ライフサイエンスコーパス: fasciculation

1 hering together in order to produce bundles (fasciculation).

2 crossing at the optic chiasm and optic tract fasciculation.

3 tivity is essential for embryonic motor axon fasciculation.

4 atalytic activity is required for motor axon fasciculation.

5 ema3D and L1 genetically interact to promote fasciculation.

6 nglion cell aggregation, and reduces neurite fasciculation.

7 fects on ENS precursor migration and neurite fasciculation.

8 dulating axon pathfinding, and driving nerve fasciculation.

9 but plays no major role in regulating their fasciculation.

10 and may play a role in axonal outgrowth and fasciculation.

11 ulus (nucMLF) by repulsion and modulation of fasciculation.

12 ciated with neurite outgrowth, guidance, and fasciculation.

13 xon initiation, elongation, pathfinding, and fasciculation.

14 er required for proper maintenance of axonal fasciculation.

15 on molecule that mediates axon outgrowth and fasciculation.

16 n to control growth cone motility and axonal fasciculation.

17 ng sites were associated with olfactory axon fasciculation.

18 outgrowth, neuronal pathfinding, and axonal fasciculation.

19 th of trigeminal neurites and promoted their fasciculation.

20 nd unzippering behavior that regulates their fasciculation.

21 n neural development: the regulation of axon fasciculation.

22 er increases in cell number, clustering, and fasciculation.

23 set of axons and are needed to maintain axon fasciculation.

24 indicating no interaction between different fasciculations.

25 ng CIs that switch rapidly from avoidance to fasciculation after midline crossing.

26 use a functional spiking model to show that fasciculation allows the network to generate reliable sw

27 es axon guidance by regulating the degree of fasciculation among axons.

28 Fasciculation and accumulation of processes suggested th

29 ann cells, collagen type V(SC) promoted axon fasciculation and association of axons with Schwann cell

30 igrations, and induce various axon-guidance, fasciculation and branching errors.

31 tant in contact-mediated axon guidance, axon fasciculation and cell migration.

32 immobilized DS and CSA/C displayed increased fasciculation and decreased branching, whereas KS caused

33 in vivo confirms the hypothesis that axonal fasciculation and defasciculation are controlled by adhe

34 Secondly, glia direct the fasciculation and defasciculation of axons, which patter

35 ped pathway undergoing coordinated rounds of fasciculation and defasciculation, which are critical to

36 of axonal material in addition to cycles of fasciculation and defasciculation.

37 tein), a Golgi protein, which interacts with fasciculation and elongation protein zeta 1 (FEZ1), an U

38 ssion of schizophrenia-associated gene Fez1 (fasciculation and elongation protein zeta 1), a gene pre

39 responding to the Aedes aegypti orthologs of fasciculation and elongation protein zeta 2 (fez2) and l

40 Here, we show that Fasciculation and Elongation Protein Zeta-1 (FEZ1) inter

41 show that NBR1 interacts with two proteins; fasciculation and elongation protein zeta-1 (FEZ1), a PK

42 involved in neuronal differentiation such as fasciculation and elongation protein zeta-1 (FEZ1), plat

43 One of the candidate gene products, FEZ1 (fasciculation and elongation protein zeta-1), a protein

44 We identified fasciculation and elongation protein zeta1 (FEZ1) as a b

45 IP1) to the light chains (LCs) or binding of fasciculation and elongation protein zeta1 (FEZ1) to the

46 itical for vomeronasal sensory neuron axonal fasciculation and for segregation of these sensory affer

47 equired during embryonic development for the fasciculation and growth of RGC axons.

48 These results suggest that defective axonal fasciculation and guidance may be primary responses to t

49 ly (IgCAMs) have been implicated in both the fasciculation and guidance of axons, but direct genetic

50 eased branching, whereas KS caused decreased fasciculation and increased branching.

51 tterns of slit1 and slit2 correlate with the fasciculation and innervation patterns of RGC axons with

52 uf cause defects in growth cone guidance and fasciculation and loss of expression of several neuronal

53 vel mechanism by which a semaphorin promotes fasciculation and modulates axon-axon interactions by re

54 teins has been implicated in axon outgrowth, fasciculation and neuronal cell migration, as well as in

55 scribed here range from abnormalities in the fasciculation and outgrowth of axons to defects in the d

56 esis and neurite outgrowth as well as axonal fasciculation and pathfinding.

