ライフサイエンスコーパス: fast

1 and dynamics (relatively slow vs. relatively fast).

2 are avoided to keep the algorithm simple and fast.

3 and leptin, were measured after an overnight fast.

4 ction, especially during states of prolonged fasting.

5 ically cooperate to restore homeostasis upon fasting.

6 s or on the pore surfaces of MOFs, in a very fast (1-2 s) and continuous way.

7 Additionally, fast (25 kHz) magic-angle spinning (MAS) provides optima

8 ll as (15)N R1 and R1rho relaxation rates at fast (60 kHz) MAS and high magnetic field (1 GHz), we we

9 l-oxidized (Mox) actin can undergo extremely fast (84 subunits/s) disassembly, which depends on F-act

10 an electrophile onto diazo compounds give a fast access into important building blocks.

11 In particular, with the fast accumulation of transcriptomic data of non-model sp

12 As a result, tree inference is fast, accurate and robust to noise.

13 There is a need for a fast, accurate assay with limited operator input to enha

14 Our work presents a fast, accurate, and straightforward method for surface c

15 novel cellular target for the development of fast-acting antidepressant drugs.

16 ons in which impending sensory events demand fast action choices, we must be ready to prioritize high

17 This procedure enables physicians to achieve fast adequate dosing of antibiotics to improve the outco

18 We experimentally demonstrate a fast adiabatic transportation of Rubidium ((87)Rb) cold

19 Fast, affordable sequencing of pathogen genomes - now a

20 atography (HPTLC) method was developed for a fast analysis of a fingerprint of bioactive compounds pr

21 Biomedical research relies on the fast and accurate profiling of specific biomolecules and

22 The presented phasor analysis is model-free, fast and accurate.

23 putationally reordered and analyzed, enables fast and affordable sequencing of full human genomes.

24 Fast and automated calculation of FragFit renders it app

25 r development of this approach could lead to fast and automated purification of DNA nanostructures of

26 microfluidic device described here provides fast and complementary detection of different pesticides

27 present work focuses on the development of a fast and cost effective method based on Laser Induced Br

28 Fast and direct detection of pyocyanin is of importance

29 Despite numerous studies, a painless, fast and direct method for the in situ detection of H. p

30 Therefore, it is crucial to develop a fast and effective filter that can detect incorrect cand

31 d-up approach), introducing fluorine-18 in a fast and efficient manner in a building block, which is

32 designate a unique direction for developing fast and efficient optoelectronic devices.

33 oaccumulation, and has immense potential for fast and high-throughput screening bacterial chemotaxis.

34 he after-depolarization (ADP); (iii) reduced fast and medium after-hyperpolarizations (AHPs); (iv) st

35 ng after-depolarizations; (iii) reducing the fast and medium after-hyperpolarizations; (iv) broadenin

36 the analytic selection method (Lasso-AL) are fast and powerful alternatives to the standard univariat

37 works, inferred from experimental data, in a fast and principled way.

38 The reaction proceeds through the fast and reversible deuteration of the 2-methyl H of the

39 that reduced Cx43 HC function could promote fast and scarless gingival wound healing.

40 versatile catalysts that are simultaneously fast and selective for the living ring-opening polymeriz

41 mputational footprint, we saw the need for a fast and simple tool for data pre-processing that could

42 The method accurately predicted the top 10 fast and slow accumulating regions.

43 Based on previous analyses of fast and slow elongating VASP proteins by in vitro total

44 mes are comprised of anatomically segregated fast and slow muscle fibers that possess different metab

45 es for a reporter gene are increased in both fast and slow Pol II mutant strains and the magnitude of

46 surements suggest that all living cells show fast and subtle mass fluctuations throughout the cell cy

47 The PCSF package performs fast and user-friendly network analysis of high-throughp

48 lated with diabetes prevalence and levels of fasting and 2-hour glucose (each P < 0.008).

49 xhibited partial nuclear localization during fasting and cAMP/cAMP-dependent protein kinase signaling

50 and temporal variation in spring polar bear fasting and food web productivity suggests that polar be

51 thm, whose amplitude depends on both feeding-fasting and light-dark cycles.

52 KATPHI is characterized by fasting and protein-induced hypoglycemia that is unrespo

53 that plasma uridine levels are regulated by fasting and refeeding in mice, rats, and humans.

