ライフサイエンスコーパス: failure of

1 year was related to a hazard ratio for heart failure of 0.77 (95% confidence interval, 0.60-0.97) in

2 treatment of adult patients with cGVHD after failure of 1 or more lines of systemic therapy.

3 an adjusted hazard ratio (aHR) for treatment failure of 20.4 (95% CI 9.1-45.5, p<0.0001).

4 ide, with an adjusted odds ratio for therapy failure of 3.00 (95% CI, 2.08-4.33) in antagonism concen

5 that capture these features: (i) spontaneous failure of a component independent of the neighborhood (

6 We find that, for a given initial failure of a fraction 1 - p of nodes, there is a critica

7 The patients showed failure of a median of 10.5 prior treatment lines for IT

8 d factors associated with the indication and failure of a medication step-down treatment.

9 k of a known correlate of protection and the failure of a neutralizing antibody to correlate with pro

10 In conclusion, our findings suggest that the failure of a repressive complex to form or stabilize in

11 al health community can judge the success or failure of a Trump presidency, based on a selection of t

12 ic inflammation can be a major driver of the failure of a variety of organs, including chronic kidney

13 prostate cancer that may help to explain the failure of Abl kinase inhibitor imatinib in prostate can

14 leads to miscarriage, and it is caused by a failure of accurate chromosome segregation during gameto

15 Remarkably, the failure of ACKR3 R142(3.50)A to degrade CXCL11 was not c

16 Failure of active resolution of inflammation pathways ha

17 osis (ALS), while rarely documented, reflect failure of adaptive complex motor skills.

18 These findings implicate failure of adaptive control of pyramidal neuron-PV circu

19 esolution of lung fibrosis is blocked by the failure of adenosine levels to subside.

20 Drug resistance was defined as failure of adequate trials of two antiepileptic drugs to

21 n and subsequent depletion, which leads to a failure of adipose tissue plasticity under positive ener

22 ed by turnover of Aep3p, as evidenced by the failure of aep3 mutants to express a recoded ARG8(m) whe

23 clinical presentation, suggesting not only a failure of age-expected white matter development but als

24 upts the autophagic pathway and leads to the failure of aggresome vimentin cage degradation.

25 ifficulty may partially explain the frequent failure of AIV to become pandemic.

26 e was treatment failure, defined as: initial failure of aneurysm treatment, intracranial haemorrhage

27 Id (Id1-4) family in mouse embryos leads to failure of anterior cardiac progenitor specification and

28 An often-cited explanation for the failure of anti-Abeta mAb trials is that they are set to

29 xpression of OSM is strongly associated with failure of anti-TNF therapy.

30 dings provide a possible explanation for the failures of anti-EGFR therapy in GBM and suggest a new a

31 lin-resistant S. aureus), is associated with failure of antibiotic therapy and elevated mortality.

32 The perception exists that failure of antibiotic treatment due to antibiotic resist

33 or selectivity of agonists, and the inherent failure of antibodies to differentiate between the large

34 Biofilm formation leads to the failure of antimicrobial therapy.

35 ss in ventilated patients with a circulatory failure of any cause.

36 WHO guidelines for these regions define failure of ART with a lenient threshold of viraemia (HIV

37 Molecular markers that predict failure of artemisinin combination therapy are urgently

38 associated protein Nogo-A contributes to the failure of axon regeneration in the mammalian central ne

39 Overcoming the failure of axon regeneration in the mammalian central ne

40 Merlin in these cells causes a catastrophic failure of axonal regeneration and remyelination in the

41 on of soluble high-molecular-weight tau, the failure of axonal transport, clumping of mitochondria, d

42 The failure of axons to regenerate was strongly correlated w

43 mergency myelopoiesis is damaged, leading to failure of bacterial clearance, and excessive stress-ind

44 The innate immune deficits included the failure of bacterial foci to attract macrophages and NK

45 This model also replicated surprising failures of bees to discriminate certain seemingly highl

46 The successes and failures of biologics in clinical trials have facilitate

47 anches, and this trend results in disastrous failures of BMGs.

