ライフサイエンスコーパス: family member

1 of the assembling flagellum by a kinesin-15 family member.

2 structural maintenance of chromosomes (SMC) family member.

3 on factor (a Ste12 family member) and a Dig1 family member.

4 specific expression differs depending on the family member.

5 ors the opportunity to provide a kidney to a family member.

6 e located in a consensus region in many GH31 family members.

7 t in BRPF1 (c.1052_1053del) in five affected family members.

8 mbination, CXCR4 pathway signaling, and BCL2 family members.

9 of both sleep EEG and metabolic traits in 48 family members.

10 Zrt, Irt-like protein (ZIP) zinc transporter family members.

11 nd loss of expression of LAT in the affected family members.

12 form similar modifications of other TGF-beta family members.

13 lp elucidate the function of the CLE peptide family members.

14 re shared identity-by-descent among affected family members.

15 gation analysis were performed in additional family members.

16 ot IgE, were similarly increased in affected family members.

17 iapoptotic B cell leukemia/lymphoma 2 (Bcl2) family members.

18 ed clinical surveillance recommendations for family members.

19 o-design event involving staff, patients and family members.

20 tate metal-binding species observed in other family members.

21 mutation at the RET gene was performed in 11 family members.

22 naling lymphocyte activation molecule (SLAM) family members.

23 ) genes, including previously unstudied gene family members.

24 , at sites distinct from the other Kinesin-6 family members.

25 he origins of selectivity for specific Bcl-2 family members.

26 ation E3s by promoting neddylation of cullin family members.

27 results and no new cases of CRC are found in family members.

28 m spectrum disorders (ASDs) as well as their family members.

29 erpinned by conflict and cooperation between family members.

30 ture has been determined among the four IRAK family members.

31 e of its low sequence homology with other Kv family members.

32 the main adaptor molecule for TLR and IL-1R family members.

33 cipher as a result of redundancy between the family members.

34 ibitors display activity toward multiple RGS family members.

35 yrosine protein kinase) in all four affected family members.

36 n and the transcription of TEA domain (TEAD) family members.

37 ng affinity of the Fc to diverse Fc receptor family members.

38 onservation, and divergence of MADS-box gene family members.

39 ardization in the production of the graphene family members.

40 c shuttling among seven canonical SR protein family members.

41 ease penetrance by cosegregation analysis in family members.

42 he transcriptomes of affected and unaffected family members.

43 dverse effects due to inhibition of multiple family members.

44 knowledged as crucial for patients and adult family members.

45 r RNA-binding protein CELF1 (CUGBP Elav-like family member 1) in the adult heart has been implicated

46 e Mouse Mammary Tumor Virus integration site family, member 10B (Wnt10b)/beta-catenin and adipogenic

47 in caspase activation and recruitment domain family member 11 (CARD11) was identified by using whole-

48 rate or by acetyl-CoA synthetase short-chain family member 2 (ACSS2) from acetate.

49 a signaling pathway-associated genes of SMAD family member 2 (SMAD2), SMAD3, SMAD4, transforming grow

50 The use of cadherin-related family member 3 (CDHR3) by RV-C as its cellular receptor

51 An L1 within ERI1 exoribonuclease family member 3 (ERI3) was found to associate with SZ.

52 C57BL/6 mice that express human regenerating family member 3 alpha (hREG3A) in hepatocytes, via the a

53 ic (TG) expression of the human regenerating family member 3 alpha gene (REG3A) alters the fecal micr

54 s, EoE associated strongly with IL-4/kinesin family member 3A (IL4/KIF3A) (P = 2.8 x 10(-6); odds rat

55 crotubule associated serine/threonine kinase family member 4 (MAST4).

56 we show that Pleckstrin homology containing family member 5 (Plekhg5) modulates autophagy of synapti

57 lar ligands, such as Tre-2/Bub2/Cdc16 domain family member 5 (TBC1D5) and VPS9-ankyrin repeat protein

58 Binding of La ribonucleoprotein domain family, member 6 (LARP6) to collagen mRNAs regulates the

59 Within the TRPM family, member 8 (TRPM8) is the primary cold and menthol

60 Cdc25 family member A (Cdc25A) is a phosphatase normally activ

61 lated by Ror2, which influenced Ras Homology Family Member A (RhoA) and Rho-Associated Coiled-Coil Ki

62 the expression and activation of Ras homolog family member A (RhoA) and subsequent activation of Rho-

63 e activation of the small GTPase Ras homolog family member A (RhoA) by the Galpha12/13 pathway.