54 idations, suggest that VALORATE is accurate, fast, and can identify both known and novel gene mutatio

55 sensors potentially provides an alternative, fast, and efficient method.

56 CT is an efficient, fast, and readily available tool for detecting the locat

57 A novel, fast, and sensitive screening method for the identificat

58 dence on the health benefits of intermittent fasting, and discuss physiological mechanisms by which i

59 critically ill patients, during feeding and fasting, and to search for a correlation with gastric em

60 By extending the study of fast-and-frugal heuristics, we view social perceptions a

61 As a result, fast animals often exhibit optical adaptations comparabl

62 insertion/deletion (indels) accumulating as fast as single nucleotide variants (SNVs), and elevated

63 ish larvae xenografts constitute a promising fast assay for precision medicine, bridging the gap betw

64 Fe(III)-reducing conditions facilitating the fast attainment of solid-solution equilibria (e.g., in s

65 nt of highly infectious agents, such as acid-fast bacilli and systemic fungi, were revealed.

66 We present a fast Bayesian sparse factor model, which takes input gen

67 e data must and will speak for themselves is fast becoming a new dogma.

68 gion on chromosome 3q26 were associated with fast beta EEG power at P<5 x 10(-8).

69 Our approach allowed us to monitor fast blinking of an organic dye, the dissociation kineti

70 hether plant gametes prevent polyspermy by a fast block.

71 d in significantly but only slightly lowered fasting blood glucose (-0.14 mmol/L; 95% CI: -0.24, -0.0

72 lycemic control (random blood glucose [RBG], fasting blood glucose [FBG], and glycated hemoglobin [Hb

73 terol, total cholesterol, triglycerides, and fasting blood glucose) and identified several cis-eGenes

74 The mice also had elevated fasting blood glucose, fatty liver, and insulin resistan

75 tic side effects, vital signs were obtained, fasting blood samples were collected, and the Adherence

76 Blood pressure, non-fasting blood sugar, body mass index and abdominal girth

77 tions were histologically stained with Luxol Fast Blue (LFB) for myelin quantification.

78 ted during behaviors that involve strong and fast body bends, more ventral, higher-Rin secondary moto

79 g solution to a divalent-free Na(+) one, and fast Ca(2+)-dependent inactivation.

80 blies and morphologies to those that promote fast Ca(2+)-triggered release.

81 explained as a mixture of two mechanisms: a fast, capacity-limited, and delay-sensitive WM process t

82 tocols have been proposed as a means to make fast changes in the Hamiltonian without exciting transit

83 multifold advantages of high power density, fast charging-discharging, and long cyclic stability.

84 t microfluidic device for the complementary, fast, cheap, reusable and reliable analysis of different

85 S) have identified >175 loci associated with fasting cholesterol levels, including total cholesterol

86 e sealed vessel method is a new approach for fast cleavage of PCB from phycocyanin and gave at 120 de

87 highly codon biased and using preferentially fast codons, are highly resilient to ribosome drop-off.

88 In human type 1 diabetes pancreatic islets, fasting conditions reduce PKA and mTOR activity and indu

89 eficient adipocytes under postabsorptive and fasting conditions, resulting from impaired signal trans

90 performed simultaneous electrophysiology and fast confocal Ca(2+) imaging to determine whether altere

91 developed a new BMI that allows arbitrarily fast control and feedback rates, and used it to dissocia

92 ell-defined "square top" openings as well as fast current fluctuations, similar to other viroporins.

93 cations is however limited by the relatively fast decay time of the hyperpolarized spin state togethe

94 ectrolytes with metal anodes in fact promote fast dendritic formation, as a result of less Li consump

95 The qualitative FAST results and FAST-derived MIC (MICFAST) correspond closely with broth

96 Ultra-fast detection (<2min) and accurate quantifications of L

97 d create more compact aggregates compared to fast dewatering.

98 ore problem is that there is no sufficiently fast diagnostic test to guide correct antibiotic prescri

99 We observe an unexpected regime of fast diffusion immediately after photoexcitation, togeth

100 f disorder, while higher disorder allows for fast diffusion, which is then accompanied by antisite an

101 ue insulin sensitivity with extended morning fasting do not necessarily require changes in insulin si

102 we show that violation of ergodicity in the fast dynamics can drive the whole system to equilibrium.

