ライフサイエンスコーパス: familial risk

1 nset adolescent depression in individuals at familial risk.

2 s were not detected in a large group at high familial risk.

3 l abnormalities as compared to youth with no familial risk.

4 lity genes explain less than half the excess familial risk.

5 k, and the remaining 91% were considered low familial risk.

6 re age 5 years is therefore a marker of high familial risk.

7 on of breast cancer in women who are at high familial risk.

8 sability in the proband appears to influence familial risk.

9 s, which individually account for >1% of the familial risk.

10 te that can explain approximately 33% of the familial risk.

11 d common genetic variants that contribute to familial risk.

12 s a systems-level endophenotype or marker of familial risk.

13 unctional neural system mechanism related to familial risk.

14 oach allows for a very precise definition of familial risk.

15 g an additive effect of CACNA1C variation on familial risk.

16 uneus in the left hemisphere, independent of familial risk.

17 cer in young men and is notable for its high familial risks.

18 ntified to date explain 37% of father-to-son familial risk, 8% of which can be attributed to the 12 n

19 The pattern of familial risks across different levels of relatedness su

20 Familial risk analysis examined the risks in first-degre

21 Patterns of familial risk analysis suggest that the association betw

22 Familial risk analysis was used to clarify the relations

23 connectivity mediated a relationship between familial risk and a neuropsychological measure of impuls

24 investigate telomere length in connection to familial risk and disease expression in bipolar disorder

25 rts are well under way, precise estimates of familial risk and heritability are lacking.

26 at estimated summary statistics of aggregate familial risk and heritability for each disorder.

27 -onset MDD (incident cases) in those at high familial risk and to postulate a theoretically informed

28 or most cancer types, there were significant familial risks and the cumulative risks were higher in m

29 relatively low incidence of lymphoma, modest familial risk, and the lack of a screening test and asso

30 e top ninth percentile were assigned as high familial risk, and the remaining 91% were considered low

31 ion of disease, to estimate the magnitude of familial risks, and to identify families at high risk of

32 en siblings and offspring in the patterns of familial risk are intriguing and should be investigated

33 s with CLL and the effects of sex and age on familial risk are unknown.

34 These familial risks are elevated for multiple lymphoma subtyp

35 tios for undiagnosed diabetes, using average familial risk as referent, were 1.7 (95% confidence inte

36 ncreased risk of major depression beyond the familial risk associated with a depressed proband.

37 We found high familial risks between some concordant histologic subtyp

38 o disengage default-mode regions in those at familial risk carrying the risk haplotype.

39 The Familial Risk-Colorectal Cancer: European Society for Me

40 ssional personality traits may be a specific familial risk factor for anorexia nervosa.

41 ivity in the dACC/MCC appears to represent a familial risk factor for developing PTSD after exposure

42 of hypertension in pregnancy may be a novel familial risk factor for future hypertension.

43 he dorsal anterior cingulate appears to be a familial risk factor for the development of PTSD followi

44 e in PTSD is an acquired characteristic or a familial risk factor.

45 nd schizophrenia is not the result of shared familial risk factors and may be causal.

46 9%) who received CPM had no major genetic or familial risk factors for contralateral disease.

47 we know little about the relationship of the familial risk factors for premenstrual symptoms and majo

48 premorbid neurodevelopmental impairments and familial risk factors for schizophrenia are prominent in

49 nia from other psychotic syndromes, and take familial risk factors into consideration.

50 enia have considered individuals with either familial risk factors or prodromal symptomatology.

51 simonious score were similar irrespective of familial risk factors.

52 D and learning disabilities is due to shared familial risk factors.

53 dence that these 2 disorders may have shared familial risk factors.

54 portant eye diseases and their behavioral or familial risk factors.

55 ximum age 38 years) to examine perinatal and familial risk factors.

56 f female individuals with ADHD are at higher familial risk for ADHD than the siblings of affected mal

57 ngs suggest that these volumes are linked to familial risk for ADHD.

58 use disorder are increased in those at high familial risk for alcoholism.

59 in a cohort of 24-month-olds at high and low familial risk for ASD reduced this confound; we reported

60 behavioural characteristics of newborns with familial risk for ASD, allowing for a prospective approa

61 in a cohort of 104 infants with and without familial risk for autism by virtue of having an older si

62 data were collected from 270 infants at high familial risk for autism spectrum disorder and 108 low-r

63 the newly emerging literature on infants at familial risk for autism to shed light on this issue.

64 measure brain volume in 6-month-olds at high familial risk for autism.

65 ngitudinal study of infants with and without familial risk for autism.

66 Individuals at high familial risk for BD homozygous for the DGKH risk haplot

67 shortened telomere length is associated with familial risk for BD.

68 scent-onset bipolar disorder and in youth at familial risk for bipolarity.

69 or assessing the probability that a youth at familial risk for BPSD will develop new-onset BPSD withi

70 predict the 5-year onset of BPSD in youth at familial risk for BPSD.

