ライフサイエンスコーパス: farnesyl diphosphate

1 phate, generating the 15-carbon product (E,Z-farnesyl diphosphate).

2 out a gene for biosynthesis of the precursor farnesyl diphosphate.

3 C]isopentenyl diphosphate incorporation into farnesyl diphosphate.

4 t only GGPP but also its metabolic precursor farnesyl diphosphate.

5 in atoms and the isoprenoid portion of bound farnesyl diphosphate.

6 E)-alpha-bisabolene as the sole product from farnesyl diphosphate.

7 he enzyme-peptide complex was not trapped by farnesyl diphosphate.

8 ith binding and utilization of the substrate farnesyl diphosphate.

9 addition to trichodiene when incubated with farnesyl diphosphate.

10 phate substrates neryl diphosphate and 2z,6z-farnesyl diphosphate.

11 ion mixtures of L-tryptophan with geranyl or farnesyl diphosphate.

12 lly phosphorylated to farnesyl phosphate and farnesyl diphosphate.

13 as altered templates for the cyclization of farnesyl diphosphate.

14 he total hydrocarbons obtained using (2E,6E)-farnesyl diphosphate.

15 g to the synthesis of farnesene isomers from farnesyl diphosphate.

16 Incubation of farnesyl diphosphate (1) with Penicillium roqueforti ari

17 Incubation of farnesyl diphosphate (1) with the W308F or W308F/H309F m

18 ion of the recombinant protein, SAV_76, with farnesyl diphosphate (1, FPP) in the presence of Mg(2+)

19 erea, catalyzes the multistep cyclization of farnesyl diphosphate (2) to the tricyclic sesquiterpene

20 color catalyzes the multistep cyclization of farnesyl diphosphate (2, FPP) to the tricyclic sesquiter

21 Incubation of (1R)-[1-(2)H]farnesyl diphosphate (2b) with recombinant presilphiperf

22 Cyclization of [13,13,13-(2)H(3)] farnesyl diphosphate (2d) gave [14,14,14-(2)H(3)]-3d, th

23 alogues of geranyl diphosphate (3-ClGPP) and farnesyl diphosphate (3-ClFPP), respectively.

24 diphosphate and dimethylallyl diphosphate to farnesyl diphosphate, a crucial metabolic intermediate i

25 yme active site, we conclude that folding of farnesyl diphosphate alone does not always dictate the s

26 e synthase (FPPS) catalyzes the synthesis of farnesyl diphosphate, an important precursor of sterols,

27 cco, alone and complexed separately with two farnesyl diphosphate analogs were analyzed.

28 Addition of a farnesyl diphosphate analogue causes no detectable chang

29 Here, the synthesis of a benzophenone-based farnesyl diphosphate analogue containing a stable phosph

30 Farnesyl diphosphate analogues with fluorine at C2 and C

31 Eleven farnesyl diphosphate analogues, which contained omega-az

32 The assays use [(3)H]farnesyl diphosphate and [(3)H]geranylgeranyl diphosphat

33 rase (PFTase) catalyzes the reaction between farnesyl diphosphate and a protein substrate to form a t

34 resulted in reduction in the k(cat)/K(m) for farnesyl diphosphate and formation of varying proportion

35 isoprenoid mevalonate pathway-intermediates, farnesyl diphosphate and geranylgeranyl diphosphate, als

36 catalyze the attachment of lipid groups from farnesyl diphosphate and geranylgeranyl diphosphate, res

37 functional, catalyzing the formation of both farnesyl diphosphate and geranylgeranyl diphosphate.

38 The sensitivity to feedback inhibition by farnesyl diphosphate and its sulfur-containing analog, f

39 ; the K(i) values were 46 and 45 micro M for farnesyl diphosphate and its thio analog, respectively.

40 omega,Z-neryl diphosphate yielding omega,E,Z-farnesyl diphosphate and omega,Z,Z-farnesyl diphosphate,

41 Both farnesyl diphosphate and peptide substrates can be accom

42 anisms, is subject to feedback regulation by farnesyl diphosphate and related compounds.