103 tation impacts on protein stability offers a fast, economical and potentially accurate alternative to

104 is of pediatric patients with pre-B-ALL, and fasting effectively inhibited B-ALL growth in a human xe

105 Fast elution kinetics in the column setup were observed

106 Also, 3D-printed muSPE devices enabled fast emulsion breaking and solvent deasphalting of petro

107 e removed only from committed substrates and fast enough to prevent their co-degradation.

108 l corrugation and longitudinal phonons whose fast escape leaves behind a 2D-projected mass density in

109 rdtii, miRNAs might be subject to relatively fast evolution and have only a minor, largely modulatory

110 ned to a standard trauma evaluation with the FAST examination by the treating ED physician or a stand

111 Today the FAST examination has evolved into a more comprehensive s

112 ional postsynaptic potentials (PSPs), with a fast excitatory component followed by a slower inhibitor

113 Fast excitatory neurotransmission is mediated by AMPA-su

114 AMPA-type glutamate receptors that underlie fast excitatory synaptic transmission in the SDH.

115 rrespond to biological reality and allow for fast exploration of TF clustering and regulatory dynamic

116 r CO2 doubling, which is notably higher than fast-feedback estimates.

117 Here we show that fast field-driven antiferromagnetic spin dynamics is rea

118 ed data demonstrate that the pressure driven fast filtration approach followed by boiling ethanol que

119 information by improving sensitivity during fast flight, but limiting acuity loss when the fly is st

120 nt breakfast and family meals, less frequent fast food and meals during television viewing, and short

121 d with people living fewer than 500 m from a fast-food outlet, those living at least 2000 m away had

122 latter case, the activation reaction was too fast for direct observation of the intermediates, but th

123 to appear natural; conversely after viewing fast-forward videos for 30 seconds, playback had to be s

124 overcome the limiting O(nlogn) complexity of fast Fourier transform algorithms.

125 Here we test this hypothesis using ultra-fast functional magnetic resonance imaging to measure BO

126 A novel combination of a fast gas-sampling valve and a soot particle aerosol mass

127 ined as having blood pressure <120/80 mm Hg, fasting glucose <100 mg/dl, glycosylated hemoglobin <5.7

128 F, we detected an interaction effect between fasting glucose and fasting triglycerides with rs9939609

129 O) criteria to define GDM: >/=7.0 mmol/L for fasting glucose and/or >/=7.8 mmol/L for 2-h post-glucos

130 The C-statistics were 0.662 for ADA fasting glucose clinical concentration categories and 0.

131 erotic cardiovascular disease, 0.701 for ADA fasting glucose concentration clinical categories and 0.

132 ripheral arterial disease, and 0.683 for ADA fasting glucose concentration clinical categories and 0.

133 SLC5A1 showed a significant association with fasting glucose in the expected opposing direction.

134 ntly of this, with a steeper increase of the fasting glucose level (beta=131; 95% CI 38-225) during f

135 0.3 vs. 2.2 +/- 0.44 kg/m(2) in persons with fasting glucose levels below and above the median, respe

136 the inclusion criteria (NAFLD with impaired fasting glucose or impaired glucose tolerance) and were

137 otein- and total cholesterol, triglycerides, fasting glucose, body mass index, waist circumference, h

138 tent variable for glycemia (diabetes status, fasting glucose, glycated hemoglobin (HbA1c), fructosami

139 g P2Y2R, in slow-growing hCPCs compared with fast growers.

140 hment of diterpenoids in the culture medium, fast-growing adventitious root cultures may hold promise

141 We utilized the fast-growing pathogenic basiodiomycete forming an induce

142 tional sample of 1 545 634 patients (959 153 fasting >/=10-12 hours; 586 481 nonfasting) from the sec

143 Our findings support the hypothesis that fast Hebbian short-term potentiation is a key WM mechani

144 Global Names Parser (gnparser) is a fast, high precision tool for biodiversity informatician

145 tained with a workflow that included initial fast, high-energy HCD (Orbitrap, FT) scans, which produc

146 These fast homeostatic changes were independent of l-type Ca(2

147 Reduced fast ice after 2006 ramped iceberg scouring, killing hal

148 either primarily through poration sites for fast ICWs or opening of mechanosensitive ion channels fo

149 nd optical sectioning and, with sufficiently fast implementations, permits live cell imaging.

