ライフサイエンスコーパス: farnesoid

1 ds resulted in deregulation of ecdysone- and farnesoid-regulated genes, accordingly with the observed

2 eticholic acid) is a potent activator of the farnesoid X nuclear receptor that reduces liver fat and

3 efflux to lumen) and retinoic acid receptor/farnesoid X receptor (cholesterol catabolism).

4 In particular, farnesoid X receptor (FXR) activation that revealed anti

5 notype in SIRT mice correlated with impaired farnesoid X receptor (FXR) activity due to persistent de

6 eatment of mouse or human hepatocytes with a farnesoid X receptor (FXR) agonist GW4064 or bile acids

7 We showed that chronic BAs or farnesoid X receptor (FXR) agonist treatment of primary

8 In an effort to develop orally active farnesoid X receptor (FXR) agonists, a series of tetrahy

9 that GS can act as an antagonist ligand for farnesoid X receptor (FXR) and decrease expression of bi

10 bile acid-activated nuclear hormone receptor farnesoid X receptor (FXR) and G protein-coupled membran

11 Since farnesoid X receptor (FXR) and its natural ligands bile

12 in bile acid homeostasis with a focus on the farnesoid X receptor (FXR) and its potential therapeutic

13 metabolic homeostasis by activating nuclear farnesoid X receptor (Fxr) and membrane G-protein-couple

14 regulation mediated by the nuclear receptor farnesoid X receptor (FXR) and other effectors.

15 e rodent Sult2A1 gene is also induced by the farnesoid X receptor (FXR) and pregnane X receptor (PXR)

16 The nuclear receptors, farnesoid X receptor (FXR) and pregnane X receptor (PXR)

17 dback loop operated by the nuclear receptors farnesoid X receptor (FXR) and small heterodimer partner

18 Nuclear receptors farnesoid X receptor (FXR) and small heterodimer partner

19 primarily regulated by the nuclear receptors farnesoid X receptor (FXR) and small heterodimer partner

20 id oxidation, and 3) decreased expression of farnesoid X receptor (FXR) and small heterodimer partner

21 Cholestasis activates bile acid receptor farnesoid X receptor (FXR) and subsequently enhances hep

22 key regulators of liver biology: C/EBPalpha, Farnesoid X Receptor (FXR) and telomere reverse transcri

23 that the fed-state sensing nuclear receptor farnesoid X receptor (FXR) and the fasting transcription

24 Bile acids also activate the farnesoid X receptor (FXR) and the G protein-coupled rec

25 are ligands for the nuclear hormone receptor farnesoid X receptor (FXR) and the G protein-coupled rec

26 The farnesoid X receptor (FXR) and the liver x receptors (LX

27 The bile acid-activated receptors, nuclear farnesoid X receptor (FXR) and the membrane Takeda G-pro

28 Farnesoid X receptor (FXR) and the microRNAs miR-185, mi

29 metabolism and inflammation via the nuclear farnesoid X receptor (FXR) and the Takeda G protein-coup

30 tor-activated receptor-alpha (PPARalpha) and farnesoid X receptor (FXR) are activated in the fasted a

31 Liver X receptors (LXRs) and farnesoid X receptor (FXR) are nuclear receptors that fu

32 The farnesoid X receptor (FXR) belongs to a family of ligand

33 This ERalpha binding site overlaps the known farnesoid X receptor (FXR) binding site in the SHP promo

34 We have shown that activation of the farnesoid X receptor (FXR) blocks mineralization of bovi

35 the postprandial state, activation of ileal farnesoid X receptor (FXR) by bile salts results in tran

36 contribute to steatosis induced by diet and farnesoid X receptor (FXR) deficiency in both genders.

37 ether fibroblast growth factor 19 (FGF19) or farnesoid X receptor (FXR) dependent signaling are invol

38 The farnesoid X receptor (FXR) functions as a bile acid (BA)

39 The nuclear receptor farnesoid X receptor (FXR) has been implicated in the co

40 Activation of the farnesoid X receptor (FXR) has indicated a therapeutic p

41 emic expression of the bile acid (BA) sensor farnesoid X receptor (FXR) has led to promising new ther

42 ontrast to mice, human BSEP was regulated by farnesoid X receptor (FXR) in an isoform-dependent manne

43 ined through positive-feedback antagonism of farnesoid X receptor (FXR) in intestine and liver.