48 We attribute these anomalies to the failure of both assumptions underlying the classical des

49 ents with classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and

50 ot defect arises during germination and is a failure of bps1 mutants to maintain their shoot apical m

51 We proposed that failure of C2 cleavage was due to the flexible nature of

52 portant to learn from the past successes and failures of cancer nanomedicines for its future applicat

53 We reasoned that the failure of catalytic p38 inhibitors may derive from thei

54 This could explain the failure of CCK agonists in previous clinical trials and

55 inflammatory cytokines may play both in the failure of CD4(+) T-cell restoration and the CD8(+) T-ce

56 The failure of cells lacking adenylyl cyclase (cyr1Delta) to

57 Functional failure of CFTR results in mucus retention and chronic i

58 resence of cancer stem cells may lead to the failure of chemotherapy.

59 tion and treatment was associated with early failure of chimerism, regardless of Treg cell administra

60 on, OLP maturation arrest and apoptosis, and failure of CNS myelination.

61 holangiopancreatography (ERCP) can result in failure of common bile duct (CBD) stone removal and panc

62 le, and if it plays a role in the success or failure of competing groups, then selection will operate

63 Failure of conventional imaging-using predominately sing

64 Pro-Gly-Pro (PGP) and rationalized that the failure of conventional LTA4H inhibitors may be that the

65 h refractory large B-cell lymphoma after the failure of conventional therapy.

66 lecular phenotypes correlated with both this failure of convergence force generation in explants and

67 Failures of coreference resolution are a common cause of

68 n with few effective options available after failure of corticosteroids.

69 nefit from a more potent ALK inhibitor after failure of crizotinib, and establish ceritinib as a more

70 The failure of cross-study validation has largely diminished

71 We set out to investigate if the failure of cultured mesenchyme cells to form bioengineer

72 industrialized countries may result from the failure of current vaccines to prevent nasopharyngeal co

73 e, knockdown of KHARON mRNA induces a lethal failure of cytokinesis in both bloodstream (mammalian ho

74 A failure of cytotoxic T cells to limit or contract inflam

75 ents with HCV genotype 1 infection and prior failure of DAA-containing therapy; RBV coadministration

76 ronal signals in the dACC, but also a common failure of dACC lesions to reliably abolish conflict-dri

77 e 1b infection, and L31M was associated with failure of daclatasvir or ledipasvir, but not ombitasvir

78 was the RAS most frequently associated with failure of daclatasvir, ledipasvir, or ombitasvir in pat

79 cium blood isolate predicted microbiological failure of daptomycin therapy, suggesting that modificat

80 donor is the most plausible explanation for failure of dechlorination.

81 Failure of Deltaami1 mutant cells to separate also led t

82 Thus, a failure of development of mesonephros/mesonephric duct g

83 rdiac remodeling and poor prognosis in heart failure of different etiologies.

84 was confirmed by in situ hybridization and a failure of disease to recur after CD3 T cell depletion.

85 Thus, it can be speculated that a failure of dopamine receptor and transporter homoeostasi

86 Recent failures of drugs that raised high-density lipoprotein (

87 In contrast, the hype and failure of early inhibitor discovery have dogged our sta

88 e over time suggests that the rim might mark failure of early lesion repair and/or irreversible tissu

89 he host response within the affected tissue; failure of effective resolution may lead to tissue injur

90 shment of pregnancy is a critical event, and failure of embryo implantation and stromal decidualizati

91 tant for reducing the risk of reintroduction failure of endangered species.

