ライフサイエンスコーパス: fast-acting

1 frontline agents has fuelled the search for fast-acting agents with novel mechanism of action.

2 ween slow-acting neuromodulator peptides and fast-acting amino acid transmitters in the control of en

3 dentate granule cells normally contain two "fast-acting" amino acid neurotransmitters, one excitator

4 ttenuated dendrodendritic inputs mediated by fast-acting AMPA receptors such that the excitation and

5 nity of structure-based drug design for this fast acting and extremely toxic high priority BoNT E.

6 The lead compound 1o is fast acting and highly active against intraerythrocytic

7 he antibiotics thiostrepton and rifampin are fast acting and might target additional processes outsid

8 ceptors represent a promising novel class of fast-acting and clinically viable antidepressant compoun

9 over the last decade is the discovery of the fast-acting and long-lasting antidepressant effects of k

10 n two neurocognitive processes, familiarity, fast-acting and relatively automatic, and recollection,

11 of electroconvulsive shock (ECS) therapy, a fast-acting and very effective antidepressant therapy, a

12 ng that microglia stimulators could serve as fast-acting anti-depressants in some forms of depressive

13 We hypothesized that combining a fast-acting anti-inflammatory agent with an ABT could li

14 rosocin and the attacins; unlike some other, fast-acting antibacterial peptides, diptericin did not l

15 l-D-aspartate (NMDA) receptor blocker, shows fast-acting antidepressant action, thus bringing fresh p

16 novel cellular target for the development of fast-acting antidepressant drugs.

17 Our findings also suggest that the fast-acting antidepressant effects of ketamine require r

18 fficacy of ketamine, its widespread use as a fast-acting antidepressant in routine clinical settings

19 However, application of the fast-acting antidepressant ketamine failed to demonstrat

20 the effects of isolation stress (IS) and the fast-acting antidepressant ketamine on anhedonia and dep

21 rtate (NMDA) receptor antagonist, produces a fast-acting antidepressant response in patients sufferin

22 this same synaptic signaling pathway to the fast-acting antidepressant responses elicited by ketamin

23 l-D-aspartate receptor) antagonist, produces fast-acting antidepressant responses in patients sufferi

24 antagonist, which on administration produces fast-acting antidepressant responses in patients with ma

25 escribed as having either active or inactive fast-acting antidepressant-like effects) followed by a 1

26 -type symptoms in humans and is a potent and fast-acting antidepressant.

27 l presynaptic avenues for the development of fast-acting antidepressants and possibly psychoactive co

28 le therapeutic target for the development of fast-acting antidepressants.

29 Herein we report a novel, in vivo active, fast-acting antimalarial chemotype based on a benzimidaz

30 f PfATP4 have highly attractive features for fast-acting antimalarials to be used in the global eradi

31 t of rapamycin (mTOR) kinase inhibitors, are fast-acting antiplasmodial compounds that unexpectedly t

32 of a target compound that could replace the fast-acting artemisinin component and harbor additional

33 ketamine and other NMDAR antagonists produce fast-acting behavioural antidepressant-like effects in m

34 e find that inhibitors of eEF2 kinase induce fast-acting behavioural antidepressant-like effects.

35 dioxide (ClO(2)), an extremely effective and fast-acting biocide.

36 ever, in the first 24 hours after treatment, fast-acting but not slow-acting drugs reduced the parasi

37 Albuterol acted as a sequential fast-acting channel blocker, increasing the mean burst d

38 The reduction in fast-acting cochlear compression associated with SNHL ex

39 clinical development candidate, SC83288, are fast-acting compounds that can cure a P. falciparum infe

40 Given their capacity to generate fast-acting currents, I suggest that the monoamine trans

41 ile the suppressive effect was mediated by a fast-acting, direct G-protein action, the facilitatory e

42 s tend to consistently focus at first on the fast-acting direction, and overlook the slower process i

43 of HOXA1-induced leukemia to the aggressive fast-acting disease elicited by HOXA9 and vice versa.

44 rticular, about the possible connectivity of fast-acting (e.g., glutamate and GABA) and slow-acting (

45 acute elevation of UA acts as "physiologic," fast-acting endogenous mediator of EPC mobilization and

46 These findings reveal a new fast-acting energy conservation strategy halting growth

47 Fast-acting excitatory neurotransmission in the retina i

48 scopy of the excised specimens, stained with fast-acting fluorescent histology dyes, could be an attr

49 s transforming the thrombin from a slow to a fast acting form toward fibrinogen.

50 approach has uncovered a previously unknown, fast acting, GluN2A-dependent neuroprotective signaling

51 port the presence of a remarkably robust and fast-acting glycinergic inhibitory system capable of sup

52 These encoded fast-acting immune responses including coagulation, phag

53 te steroid treatment or the immediate use of fast-acting immune therapies, such as rituximab.

54 he serpin superfamily of proteins and is the fast acting inhibitor of both urinary plasminogen activa

55 rfamily protein characterized initially as a fast-acting inhibitor of neutrophil elastase.