150 fast-moving sports, we must be ready to act fast in response to sensory events and, in our preparati

151 The results suggest that lacosamide binds to fast-inactivated states in a manner similar to other ant

152 azepine and phenytoin, which bind tightly to fast-inactivated states.

153 Dysfunction of the fast-inactivating Kv3.4 potassium current in dorsal root

154 otent and selective inhibitory effect on the fast inactivation process of NaV1.1 and 1.3.

155 ean individuals, 6 weeks of extended morning fasting increases the expression of genes involved in li

156 Interest on Tau protein is fast increasing in Alzheimer's disease (AD) diagnosis.

157 ficiency of the Tgr5 gene in mice alleviated fasting-induced hepatic lipid accumulation.

158 resistant to acetaminophen hepatotoxicity or fasting-induced steatosis.

159 Interestingly, fasting induction of fibroblast growth factor 21 in live

160 We demonstrate imaging of the fast initiation and propagation of action potential with

161 rs35929 modified the association of uMg with fasting insulin and fat mass in a general population.

162 etween maternal protein intake and offspring fasting insulin and homeostasis model assessment of insu

163 und significant heritability for measures of fasting insulin sensitivity and beta-cell function, for

164 dipose DI was calculated as ATIS: (1/GlyRa x fasting insulin) x first-phase insulin secretion.

165 Body weight, food intake, adiposity index, fasting insulin, triglycerides and cholesterol levels we

166 oxygen partial pressure continuously with a fast intra-vascular sensor in the carotid artery of anae

167 ty than typical solids or how one can design fast ion conductors following simple principles.

168 Fast ion transport and superior mechanical properties of

169 s in batteries, improved thermoelectrics and fast-ion conductors in super-capacitors and fuel cells.

170 ating these ion accelerators, to convert the fast ions to neutral atoms with little change in momentu

171 ssociation assay that enables the relatively fast kinetic screening of multiple compounds.

172 Thus, transient species possessing fast kinetics are enhanced relative to other components

173 We demonstrate that a fast life-history strategy, in turn, was associated with

174 Fasting lipid fractions (triglycerides [TGs], high-densi

175 The proposed method is simple, fast (<12.0min), present linear calibration curves (r(2)

176 each end of the squaraine core that ensures fast macrocycle threading kinetics, and (c) sialic acid

177 quantitative clinically-targeted MRI method, fast macromolecular proton fraction (MPF) mapping demons

178 fatty acid-containing medium promotes their fast maturation into adult-like CMs with higher oxidativ

179 lin E overproduction uncouples short G1 from fast MCM loading.

180 Here we present a fast method to predict potential phosphorylation switche

181 Four QIs were not recorded in FAST-MI 2010 and 4 in 2005, either because of treatment

182 ysiological mechanisms by which intermittent fasting might lead to improved health outcomes.

183 mensional motion inside the droplet and thus fast mixing.

184 s is based mostly on paleoseismic studies of fast-moving plate-boundary faults.

185 FICANCE STATEMENT In many situations such as fast-moving sports, we must be ready to act fast in resp

186 Our results identify that MCAK promotes fast MT growth speeds in ECs cultured on compliant 2D EC

187 c and microRNA transcriptome of the slow and fast muscles of Chinese perch (Siniperca chuatsi).

188 aid in design of vaccine strategies against fast mutating pathogens.

189 ted at a systems level by combining slow and fast myosin isoforms heterogeneously.

190 ross-frequency interactions between slow and fast neuronal oscillations.

191 the communication across different slow and fast neurotransmitter systems through intracellular sign

192 nce localized, additional properties such as fast neutron energy spectra and time-dependent neutron c

193 focus on optical spectroscopy can provide a fast, nondestructive method for monitoring chemical spec

194 Due to a fast occurring cyclization of l-glutamine to pyroglutami

195 rug memantine, representing an uncompetitive/fast off-rate antagonist of NMDA-type glutamate receptor

196 Preclinical identification of fast-onset antidepressants requires animal models that c

197 or has a wide dynamic range, high linearity, fast operation and low-cost.