92 ts with A. arenosa pollen donors resulted in failure of endosperm cellularization, whereas the endosp

93 uch spatial metabolic dysfunction suggests a failure of energy homeostasis and/or oxidative stress, s

94 e the life expectancy, breakdown, and device failure of engineered skeletal muscle bio-bots as a resu

95 HSCR is caused by the developmental failure of ENS progenitors to migrate into the gastroint

96 tal obstruction of the bowel, results from a failure of enteric nervous system (ENS) progenitors to m

97 ND & AIMS: Hirschsprung disease is caused by failure of enteric neural crest cells (ENCCs) to fully c

98 en diameters expand aberrantly, resulting in failure of epithelial tubulogenesis and ductal plexus fo

99 Primary failure of ESAs was associated with a higher risk of acu

100 Early failure of ESAs was associated with a higher risk of AML

101 y a narrow reaction toolkit and the frequent failure of even these reactions with polar and functiona

102 We explain the failure of existing classes of therapeutic agents such a

103 as a central target in glioma and traces the failure of existing drugs to incomplete/nondurable inhib

104 that disrupted endocytic trafficking led to failure of F to function with M for VLP assembly.

105 d, suggesting a new approach to overcome the failure of ferroelectric retention.

106 Currently, after failure of first line ALK TKI therapy, another ALK TKI i

107 ich led to significant pro-M I/M Iarrest and failure of first polar body (PB1) extrusion.

108 -Saharan Africa in patients with virological failure of first-line combination antiretroviral therapy

109 22%, respectively) at highest risk of early failure of first-line immunochemotherapy and death, incl

110 mutations (TAM) in patients with virological failure of first-line tenofovir-containing ART.

111 TATION: TAMs are common in patients who have failure of first-line tenofovir-containing regimens in s

112 Of 712 individuals with failure of first-line tenofovir-containing regimens, 115

113 Failure of fission caused defective sorting of mannose 6

114 The disappointing recent failure of fluoroquinolone-containing regimens to shorte

115 cell fusion assays show a strain-independent failure of fusion pore enlargement among H2 (A/Japan/305

116 rovides basic information for the mechanical failure of gas-adsorbed graphene and guidance for manufa

117 Conversely, the GATA4-G296S mutation led to failure of GATA4 and TBX5-mediated repression at non-car

118 Self-heating induced failure of graphene devices synthesized from both chemic

119 Failure of grassland soils to accumulate SOC was attribu

120 logistical regression analysis revealed that failure of H. pylori eradication (Odds = 4.013, 95% CI:

121 One major reason for failure of HBV treatment is the inability to eradicate o

122 lation outside the ICU for acute respiratory failure of heterogeneous causes and to identify the pred

123 Despite the consistent failures of HSV subunit vaccines in clinical trials span

124 obulin in certain endemic regions as well as failure of immunoprophylaxis.

125 for patients with NRAS-mutant melanoma after failure of immunotherapy.

126 Failure of implantation and the subsequent decidualizati

127 The mechanisms underpinning the failure of inflammation to resolve in diseased musculosk

128 3PHD-H3K4me3 binding was demonstrated by the failure of ING3PHD mutant proteins to enhance ING3-media

129 risk of type 2 diabetes, culminating in the failure of insulin secretion from pancreatic beta-cells.

130 ose homeostasis is driven by a near complete failure of insulin to suppress hepatic glucose productio

131 Progressive failure of insulin-producing beta-cells is the central e

132 Failure of interferon (IFN)-alpha-based treatment is rel

133 before the onset of angiogenesis resulted in failure of invading endothelial cells to recruit pericyt

134 These data suggest that a failure of iron homeostasis with increased iron availabi

135 Motivated by the failure of LMMs to control type I errors in a GWAS of as

136 us, peroxisomal dysfunction causes secondary failure of local lysosomes, thereby impairing the turnov

137 ffects endosomes and induces the progressive failure of lysosomes, each of which are directly linked

138 are critical for control of C. neoformans, a failure of macrophage response is not the limiting defec

139 dystrophy (NCMD) is believed to represent a failure of macular development.

140 pose To assess the determinants of technical failure of magnetic resonance (MR) elastography of the l

141 m cells in an age-dependent manner, implying failure of maintaining the spermatogonial stem cell nich

142 The failure of maternal plasma volume expansion has been imp

143 Due to failure of medical treatment in controlling the glaucoma

144 e asthma with respiratory muscle fatigue and failure of medical treatment.

145 impairment involves rapid decay rather than failure of memory acquisition.