64 e, we show that knocking out the Ras homolog family member A (RhoA) gene in normal fibroblasts decrea

65 num toxin substrate 1 and Ras homologue gene family, member A (RhoA) guanine nucleotide exchange fact

66 es with increased levels of Ras homolog gene family, member A (RhoA), a KCTD13/CUL3 ubiquitin ligase

67 show that a pharmacologic inhibitor of Cdc25 family members (A, B, and C) protects mouse primary neur

68 We report two family members, a 64-year-old woman (patient 1) and her

69 views with palliative care patients or their family members; a co-design event involving staff, patie

70 Bacterial permeability family member A1, BPIFA1, is a secreted innate defence p

71 Interestingly, miR-24, unlike other family members, actually promotes Th1 and Th17 responses

72 nes, including mutations of different HLA-DR family members affecting OX40 signaling pathway, which c

73 Medical staff, family members, ancillary staff, and interpreters.

74 showed that TRIM28 is the most abundant TRIM family member and is localized in nuclei of ECs.

75 1738-1753) identify the p53 family member and p73 isoform TAp73 as a crucial factor

76 post-translational modification of this TTSP family member and potentially other members of this fami

77 emistructured qualitative interviews with 76 family members and 150 clinicians participating in the T

78 ovel finding has implications for other SLC7 family members and additional eukaryotic transporters th

79 tic and postsynaptic localization of all APP family members and could show that heterologous expressi

80 Whole exome sequencing in five affected family members and five healthy members revealed a stop

81 ated interaction network between MDGA and NL family members and helped rationalize the impact of auti

82 Genetic diagnosis in affected family members and insight into the formation of large d

83 sights into the functional evolution of ABHD family members and the structural basis of lipase regula

84 risk of colonic and extracolonic cancers in family members and their relatives.

85 This mutation was present in unaffected family members and unaffected Lebanese controls.

86 hat includes a transcription factor (a Ste12 family member) and a Dig1 family member.

87 ts digestive system by comparison with other family members, and the loss of morphological features a

88 One specific family member, APOBEC3A (A3A), has been shown to readily

89 Some family members are also enriched in neural tissues in bo

90 ily members are hemizygotes, whereas healthy family members are either heterozygote or homozygote for

91 We report here that let-7 family members are expressed in retinal and choroidal en

92 in an X-linked pattern, as all the affected family members are hemizygotes, whereas healthy family m

93 ugh well-studied cold-shock protein A (CspA) family members are induced and function at low temperatu

94 linkers tethering WW domains in several HECT family members are key regulatory elements of their cata

95 Cytochrome P450 (CYP) family members are known to be present in the olfactory

96 Prominent family members are the neural cell adhesion molecules NC

97 nd epsilon-tubulin, two less-studied tubulin family members, are required.

98 ered from blocking Mdm2 interaction with p53 family members, as Nutlin-3 induced G1 arrest but did no

99 , CD14+, CD19+, and ILC2 cells from affected family members, as were IL-5 protein levels in supernata

100 cial differences in exposure to the death of family members at different ages, beginning in childhood

101 attenuated maturation of miR-466 and miR-200 family members at precursor miR levels through the regul

102 t the privacy of study subjects and of their family members at risk.

103 ration promoted by overexpression of the TAM family members AXL or TYRO3 depends on gamma-secretase c

104 hosphorylation site of the proapoptotic Bcl2 family member Bax as an anticancer strategy.

105 ed cell subsets from affected and unaffected family members belonging to a single large kindred.