198 take, but did not decrease food intake after fasting or salt intake following salt depletion; inactiv

199 A new device architecture for fast organic transistor memory is developed, based on a

200 Fast oscillatory synchrony in the activity of output mit

201 rates remain strictly positive only when the fast particle dynamics reveal two or more ergodic compon

202 Concomitantly, a longer fasting period with breakfast skipping also increased th

203 The fast phase desorption process becomes unimportant for li

204 ase of relaxation and decreased rates of the fast phase.

205 increased the CYP46A1 kcat, the rate of the "fast" phase of the enzyme reduction by the redox partner

206 and automated image analysis can be used for fast phenotyping of functionally diverse cell population

207 uterium exchange mass spectrometry (HDX-MS), fast photochemical oxidation of proteins (FPOP), alanine

208 rly women in Denmark, we found that impaired fasting plasma glucose concentration was associated with

209 to <40 mg/dL, which is well below the normal fasting plasma glucose concentration.

210 quency allele associated with an increase in fasting plasma insulin level and risk of type 2 diabetes

211 HaploForge takes advantage of HTML5 to be fast, portable and avoid the need for local installation

212 In comparison to spoligotyping of acid-fast-positive MGIT cultures, percent agreement between p

213 the same location can provide a new class of fast, powerful and efficient general-purpose computers.

214 timation method, to test the hypothesis that fast privatisation increased mortality in Russia.

215 Fast privatisation was strongly associated with higher w

216 his work presents an inexpensive, simple and fast procedure to purify trypsin based on affinity bindi

217 he transport layers, to achieve reliable and fast programming and erasing of the threshold voltage sh

218 Fast radio bursts are astronomical radio flashes of unkn

219 However, if other fast radio bursts have similarly faint radio and optical

220 reep) in iron-based superconductors unveiled fast rates (S) comparable to measurements of YBa 2Cu3O7-

221 V-Visible and LC-MS analyses showed that the fast reaction corresponds to beta-adduct formation (the

222 e capacity of 1,327 mAh/(g of S), along with fast reaction kinetics and negligible polysulfide dissol

223 uses the fact that fast species regulated by fast reactions quickly equilibrate to their stationary d

224 idenced high selectivity and sensitivity and fast recognition for CN(-) with a detection limit of 6.8

225 A fast recovery fast spin echo MR sequence was selected fo

226 ew is to provide an overview of intermittent fasting regimens, summarize the evidence on the health b

227 gnificant reduction and desynchronization of fast release.

228 d the roles of Syt1 and Syt2 at two types of fast-releasing inhibitory connections in the mammalian C

229 In the present work a fast, reliable and safe Ion Exchange Chromatography-Puls

230 entire immunosensor fabrication process was fast, requiring overall 45min to be completed before ana

231 ear range, high sensitivity and selectivity, fast response time and low oxygen-, temperature- and pH-

232 or offers a large phase change while keeping fast response time due to the decoupling between phase c

233 e to their high sensitivity, portability and fast response time.

234 excellent sensitivity, acceptable stability, fast response, and high electrocatalytic activity toward

235 Thus, with a fast response, significant stability and repeatability,

236 equipped Google Street View vehicles with a fast-response pollution measurement platform and repeate

237 The use of fast-response, pressure-driving pumps allows the microfl

238 mic responses involving appetite-stimulating fasting-responsive hypothalamic neurons expressing agout

239 The qualitative FAST results and FAST-derived MIC (MICFAST) correspond c

240 Interictal very fast ripples (VFRs; 500-1,000Hz) were detected in 23 of

241 pens clearly novel avenues in biosensing for fast screening diagnostics, decentralized monitoring and

242 co-oxidation with the substrate, due to very fast self-termination and cross-termination of the oxida

243 A very cost-effective, fast, sensitive and specific imprinted polymer modified

244 A simple, fast, sensitive, and robust gas chromatography-mass spec

245 ABSTRACT: Vertebrates rely on fast sensory encoding for rapid and precise initiation o

246 quid chromatography stationary phase allowed fast separation of both individual lipid species and cat

247 food-frequency questionnaire and provided a fasting serum sample before study randomization (1985-19

248 Eight hours of fasting significantly increased the expression of two cr

249 tate transition in fully activated fibers of fast skeletal muscle of the rabbit occurs during transit

250 for human alpha-cardiac myosin S1 and rabbit fast skeletal muscle S1.