43 adds seven more isoprene units to omega, E,Z-farnesyl diphosphate and releases decaprenyl diphosphate

44 the cell membrane that synthesizes omega,E,Z-farnesyl diphosphate and the other present in the cytoso

45 over experiments with the yeast enzyme using farnesyl diphosphate and the short peptide RTRCVIA as su

46 was inactive, whereas the LSU produced GPP, farnesyl diphosphate, and geranylgeranyl diphosphate (GG

47 diphosphate precursors, geranyl diphosphate, farnesyl diphosphate, and geranylgeranyl diphosphate, to

48 quitination and degradation was derived from farnesyl diphosphate, and thus implied conservation of a

49 required for the conversion of mevalonate to farnesyl diphosphate are found in the peroxisome.

50 useful for identifying enzymes that utilize farnesyl diphosphate as a substrate.

51 The use of (2Z,6E)-farnesyl diphosphate as an alternate substrate for recom

52 cell-free extracts from grand fir stem with farnesyl diphosphate as substrate indicated that the con

53 FDS-1 and FDS-2 synthesized farnesyl diphosphate as the final chain elongation produ

54 picture of the conformation of enzyme-bound farnesyl diphosphate at the active site of presilphiperf

55 o be involved in isopentenyl diphosphate and farnesyl diphosphate biosynthesis leading to AN were not

56 essarily reflect the original orientation of farnesyl diphosphate bound in the corresponding enzyme a

57 osphate bound and with the product mimic E,E-farnesyl diphosphate bound.

58 ntha x piperita) and can be synthesized from farnesyl diphosphate by a cell-free extract of peppermin

59 s an isomerization to form a tighter FTase*--farnesyl diphosphate--BZA2-B complex.

60 Recombinant Mg25 converted farnesyl diphosphate (C(15)) predominantly to beta-cubeb

61 gh either geranyl diphosphate (C10) or trans-farnesyl diphosphate (C15), to yield monoterpenes and se

62 he active site which can be modeled as bound farnesyl diphosphate carried through the enzyme purifica

63 ation of isopentenyl diphosphate (IPP), with farnesyl diphosphate catalysed by a cis-isoprenyltransfe

64 rapping experiments revealed that the enzyme-farnesyl diphosphate complex was efficiently trapped by

65 otion that the inhibitor binds to the FTase--farnesyl diphosphate complex which then undergoes an iso

66 pressed C-terminal domain of SC9B1.20 had no farnesyl diphosphate cyclase activity.

67 ogenes lacking conserved motifs required for farnesyl diphosphate cyclase activity.

68 r elongation factor, interacts directly with farnesyl diphosphate during rubber biosynthesis.

69 ed with the SNP rs2645424 on chromosome 8 in farnesyl diphosphate farnesyl transferase 1 (FDFT1) (P =

70 emethylase (CYP51A1), and squalene synthase (farnesyl diphosphate farnesyl transferase 1)) via novel

71 ll interfering RNA showed that inhibition of farnesyl-diphosphate farnesyl transferase (squalene synt

72 Squalene synthetase (farnesyl-diphosphate:farnesyl-diphosphate farnesyltransf

73 coamplified genes from this region including farnesyl-diphosphate farnesyltransferase (FDFT1), arylam

74 enzyme GGDP synthase (GGDPS) that condenses farnesyl diphosphate (FDP) and isopentenyl pyrophosphate

75 10-geranyl diphosphate (GDP) and only 4% C15-farnesyl diphosphate (FDP) in the presence of Co(2+) or

76 in order of increasing potency at inhibiting farnesyl diphosphate (FDP) synthase (their intracellular

77 zes the metal-dependent cyclization of (E,E)-farnesyl diphosphate (FDP) to the cadinane sesquiterpene

78 idago canadensis catalyzes the conversion of farnesyl diphosphate (FDP) to the plant sesquiterpene (+

79 Unlike the related polyisoprenyl phosphate farnesyl diphosphate (FDP), PSDP was not a substrate for

80 e conversion of the isoprenoid intermediate, farnesyl diphosphate (FDP), to sesquiterpene phytoalexin

81 products from its natural substrate (2E,6E)-farnesyl diphosphate (FDP).