146 Nearly 90 per cent of service failures of metallic components and structures are cause

147 ating disease progression that culminates in failure of mitochondrial energy production and cell loss

148 ontributes to inflammatory changes through a failure of mitochondrial structure and function as well

149 Newer statistical approaches are prone to failure of model convergence, especially in settings whe

150 on deficit is associated with the widespread failure of models in capturing strong rainfall events in

151 lationship between programmed parameters and failure of modern ICDs to treat VF.

152 methodology for interface-initiated fatigue failures of monolithic ceramic crowns under simulated ma

153 One practical consequence is the failure of most quantification assays to properly detect

154 of 3.0 T were significantly associated with failure of MR elastography (P < .004).

155 sease were all significantly associated with failure of MR elastography (P < .004); but on the basis

156 ditional independent factors associated with failure of MR elastography of the liver with a two-dimen

157 ss potential predictive factors of technical failure of MR elastography.

158 was determined to be primarily the result of failure of mutation probe hybridization and not the resu

159 thy, whereas complete loss of Tmods leads to failure of myofibril assembly and developmental defects.

160 substrate under certain conditions can cause failure of N-removal processes relying on anaerobic ammo

161 Single-point failures of natural gas infrastructure can hamper methan

162 For example, failure of neural fold fusion during neurulation leads t

163 ral tube defects (NTDs), which result from a failure of neural tube closure during embryogenesis.

164 otor learning theoretical context and on the failure of neuroelectric brain-computer interface (BCI)

165 impaired glutamate uptake leads to recovery failure of neurons from SD.

166 was defined as symptomatic congestive heart failure of New York Heart Association class III or IV, c

167 -cell defect induced by GVHD resulted in the failure of NK-cell-dependent in vivo cytotoxicity and gr

168 Failure of NKp65 to recruit Syk is not due to an alterat

169 Failure of noninvasive mechanical ventilation did not in

170 ions with a complex etiology that reflects a failure of normal facial development.

171 Liljencrantz et al report the failure of observing contagious itch behavior using mice

172 Failure of OFOQ to detect HIV-1 infection was frequent a

173 tn mutant mice, which is consistent with the failure of OHC stereocilia to maintain stable interactio

174 vailable in the clinic to prevent restenotic failure of open vascular reconstructions.

175 association and causation may result from a failure of oral vitamin D to mimic the effect of dermall

176 are needed for robust growth, explaining the failure of our initial design.

177 AH, we demonstrated reduced FA oxidation via failure of palmitoylcarnitine to stimulate oxygen consum

178 acity in patients who are predisposed to the failure of pancreatic beta-cell function is a major conc

179 The failure of pancreatic islet beta-cells is a major contri

180 ipitates a neural differentiation defect and failure of PAX6 induction during differentiation.

181 Disrupting both domains led to a complete failure of Pcdh15a to localize to the hair bundle.

182 ition of a TIM-3 blocking antibody following failure of PD-1 blockade.

183 The reasons behind the failure of PGMK30FRhL3 during phase 1 clinical trial, de

184 Failure of phagocytosis could be induced experimentally

185 TP/GTP binding motifs of SQU and KEW lead to failure of phosphorylation, and transgenic plants bearin

186 further identify factors that contribute to failure of PIMT compliance.

187 ity of pazopanib in urothelial cancers after failure of platinum-based chemotherapy.

188 Sudden death is associated with failure of postnatal organ maturation.

189 The failure of ppk1 spores to accumulate polyP results in a

190 ly-encoded transcripts frequently results in failure of preimplantation embryonic development, but th

191 that PAD-induced spiking does not represent failure of presynaptic inhibition.

192 proximal, and remediable explanation for the failure of prior clinical trials of targeted therapy.

193 nal suppressive mechanism cannot explain the failure of producing E-cadherin protein in metastatic br

194 This leads to a failure of proepicardial cell migration and adhesion to

195 reduction in proliferation, suggesting that failure of progenitor proliferation contributes to the h

196 Technical failure of PTA was predictive of elastic recoil (P < .00

197 ments was the sole independent predictor for failure of PVS to induce ejaculation.

