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1 ng also occurs for IL-23alpha, another IL-12 family protein.
2 hosphatase fused to a TenA (thiamin salvage) family protein.
3 ion gene, spenito (nito) that encodes a SPEN family protein.
4 am effector Wash, a Wiskott-Aldrich syndrome family protein.
5 he TetR superfamily, whereas MmpR5 is a MarR family protein.
6 d degradation of Mcl-1, a pro-survival Bcl-2 family protein.
7 ng diapause, requires the presence of the RB family proteins.
8 onserved endoplasmic reticulum-localized Orm family proteins.
9 s and autophagy mechanisms governed by Bcl-2 family proteins.
10 h, MOMP is subject to tight control by Bcl-2 family proteins.
11 own to express multiple anti-apoptotic Bcl-2 family proteins.
12 nd its interaction with members of the Bcl-2 family proteins.
13 mediated by the serial activation of caspase family proteins.
14 eveal a two-step activation mechanism of MLL family proteins.
15 f an interdomain linker element in DnaI/DnaC-family proteins.
16 luding E2F-1, p21(CIP1), p27(KIP1) and Bcl-2 family proteins.
17 epend on the regulated expression of claudin family proteins.
18 l strategies for studying DNA repair by AlkB family proteins.
19 nd active role in the mode of action of BCL2 family proteins.
20 nsufficient to drive target selection by MSI family proteins.
21 e embryonic lethal abnormal vision (ELAV)/Hu family proteins.
22 sight into the assembly determinants of TRIM family proteins.
23 ll factor/lymphoid enhancer factor (TCF/LEF) family proteins.
24 tems involved in the secretion of the ESAT-6 family proteins.
25 Kgamma does not interact with mammalian Atg8-family proteins.
26 . tuberculosis genome encodes 23 such ESAT-6 family proteins.
27 factors, such as membrane-associated EGF-CFC family proteins.
28 cription appear to differ for each of the Rb family proteins.
30 e-1 activation occurs by a Nod-like receptor family protein 3-independent mechanism because radiation
31 Here, we identify Acf7a (actin crosslinking family protein 7a) as a protein positioned to bridge the
32 ts showed SNPs in Ankyrin-like protein, IKI3 family protein, ABC transporter G family and pentatricop
33 Previously, we identified the AF4/FMR2 (AFF) family protein AFF3 within the transcription elongation
34 dation for further investigation of how UbiB family proteins affect diseases and diverse biological p
35 extracellular heat shock protein-90 (Hsp90) family proteins (alpha and beta) have been shown to supp
39 ancer cells with causing modulation of Bcl-2 family proteins and activation of caspase 9/3 cascade.
40 verified the involvement of additional F-Box family proteins and confirmed the suppression of snail n
41 teraction characteristics of IQGAP1 with RHO family proteins and highlights the complementary importa
43 atins is independent from prenylation of RAS family proteins and is associated with a cancer cell EMT
45 s under the control of Mcl-1 and other Bcl-2 family proteins and requires caspase-9, caspase-3/7 and
46 e of a Nur77 peptide on anti-apoptotic Bcl-2 family proteins and reveal a novel interaction surface.
47 of the membrane-docking mechanism for GOLPH3 family proteins and reveals how an effector of phosphoin
48 tor 4 (IRF4) with activator protein 1 (AP-1) family proteins and STAT3 in the assembly of complexes t
49 st cell-active chemical probes targeting RAB-family proteins and support the role of RAB25 in regulat
50 5 and 120 results in an interaction with Crk family proteins and the p85 regulatory subunit of PI3-Ki
52 Despite a close relationship between the Crk family proteins and tumorigenesis, how Crk and CrkL cont
53 (TNFRSF8), a tumor necrosis factor receptor family protein, and CD30 variant (CD30v), a ligand-indep
54 DREAM contains an E2F, a retinoblastoma (RB)-family protein, and the MuvB core (LIN9, LIN37, LIN52, L
55 STANT1, a translation initiation factor SUI1 family protein, and two genes of unknown function) is co
57 9 can occur from up-regulation of other BCL2 family proteins, and this resistance can be mimicked by
60 P (thrombospondin-related anonymous protein) family proteins are conserved across the phylum of apico
75 ation may represent a mechanism by which CDC-family proteins are posttranslationally modified and reg
78 her, the present study demonstrates that Cbl family proteins are required to protect MECs from proteo
81 e nuclear factor of activated T cells (NFAT) family proteins are transcription factors that regulate
83 ogether, these data reveal that the arrestin family protein Art1 regulates the protein levels and loc
84 he concept of TATA-box-binding protein (TBP) family proteins as "system factors" that each supports a
85 reveals the acquisition of mutations in BCL2 family proteins as a novel mechanism of apoptosis resist
87 1 and excellent selectivity over other BCL-2 family proteins as well as multiple kinases and GPCRs.