82 ur, which in turn facilitates cyclization of farnesyl diphosphate for the exclusive formation of tric

83 sensitive method was developed for measuring farnesyl diphosphate (FPP) accumulation in a mutant stra

84 Certain farnesyl diphosphate (FPP) analogs are potent inhibitors

85 ld in a ternary complex with an enzyme-bound farnesyl diphosphate (FPP) analogue, indicating that the

86 Here, the syntheses of two new farnesyl diphosphate (FPP) analogues containing photoact

87 Farnesyl diphosphate (FPP) analogues have proven to be b

88 a non-sterol isoprenoid signal derived from farnesyl diphosphate (FPP) and a sterol-derived signal a

89 trates for modification with the isoprenoids farnesyl diphosphate (FPP) and anilinogeranyl diphosphat

90 In plants, farnesyl diphosphate (FPP) and geranylgeranyl diphosphat

91 The polyisoprenoid diphosphates farnesyl diphosphate (FPP) and geranylgeranyl diphosphat

92 Farnesyl diphosphate (FPP) and geranylgeranyl diphosphat

93 GGTase-I discriminates against farnesyl diphosphate (FPP) at the product turnover step

94 lyl diphosphate (DMAPP) to the C(15) product farnesyl diphosphate (FPP) by addition of two molecules

95 ly synthesizes the "regular" sesquiterpenoid farnesyl diphosphate (FPP) by coupling isopentenyl dipho

96 in the assay buffer increases the potency of farnesyl diphosphate (FPP) competitive inhibitors.

97 ous or monitor pyrophosphate release and not farnesyl diphosphate (FPP) creation.

98 zyme, the fact that the isoprenoid substrate farnesyl diphosphate (FPP) forms part of the binding sit

99 We now demonstrate that farnesyl diphosphate (FPP) is the source of the positive

100 tep in its biosynthesis, condensation of two farnesyl diphosphate (FPP) molecules to dehydrosqualene,

101 sor, through a reductive dimerization of two farnesyl diphosphate (FPP) molecules.

102 A cDNA encoding farnesyl diphosphate (FPP) synthase (FPPS) has been clon

103 -regulated transcription of the gene for rat farnesyl diphosphate (FPP) synthase (geranyl-diphosphate

104 ntly demonstrated that mevalonate kinase and farnesyl diphosphate (FPP) synthase are localized predom

105 Farnesyl diphosphate (FPP) synthase catalyzes the consec

106 Sterol-regulated transcription of the farnesyl diphosphate (FPP) synthase gene is dependent on

107 control of promoters derived from either the farnesyl diphosphate (FPP) synthase, 3-hydroxy-3-methylg

108 ethylglutaryl coenzyme A (HMG-CoA) synthase, farnesyl diphosphate (FPP) synthase, and the low density

109 transfer of a 15-carbon farnesyl group from farnesyl diphosphate (FPP) to a conserved cysteine in th

110 transfer of a 15-carbon farnesyl moiety from farnesyl diphosphate (FPP) to a cysteine residue near th

111 nsfer of the hydrophobic farnesyl group from farnesyl diphosphate (FPP) to cellular proteins such as

112 ase) catalyzes the transfer of farnesyl from farnesyl diphosphate (FPP) to cysteine residues at or ne

113 irst is the condensation of two molecules of farnesyl diphosphate (FPP) to form a cyclopropylcarbinyl

114 talyzes the condensation of two molecules of farnesyl diphosphate (FPP) to form presqualene diphospha

115 an initial condensation of two molecules of farnesyl diphosphate (FPP) to form presqualene diphospha

116 yzes the ionization-dependent cyclization of farnesyl diphosphate (FPP) to form the bicyclic eremophi

117 nthesis-the condensation of two molecules of farnesyl diphosphate (FPP) to form the cyclopropylcarbin

118 talyzes the condensation of two molecules of farnesyl diphosphate (FPP) to give presqualene diphospha

119 Transfer of the farnesyl group from farnesyl diphosphate (FPP) to proteins is catalyzed by p

120 trichodiene synthase-catalyzed conversion of farnesyl diphosphate (FPP) to trichodiene at 15 degrees

121 6 complexed with farnesyltransferase (FTase)-farnesyl diphosphate (FPP) were determined, and they pro

122 te presqualene diphosphate (PSPP) from trans-farnesyl diphosphate (FPP) with reduced production of sq

123 hosphate (DMAPP), geranyl diphosphate (GPP), farnesyl diphosphate (FPP), and geranylgeranyl diphospha

124 The universal sesquiterpene precursor, farnesyl diphosphate (FPP), is cyclized in an Mg(2+)-dep

125 -carbon geranyl diphosphate (GPP), 15-carbon farnesyl diphosphate (FPP), or 20-carbon geranylgeranyl

126 de, and L-739,750 peptidomimetic with either farnesyl diphosphate (FPP), or a nonreactive analogue.