44 CYP7A1 transcription by bile acid-activated farnesoid X receptor (FXR) in its native promoter and ce

45 UCA) in the regulation of the orphan nuclear farnesoid X receptor (FXR) in vivo.

46 nd synthetic (i.e. GW4064) activators of the farnesoid X receptor (FXR) increased FGF21 gene expressi

47 We found that farnesoid X receptor (FXR) inhibits expression of gankyr

48 e report that the nuclear bile acid receptor farnesoid X receptor (FXR) inhibits microRNA-34a (miR-34

49 Farnesoid X receptor (FXR) is a bile acid sensor that re

50 Farnesoid X receptor (FXR) is a bile acid sensor that re

51 Farnesoid X receptor (FXR) is a bile acid-activated tran

52 Farnesoid X receptor (FXR) is a bile acid-activated tran

53 The farnesoid X receptor (FXR) is a member of the "metabolic

54 Farnesoid X receptor (FXR) is a member of the nuclear ho

55 The Farnesoid X receptor (FXR) is a member of the nuclear ho

56 The farnesoid X receptor (FXR) is a member of the nuclear re

57 Farnesoid X receptor (FXR) is a member of the nuclear re

58 The farnesoid X receptor (FXR) is a nuclear bile acid recept

59 Farnesoid X receptor (FXR) is a nuclear receptor for bil

60 The farnesoid X receptor (FXR) is a nuclear receptor that ac

61 The farnesoid X receptor (FXR) is a nuclear receptor that pl

62 The nuclear bile acid receptor farnesoid X receptor (FXR) is an important transcription

63 Farnesoid X receptor (FXR) is considered a therapeutic t

64 ation of bile acid synthesis mediated by the farnesoid X receptor (FXR) is disrupted in the mutant mi

65 igand activated transcription factor nuclear farnesoid X receptor (FXR) is involved as a regulator in

66 Farnesoid X receptor (FXR) is the master regulator of bi

67 The farnesoid X receptor (FXR) is the transcriptional regula

68 s were performed with islets from wild-type, farnesoid X receptor (FXR) knockout (KO), and beta-cell

69 The primary bile acid receptor farnesoid X receptor (FXR) maintains lipid and glucose h

70 Activation of farnesoid X receptor (FXR) markedly attenuates developme

71 dy, we show that LPS significantly decreases farnesoid X receptor (FXR) mRNA in mouse liver as early

72 Ligand-dependent SUMOylation of farnesoid X receptor (FXR) negatively regulates the expr

73 T-beta-MCA is an farnesoid X receptor (FXR) nuclear receptor antagonist,

74 cholestasis by altering the activity of the farnesoid X receptor (FXR) or by impairing the structure

75 As a cellular bile acid sensor, farnesoid X receptor (FXR) participates in regulation of

76 The nuclear receptor farnesoid X receptor (FXR) plays a major role in the ent

77 Farnesoid X receptor (FXR) plays a pivotal role in the r

78 Farnesoid X receptor (FXR) plays an important role in ma

79 Farnesoid X receptor (FXR) plays important regulatory ro

80 Two-fold increase of BA-activated farnesoid X receptor (FXR) protein levels were seen in a

81 The farnesoid X receptor (FXR) regulates bile acid, lipid an

82 um bile acids, and activation of the hepatic farnesoid X receptor (FXR) regulatory pathway.

83 The nuclear receptor farnesoid X receptor (FXR) shows potent antifibrotic act

84 xamined, and expression of genes involved in farnesoid X receptor (FXR) signaling in the liver and in

85 The farnesoid X receptor (FXR) signaling pathway regulates b

86 Further, dietary TCDF inhibited the farnesoid X receptor (FXR) signaling pathway, triggered

87 SIRT1 iKO mice had reduced intestinal farnesoid X receptor (FXR) signaling via hepatocyte nucl

88 e acid metabolites that inhibited intestinal farnesoid X receptor (FXR) signaling.