88 ROL NONREPRESSIBLE4 (GCN4), an AAA(+)-ATPase family protein, as one of the key proteins regulating st
93 maf musculoaponeurotic fibrosarcoma oncogene family, protein B, which promotes beta-cell function thr
94 of the antiapoptotic B-cell lymphoma (BCL)2 family proteins, BA treatment induces the proapoptotic p
97 cells, and the multi-domain pro-death BCL-2 family proteins BAX and BAK are required for its activat
98 nd on the presence of the proapoptotic Bcl-2 family proteins Bax or Bak, indicating that both events
103 ertheless binds certain anti-apoptotic Bcl-2 family proteins (Bcl-2, Bfl-1, and Bcl-B), modulating th
104 ports suggested that the antiapoptotic Bcl-2 family protein Bcl2a1/Bfl-1/A1 plays a critical role in
105 ownregulates expression of B-cell lymphoma 2 family proteins (Bid, Bcl-xl, and Mcl-1) and stimulates
106 nduction of the proapoptotic B-cell lymphoma-family protein Bim to produce mitochondria-dependent apo
108 is mediated mainly by the proapoptotic BCL-2 family proteins BIM and BMF, and their proapoptotic func
111 reates a docking site on Bfa1 for the 14-3-3 family protein Bmh1, which in turn weakens Bfa1-centroso
115 nes are the main locus of action of all BCL2 family proteins, but it is difficult to obtain a precise
117 inhibitors of APC are members of the serpin family: protein C inhibitor (PCI) and alpha1-antitrypsin
119 e malaria parasite Plasmodium express a TRAP family protein called merozoite-TRAP (MTRAP) that has be
121 Post-translational modification of MAGUK family proteins can drive their membrane localization, y
122 in otoferlin, a C2 domain-containing ferlin family protein, cause non-syndromic hearing loss in huma
123 romatin is thought to be mediated by the Cbx family proteins (Cbx2/4/6/7/8) binding to histone H3 wit
124 esulted in activation of the GTP-binding Rho family protein Cdc42 and accounted for hematopoietic def
125 namics via activation of the GTP-binding Rho family protein Cdc42 by the guanine nucleotide exchange
127 The bromodomain and extra-terminal (BET) family proteins, consisting of BRD2, BRD3, BRD4, and tes
128 ced proteins with tetratricopeptide repeats) family proteins constitute a major subclass of ISG prote
133 has the same three-dimensional fold as Bcl-2 family proteins despite lacking identifiable sequence si
134 e around the Golgi apparatus with the formin-family protein Diaphanous, and loss of either isoform pe
135 ed at mitotic chromosomes, whereas other Cbx-family proteins dynamically bind to mitotic chromosomes.
136 -tracking proteins (+TIPs) including the EB1 family protein EBA that decorated the MT plus ends under
138 Analysis of mutants in Drosophila ELAV/Hu family proteins ELAV, FNE, and RBP9 and of genetic inter
139 rther, we showed that M. tuberculosis ESAT-6 family protein EsxL, encoded by Rv1198, is responsible f
140 NAs) are small noncoding RNAs that bind PIWI family proteins exclusively expressed in the germ cells
142 h an F-box protein, MAX2, to target SMXL/D53 family proteins for proteasomal degradation, and genetic
145 Characterization of two additional AlkB family proteins, FTO and ALKBH5, showed that they posses
151 vestigate the mechanistic nature of the Snf2 family protein HARP, mutations of which are responsible
152 isregulation of mixed lineage leukemia (MLL) family proteins has been associated with acute leukemia,
153 and aberrant, or loss of, expression of MS4A family proteins has been observed in colon and lung canc
154 gh the pathogenic relevance of LytR-CpsA-Psr family proteins has been studied in a few bacterial path
155 years, the disruption or activation of Rab5 family proteins has been used as a tool to understand gr
158 tors of bromodomain and extra-terminal (BET) family proteins have shown growth-inhibitory activity in
159 TEK encodes an AT-hook nuclear localized family protein highly expressed in tapetum during the te
160 bind and neutralize the anti-apoptotic Bcl-2 family proteins, how this neutralization leads to Bax/Ba
161 re, we identify Ccp1, an uncharacterized NAP family protein in fission yeast that antagonizes CENP-A
162 factor SOX4 is the most highly expressed SOX family protein in pancreatic islets, and mutations in So
163 fore highlight an unanticipated role for p53 family proteins in a regulatory network that integrates
164 em, analogous to the role postulated for APP family proteins in controlling migration within the mamm
165 vival pathways, shifted the balance of Bcl-2 family proteins in favor of apoptosis, and decreased mig
166 und that depleting zonula occludens 1 (ZO-1) family proteins in MDCK cells induces a highly organized
169 e double-bromodomain and extraterminal (BET) family proteins in regulating dendrite arbor complexity.