127 sphates were good alternative substrates for farnesyl diphosphate (FPP).

128 ates containing a C-terminal "CaaX" motif by farnesyl diphosphate (FPP).

129 sphate (GPP) and between IPP and GPP to give farnesyl diphosphate (FPP).

130 volving rupture of the carbon-oxygen bond in farnesyl diphosphate (FPP).

131 atom from the alpha- and beta-phosphates of farnesyl diphosphate (FPP).

132 and a sesquiterpene, nerolidol, derived from farnesyl diphosphate (FPP).

133 Toxoplasma gondii possesses a bifunctional farnesyl diphosphate (FPP)/geranylgeranyl diphosphate (G

134 to an allylic diphosphate initiator, such as farnesyl diphosphate (FPP, 1), in the presence of a diva

135 te synthase (FPS) catalyzes the synthesis of farnesyl diphosphate from isopentenyl diphosphate and di

136 In summary, we report the first bifunctional farnesyl-diphosphate/geranylgeranyl-diphosphate synthase

137 n adds a further seven isoprene units to E,Z-farnesyl diphosphate in a processive manner to generate

138 ne cyclase that catalyzes the cyclization of farnesyl diphosphate in the first committed step of the

139 ta-caryophyllene and alpha-humulene from E,E-farnesyl diphosphate in trichomes of leaf but not of ste

140 f the tomato sesquiterpene synthases use z,z-farnesyl diphosphate in vitro as well, or more efficient

141 TCs from Dictyostelium discoideum converted farnesyl diphosphate into (2S,3R,6S,9S)-(-)-protoillud-7

142 produced protein catalyzed the conversion of farnesyl diphosphate into over 15 sesquiterpenes in simi

143 features responsible for the cyclization of farnesyl diphosphate into the tricyclic hydrocarbon pent

144 hese results established that cyclization of farnesyl diphosphate involves displacement of the diphos

145 A possible metabolic fate for farnesyl diphosphate is its conversion to farnesol, then

146 alytic efficiency is greatest when omega,E,Z-farnesyl diphosphate is used as the allylic acceptor, su

147 In M. smegmatis, the omega,E, Z-farnesyl diphosphate is utilized by a membrane-associate

148 The product of this enzyme, omega,E,Z-farnesyl diphosphate, is an intermediate for the synthes

149 l cation, the product of 11,1-cyclization of farnesyl diphosphate, is the product of the first commit

150 The product, omega,E, Z-farnesyl diphosphate, is the putative substrate of the s

151 -cadinene (5%) with the native C15 substrate farnesyl diphosphate (Km approximately 0.6 microM; Vrel

152 tic roles in enhancing the reactivity of the farnesyl diphosphate leaving group.

153 ion that following the initial ionization of farnesyl diphosphate, minimal enzymatic intervention may

154 of 6.2 +/- 0.5 x 10(-3) s(-1) and a K(m) for farnesyl diphosphate of 62 +/- 8 nM.

155 yl diphosphate, neryl diphosphate, omega,E,E-farnesyl diphosphate, omega,E,Z-farnesyl diphosphate, or

156 e synthase from Aspergillus terreus cyclized farnesyl diphosphate only to (+)-aristolochene (4).

157 d by human PGGTase-I with either (S)-[1-(2)H]farnesyl diphosphate or (S)-[1-(2)H]GGPP.

158 osphate (2-diazo-3,3,3-trifluoropropionyloxy-farnesyl diphosphate or DATFP-FPP) inhibits mevalonate-d

159 vine brain cytosol in the presence of either farnesyl diphosphate or geranylgeranyl diphosphate, GST-

160 e, omega,E,E-farnesyl diphosphate, omega,E,Z-farnesyl diphosphate, or omega,E,E,E-geranylgeranyl diph

161 fuels and the rapid engineering of microbial farnesyl diphosphate-overproducing platforms for the pro

162 of a catalytically competent ternary enzyme-farnesyl diphosphate-peptide complex.

163 omega,E,Z-farnesyl diphosphate and omega,Z,Z-farnesyl diphosphate, respectively.

164 cells overexpressing Rv2361c incubated with farnesyl diphosphate showed a 10-fold increase of [(14)C

165 Binding of the substrate farnesyl diphosphate similarly may trigger this conforma

166 may be significantly more selective for the farnesyl diphosphate substrate than the active site bind

167 the abilities of all the mutants to bind the farnesyl diphosphate substrate were similar to that of t

168 o as well, or more efficiently than, the e,e-farnesyl diphosphate substrate.