89 ctivate small heterodimer partner (SHP) upon farnesoid X receptor (FXR) stimulation by increasing BA

90 re we report that Foxm1b is the first direct farnesoid X receptor (FXR) target gene known to be invol

91 that the MDR3 gene is trans-activated by the farnesoid X receptor (FXR) via a direct binding of FXR/r

92 given an intracerebroventricular infusion of farnesoid X receptor (FXR) Vivo-morpholino before AOM in

93 Farnesoid X receptor (Fxr)(-/-), small heterodimer partn

94 Our previous studies have shown that the farnesoid X receptor (FXR), a bile acid-activated nuclea

95 is and mutations in NR1H4, which encodes the farnesoid X receptor (FXR), a bile acid-activated nuclea

96 The farnesoid X receptor (FXR), a member of the nuclear horm

97 signal through two major receptor pathways: farnesoid X receptor (FXR), a member of the nuclear horm

98 ne is a highly efficacious antagonist of the farnesoid X receptor (FXR), a nuclear hormone receptor t

99 Here we show that the farnesoid X receptor (FXR), a nuclear receptor for bile

100 is strongly up-regulated by agonists of the farnesoid X receptor (FXR), a nuclear receptor for bile

101 and-binding domain (LBD) of human and murine farnesoid X receptor (FXR), a nuclear receptor for bile

102 t studies to serve as a binding site for the farnesoid X receptor (FXR), a nuclear receptor for bile

103 n of hepatic SIRT1 reduces the expression of farnesoid X receptor (FXR), a nuclear receptor that regu

104 is mediated through the bile acid-activated farnesoid X receptor (FXR), a recently characterized mem

105 bile acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor.

106 sodium-dependent bile acid transporter, the farnesoid X receptor (FXR), and familial intrahepatic ch

107 The nuclear bile acid receptor, farnesoid X receptor (FXR), is an important transcriptio

108 Expression of nuclear receptors farnesoid X receptor (FXR), LXRalpha, liver receptor hom

109 luding those of nuclear receptors, primarily farnesoid X receptor (FXR), membrane BA receptors, and F

110 mice with intestine-specific knockout of the farnesoid X receptor (FXR), mice that express an FXR tra

111 Enterohepatic nuclear receptors including farnesoid X receptor (FXR), pregnane X receptor (PXR), a

112 Geniposide also down-regulated expression of Farnesoid X receptor (FXR), small heterodimer partner (S

113 Although bile acids activate the farnesoid X receptor (FXR), the mechanism underlying bil

114 Farnesoid X receptor (FXR), the primary bile acid-sensin

115 holesterol, liver X receptors (LXRs) and the farnesoid X receptor (FXR), together with other members

116 n of BSEP gene expression is mediated by the farnesoid X receptor (FXR), which binds as a heterodimer

117 The farnesoid X receptor (FXR), which is activated by bile a

118 ntagonist ligands for the bile acid receptor farnesoid X receptor (FXR), which is an important regula

119 al and transactivational regulator of murine farnesoid X receptor (Fxr), which is the primary bile ac

120 An antagonist of bile acid receptor farnesoid X receptor (FXR), Z-guggulsterone, reduced the

121 gulates triglyceride metabolism through both farnesoid X receptor (FXR)-dependent and -independent pa

122 Cholate treatment was associated with a farnesoid X receptor (FXR)-dependent increase in hepatic

123 ntracellular bile acids results in repressed farnesoid X receptor (FXR)-FGF15 signalling, leading to

124 pact of sulfated progesterone metabolites on farnesoid X receptor (FXR)-mediated bile acid homeostasi

125 Chenodeoxycholic acid (CDCA) and the farnesoid X receptor (FXR)-specific agonist GW4064 stron

126 y by downregulating the transcription factor farnesoid X receptor (FXR).

127 ve been identified as potent agonists of the farnesoid X receptor (FXR).

128 cirrhosis and liver cancer also have reduced farnesoid X receptor (FXR).

129 1 (FIC1)] posttranslationally activated the farnesoid X receptor (FXR).

130 tagonism of the receptor for bile acids, the farnesoid X receptor (FXR).

131 regulated by ligands of the nuclear receptor farnesoid X receptor (FXR).

132 hat bile acids are physiological ligands for farnesoid X receptor (FXR).

133 molecules that activate the nuclear receptor farnesoid X receptor (FXR).

134 re ligands for the nuclear hormone receptor, farnesoid X receptor (FXR).

135 acids and transactivated by nuclear receptor farnesoid X receptor (FXR).