57 phB proteins which helps maintain tight axon fasciculation and prevents aberrant axon growth into ven

58 expressing the same receptor display reduced fasciculation and project to multiple targets in the olf

59 Here, we show that radial bundle fasciculation and synapse formation are disrupted when P

60 een shown to play a prominent role in axonal fasciculation and synapse formation during motor neuron

61 asal pathway results in considerable HOA-AVG fasciculation and synapse formation in the absence of th

62 ors Neurod2 and Neurod6 as key regulators of fasciculation and targeted axogenesis in the mouse neoco

63 may mediate cell movement as well as process fasciculation and that different regions of the protein

64 anti-N-cadherin each decreased the amount of fasciculation and that sensory axons are less able to tr

65 geting of retinal axons, the control of axon fasciculation and the intrinsic organization of the tect

66 idance within specific cell types to prevent fasciculation and to preserve mosaic spacing.

67 tion of glia results in abnormalities in SAT fasciculation and trajectory.

68 minant ataxia, the MJD phenotype with facial fasciculations and lid retraction, and early-onset ataxi

69 the development of clinical features such as fasciculations and neurodegeneration.

70 e classical signs of MND, including wasting, fasciculations and severe bulbar symptoms, occurred over

71 this study was to determine first, if benign fasciculations and those in amyotrophic lateral sclerosi

72 n molecule 1 (Dscam1) show aberrant overlap, fasciculation, and accumulation of dendrites and axons,

73 In vitro DSCAM promotes RGC axon growth and fasciculation, and can act independently of cell contact

74 s, including motor neuron hyperexcitability, fasciculation, and differential vulnerability of motor n

75 Thus, olfactory axon trajectory, fasciculation, and growth cone morphology change within

76 including cell migration, axon guidance and fasciculation, and growth control and tumorigenesis.

77 ns function together in cell migration, axon fasciculation, and morphogenesis.

78 diversity in neuron-target recognition, axon fasciculation, and neuron self-recognition.

79 S), including axon outgrowth, axon guidance, fasciculation, and neuronal migration during cortical de

80 lecule L1, which mediates neurite outgrowth, fasciculation, and pathfinding, is expressed on tumor va

81 ial cells are required for axon guidance and fasciculation, and pioneer neurons for trophic support o

82 d semaphorins and slits in axonal targeting, fasciculation, and segregation of olfactory sensory neur

83 o be important in controlling axon guidance, fasciculation, and synapse formation.

84 hat mediates mechanosensory axonal guidance, fasciculation, and synaptic target selection within the

85 ture, L1 stimulates axon growth and enhances fasciculation, and that these processes contribute to th

86 unctional roles in olfactory axon outgrowth, fasciculation, and/or guidance.

87 phagia, diffuse skeletal muscle atrophy with fasciculations, and tongue atrophy were absent or mild i

88 fects on ENS precursor migration and neurite fasciculation appear to be mediated at least in part by

89 ddition, we find that axonal pathfinding and fasciculation are abnormal in corticospinal tracts of Sc

90 Fasciculations are distinct from the recurrent trains of

91 In conclusion, benign and malignant fasciculations are not distinguishable on the basis of w

92 evidence of multifocal distal generation of fasciculations, axonal conduction block in the motor uni

93 lthough midline fusion was normal, selective fasciculation between commissural axons was inhibited, a

94 cell surface proteins independently promote fasciculation between sensory neuron HOA and its postsyn

95 'generic' neural functions, such as neurite fasciculation, branching, and synapse formation.

96 t it plays an important role in sensory axon fasciculation, but the relative contributions of its int

97 nd had a greater number of turns than benign fasciculations, but, although irregular in both conditio

98 a3D), a classic repulsive molecule, promotes fasciculation by regulating L1 CAM levels and axon-axon

99 Fasciculation can be regulated by cell adhesion molecule

100 We show how fasciculation can help to ensure axons grow in the corre

101 lisation and breathing, and possibly diffuse fasciculation, characteristic of ALS.

102 stem development, growth cone pioneering and fasciculation contribute to nerve bundle structure.

103 2, indicate that it influences the circadian fasciculation cycle within pacemaker neurons, and sugges

104 ow here that Mef2 is required for this daily fasciculation-defasciculation cycle.

105 tolloid-related (tlr) is required for proper fasciculation/defasciculation of motor axons in the CNS

106 toneuron subclass and can also rescue the TN fasciculation defects observed in islet and Lim3 mutants

107 We describe fasciculation defects of animals with mutations in the C

108 lly, Efnb2 deletion in SGNs leads to similar fasciculation defects, suggesting that ephrin-B2/EphA4 i

109 of enteric NCCs, leading to defective axonal fasciculation, delayed gut colonization, or intestinal h

110 of fasciculation in ALS remains incomplete, fasciculations derive from ectopic activity generated in

111 on molecule L1 regulates axonal guidance and fasciculation during development.

112 n molecule L1 mediates neurite outgrowth and fasciculation during embryogenesis and mutations in its

113 SPG in the regulation of axon trajectory and fasciculation during hippocampal axon tract formation.

114 d by Slit, ranging from branch formation and fasciculation during neurite outgrowth to tumor progress

115 monstrate that En1 regulates pathfinding and fasciculation during the second phase of EN1 axon growth

116 er important functions required for neuronal fasciculation, fertility, and normal viability.