56 cin B (LMB), a noncompetitive, specific, and fast-acting inhibitor; and HTLV1-Rex protein, a potent c

57 been a limiting factor in the development of fast acting insulin analogues, creating a demand for exc

58 Devices containing aspart, a fast-acting insulin analog, could achieve glycemic contr

59 lbulin therapy in combination with available fast-acting insulin derivatives.

60 The fast acting ionotropic Glu receptors (iGluRs) are ligand

61 ponse through the synaptic activation of the fast-acting ionotropic receptor, LGC-55, and extrasynapt

62 A conditional gene expression system that is fast-acting, is tunable and achieves single-gene specifi

63 ike proteases that are abundantly available, fast-acting ligases are rare.

64 of these elements is most likely mediated by fast-acting long-term potentiation (LTP), which relies o

65 Most neurons release a single fast-acting low-molecular-weight transmitter at synapses

66 This constitutes an important, fast-acting mechanism of ligand-controlled transcription

67 e, we monitored metaphase I spindles after a fast-acting mei-1(ts) mutant was shifted to a nonpermiss

68 ion to meet the physiologic requirement of a fast-acting membrane fission apparatus.

69 Together, our results implicate the MBs in a fast-acting, memory-independent olfactory modification o

70 and covalent modification are major means of fast-acting metabolic regulation.

71 formulations both for native insulin and for fast-acting monomeric insulin analogues through ligand-m

72 viding novel targets for a new generation of fast-acting, more efficacious therapeutic agents.

73 togen-activated protein kinase Fus3 mediates fast-acting negative feedback that adjusts the dose resp

74 osmo-adaptation response are dominated by a fast-acting negative feedback through the kinase Hog1 th

75 nthesis of gamma-aminobutyric acid (GABA), a fast-acting neurotransmitter implicated in the modulatio

76 study reveals that STAT3 signaling, but not fast-acting neurotransmitter release, is required for le

77 Neurons that contain a fast-acting neurotransmitter, such as glutamate or GABA,

78 citation of the eyeblink circuit by way of a fast-acting neurotransmitter.

79 Most fast-acting neurotransmitters are rapidly cleared from s

80 To examine the role of fast-acting neurotransmitters glutamate and gamma-aminob

81 and by regulating the efficiency with which fast-acting neurotransmitters produce their effects on p

82 Fast-acting neurotransmitters, e.g., glutamate (excitato

83 ally regarded as neuromodulators rather than fast-acting neurotransmitters.

84 The data revealed a fast-acting NHEJ and a slow-acting alterative end joinin

85 patients without dyskinesias received 200mg fast-acting oral levodopa following prolonged withdrawal

86 ed a role in this pathway for the relatively fast-acting p38 mitogen-activated protein kinase (MAPK).

87 mparison across species of [(18) F]Nifene, a fast acting PET imaging agent for alpha4beta2* nAChRs.

88 that GLO1 inhibitors may provide a novel and fast-acting pharmacotherapy for depression.

89 ight be bi-directional: A causes B through a fast-acting physiological process, while B causes A thro

90 pport the utility of inhaled antibodies as a fast-acting postexposure treatment for plague.

91 In conclusion, VSV-EBOV remains a potent and fast-acting prophylactic vaccine but demonstrates only l

92 A fast-acting recalibration mechanism provides a means for

93 k enhanced by dopamine relied on a positive, fast-acting recurrent corticoefferent loop, most likely

94 e shown that a low dose of ketamine exhibits fast-acting relatively sustained antidepressant action,

95 tional activator Gal4p absent, the system is fast-acting, resulting in readily detectable transcripti

96 e area of endemicity highlights the need for fast-acting, safe, and efficacious vaccines.

97 rally occurring scrapie samples, including a fast-acting scrapie inoculum for which incubation time i

98 NF, via activation of the MAPK pathway, is a fast-acting selective agent to reduce the motivation to

99 e propose that this rapid recalibration is a fast-acting sensory effect, rather than a higher-level c

100 dulation of spontaneous synaptic activity by fast-acting serotonin receptors is reflected in an inhib

101 ation and brief culture in vitro, implying a fast-acting "switch".

102 To take full advantage of fast-acting temperature-sensitive mutations, thermal con

103 To date, there are no fast-acting therapeutic tools capable of terminating sec

104 otor adaptability ranges from the simple and fast-acting to the complex and long-lasting and is a req

105 should be considered a relatively simple and fast-acting tool to facilitate or even enable liver tran

106 These compounds display a "fast-acting" toxicity in the traditional mouse bioassay

107 ntestine, establish CPB as a very potent and fast-acting toxin in the small intestines, and confirm a

108 Due to the potential use of ricin and other fast-acting toxins as agents of bioterrorism, there is a

109 prime word processing, hence generating very fast-acting translation priming effects when primes are

110 As the fast-acting transmitters GABA and glutamate underlie the

111 sters of receptors that respond to different fast-acting transmitters with opposing functions may rep

112 n cells that endophilin marks and controls a fast-acting tubulovesicular endocytic pathway that is in

113 irus (VSV)-EBOV, also known as rVSV-ZEBOV, a fast-acting vaccine against EBOV and so far the only vac

114 A fast-acting water-soluble cyclodextrin-encapsulated E(2)