136 (PPAR) family, liver X receptors (LXRs), and farnesoid X receptor (FXR).

137 GP-BAR1, and nuclear receptors, such as the farnesoid X receptor (FXR).

138 in part through their binding to the nuclear farnesoid X receptor (FXR).

139 r receptors PPARalpha (encoded by NR1C1) and farnesoid X receptor (FXR, encoded by NR1H4) are activat

140 Farnesoid X receptor (FXR, NR1H4) is a bile acid-activat

141 The farnesoid X receptor (FXR, NR1H4) is a bile acid-respons

142 Activation of farnesoid X receptor (Fxr, Nr1h4) is a major mechanism i

143 Farnesoid X receptor (FXR, NR1H4) is a member of the nuc

144 ation of the nuclear and membrane receptors, farnesoid X receptor (FXR-alpha) and TGR5 (G-protein-cou

145 G37) and nuclear hormone receptors including farnesoid X receptor (FXR; also known as NR1H4).

146 The bile acid receptor farnesoid X receptor (FXR; NR1H4) is a central regulator

147 The farnesoid X receptor (FXR; NR1H4) is an intracellular bi

148 The farnesoid X receptor (FXR; NR1H4) regulates bile acid an

149 lic acid, and deoxycholic acid activated the farnesoid X receptor (FXR; NR1H4), an orphan nuclear rec

150 he decreased sensitivity of mice lacking the farnesoid X receptor (FXR; nuclear receptor subfamily 1,

151 1, higher Srepb2 messenger RNA (mRNA), lower farnesoid X receptor (Nr1h4) mRNA, and lower Cyp7a1 mRNA

152 eptor subfamily 1 group H member 4 (NR1H4 or farnesoid X receptor [FXR]) regulates bile acid synthesi

153 5 agonist, INT-777 (50 muM), but not by the farnesoid X receptor agonist, GW4064 (10 muM).

154 Obeticholic acid, a farnesoid X receptor agonist, has shown potential benefi

155 Further understanding of the role of farnesoid X receptor agonists and the potential role of

156 s of BS synthesis-suppressing drugs, such as farnesoid X receptor agonists, is greatest when optimal

157 ated receptor alpha (PPARalpha) and RXRalpha/farnesoid X receptor alpha (FXRalpha) heterodimeric nucl

158 ed receptor alpha (PPARalpha), RXRalpha plus farnesoid X receptor alpha (FXRalpha), liver receptor ho

159 n, it appears that retinoid X receptor alpha/farnesoid X receptor alpha and liver receptor homolog 1

160 pathway inhibition induced the expression of farnesoid X receptor alpha, a transcription factor that

161 Bile acids and farnesoid X receptor also inhibited mouse HNF4alpha gene

162 s, has been recently shown to antagonize the farnesoid X receptor and decrease the expression of bile

163 lase most likely resulted from activation of farnesoid X receptor and induction of fibroblast growth

164 the orchestrated regulation mediated by the farnesoid X receptor and small heterodimer partner that

165 tant metabolic regulators acting through the farnesoid X receptor and TGR5 receptor.

166 dulation of bile acid receptors, such as the farnesoid X receptor and TGR5, and transporters, such as

167 drug targets include the bile BA receptors, farnesoid X receptor and TGR5, the BA-induced gut hormon

168 The farnesoid X receptor and the liver X receptor (LXR) are

169 imetastatic effects of guggulsterone (GS), a farnesoid X receptor antagonist, are linked to its abili

170 Ablation of farnesoid X receptor dramatically increases enterohepati

171 rol saturation index, a 2.5-fold increase in farnesoid X receptor expression, a 5-fold increase in LX

172 DCs expressed the farnesoid X receptor for UDCA.

173 is mediated through the retinoid X receptor/farnesoid X receptor heterodimer and is independent of b

174 nd suggest that pharmacological targeting of farnesoid X receptor in vivo can be used to reverse the

175 Farnesoid X receptor knockout mice (with a hydrophilic B

176 In addition, ASBT expression in farnesoid X receptor null mice was unresponsive to bile

177 Furthermore, bile acids and farnesoid X receptor reduced the expression of nuclear H

178 ulation of ASBT by bile acids is mediated by farnesoid X receptor via small heterodimer partner-depen