170 Our data reveal a novel function for MS4A family proteins in regulating trafficking and signaling,
171 ion and revealed novel mechanisms of the GGA family proteins in the forward trafficking of a cell sur
172 teractions between B cell lymphoma 2 (Bcl-2) family proteins in the intrinsic apoptotic cell death pa
173 Here we investigate the role of the Bcl-2 family proteins in the response of cancer cells to immun
175 portant O-GlcNAcylation events on other KLHL family proteins in various experimental and disease cont
178 d inhibition by (+)-JQ1, an inhibitor of BET family proteins including BRD4, reduced Adipoq expressio
181 w that the RNA binding activity of the Rbfox family protein is crucial for its localization into stre
184 blished that MG53, a TRIM (tripartite motif) family protein, is an essential component of the cell me
185 rough inactivating the activities of the pRb family proteins, is better understood than the activitie
186 roliferation and morphogenesis; the NDR/LATS family protein kinases, which associate with "Mob" coact
188 eleting two further genes encoding DacB/PBP4 family proteins, known to decrosslink and round prey pep
189 hat PUM posttranscriptionally regulates LSD1 family protein levels in flies and human cells, indicati
190 ting the level of Sirt3, a member of Sirtuin family protein located in mitochondria, which regulates
191 nucleotide polymorphism rs2572886 in the LY6 family protein locus has been shown to associate with ac
195 arum erythrocyte membrane protein 1 (PfEMP1) family proteins mediate the adherence of infected erythr
196 hus the inhibitory mechanisms of UL97 for Rb family protein-mediated repression of E2F-responsive tra
197 l by which the biological activities of TRIM family proteins might be dissected to better understand
199 During DNA recombination and repair, RecA family proteins must promote rapid joining of homologous
202 covery of consecutive DNA conversions by TET family proteins of 5-methylcytosine into 5-hydroxymethyl
205 ork establishes SORB-1 as a bona fide sorbin family protein-one of the late additions to the dense bo
207 promoted early in vivo expression of the TNF family protein OX40 ligand on lung dendritic cells that
210 usly reported that the mitochondrial carrier family protein Pic2 in budding yeast is a copper importe
214 The plant-specific GAI, RGA and SCR (GRAS) family proteins play critical roles in plant development
216 mall leucine-rich repeat proteoglycan (SLRP) family proteins play important roles in a number of biol
218 pands the number of critical roles that WASP-family proteins play in the assembly of branched actin n
219 val members of the B-cell lymphoma-2 (Bcl-2) family proteins play key roles in regulation of the mito
220 or of growth 4 (ING4), a novel member of ING family proteins, plays a critical role in the developmen
221 secondary structure and dynamics of the DP1 family protein produced from the YOP1 gene (Yop1p) and i
223 e, the UNC-40-binding protein MADD-2 (a TRIM family protein) promotes ligand-independent clustering a
224 Salmonella and the broad distribution of Rid family proteins provide exciting opportunities for futur
225 n of RNA polymerase I by L-Myc and other MYC family proteins provides an axis of vulnerability for th
226 hese effectors display a preference for Rab8 family proteins (Rab8, 10, 13 and 15) and that some of t
227 nally, we documented that the Retinoblastoma-family protein (Rbf), a proven regulator of cell prolife
228 d MurB (peptidoglycan synthesis), glyoxalase family proteins (reactive electrophile response) and rib
230 (NEPFs) such as Ena/VASP, formins, and WASP-family proteins recruit profilin:actin for filament form
232 their canonical roles in the cell cycle, RB family proteins regulate numerous developmental pathways
233 orylation of Heterochromatin Protein 1 (HP1) family proteins regulates heterochromatin dynamics, its
234 a an Akt-dependent mechanism involving Bcl-2 family protein regulation and inhibition of the mitochon
236 Sequence comparison of these two stealth family proteins revealed a C-terminal extension in CsxA,