106 We sought to evaluate inhibitors of p90RSK family members: BI-D1870 and BRD7389, for their ability

107 riptional regulation of the proapoptotic BH3 family members BimEL, Harakiri,and Puma, culminating in

108 by the highly labile and ER-associated BCL-2 family member BOK, which is controlled at the level of p

109 In this study, we report that the BET family members Brd2 and Brd4 exert distinct genomic func

110 Here we identify the short isoform of BET family member BRD4 (BRD4S) as a corepressor of HIV-1 tra

111 tor of the bromodomain and PHD finger (BRPF) family member BRPF2 and the TATA box binding protein-ass

112 eracts on chromatin with PBX, MEIS, and PREP family members, but not with TGIF, suggesting that TGIF

113 ) phosphorylation and the expression of AP-1 family members (c-Fos/c-Jun).

114 erexpressed, the SRCR repeats from other LOX family members can catalyze protein deacetylation/deacet

115 Moreover, cascade genetic testing in family members can identify those who are at risk or wit

116 s of the disease, whereas 10 (32%) of the 31 family members carrying one of these deletions fulfilled

117 resence of the disease in about one third of family members carrying the CNV, underlying the role of

118 ) exhibits great phenotype variability among family members carrying the same mutation, which can be

119 HODS AND Clinical data of 23 probands and 35 family members carrying this variant were retrospectivel

120 ral and functional analysis of the anophelin family member cE5, a salivary protein from the major Afr

121 The C-type lectin domain containing group 14 family members CLEC14A and CD93 are proteins expressed b

122 , we recruited 21 families with at least one family member clinically diagnosed with Robinow or Robin

123 e in number was observed in ASD patients and family members compared to controls, there were no signi

124 hat asbestos activates the nod-like receptor family member containing a pyrin domain 3 (NLRP3) inflam

125 arching ability observed among the DNA Pol X family members correlated with their proposed biological

126 idated that mRNA of MEX3D (mex-3 RNA binding family member D) was lower in NF1-iN cells by real-time

127 act of more frequent and earlier exposure to family member deaths in the process of cumulative disadv

128 onstrate that COMPASS H3K4 methyltransferase family members differentially regulate BRWD2/PHIP chroma

129 be their typical interactions with patients, family members, doctors, and nursing colleagues.

130 Aberrant regulation of BCL-2 family members enables evasion of apoptosis and tumor re

131 awake, cognitively engaged, and mobile with family members engaged as partners with the ICU team at

132 ion of Aiolos or Ikaros, but not the related family member Eos, was sufficient to induce Bcl6 promote

133 While knockdown of Etv4 and another ETS family member Etv5 showed limited effects on the decreas

134 lial cells, where it works with the Ena/VASP family member EVL to assemble the actin cytoskeleton in

135 ession of all 18 carotenogenic genes or gene family members examined, or sequence or abundance of mRN

136 and the related IL-1R8, but not other IL-1R family members, exhibit an amino acid sequence similar t

137 Survivin, an inhibitor of apoptosis (IAPs) family member, exhibited a decreased expression level af

138 CD27 is a TNFR family member expressed on T cells, and its ligand, CD70

139 vidence on the topics of: communication with family members, family presence, family support, consult

140 of Taipei City Hospital system and enrolled family members for 106 patients (73.1%).

141 etics-driven approach to identifying at-risk family members for clinical screening and early interven

142 inhibitors and provides insight into the RGS family members for which drug discovery efforts may be m

143 argets in PCa cells including the Rho GTPase family members (for example, CDC42, CDC42EP3, RAC1 and A

144 me sequencing in 5 probands and 2 unaffected family members from 4 unrelated families.

145 Samples were collected from 16 children and family members from five different cities of Iran.

146 Five of these Ros/MucR family members from Mesorhizobium loti (Ml proteins) hav

147 KLF1 and related family members function as transcriptional activators vi

148 Transport of the ATG8 family member GABARAP from the centrosome occurs during

149 ociated with mutations in two prominent GATA family members, GATA1 and GATA2.

150 rtant for expression of IL-10, including Jun family members, GATA3, E4BP4, and IFN regulatory factor

151 arge and multigenerational families with 433 family members (GeneQuest II).

152 al 3D structures and sequences, each KIM-PTP family member has a unique oxidation profile.