251 viewed clips played at standard speed as too fast, so playback had to be slowed down in order for it

252 y to resolve this problem uses the fact that fast species regulated by fast reactions quickly equilib

253 Recently, several fast species tree inference methods have been developed,

254 citatory regular-spiking (RS) and inhibitory fast-spiking (FS) V1 cells had similar EPSP characterist

255 Interestingly, fast-spiking and non-fast-spiking INs displayed differen

256 tures called perineuronal nets (PNNs) around fast-spiking inhibitory interneurons, in a rat model of

257 Interestingly, fast-spiking and non-fast-spiking INs displayed differential modulation by gl

258 Before song learning, fast-spiking interneurons (FSIs) densely innervated glut

259 the hippocampus and neocortex, particularly fast-spiking parvalbumin-positive (PV+) basket cells.

260 tal sequences were predominantly composed of fast-spiking, putative inhibitory neurons, which display

261 A fast recovery fast spin echo MR sequence was selected for high RF powe

262 magnetic resonance (MR) imaging with a mixed fast spin-echo pulse sequence were assessed.

263 cuate nucleus (ARC) neurons sense the fed or fasted state and regulate hunger.

264 meostatic control of serum triglyceride in a fasted state.

265 ne and at the end of each 4-wk period in the fasting state for metabolomics analysis by using liquid

266 ndicate that oral glucose consumption in the fasting state is followed by increased glucose levels in

267 endent pathway and therefore responds to fed/fasted states of the animal.

268 y to assess for the first time the impact of fasting status on novel LDL-C accuracy.

269 to a greater global warming potential in the fast (step) warming treatment.

270 We investigated the role of gamma during fast stopping and recorded scalp electroencephalogram an

271 glucose level also was observed in overnight-fasted, streptozotocin-treated ghrelin receptor-null mic

272 hanism by which GABABRs are able to modulate fast synaptic inhibition.

273 onotropic neurotransmitter receptors mediate fast synaptic transmission by functioning as ligand-gate

274 imensional dynamic visualization study using fast synchrotron X-ray micro-tomography to provide new i

275 pe subdivisions preferentially responding to fast temporal frequencies are more myelinated.

276 ate of the EBI Search engine, an easy-to-use fast text search and indexing system with powerful data

277 d H-shift rate coefficients are sufficiently fast that, as a result of ongoing NO x emission reductio

278 tion with confocal microscopy are simple and fast, the method can serve as a primary screening tool f

279 , during the rapid muscle atrophy induced by fasting, the desmin cytoskeleton and the attached Z-band

280 tion in proteins, in particular, affects how fast they fold or find their binding targets and, as suc

281 ese peptides named "avathrin." Avathrin is a fast, tight binding competitive inhibitor with an affini

282 A3G converts from a fast to a slow binding state through oligomerization, wh

283 through life history decision nodes (eg, how fast to grow, when to mature, and how long to live).

284 thite and hematite changed from complete and fast to incomplete and slow as DeltarG values became les

285 Raman spectroscopy has been growing as a fast tool to food analysis, especially for detection of

286 teraction effect between fasting glucose and fasting triglycerides with rs9939609 on BMI (p = 0.0005

287 (OPG-Fc) completely restore the function of fast-twitch extensor digitorum longus muscles in dystrop

288 nzee muscle is composed of approximately 67% fast-twitch fibers (MHC IIa+IId).

289 affects muscle mass over time, particularly fast-twitch muscles, which should be taken into consider

290 We conclude that morning fasting up-regulates lipid turnover genes in SCAT of lea

291 Both fast uptake kinetics and great sorption selectivity towa

292 Fasting venous ammonia levels were estimated daily from

293 resolution ocean model, it is shown that the fast vertical spreading of tracer occurs when it comes i

294 low activation energy, and is likely due to fast vibrations that may be enabled by water mobility on

295 fluorogenic activation of the dye, enabling fast voltage imaging in defined neurons with sensitivity

296 cy, which depends on the gating rates of the fast voltage-gated Na(+) current.

297 d mortality ratio in men aged 20-69 years in fast vs slow privatised towns: 1.13, SMR 0.83, 95% CI 0.

298 9% adjusted) sustained monomorphic VT in the fast VT zone, 509 of 590 (85% adjusted) in the VT zone,

299 d by the hydrophilic core, which also showed fast water exchange.

300 his buffering function is most visible after fasting, when liver triglyceride increases manyfold but