71 have not considered the heterogeneity of the familial risk for breast cancer in a systematic way.

72 g Nordic twins, there was significant excess familial risk for cancer overall and for specific types

73 processing in 36 prereading children with a familial risk for DD (n = 18, average age = 66.50 mo) co

74 Familial risk for depression affects neural mechanisms u

75 Children at familial risk for depression exhibited atypical function

76 ased on rs-fcMRI, individuals at high vs low familial risk for depression showed increased DMN connec

77 t episodes of depression (i.e., daughters at familial risk for depression) or with no history of psyc

78 dividuals, aged 11-60 years, at high and low familial risk for depression.

79 er ill persons who have either a high or low familial risk for depression.

80 hed with persons who were at higher or lower familial risk for developing depression based on being b

81 ves do not have MDD but who are at increased familial risk for developing the illness.

82 of depressive illness in individuals at high familial risk for major depression, possibly by expandin

83 Bipolar Disorder, or persons at high or low familial risk for Major Depressive Disorder, our method

84 By studying individuals at high familial risk for MDD, we aimed to identify potential bi

85 These analyses provide strong evidence that familial risk for neuropsychiatric disease becomes more

86 Moreover, there was no evidence of increased familial risk for non-right-handedness.

87 parate twin modeling analyses confirmed that familial risk for OCD was largely attributable to additi

88 nction of panic disorder diagnosis, sex, and familial risk for panic.

89 Familial risk for PD in children and adolescents may be

90 risk loci that explain approximately 33% of familial risk for prostate cancer (PrCa), their function

91 youths, reflecting a connectome signature of familial risk for psychotic illness.

92 The familial risk for rheumatoid arthritis was similar in pa

93 g that personality might be one indicator of familial risk for substance use disorders during this de

94 aspects of atypical activation as markers of familial risk for the condition from those that are auti

95 nctional endophenotype of autism, related to familial risk for the condition shared between individua

96 renia (Sz) and have been associated with the familial risk for the disorder.

97 ate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry popu

98 ty loci, explaining approximately 30% of the familial risk for this disease, have now been identified

99 Our results suggest that some familial risks for carcinoma will be evident only throug

100 sive melanoma was slightly lower in the high-familial-risk group (57 v 60 years; P = .03).

101 BRCA mutation carriers and women with a high familial risk (> 20% lifetime risk) for breast cancer we

102 twin concordance, and ethnic differences in familial risks have established that CD and UC are compl

103 ly developing infants, either at High or Low familial Risk (HR or LR, respectively) for developing Au

104 s in 6-to 9-month-old infants at high or low familial risk (HR/LR) of ASD while they viewed static im

105 tions and provide more rigorous estimates of familial risk in a population-based study.

106 a modest effect on the risk of HL; however, familial risk in NLPHL has not been previously examined.

107 ing the Finnish registries and evaluated the familial risk in NLPHL.

108 The familial risk in sisters (9.4-fold; 95% CI, 5.9- to 14-f

109 ty loci, explaining approximately 25% of the familial risk in this disease, have now been identified.

110 In contrast to women with genetic or familial risk, in HL survivors breast MRI was not more s

111 at onset has been associated with increased familial risk, increased clinical severity, and distinct

112 lected from 97 infants, of whom 16 were high-familial-risk infants later classified as having an ASD,

113 er classified as having an ASD, 40 were high-familial-risk infants who did not later meet ASD criteri

114 al health resilience in young people at high familial risk is an internationally recognised priority.

115 offspring support other data indicating that familial risk is genetically determined.

116 Some of the unexplained familial risk is presumably due to high-penetrance mutat

117 The remainder of the unexplained familial risk is presumably due to other high-penetrance

118 one-third of colon cancers exhibit increased familial risk, likely related to inheritance.

119 was obtained for CO(2) hypersensitivity as a familial risk marker for PD in children and adolescents.

120 de (CO(2)) sensitivity is postulated to be a familial risk marker of panic disorder (PD).

121 The overlap in familial risk may reflect shared genetic susceptibility.

122 elevated levels of aggression, impulsivity, familial risk of aggression, and abnormalities in neurob

123 ve neuroimaging study of 106 infants at high familial risk of ASD and 42 low-risk infants, we show th

124 ive brain-imaging studies of infants at high familial risk of ASD might identify early postnatal chan

125 cokinetic effects (eg, absorption rates), or familial risk of AUDs.

126 Studies of infants at high familial risk of autism can provide insight into the ear

127 on to social stimuli in newborns with a high familial risk of autism.

128 roups consisted of young individuals at high familial risk of BD (n=81) and a comparison group of hea

129 died 98 young unaffected individuals at high familial risk of BD and 58 healthy controls using functi

130 nset bipolar spectrum disorders in youths at familial risk of bipolar disorder ("at-risk" youths).