198 he affected region permanently stall, so the failure of R-loop removal in RNase H-deficient bacteria

199 Failure of regeneration was associated with increased re

200 This is associated with a failure of regulatory T-cell (Treg) homeostasis and cGVH

201 d MS susceptibility, particularly due to the failure of remyelination associated with progressive MS.

202 of myelin (demyelination) within the CNS and failure of repair (remyelination).

203 Failure of RipA processing in MarP-deficient cells leads

204 d severity of IgA nephropathy, may reflect a failure of rituximab to reduce levels of specific antibo

205 fect in gene transcription and the technical failure of RNA transcript capture, often render traditio

206 Current theories attribute aging to a failure of selection, due to either pleiotropic constrai

207 Thus, a seeming failure of self-control in reactive violence could be ca

208 veral RASs were specifically associated with failure of simeprevir (Q80K/R in patients with genotype

209 These failures of single-antigen vaccines have prompted ongoin

210 sulted in mitochondrial oxidative damage and failure of SODA/DeltasodA promastigotes to differentiate

211 dity acts as a key control parameter for the failure of solids under stress.

212 ever, it is becoming increasingly clear that failure of some patients to respond to checkpoint inhibi

213 indicative of elevated oxidative stress and failure of some upregulated antioxidant genes to be tran

214 tation of the GLR genes GLR1 and GLR2 causes failure of sperm cells to target the female reproductive

215 Disruption of Mkrn2 also caused failure of sperm release (spermiation failure) and misar

216 Failure of spinal closure in pre-spina bifida Zic2(Ku) m

217 Failure of SRY expression due to hypermethylation was fu

218 e the efficacy, safety, and risk factors for failure of standalone ab interno gelatin microstent impl

219 that dwell time was the only risk factor for failure of standard retrieval technique (odds ratio, 1.0

220 bility criteria included measurable disease, failure of standard therapy, and Eastern Cooperative Onc

221 hermal sensitivity in predicting the success/failure of symbionts to spread into novel species follow

222 ich result in increased transmitter release, failure of synaptic plasticity, and memory loss.

223 sential for this nuclear localization, and a failure of TCA cycle enzymes to enter the nucleus correl

224 We sought to understand the mechanism of failure of Th17 immunity resulting in S. pneumoniae infe

225 rm and its derivatives, including a complete failure of the anterior extension of axial mesoderm.

226 The failure of the antioxidant scavenging system in advanced

227 This is a result of a failure of the Badger relationship (the shorter bond is

228 th the autophagy inhibitor chloroquine after failure of the BRAF(V600E) inhibitor vemurafenib, sugges

229 e for drugs, it could equally well reflect a failure of the brain mechanisms that allow addicts to le

230 6) identifies a form of ASD resulting from a failure of the brain to properly import amino acids.

231 mediated knockdown of KHARON mRNA results in failure of the calcium channel to enter the flagellar me

232 Reciprocity failure of the diffraction efficiency according to the p

233 Failure of the DvH to successfully transition contribute

234 r abnormalities in HF development, including failure of the E-cadherin suppression required for folli

235 Our results implicate failure of the ER-endosome contact process in axonopathy

236 ecreased Akt phosphorylation, resulting from failure of the exocyst to deliver basolateral proteins t

237 is a pathology of pregnancy that results in failure of the fetus to reach its genetically determined

238 rophic non-union is attributed to biological failure of the fracture repair process.

239 connotes severe deficiency, resulting from a failure of the gastric or ileal phase of physiological B

240 The failure of the Global Malaria Eradication Program (GMEP)

241 Failure of the immune system to eradicate viruses result

242 troduced either immediately (N = 6) or after failure of the initial treatment (N = 10) or failed atte

243 Freedom from failure of the integrated driveline was 79% at 3 years f

244 The loss of efficacy correlated with failure of the knockout CTLs to infiltrate into tumors u

245 system size on the shock response and spall failure of the metal.

