly,

109 nnels arachidonic acid into EETs, whereas in failing hearts, increased iPLA2gamma activity channels A

110 idates are often differentially expressed in failing hearts, with an inverse correlation between 3'UT

111 deltac-dependent arrhythmogenic disorders in failing hearts.

112 tion of Ca cycling by protecting stressed or failing hearts.

113 l JMC protein SPEG is downregulated in human failing hearts.

114 uclear-1 were substantially downregulated in failing hearts.

115 or lipoxygenases attenuated mPTP opening in failing hearts.

116 umol/L peroxide exposure and in myocyte from failing hearts.

117 ts an additional layer of gene regulation in failing hearts.

118 of normalizing NADH/NAD(+) imbalance in the failing hearts.

119 pic slices isolated from donor and end-stage failing hearts.

120 been shown to provide functional support to failing hearts.

121 icular wedge preparations of human donor and failing hearts.

122 shortened action potential duration only in failing hearts.

123 of JMCs underlies contractile dysfunction in failing hearts.

124 hematopoiesis, which may include support to failing hematopoiesis.

125 found that RBFox1 is markedly diminished in failing human and mouse hearts.

126 rent membrane microdomains of nonfailing and failing human and rat ventricular myocytes.

127 tly attenuated activation characteristics of failing human cardiac fibroblasts isolated from end-stag

128 hondrial oxidation and ultrastructure in the failing human heart by using respirometry, transmission

129 increased ketone utilization in the severely failing human heart independent of diabetes mellitus, an

130 The failing human heart is characterized by metabolic abnorm

131 studies of demographically matched donor and failing human heart left ventricular (LV) tissues.

132 easure global patterns of APA in healthy and failing human heart specimens.

133 idation as a key metabolic adaptation in the failing human heart.

134 Explants from healthy and failing human hearts were compared using radiocaine auto

135 re, FYN expression was markedly decreased in failing human hearts, corroborating its role as a regula

136 Stable isotope kinetics revealed that in non-failing human hearts, cPLA2zeta metabolically channels a

137 d messenger RNA expression in nonfailing and failing human hearts.

138 erent between nonfailing donor and end-stage failing human hearts.

139 ed the downregulation of SPEG mRNA levels in failing human hearts.

140 oss of titin distensibility were assessed in failing human hearts.

141 d chymase activity elevated Ang II levels in failing human hearts.

142 ning OM-induced modulation of XB behavior in failing human myocardium are unclear.

143 yocyte stiffness contributed to stiffness of failing human myocardium because of reduced titin disten

144 ed the Ca(2+)-induced opening of the mPTP in failing human myocardium, and the highly selective pharm

145 In contrast, iPLA2gamma predominated in failing human myocardium.

146 Ca(2+)-activated K(+) (SK) current (IKAS) in failing human ventricles remains unclear.

147 mportant in the transmural repolarization in failing human ventricles.

148 Multiple approaches to ablate biofilms on failing implants have been proposed and include use of l

149 is an essential catabolic process frequently failing in neurodegeneration.

150 a long and difficult course with 3 compounds failing in phase III clinical trials.

151 etects malignancy about 80-90% of the times, failing in places when (1) the tumor is small at early s

152 Recent reports into egregious failing in the quality and safety of healthcare in the U

153 regeneration of nephrons in situ to restore failing kidney function.

154 obstructive pulmonary disease, cancer, weak/failing kidneys, diabetes, hepatitis, depression, and he

155 nary disease: OR 1.65; cancer: OR 1.23; weak/failing kidneys: OR 2.29; diabetes: OR 1.56; hepatitis:

156 Surprisingly, respiratory capacities for failing LV isolated mitochondria (n = 9) were not signif

157 processing gene expression between donor and failing LVs revealed 0.64-fold reduced transcript levels

158 ical therapy is largely reserved for infants failing medical management.

159 tension/inner unrest (37 [69%] vs 50 [88%]), failing memory (41 [76%] vs 44 [77%]), and weight gain (

160 ified as nonfailing (MINF) and 28 MI rats as failing (MICHF).

161 Six of 7 patients failing moxifloxacin treatment received pristinamycin, a

162 Mycoplasma genitalium samples from cases failing moxifloxacin were sequenced for fluoroquinolone

163 in were treated with moxifloxacin, and those failing moxifloxacin were treated with pristinamycin.

164 pathway was up-regulated in human and murine failing myocardia.

165 mitochondrial-LD tether, perilipin 5, in the failing myocardium (P = 0.003).

166 eration in strained cell cultures and in the failing myocardium (P<0.05).

167 NOD1 was examined in human failing myocardium and in a post-myocardial infarction (

168 nd locally sourced macrophages isolated from failing myocardium expressed different genes in a patter

169 In the failing myocardium there is no change to the number of I

170 In failing myocardium, confocal laser microscopy revealed a

171 In human failing myocardium, where TNF-alpha expression is upregu

172 nt expansion of CD8(+) and CD4(+) T cells in failing myocardium, with increased Th1, Th2, Th17, and T

173 ing of human mitochondrial phospholipases in failing myocardium.