153 izarre symptoms, such as the delusion that a family member has been replaced by an imposter (Capgras

154 ndividual inactivation of the MLL1-4/COMPASS family members has little effect on early Hox gene activ

155 These results reveal that mammalian MEF2 family members have distinct transcriptional functions i

156 However, certain SecB family members have diverged to become specialized towar

157 None of the other reticulon family members have the ability to induce fragmentation

158 Animal apoptotic regulators, including Bcl-2 family members, have not been identified in plants but e

159 istone deacetylase 6 (HDAC6) and the related family member HDAC10 are markedly reduced in adipose tis

160 Another RELM family member, human resistin, was also bactericidal, su

161 atus In this study, we investigated the IL-1 family member IL-33 in lung defense against A. fumigatus

162 tion and release of the interleukin-1 (IL-1) family members, IL-1beta and IL-18.

163 nly sorbin and SH3 domain-containing protein family member in Caenorhabditis elegans SORB-1 is strong

164 The family member in kinetoplastids, KKT-interacting protein

165 The evidence for an involvement of TRP family members in adipogenesis, however, is scant.

166 or complexes mediated by IL-23, and by IL-12 family members in general, have remained elusive.

167 further indicate limited redundancy for NSD family members in HPV-negative HNSCCs and suggest a pote

168 lar-weight carnitine and phosphatidylcholine family members in specific cardiac regions of mice infec

169 work, we explored the role of all five LRRC8 family members in the release of organic osmolytes from

170 es are nevertheless healthy despite affected family members in the same environment.

171 myosin phosphatase targeting subunit (MYPT) family member, in addition to MLCP regulatory subunit MY

172 , an adenosine triphosphate-binding cassette family member, in the maintenance of erythrocyte volume

173 appaB-inducing kinase (NIK) and TNF receptor family members including lymphotoxin-beta receptor (LTbe

174 treatment with a combination of Src and HER-family member inhibitors resulted in synergistic growth

175 IL-1 family member interleukin 37 (IL-37) has broad antiinfla

176 Sirtuin 6 (SIRT6) is a sirtuin family member involved in a wide range of physiologic an

177 nt questions about how the assembly of IL-12 family members is regulated and controlled in the cell.

178 s mode of regulation extends to related FOXO family members is unknown.

179 sialic acid-binding Ig-type lectin (Siglec) family member, is an inhibitory coreceptor of the BCR wi

180 LAG-2, a founding DSL ligand family member, is produced in the DTC and activates the

181 a minority of patients with cancer and their family members, is positively associated with other indi

182 ally express high levels of the Notch ligand family member, Jagged 1 (Jag1).

183 s, little is known regarding the role of the family member Katanin p60 subunit A-like 1, KATNAL1, in

184 The kinesin-3 family member KIF1A has been shown to be important for e

185 We now show that the Kruppel family member KLF7 promotes the corneal progenitor cell

186 med it would be effective if needed and that family members knew their wishes.

187 only in the index case individual, the only family member lacking LTA-specific antibodies (Abs).

188 Compared with family members lacking the mutation, individuals with AP

189 GABARAP, but not another ATG8 family member LC3B, binds directly to PCM1 through a can

190 The evolutionarily conserved beta-importin family member Los1 (Exportin-t) has been the only export

191 , we describe data indicating that the yeast family members Ltc1 and Ltc3/4 function at the vacuole a

192 encoded S100 calcium-binding protein (S100A) family members, mainly S100A7, S100A8, and S100A9 (S100A

193 ell-known reduction of the prosurvival Bcl-2 family member, Mcl-1, following inhibition of protein sy

194 ression of STAT-regulated anti-apoptotic BH3 family members MCL1 and BCL-XL sensitizing PTCL cells to

195 Cyclic nucleotide-gated channel (CNGC) family members mediate Ca(2+) influx from cellular store

196 Here we show that one of the miR-200 family members, miR-141, is under-expressed in several p

197 f BCL-2 but not with expression of the BCL-2 family members myeloid cell leukemia 1 (MCL-1) and BCL-X

198 We conducted face-to-face interviews with family members (N = 15) who had direct experience with u

199 de nanoRNAs, such as the DHH phosphoesterase family member NanoRNase A (NrnA).