117 Fasciculation firing rate and the frequency of double fa

118 Thus the characteristics of 430 fasciculations from patients with amyotrophic lateral sc

119 nt roles in the developing brain during axon fasciculation, growth cone guidance, and neuron survival

120 del of neural development in which selective fasciculation helps to define accurate axonal projection

121 2-year-old brother had progressive weakness, fasciculations, hyperreflexia, and active denervation on

122 has been demonstrated to play a role in axon fasciculation in a number of other neural systems.

123 clearly regulates cell spacing and dendritic fasciculation in a specific class of retinal ganglion ce

124 While an understanding of the role of fasciculation in ALS remains incomplete, fasciculations

125 Although we study fasciculation in one particular organism, our approach t

126 GN defects, and exogenous EphA4 promotes SGN fasciculation in the absence of Pou3f4.

127 cules involved in axon growth, guidance, and fasciculation in the central nervous system (CNS).

128 o play a necessary role in axon guidance and fasciculation in the developing nervous system.

129 It is necessary for correct axon routing and fasciculation in the Drosophila visual system.

130 ms likely to contribute to the generation of fasciculation in the early stages of ALS, while distal s

131 e and nerve layer as well as abnormal axonal fasciculation in the sorting zone.

132 gene superfamily, regulates axon growth and fasciculation in vitro, but its role in vivo is unknown.

133 n neurological practice, with an emphasis on fasciculations in amyotrophic lateral sclerosis (ALS), a

134 sent on electromyography, the firing rate of fasciculations in amyotrophic lateral sclerosis was high

135 The waveforms of fasciculations in amyotrophic lateral sclerosis were on

136 iew considers the origin and significance of fasciculations in neurological practice, with an emphasi

137 Double fasciculations in which the second discharge was differe

138 Double fasciculations in which the waveforms of the two potenti

139 tion firing rate and the frequency of double fasciculations increases in amyotrophic lateral sclerosi

140 l mice show defective CGN axon extension and fasciculation indicating that beta1 plays a role in cere

141 dorsal root gangliogenesis and motor axonal fasciculation into ventral roots.

142 In addition, PG neuron axon fasciculation is abnormal in many gt hypomorphic larvae.

143 This suggests that although fasciculation is important in sensory axon guidance, sen

144 glomerulus, it appears that stable homotypic fasciculation is not a prerequisite for correct targetin

145 lly spreads to the whole neuron and involves fasciculation-like spiking events.

146 destined for the same nerve, suggesting that fasciculation may aid pathfinding.

147 Fasciculation mediated by a number of cell adhesion mole

148 together, these studies suggest that axonal fasciculation mediated by CAMs and regulated by PSA infl

149 ed in cell motility, neurite outgrowth, axon fasciculation, myelination, and synaptic plasticity.

150 1 mediates the axon outgrowth, adhesion, and fasciculation necessary for proper development of synapt

151 tion, ganglion cell aggregation, and neurite fasciculation necessary to form the enteric nervous syst

152 ts demonstrate that the somal clustering and fasciculation observed in the Dscam mutant retina are no

153 A second band of double fasciculation occurred in the tibialis anterior at an in

154 in kinase C reduced neuronal aggregation and fasciculation of axons, i.e., promoted uniform architect

155 ontrast to Sema3F, Slit-1 is dispensable for fasciculation of basal vomeronasal neuron axons but is c

156 ical lamination, suggesting that the lack of fasciculation of callosal axons is not an inherent manif

157 Mutations in Dscam cause the fasciculation of dendrites of neighboring homotypic neur

158 ibiting an aberrant clustering of somata and fasciculation of dendrites.

159 Selective fasciculation of fast- and slow-projecting motoneurons w

160 these events are essential for the selective fasciculation of follower axons along the longitudinal p

161 h the longitudinal axon tracts, to guide the fasciculation of follower neurons along specific fascicl

162 substrate gradients can regulate length and fasciculation of neurites and have a limited capability

163 ression correlates with increased growth and fasciculation of olfactory axons in vitro.

164 CAM and L1 are associated with extension and fasciculation of olfactory axons.

165 ired during embryogenesis for normal process fasciculation of one class of head sensory neuron.

166 transactivation also disrupted extension and fasciculation of parallel fibers as well as CGN migratio

167 We observed disrupted fasciculation of parallel fibers in the P5 null cerebell

168 In addition, abnormal midline fasciculation of photoreceptor axons resulted from the e

169 AM/mamFas II might play a role in growth and fasciculation of primary olfactory axons during developm

170 n the early postnatal period, L1 may support fasciculation of retinal fibers, maintaining them within

171 rmissive signal that promotes the growth and fasciculation of RGC axons, controlling the timing of wh

172 sion mediated by DM-GRASP may play a role in fasciculation of secondary motoneuron axons but not in p

173 Npn-2 is required for the organization and fasciculation of several cranial nerves and spinal nerve

174 settling patterns in the neural tube, or the fasciculation of spinal nerves.