174 /-) mice, reducing macrophage numbers in the failing myocardium.

175 diastolic [Ca(2+) ] are present, such as the failing myocardium.

176 ontribute to the high diastolic stiffness of failing myocardium.

177 Reintroduction of caveolin-3 in the failing myocytes is able to normalize the distribution o

178 ined for biochemical analyses from explanted failing (n=18) and nonfailing (n=7) hearts.

179 Entire SAN complexes were isolated from failing (n=5) and nonfailing (n=9) human hearts cardiopl

180 left ventricular wedge preparations from 12 failing native hearts and 2 rejected cardiac allografts

181 orial increase in possible sets of initially failing nodes.

182 and RNase H domains of RT in HIV-2 patients failing NRTI-containing therapies.

183 The failings of the guide-specific approach highlights the n

184 discharges of poorly treated wastewater from failing or outdated septic systems.

185 with a 35% lower clearance compared with one failing organ.

186 r clearance compared with 10 mg/L, and three failing organs were associated with a 35% lower clearanc

187 c Logistic Organ Dysfunction); and number of failing organs were prospectively collected.

188 by 20% and 85.7%, respectively, of patients failing previous anti-TNF treatment.

189 buting to focal arrhythmia in the intact non-failing rabbit heart using optical mapping and pharmacol

190 rcolemma to the myofilaments in hypertrophic failing rabbit myocytes.

191 regulation of caveolin-3 in the hypertrophic failing rabbit myocytes.

192 ed the literature based on whether normal or failing rat heart models were used.

193 growth stimulation that was concealed due to failing regeneration in several species.

194 herapeutic strategies to treat patients with failing regenerative responses.

195 retreatment of the small number of patients failing regimens containing an NS5A inhibitor.

196 mortality of patients returning to HD with a failing renal allograft is unknown.

197 se were shown to be false-positive findings, failing replication with polymerase chain reaction.

198 Acutely failing respiratory mechanics can be caused by central a

199 of Cardiology risk score was higher in those failing screening (risk score 5.5% [interquartile range,

200 munodeficiency virus (HIV)-infected children failing second-line antiretroviral therapy (ART) have no

201 etectable drug levels were at higher risk of failing second-line ART and thus should be closely monit

202 We hypothesize that failing shear adaptation is an essential part of the end

203 Algae are a valuable and never-failing source of bioactive compounds.

204 Plasmodium falciparum malaria in response to failing SP efficacy.

205 at has not been addressed is how to repair a failing system before it suffers total breakdown.

206 switched to nilotinib 400 mg twice daily for failing the same target 3 months later.

207 nscriptase enzyme was identified in patients failing therapies containing nucleoside analogues.

208 n patterns observed in HIV-infected patients failing therapy and those seen in TDR.

209 lasty may lead to greater wound healing, but failing this, any straight-line flow into the foot is pu

210 rweight risk paradox may result in part from failing to account for central adiposity, rather than re

211 ults, in part, from the predictive equations failing to account for colloid deposit morphology.

212 Failing to account for denitrification products, especia

213 Our results demonstrate that failing to account for nonbreeders in population studies

214 We show that failing to account for these factors leads to an underes

215 omprehensive Epilepsy Programme, the odds of failing to achieve 1-year seizure freedom were significa

216 85; P < .001) were independent predictors of failing to achieve complete dosing; private insurance st

217 mance index highlighted countries at risk of failing to achieve the GVAP target of 90% coverage by 20

218 some datasets having as much as 80% of reads failing to align.

219 Proteins failing to attain their native conformation are degraded

220 s suggest that large numbers of patients are failing to be assessed properly with a risk of patient h

221 mall data sets, which have led to many genes failing to be consistently associated with transplant ou

222 rfectly-fabricated single quantum dot device failing to behave in accordance with design.

223 plexes are highly dynamic with many proteins failing to bind during PTBP1 arrest.

224 climate due to reduced chilling, with trees failing to capture favorable conditions in the earlier p

225 sing the resulting analyses, and in general, failing to capture sequences novel to a given genome.

226 alyzed one trait and one SNP at a time, thus failing to capture the underlying complexity of the data

227 Failing to complete chemotherapy adversely affects survi

228 Seemingly, the risk of failing to complete replication prior to mitosis is suff

229 utations Y370C and E395C within EL5, whereas failing to confer sensitivity to MTS, nevertheless, redu

230 Further, failing to consider submaximal but reliable population r

231 ith theoretical and empirical advances often failing to cross taxonomic and sensory divides.

232 azzled mutants, resulting in many more axons failing to cross the midline, although mutations in mud

233 ce between published data and a recent study failing to detect a common strain in infants with NEC, m

234 attachment by continuing to proliferate and failing to differentiate.

235 although in slightly different ways, thereby failing to direct full-length APP into the retromer-recy

236 Failing to distinguish between perception and judgment i

237 of SVR12 (90% confidence interval, 36%-78%), failing to establish noninferiority.

238 Despite being poorly cytolytic in vivo and failing to expand after encountering Ag, airway CD8 TRM

239 ents and had normal A11 localization despite failing to form immature virions.