237 omb repressive complex (PRC) 1 proteins (Cbx-family proteins, Ring1b, Mel18, and Phc1) exhibit variab
239 , the results from our studies show that CRK family proteins selectively regulate T cell adhesion and
240 dy of pro-apoptotic and anti-apoptotic Bcl-2 family proteins showed that neonatal platelets had highe
241 ing, sleep, and a glial function for the App family proteins.SIGNIFICANCE STATEMENT The amyloid precu
242 RQT) subcomplex composed of the RNA helicase-family protein Slh1/Rqt2, the ubiquitin-binding protein
245 Hh activates its signal transducer and GPCR-family protein Smoothened (Smo) by inducing Smo phosphor
246 s (Ci) and G protein coupled receptor (GPCR) family protein Smoothened (Smo) in Drosophila, but how P
248 provide evidence for a novel role for sorbin family proteins: SORB-1 is required for normal positioni
250 expression, a gene encoding a partner of MYC family proteins, strongly activates expression of germ c
254 Finally, we demonstrate that multiple WASP family proteins synergistically activate Arp2/3 complex
257 Myeloid cell leukemia 1 (MCL-1) is a BCL-2 family protein that has been implicated in the progressi
258 nd in VPS33B, encoding VPS33B, a Sec1/Munc18 family protein that interacts with Rab11a and Rab25 prot
259 NL3 is expressed more widely and is a formin family protein that is involved in the regulation of cel
261 endoplasmic reticulum (ER)-associated Hsp40 family protein that recruits Hsp70 to the ER surface to
263 dy, we tested whether DsbG and DsbC, two Trx family proteins that function in reducing pathways in th
264 findings extend our understanding of APOBEC family proteins that have important roles in diverse bio
265 1 in Saccharomyces cerevisiae, are conserved family proteins that regulate actin binding and endocyto
266 ns can function as authentic ligands for APP family proteins that regulate APP-dependent responses in
267 l, our study uncovers a novel ability of TIM-family proteins to block the release of HIV-1 and other
269 Here, we use biased simulations of Bcl-2-family proteins to generate ensembles of low-energy conf
271 d by WASP (Wiskott-Aldrich syndrome protein) family proteins to nucleate branched actin filaments tha
274 In this study, we determine that the tubby family protein TULP3 functions as a general adapter for
277 macological inhibitors of Janus kinase (JAK) family protein tyrosine kinases, downstream effectors of
281 T movement to a single layer, and other BIRD family proteins were postulated to counteract JACKDAW's
285 mjC domain-containing histone demethylase 2) family protein, which modulates defense against pathogen
286 omic approach, we have identified angiomotin family proteins, which are known negative regulators of
287 in-like 2 (AMOTL2) is a member of Angiomotin family proteins, which are potent inhibitors for the Hip
288 iliary tumorigenesis, including that of ARID family proteins, which have recently been reported to be
289 w focuses on functional aspects of the ORMDL family proteins, which may serve as new therapeutic targ
290 e for lymphoid enhancer factor/T-cell factor family proteins, which mediate the transcriptional regul
292 ma 2 (BCL-2) ovarian killer (BOK) is a BCL-2 family protein with high homology to the multidomain pro
293 terations in formation of complexes of C/EBP family proteins with chromatin remodeling proteins.
294 protein interactions, the interaction of pRb family proteins with conserved region 2 (CR2) of E1A is
295 f that is essential for the binding of RASSF family proteins with microtubule-associated proteins.
296 Lactoglobulin (BLG) is a member of lipocalin family, proteins with ability to bind small hydrophobic
297 are likely to similarly impact mammalian RB family proteins, with important implications for develop
298 regulators of cell life and death are Bcl-2 family proteins, with the founding member of the family
299 pe, elongation, division, sporulation (SEDS)-family proteins working within the cytoskeletal machines
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