175 etically by its effect on axon outgrowth and fasciculation of the Bolwig nerve, encodes a new Drosoph

176 ited normal crossing at the optic chiasm and fasciculation of the optic nerve.

177 g range migrations of three neuron types and fasciculation of the ventral nerve cord are defective.

178 n or misguidance of axon tracts, or abnormal fasciculation of tracts that normally form separate path

179 PolySias promote fasciculation of trigeminal axons in vivo and in vitro,

180 Regardless of origin, fasciculations often present as the initial abnormality

181 characteristics, and second to determine how fasciculation parameters evolved with progression of amy

182 pathway revealed normal growth kinetics and fasciculation patterns between embryonic days 17.5 and 1

183 The fasciculation phenotype in the Dscam-/- retina was parti

184 nd Dscam+/- retinas, also had clustering and fasciculation phenotypes that were intermediate to retin

185 While axon fasciculation plays a key role in the development of neu

186 amyotrophic lateral sclerosis was higher but fasciculation potential amplitude, area and indices of w

187 Fasciculation potential amplitude, area, turns, duration

188 Fasciculation potentials (FPs) may arise proximally or d

189 ble on the basis of waveform; highly complex fasciculation potentials can be seen in both conditions.

190 cle, at a single site, up to 15 identifiable fasciculation potentials could be recognized.

191 Fasciculation potentials recorded from 63 muscles of 28

192 within the diencephalon by regulating their fasciculation, preventing them or their branches from in

193 s or fascicles, but the molecules regulating fasciculation remain incompletely characterized.

194 Fasciculation represents a brief spontaneous contraction

195 fy enteric neurons and glia and analyze axon fasciculation, respectively.

196 esenchyme establishes an Eph/ephrin-mediated fasciculation signal that promotes inner radial bundle f

197 hosphorylation may play an important role in fasciculation, suggesting that complex intracellular pat

198 spinal origin, were most frequent in benign fasciculation syndrome (44%) (P < .001) and amyotrophic

199 ely to arise distally and that FPs in benign fasciculation syndrome more frequently arise proximally.

200 a, neuromyotonia, Isaacs' syndrome and Cramp-Fasciculation Syndrome to describe the motor manifestati

201 increased tendon reflexes suggests a benign fasciculation syndrome, even when of sudden onset.

202 om 21 muscles of 11 patients with the benign fasciculation syndrome.

203 ophic lateral sclerosis (ALS), and in benign fasciculation syndromes.

204 ema3F) and Slit-1, in olfactory sensory axon fasciculation, targeting, and segregation.

205 1 mediates the axon outgrowth, adhesion, and fasciculation that are necessary for proper development

206 PSA removal may cause an increase in fasciculation that forces sensory axons to track along n

207 siae) or asynchronous motor-unit activation (fasciculation) that result from a period of limb ischaem

208 ceptors and ephrins mediate axon sorting and fasciculation through repulsive axon-axon interactions.

209 tro, Slit2 secreted by motoneurons regulated fasciculation through Robo1 and Robo2.

210 ts support the idea that Slit2 promotes axon fasciculation via an autocrine and/or juxtaparacrine mec

211 ach occasion, suggesting reactivation of the fasciculation via the F-wave route.

212 aveform was variable in shape but the second fasciculation was the same on each occasion, suggesting

213 -sigma, or PTPRO, this nerve showed abnormal fasciculation, was reduced in size, or was missing entir

214 Here, the first fasciculation waveform was variable in shape but the sec

215 In support of the model that MMPs promote fasciculation, we find that the defasciculation observed

216 amyotrophic lateral sclerosis and 191 benign fasciculations were analysed.

217 variability and propensity to produce double fasciculations were measured.

218 otoneurons, SPON-1 acts in axon guidance and fasciculation, whereas in interneurons SPON-1 maintains

219 ctions in a pro-adhesive fashion to regulate fasciculation, while Beat Ia (the original secreted Beat

220 Giant Fibre morphogenesis normally relies on fasciculation with its major motorneuronal target.

221 adjustments that may be due to differential fasciculation with longitudinal axons.

222 th guidance cues, and, in trailing axons, by fasciculation with pioneer fibers.

223 in is involved in guidance through selective fasciculation with pre-existing axons within the ganglio

224 ility of the EP cells as well as maintaining fasciculation with their pathways.

225 These axons show increased fasciculation within the internal capsule, as well as ab

226 Fasciculation within the optic tract and adhesion within

227 In the vomeronasal system, axonal fasciculation within the vomeronasal nerve is affected;

228 Fasciculation without weakness, muscle atrophy or increa