131 affected with bipolar disorder (BP), at high familial risk of BP, and at low risk to identify endophe

132 genetic risk variants explain ~10% of excess familial risk of breast cancer in Asian populations.

133 ility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic

134 family cancer cohort studies, 2 enriched for familial risk of breast cancer.

135 s would account for just 0.32% of the excess familial risk of breast cancer.

136 We aimed to provide the familial risk of classical Hodgkin lymphoma (HL) by rela

137 Moreover, given the strong familial risk of CLL, we further subset our GWA analysis

138 oscopy screening in individuals at increased familial risk of colorectal cancer (CRC) is suboptimal,

139 A proportion of the familial risk of common cancers may be attributable to v

140 We compared 27 individuals without a familial risk of dependence who had been using cocaine r

141 order (MDD) is common in individuals at high familial risk of depression and is associated with poor

142 ight be present in young people at increased familial risk of depression but with no personal history

143 salivary cortisol levels in young people at familial risk of depression but with no personal history

144 dings suggest that young people at increased familial risk of depression have altered neural represen

145 ssed individuals, and 30 individuals at high familial risk of developing depression underwent functio

146 on and otherwise healthy individuals at high familial risk of developing depression.

147 significant thinner cortex associated with a familial risk of developing depressive illness.

148 is the first to demonstrate that children at familial risk of developing MDD are characterized by acc

149 1) with a model (model 2) that also included familial risk of diabetes (average, moderate, and high).

150 hysical activity of sedentary individuals at familial risk of diabetes.

151 We examined familial risk of disease in relation to age at onset in

152 Familial risk of early ischemic stroke almost doubled wh

153 Almost all previous studies of familial risk of epilepsy have had potentially serious m

154 Previous studies on familial risk of ischemic stroke have supported genetic

155 As familial risk of lung disease is better defined, referra

156 s was conducted in unaffected individuals at familial risk of mood disorder (n = 70) and comparison s

157 11 initially unaffected young adults at high familial risk of mood disorders and 93 healthy control s

158 rum CA-125 measurement in women at increased familial risk of ovarian cancer is ineffective in detect

159 ng chemopreventive strategy in women at high familial risk of ovarian cancer.

160 even loci explained approximately 13% of the familial risk of PDB.

161 87 years) in a cohort of individuals at high familial risk of schizophrenia (n = 142) and control sub

162 gether account for an additional 4-6% of the familial risk of TGCT.

163 Compared with individuals at low familial risk of the development of depression, high-ris

164 t these explain only a small fraction of the familial risk of the disease.

165 cancer, explaining approximately 14% of the familial risk of the disease.

166 nd these account for approximately 9% of the familial risk of the disease.

167 25 variants explain approximately 16% of the familial risk of this breast cancer subtype.

168 ling, stratified by sex and age, to estimate familial risk of tooth loss as well as estimates of heri

169 embolism (VTE) clusters in families, but the familial risk of VTE has not been determined among adopt

170 We investigate the familial risks of cancers of the breast and ovary, using

171 Family-Cancer Database to test for increased familial risks of CLL and other lymphoproliferative tumo

172 thermore, new light is shed on the different familial risks of seminoma and nonseminoma.

173 er in young men and have an unusually strong familial risk, only one low-frequency susceptibility gen

174 There were no differences in familial risk or heritability between male and female pa

175 development of depression, as a function of familial risk or, in the absence of familial risk, stres

176 hird-generation offspring of depressed (high familial risk) or nondepressed (low familiar risk) proba

177 ccount for more than a small fraction of the familial risk, perhaps because the responsible variation

178 To estimate the familial risk ratio (lambda) of sarcoidosis in sibs and

179 The familial risk ratio for childhood obesity when a parent

180 ver, approximately two-thirds of the overall familial risk remain unexplained.

181 : 2.2, 6.3) for those with moderate and high familial risk, respectively.

182 Time-to-event analyses were used to estimate familial risk (risk of cancer in an individual given a t

183 A familial risk score was calculated for each subject.

184 The familial risk status of the subjects and greater EEG sen

185 ction of familial risk or, in the absence of familial risk, stressful life events.

186 High-familial-risk subjects had more melanomas diagnosed at a

187 ears) had slightly (nonsignificantly) higher familial risk than the total sample, although this was s

188 The familial risk to CD is composed of 2 discrete dimensions

189 Familial risk was higher in full (relative risk, 1.64; 9

190 The highest familial risk was observed among first-degree relatives

191 test, p=0.006), but higher than expected if familial risk was simply polygenic.

192 Familial risks were even higher when multiple relatives

193 Although familial risks were highest at ages below 60 years, most

194 velop MDD from healthy controls and those at familial risk who remain well.

195 tical thickness mediated the associations of familial risk with inattention, visual memory, and clini

196 carry deleterious BRCA mutations as in high familial-risk women who are noncarriers, but occurs at a