169 a2 T cells as a consequence of inhibition of farnesyl diphosphate synthase (a key enzyme of the meval

170 eactions, chimeric proteins constructed from farnesyl diphosphate synthase (chain elongation) and chr

171 Farnesyl diphosphate synthase (FDPS) catalyzes the conve

172 stimulate Vgamma2Vdelta2 cells by inhibiting farnesyl diphosphate synthase (FDPS) in the mevalonate p

173 y unrecognized beta2AR regulators, including farnesyl diphosphate synthase (FDPS).

174 nts of the first two enzymes in the pathway, farnesyl diphosphate synthase (FDS) and carotenoid synth

175 The amino acid sequences of farnesyl diphosphate synthase (FPPase) and chrysanthemyl

176 Farnesyl diphosphate synthase (FPPase) catalyzes chain e

177 ISPP and GSPP were substrates for avian farnesyl diphosphate synthase (FPPase).

178 esized and evaluated as substrates for avian farnesyl diphosphate synthase (FPPase).

179 r therapeutic agents involving inhibition of farnesyl diphosphate synthase (FPPS) and geranylgeranyl

180 alysis and pharmacophore modeling studies of farnesyl diphosphate synthase (FPPS) inhibition, human V

181 n between cell growth inhibition and E. coli farnesyl diphosphate synthase (FPPS) inhibition.

182 They function by inhibiting the enzyme farnesyl diphosphate synthase (FPPS), but the details of

183 to the isoprene biosynthesis pathway enzymes farnesyl diphosphate synthase (FPPS), isopentenyl diphos

184 r possible binding to the allosteric site in farnesyl diphosphate synthase (FPPS).

185 s modulated by the lipid biosynthesis enzyme farnesyl diphosphate synthase (FPPS).

186 Farnesyl diphosphate synthase (FPS) catalyzes the synthe

187 ted mutagenesis to transform wild-type avian farnesyl diphosphate synthase (FPS) into synthases capab

188 of the x-ray structure of homodimeric avian farnesyl diphosphate synthase (geranyltransferase, EC 2.

189 related Z-prenyl diphosphate synthases, E,Z-farnesyl diphosphate synthase (Rv1086) and decaprenyl di

190 n at the low nanomolar level of the T. cruzi farnesyl diphosphate synthase (TcFPPS).

191 neryl diphosphate synthase1 (NDPS1) and Z,Z-farnesyl diphosphate synthase (zFPS), which are encoded

192 e levels of geranyl diphosphate synthase and farnesyl diphosphate synthase activities did not correla

193 y by the targeted overexpression of an avian farnesyl diphosphate synthase along with two versions of

194 expression in either compartment of an avian farnesyl diphosphate synthase and an appropriate terpene

195 ylamines were found to be weak inhibitors of farnesyl diphosphate synthase and caused accumulation of

196 Unlike farnesyl diphosphate synthase and geranylgeranyl diphosp

197 a subgroup of prenyltransferases, including farnesyl diphosphate synthase and geranylgeranyl diphosp

198 Z-Farnesyl diphosphate synthase catalyzed the addition of

199 Farnesyl diphosphate synthase catalyzes the sequential c

200 Farnesyl diphosphate synthase catalyzes the sequential h

201 compounds revealed that the active site of Z-farnesyl diphosphate synthase differs substantially from

202 sphate synthase differs substantially from E-farnesyl diphosphate synthase from pig brain (Sus scrofa

203 We screened 26 bisphosphonates against a farnesyl diphosphate synthase from Plasmodium vivax, fin

204 ncer cells to pitavastatin is potentiated by farnesyl diphosphate synthase inhibitors or geranylgeran

205 In plants the presence of farnesyl diphosphate synthase isozymes offers the possib

206 at of the chain elongation prenyltransferase farnesyl diphosphate synthase rather than squalene synth

207 We have now purified Z-farnesyl diphosphate synthase to near homogeneity using

208 Inhibitors of the Z-farnesyl diphosphate synthase were designed and chemical

209 ogen-containing bisphosphonates that inhibit farnesyl diphosphate synthase were effective in inhibiti

210 re excellent competitive inhibitors of avian farnesyl diphosphate synthase with KI = 1.0 +/- 0.12 muM

211 iguration, indicating that Rv1086 (omega,E,Z-farnesyl diphosphate synthase) and Rv2361c act sequentia

212 l diphosphate synthase (but not, apparently, farnesyl diphosphate synthase) to favor the production o

213 gen-containing BPs (N-BPs) was identified as farnesyl diphosphate synthase, an enzyme in the mevalona

214 lglutaryl coenzyme A synthase and reductase, farnesyl diphosphate synthase, and squalene synthase.