179 The bile acid receptor FXR (farnesoid X receptor) activates expression of fibroblast

180 The nuclear receptor FXR (farnesoid X receptor), a multiple functional transcripti

181 ry activities of the hepatic TR, NR1H4 (FXR; farnesoid X receptor), as our model system to tackle thi

182 ptors, particularly the primary BA receptor, farnesoid X receptor, and small heterodimer partner, whi

183 Bile acid response was mediated by the farnesoid X receptor, as shown by the fact that overexpr

184 d nuclear receptors (i.e., liver X receptor, farnesoid X receptor, estrogen receptor alpha, peroxisom

185 of mice with GW4064, a synthetic agonist for farnesoid X receptor, induced SHP expression and decreas

186 1 (LSD1) is directly induced by BA-activated farnesoid X receptor, is recruited to the BA synthetic g

187 p7b1, and produces partial resistance to the farnesoid X receptor, leading to a lithogenic bile salt

188 d B6J mice, including the bile acid receptor farnesoid X receptor, oxysterol 7alpha-hydroxylase, ster

189 ty to modulate bile acid activated proteins: farnesoid X receptor, vitamin D receptor, pregnane X rec

190 deoxycholic acid, the natural agonist of the farnesoid X receptor, which is a nuclear hormone recepto

191 anscription of the gene (Nr1h4) encoding the farnesoid X receptor-1 (Fxr-1), thereby leading to reduc

192 Thus, farnesoid X receptor-mediated regulation was preserved.

193 pd3 expression was attenuated in LCA-treated farnesoid X receptor-null mice that are resistant to LCA

194 binding to the mammalian bile acid receptor farnesoid X receptor.

195 ired early growth response factor-1, but not farnesoid X receptor.

196 gene expression is regulated by the nuclear farnesoid X receptor.

197 factor-kappaB (NF-kappaB) rather than by the farnesoid X receptor.

198 15 (FGF15), a target gene of the BA receptor farnesoid X receptor.

199 ogenous bile acids, indicating activation of farnesoid X receptor.

200 alized using a sensor based on the zebrafish farnesoid X receptor.

201 The farnesoid X receptor/bile acid receptor (FXR) is a recen

202 The farnesoid X receptor/fibroblast growth factor axis and i

203 receptor (LXR)/retinoid X receptor (RXR) and farnesoid X receptor/RXR nuclear receptor signaling amon

204 Farnesoid X receptor; Small Heterodimer Partner double k

205 me proliferator-activated receptors (PPARs), farnesoid X receptors (FXRs), liver X receptors (LXRs),

206 ated receptor (clofibrate or linoleic acid), farnesoid X-activated receptor (farnesol or juvenile hor

207 xpressed in human livers and is regulated by farnesoid X-activated receptor (FXR) in response to FXR

208 Farnesoid X-activated receptor (FXR) is a key transcript

209 tamins and are physiological ligands for the farnesoid X-activated receptor (FXR), a member of the nu

210 iferator activated receptors (PPARs) and the farnesoid X-activated receptor (FXR), on the development

211 d to isolate genes that are regulated by the farnesoid X-activated receptor (FXR, NR1H4).

212 The farnesoid X-activated receptor (FXR; NR1H4) is a member

213 e proliferator-activated receptor and of the farnesoid X-activated receptor accelerate epidermal barr

214 or-alpha ligand, and juvenile hormone III, a farnesoid X-activated receptor activator, markedly accel

215 eroxisome proliferator-activated receptor or farnesoid X-activated receptor activators, or by an acti

216 eroxisome proliferator-activated receptor or farnesoid X-activated receptor are involved in this gluc

217 Farnesoid X-activated receptor mRNA was not detected in

218 that the class II nuclear hormone receptor, farnesoid X-receptor (FXR), incorporates histone methylt

219 and transfected with expression plasmids for farnesoid X-receptor (FXR), short heterodimer partner (S

220 d to isolate genes that are regulated by the farnesoid X-receptor (FXR, NR1H4).

221 To address the importance of the farnesoid X-receptor (FXR; NR1H4) for normal cholesterol

222 t that overexpression of a dominant-negative farnesoid X-receptor eliminated the bile acid mediated d

223 regulation is provided by bile acids through farnesoid-X-receptor (FXR) (NR1H4).

224 antagonist of the mammalian bile acid sensor farnesoid-X-receptor (FXR).