246 The adjusted HR of failure of the microstent relative to trabeculectomy was

247 reactivation which is likely linked with the failure of the monocytes to differentiate to a DC phenot

248 rative disease, characterised by progressive failure of the neuromuscular system.

249 However, repair is limited because of the failure of the newly produced glial cells to differentia

250 tigorite dehydration triggered dynamic shear failure of the olivine load-bearing network.

251 Failure of the optic fissure to close gives rise to an o

252 ce demanding, thereby increasing the risk of failure of the overall antibody discovery program.

253 er of undesirable side effects and resultant failure of the patients to adhere to treatment.

254 induce macrophage death, as evidenced by the failure of the phagosome escape-deficient mutant SCHU S4

255 ions in the fibrous cap may promote material failure of the plaque, but that large calcifications can

256 Owing to the failure of the present pharmaceutical options, such as c

257 -Fe oxide nanoparticles originating from the failure of the reactor pressure vessels.

258 hile FEF activity corresponded to success or failure of the response inhibition regardless of the sti

259 of ccTGA effectively resolves the problem of failure of the systemic RV and has good early and midter

260 Our results illustrate the failure of the traditional quasiclassical model of photo

261 The primary endpoint was failure of the treatment strategy, defined as the absenc

262 toimmune disorder that is characterized by a failure of the unfolded protein response in islet beta c

263 unction the result of a maladaptive UPR or a failure of the UPR to adequately adapt?

264 Failure of the urea cycle and hyperammonemia are common

265 Virological failure of the WHO-recommended first-line NNRTI-based re

266 muscle tissues is a potential cause for the failure of therapeutic angiogenesis.

267 The failure of therapeutically relevant isradipine levels to

268 ed as a major mechanism underlying treatment failure of these molecule-targeted agents.

269 The failure of these phases to occur in a timely, progressiv

270 The failure of these technologies may be due to the limitati

271 Failure of this activity results in severe metabolic dis

272 Failure of this closure process leads to open spina bifi

273 rosine kinase Kit are thought to represent a failure of this colonization, either due to impaired mig

274 Failure of this mechanism is a hallmark of type 2 diabet

275 Failure of this migration during neuroepithelium formati

276 Failure of this protective mechanism may contribute to d

277 damage, and restore tissue homeostasis, and failure of this response contributes to the pathology of

278 The failure of this system in ALS may translate into the spl

279 Failure of this transition leads to pulmonary hypertensi

280 outpatient setting, and 26 (15%) because of failure of timely outpatient follow-up.

281 microscopic failures cascade to macroscopic failures of tissues, organs and ultimately the organism.

282 Failure of trabecular myocytes to undergo appropriate ce

283 otective agents in stroke has been a notable failure of translation from medical research into clinic

284 s have also substantially contributed to the failure of translation of cardioprotection to clinical p

285 sregulated immunity, which correlated with a failure of Treg expansion following infection.

286 hway for both prevention of autoimmunity and failure of tumor rejection.

287 phoblastic leukemia (ALL) who progress after failure of tyrosine kinase inhibitor (TKI) -based therap

288 t immunization schedules, exacerbated by the failure of vaccines to work in the first months of life.

289 end points were restenosis, thrombosis, and failure of vascular access.

290 ice died 2 to 3 weeks after infection due to failure of viral clearance.

291 Despite the failure of virus spread to the tumor, infection resulted

292 Our results suggest that the success or failure of VPA treatment is dependent on genotype and th

293 with composite properties, allowing a staged failure of water supply.

294 ss the impact of reaction-induced mechanical failure of wellbore cement by coupling sensitivity analy

295 e of endosomes containing internalized PRRs, failure of which resulted in enhanced signaling and expr

296 Overall, we demonstrate failure of white matter maturational changes and progres

297 However, many studies indicate that failure of white matter repair goes beyond the intrinsic

298 to Minimize Outcomes in Patients With Heart Failure), of whom 3575 (24%) had AF on their baseline EC

299 tervention group had immunological treatment failure, of whom 332 (30%) and 727 (54%), respectively,

300 logical factors rather than a pathology or a failure of willpower.