215 res of one sulfonium bisphosphonate bound to farnesyl diphosphate synthase, finding that it binds exc

216 3-hydroxy-3-methylglutaryl-CoA reductase or farnesyl diphosphate synthase, reduced endometrial organ

217 ar to the isoprenoid chain elongation enzyme farnesyl diphosphate synthase, which also contains two a

218 similar in some respects to that of dimeric farnesyl diphosphate synthase, which is not a cyclase.

219 (nBPs) are bone-specific agents that inhibit farnesyl diphosphate synthase.

220 IP and DMAP can also competitively inhibit farnesyl diphosphate synthase.

221 her gene involved in cholesterol metabolism, farnesyl diphosphate synthase.

222 Farnesyl-diphosphate synthase (FPPS) catalyzes the synth

223 nd characterization of two Toxoplasma gondii farnesyl-diphosphate synthase (TgFPPS) homologs.

224 is of the pathway revealed that two enzymes, farnesyl-diphosphate synthase and geranylgeranyl-diphosp

225 synthesize long-chain trans-polyisoprene via farnesyl diphosphate synthases (FPSs).

226 noterpene synthases and three that preferred farnesyl diphosphate, the substrate for sesquiterpene sy

227 Farnesyl diphosphate, the substrate for squalene synthas

228 mutant proteins retained the ability to bind farnesyl diphosphate, they were found to have lost essen

229 Addition of both peptide and farnesyl diphosphate to give the product complex causes

230 nene synthase, catalyzing the cyclization of farnesyl diphosphate to pentalenene, the parent hydrocar

231 zes the conversion of two molecules of (E,E)-farnesyl diphosphate to squalene via the cyclopropylcarb

232 by aspartate beta352 and the diphosphate of farnesyl diphosphate to stabilize the developing charge

233 zes the covalent attachment of the 15-carbon farnesyl diphosphate to the C terminus of regulatory pro

234 e a fully functional cyclase which converted farnesyl diphosphate to the identical sesquiterpene alco

235 e synthase that catalyzes the cyclization of farnesyl diphosphate to the novel tricyclic hydrocarbon,

236 catalyze the Mg(2+)-dependent conversion of farnesyl diphosphate to the sesquiterpene alcohol (4S, 7

237 odiene synthase catalyzes the cyclization of farnesyl diphosphate to the sesquiterpene hydrocarbon tr

238 ent metal ion-dependent cyclization of [1-3H]farnesyl diphosphate to these same sesquiterpene olefins

239 step in HA biosynthesis is the conversion of farnesyl diphosphate to trichodiene (TD), a volatile org

240 , whereas VoTPS1 catalyzes the conversion of farnesyl diphosphate to valerena-1,10-diene.

241 c activity with native substrates (H-Ras and farnesyl diphosphate) to about 50% of that of the zinc-c

242 on of the universal sesquiterpene precursor, farnesyl diphosphate, to form the bicyclic hydrocarbon a

243 e universal sesquiterpene cyclase substrate, farnesyl diphosphate, to form the bicyclic hydrocarbon a

244 istry revealed that all of the overexpressed farnesyl diphosphate was in the omega,E, Z-configuration

245 ations of isotopically pure [2-(2)H(1)](E,E)-farnesyl diphosphate with recombinant patchoulol synthas

246 Incubation of farnesyl diphosphate with recombinant yeast squalene syn

247 scherichia coli, and demonstrated to cyclize farnesyl diphosphate, yielding beta-selinene as the domi

248 substrates neryl diphosphate (NPP) and 2Z,6Z-farnesyl diphosphate (Z,Z-FPP).

249 beetle protein extracts, but only when (Z,E)-farnesyl diphosphate [(Z,E)-FPP] was offered as a substr

250 squiterpene synthases, exclusively using Z-Z-farnesyl-diphosphate (zFPP) in plastids, probably arisen