200 Broad TGF-beta inhibition suggests another family member negatively regulates muscle mass, and its

201 The NLR family member NLRC5 regulates major histocompatibility c

202 main leucine-rich repeat containing receptor family member Nlrp12 in modulating neutrophilic response

203 s include the family of Neuron-Specific Gene family members (Nsg), NEEP21 (Nsg1), and P19 (Nsg2).

204 Escherichia coli CNT family member NupC resembles hCNT1 in permeant selectivi

205 or loss-of-function of NXF3, but not related family member NXF1, decreases or increases cytosolic Rpl

206 ansion and diversification of most PP2A gene families, members of functionally specialized subclades

207 Dengue virus (DENV) is a close family member of ZIKV and co-circulates with ZIKV.

208 We identified the family members of 145 consecutive patients with prolonge

209 % of whom had 5 or more comorbid conditions; family members of patients (n = 30); and surgeons (n = 1

210 Family members of patients who die in the ICU often rema

211 oencephalographic tests, and interviews with family members of patients with epilepsy who died sudden

212 Higher-risk asymptomatic family members of patients with MS are more likely to ha

213 These zDABM-containing proteins included all family members of the SNAP25, sprouty, cornifelin, ankyr

214 NA BLINDBEN belongs to the TOE-type AP2 gene family, members of which control flowering time in Arabi

215 nearly half of black women currently have a family member or extended family member who is in prison

216 ex family with U-HAE but not in asymptomatic family members or an additional 20 patients with familia

217 trix deposition was lost while other fibulin family members or LTBPs remained unaffected.

218 R4b directly interacted with three rice CAF1 family members: OsCAF1A, OsCAF1G and OsCAF1H.

219 (P = .02), and absence of multiple affected family members (P = .04) were significantly more frequen

220 NF-kappaB family members p100 and RelB translocate to the nucleus

221 Here, we identify the other Rb family members p107 and p130 as novel targets of UL97.

222 d and highly expressed together with the p53 family member p63 in head and neck squamous cell carcino

223 by the up-regulation of the closely related family member plakoglobin (gamma-catenin) that maintaine

224 Epidermal growth factor receptor (EGFR) family members play pivotal roles in cell proliferation,

225 n the present study we report that among PLK family members, PLK3 is also able to catalyze alpha-syn

226 phosphorylated by a second kinase, the DYRK family member Pom1 [8].

227 t clear what unique functions, if any, miRNA family members possess.

228 T modules in the polymerase domains of other family members produce diversified OPS structures.

229 brane-associated proteins, including the Rab family members Rab3, Rab15, and Rab27a, have been implic

230 of EGFR regulation through the importin beta family member RAN-binding protein 6 (RanBP6), a protein

231 24.8 years; 43 male patients), 64 unaffected family members (referred to as familial noncarriers; age

232 Approximately half of the family members regretted having chosen prolonged mechani

233 ase (AID) and ten-eleven-translocation (TET) family members regulate active DNA demethylation.

234 te, the neurophysiological functions of most family members remain unknown.

235 d diseases, the role of other IL-17 cytokine family members remains unclear.

236 We conclude that alterations of KDM family members represent a disease-driving mechanism and

237 oma-extra large (Bcl-xL), Mdm4, and two TP53 family members, resulting in expression of the TP53 domi

238 gnition sequences, instead binding with SMAD family member(s) at SMAD-response elements.

239 levels correlated more closely with the S100 family member S100P.

240 Of the 66 family members screened for the DES-p.Glu401Asp mutation

241 Like other SENP family members, SENP7S has SUMO isopeptidase activity bu

242 Among the five serine incorporator (SERINC) family members, SERINC5 (Ser5) was reported to strongly

243 neonates/infants with an affected C1-INH-HAE family member should be screened for C1-INH deficiency.

244 amely, a reluctance to donate now lest one's family member should need a transplant in the future.

245 We review how TGF-beta family member signaling is altered during development of

246 mors contain mutations that disrupt TGF-beta family member signaling.

247 e binding site is unique to SNX5 and related family members SNX6 and SNX32.