240 ulation with pre-existing particles, thereby failing to form new cloud condensation nuclei that are t

241 ely after viral entry, with incoming virions failing to form replication complexes.

242 pted spindles, producing dead spores or even failing to form spores.

243 ed blastocysts no longer retain totipotency, failing to form TE and generating PE on their surface.

244 ificant health- and pain-related risks while failing to fulfill smokers' expectations of affect regul

245 proved vision post implantation, with 7 eyes failing to gain vision as a result of pre-existing glauc

246 layed profound defects upon differentiation, failing to generate chimeric embryos and preferentially

247 point where apoptotic infected macrophages, failing to get engulfed, necrose.

248 n the treatment of fractures at high risk of failing to heal and developing non-union.

249 hat the current certification process may be failing to identify individuals who have demonstrated te

250 e number of infants screened for ROP without failing to identify infants requiring treatment.

251 sly applied dsRNAs, either degrading them or failing to import them into the cytoplasm.

252 ion fully rescued locomotor deficits despite failing to improve cerebellar learning in AS mice, sugge

253 Failing to incorporate DHRs into readmission measurement

254 generation with pro-inflammatory macrophages failing to infiltrate the regeneration blastema.

255 Fast errors result from failing to inhibit the quick automatic responses and the

256 e time frame and show that these efforts are failing to keep pace with the rate of wilderness loss, w

257 However, failing to maintain coverage levels of 2011-13 is predic

258 nia demonstrate altered effort allocation by failing to make high-effort response choices to maximize

259 ta polyxystra and 2/14 Merluccius gayi, thus failing to match the ingredient list on the label.

260 This paradox may also arise from BMI failing to measure fat redistribution to a centralized p

261 ical trial outcomes have been underwhelming, failing to meet any primary endpoints.

262 ith higher pleurodesis failure (30% vs 24%), failing to meet noninferiority criteria (difference, -6%

263 abilities of survival and reduce the risk of failing to meet the minimum needs for survival.

264 nsidering alternative causes of symptoms, or failing to obtain complete psychiatric histories.

265 rations in BAP1 outside the UCH domain, each failing to productively recruit ASXH to the wild-type BA

266 innovation in early stage drug discovery are failing to promote progress quickly enough.

267 ity, maintaining expression of Cyclin A2 and failing to properly express many meiotic markers.

268 ctivity is weak, with a recent meta-analysis failing to provide strong evidence for either HER2 or TO

269 nts of controversial receptor localizations, failing to provide support for CRF1 expression in centra

270 stops before the previous Okazaki fragments, failing to rapidly process them.

271 Failing to reach such subpopulations with high coverage

272 The number of children globally failing to reach their developmental potential remains l

273 However, failing to recognize the additional role of environmenta

274 signal-regulated kinase 1/2 signaling while failing to recruit arrestin, activate inositol phosphate

275 and biological assumptions are misinformed, failing to refute the previously existing hypothesis tha

276 ocalization of distal appendage proteins and failing to remove the ciliation inhibitor CP110.

277 t global approaches have been criticized for failing to render global biodiversity value at a scale s

278 Models failing to resolve these trophodynamic patterns may sign

279 Interestingly, despite failing to restore matrix NADH/NAD balance, pyruvate doe

280 Moreover, induction chemotherapy failing to restore normal vasculature was associated wit

281 often just that, with genome data routinely failing to reveal useful insights about disease in gener

282 be linked to its regulatory role mean that, failing to scale the data prior to the network analysis,

283 responsible for effective active treatments failing to separate from placebo.

284 e, all species had similar microbiotas, thus failing to support predictions of the phylosymbiosis hyp

285 g truncation of actin microfilament, thereby failing to support the Sertoli cell morphology and adhes

286 -) nTreg displayed instability in the graft, failing to suppress Ag-specific CD4(+) T cells and preve

287 fection resulting in only local shedding and failing to transmit fully through the gastro-intestinal-

288 g internalized and initiating hemifusion but failing to uncoat the viral nucleocapsid and to replicat

289 nd defect in lung development with lung buds failing to undergo branching morphogenesis and progressi

290 at the 1-2 cell stage, with arrested embryos failing to undergo the maternal-to-zygotic transition.

291 Forty patients with a failing tooth in the esthetic zone and a labial bony def

292 coma that had failed or were at high risk of failing trabeculectomy were randomized to receive an Ahm

293 y of whom had failed or were at high risk of failing trabeculectomy.

294 esistance rates continue to rise, leading to failing treatment regimens.

295 nflammation are at particularly high risk of failing treatment, and understanding the pathogenesis co

296 considered a viable option for treatment of failing TV bioprostheses.

297 ponent contributes to Ca(2+) accumulation in failing VCMs and modulates AP shape and duration.

298 The expression of six Navs was observed in failing VCMs as follows: Nav1.5 (57.3%) > Nav1.2 (15.3%)

299 Failing VCMs showed up-regulation of Nav1.1 expression,

300 lso showed no ultrastructural remodeling for failing vs. donor mitochondria; however, the fraction of