248 sion of SQUAMOSA PROMOTER BINDING-LIKE (SPL) family members, SPL3, SPL5, and SPL9, is upregulated in

249 he major inflammatory mediators include IL-1 family members, such as IL-1beta, and the functional act

250 These results indicate that some CAP family members, such as Pry1, can bind different lipids,

251 mutant phenotypic analysis of SWIB5 and SWIB family members suggests a link between organellar genome

252 We thereby identify the HSPG family members syndecan-3 and syndecan-4 as functional r

253 (TLRs), macrophages generate IL-33, an IL-1 family member that induces innate immune responses throu

254 C12, which encodes a heat shock co-chaperone family member that interacts with phenylalanine, tyrosin

255 KIF16B is a highly processive kinesin-3 family member that participates in the trafficking and t

256 2) is an adhesion G protein-coupled receptor family member that plays a pivotal role in brain angioge

257 es the interaction with SRSF3, an SR protein family member that promotes pri-miRNA processing.

258 ort that TIP39, a parathyroid hormone ligand family member that was recently identified to be express

259 Remarkably, MpPR-1 family members that do not bind sterols can be converted

260 wth factor 1 receptor (IGF-1R) and its close family member, the insulin receptor (IR).

261 As opposed to closely related family members, the intermediates in this pathway are li

262 eased in freshly isolated PBMC from affected family members, this was not accompanied by increased mR

263 ng catalytic activation and stability of PKC family members to allow for flexible and dynamic control

264 ochemical and molecular study of all KIM-PTP family members to determine their H2O2 oxidation profile

265 These variants were also genotyped in all family members to establish genotype-phenotype cosegrega

266 r of condolence and letters written by these family members to the ICU team.

267 Including affected family members (total n=412), cluster-adjusted analyses

268 The founding tubby family member TUB also localizes to cilia similar to TUL

269 The kinesin-3 family member Unc-104/KIF1A is required for axonal trans

270 ut also specialized functions for individual family members under stress conditions.

271 ligands of IL-1 receptor/Toll-like receptor family members via the activation of NF-kappaB in cultur

272 The phenotype in probands and family members was characterized by atrioventricular con

273 The expression of miR-200 family members was markedly downregulated upon wounding

274 inding of p65/RelA (the prototypic NF-kappaB family member) was reduced at IL-6 and CCL5 promoters.

275 natural and engineered alleles for multiple family members, we achieved a continuum of inflorescence

276 se MT localization is a hallmark of most IQD family members, we quantitatively analyzed GFP-labeled M

277 among general pediatrics patients), whether family members were absent from the patient's bedside (6

278 st reported in 1991 by Balaji et al in which family members were also reported to have a mild skeleta

279 Family members were genotyped by Sanger sequencing and c

280 All family members were genotyped with markers spaced by eve

281 We found that all three family members were upregulated during postnatal develop

282 pendent degradation of distinct SMXL protein family members, which is key for mediating hormonal effe

283 n currently have a family member or extended family member who is in prison.

284 Family members who lost a loved one in the ICU and who r

285 itative study using interviews with bereaved family members who received a letter of condolence and l

286 d in patients with Alport syndrome, even for family members who share the same COL4 mutation.

287 dominant congenital cataracts, we recruited family members who underwent comprehensive ophthalmic ex

288 -risk HLA-DR-DQ genotypes, relationship to a family member with T1D, autoantibody at seroconversion,

289 following 2 subgroups based on the number of family members with a neuropsychiatric condition: expect

290 n and activity compared with cell lines from family members with identical coding mutations.

291 ions of the lipid-binding activity of MpPR-1 family members with regard to the mode of action of thes

292 Treating patients and family members with respect and dignity is a core object

293 exome sequencing and segregated perfectly to family members with severe atopy only but was not found

294 e selectivity, typically inhibiting multiple family members with similar potencies.

295 stem cells were isolated and cultured from 2 family members with the DES mutation (1 with mild and 1

296 nd CLIP-170 plus end-tracking protein (+TIP) family members with the TORC1 subunit Kog1/Raptor, which

297 of Mcl-1, an antiapoptotic B-cell lymphoma 2 family member, with selective reduction of delayed intra

298 avoring such a role for the noncanonical WNT family member Wnt5a.

299 SFK family member YES1 was amplified in osimertinib-resistan

300 n of some transient receptor potential (TRP) family members, yet their role in regulating the TRP van