ライフサイエンスコーパス: fasting-induced

1 Bioluminescence imaging demonstrated that fasting induced a 7-fold increase in p21 expression in l

2 omain of the CREBH protein is the site where fasting-induced acetylation/deacetylation occurs.

3 the inhibition of mTORC1 is required for the fasting-induced activation of PPARalpha (peroxisome prol

4 ed nadir corticosterone as well as a blunted fasting-induced activation of the axis.

5 Fasting-induced adipocyte factor (Fiaf), a member of the

6 occludin) and limiting triglyceride storage (fasting-induced adipocyte factor).

7 e differentiation-related protein (ADRP) and fasting induced adipose factor (FIAF) mRNA in cultures k

8 receptor (PPAR)-gamma angiopoietin-related, fasting induced adipose factor, and hepatic fibrinogen/a

9 Using knockout mice, we found that fasting-induced adipose factor (Fiaf) is required for fu

10 Moreover, GF knockout mice lacking fasting-induced adipose factor (Fiaf), a circulating lip

11 udies of gnotobiotic knockout mice that lack fasting-induced adipose factor (Fiaf), a fibrinogen/angi

12 Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor), a protein inhibitor of

13 clude adipsin, adiponectin, aP2, caveolin-1, fasting-induced adipose factor, fat-specific gene 27 (FS

14 ation of Akt in skeletal muscle and impaired fasting-induced atrophy.

15 Furthermore, E2 treatment suppresses fasting-induced c-Fos activation in AgRP and NPY neurons

16 fect on neuropeptide expression, C75 blocked fasting-induced c-Fos expression in the arcuate nucleus

17 elin regulates leptin and insulin secretion, fasting-induced changes in serum levels of leptin and in

18 In contrast to findings in mice, fasting-induced changes in the hypothalamic-pituitary-ad

19 hormone pulse frequency but had no effect on fasting-induced changes in thyroid-stimulating hormone p

20 ontrast to the short-term effects of C75 on "fasting-induced" changes of hypothalamic orexigenic and

21 However, the fasting-induced decrease in baseline blood glucose conce

22 ent increases in gene transcription and that fasting-induced decreases in leptin can regulate this CR

23 The partial mimicking of these fasting-induced effects in ad libitum-fed rats after GLP

24 well with its ability to interfere with the fasting-induced effects on the expression of key orexige

25 organizes liver chromatin, exposing numerous fasting-induced enhancers.

26 of PGC-1alpha to the Cyp7A1 promoter and the fasting-induced expression of CYP7A1 mRNA.

27 Decreasing the fasting-induced fall in leptin by leptin administration

28 os immunoreactivity and appeared to suppress fasting-induced Fos immunoreactivity by about 35% (altho

29 of total myocardial lipid mass; and 3) acute fasting-induced hemodynamic dysfunction.

30 we show that p16(Ink4a) deficiency enhances fasting-induced hepatic glucose production in vivo by in

31 ficiency of the Tgr5 gene in mice alleviated fasting-induced hepatic lipid accumulation.

32 etylation, and its functional involvement in fasting-induced hepatic lipid metabolism.

33 Double knockout mice were protected against fasting-induced hepatic steatosis (a model of enhanced e

34 ermore, the suppressive effects of leptin on fasting-induced hepatic steatosis are absent in mice lac

35 Here, we show that fasting-induced hepatic steatosis is under genetic contr

36 in determining bile acid composition and in fasting-induced hepatic steatosis through a novel mechan

37 eptin receptors from AGRP neurons diminishes fasting-induced hepatic steatosis.

38 ce to fibroblast growth factor 21 (FGF21), a fasting-induced hepatokine, mimics infertility secondary

39 These data establish FGF21 as a fasting-induced hormone in humans and indicate that FGF2

40 Asprosin is a recently discovered fasting-induced hormone that promotes hepatic glucose pr

41 ulin tolerance but showed markedly increased fasting-induced hyperphagia (P < 0.001).

42 Also, fasting-induced hyperphagia and after acute or chronic p

43 The POMC transgene attenuated fasting-induced hyperphagia in wild-type mice.

44 nduction of mitoNEET in alpha-cells leads to fasting-induced hypoglycemia and hypersecretion of insul

45 of which is similar to the life-threatening, fasting-induced hypoglycemia observed in infants treated

46 trols and, as a result, delayed the onset of fasting-induced hypoglycemia.

47 ls with streptozotocin completely blocks the fasting-induced hypoglycemia/hypertriglyceridemia, sugge

48 In this study, we show that fasting-induced hypoleptinemia in (NZB x NZW)F(1) lupus-

49 Loss of neuropeptide Y prevents a fasting-induced increase in epinephrine release and resu

50 rotransmitters from sympathetic neurons, the fasting-induced increase in plasma ghrelin was blocked.

51 culating leptin levels did not eliminate the fasting-induced increase in quadriceps UCP3 expression.

52 BNP inhibited the fasting-induced increase in total and acylated ghrelin c

53 e its effect in lean mice, C75 prevented the fasting-induced increase of hypothalamic NPY and AgRP mR

54 in) administered to fasted men prevented the fasting-induced increase of sOB-R levels, and pharmacolo

55 4 is a glucocorticoid-responsive mediator of fasting-induced intracellular lipolysis and stimulates c

56 Prolonged fasting induced lipid deposition in livers of control mi

57 t (hLrp1(-/-)) mice were more susceptible to fasting-induced lipid accumulation in the liver.

58 iobasal hypothalamus (MBH), display impaired fasting-induced lipolysis accompanied by a decreased nor

59 ediated silencing of hepatic Fsp27 abolishes fasting-induced liver steatosis in the absence of change

60 ting-induced white adipose tissue lipolysis, fasting-induced liver triglyceride accumulation, fasting

61 However, fasting induced metabolic alterations might interfere wi

62 mdt-15 by RNA interference (RNAi) prevented fasting-induced mRNA accumulation of NHR-49 targets in v

63 , chronic hyperglycemia is associated with a fasting-induced paradoxical increase in glucose-potentia

64 Here, we show that fasting induced PGC-1alpha deacetylation in skeletal mus

65 Fasting-induced PPARalpha activation was drastically pre

66 We have identified a fasting-induced protein hormone that modulates hepatic g

67 ciency blunted C-Fos induction in the PVH by fasting-induced re-feeding, and insulin and NPY induced

68 Fasting-induced refeeding is unchanged in younger Y5R-nu

69 Compound 38 temporarily reduces fasting-induced refeeding of mice, thereby emulating the

70 ing-induced liver triglyceride accumulation, fasting-induced refeeding, and fasting-induced regulatio

71 accumulation, fasting-induced refeeding, and fasting-induced regulation of the adipostatic and hypoth

72 hus, in lean mice C75 seems to interrupt the fasting-induced signals that activate expression of NPY

73 e, we found that this hypothalamic-specific, fasting-induced SIRT1 regulation is altered in leptin-de

74 neurons is both necessary and sufficient for fasting-induced spinogenesis and excitatory synaptic act

75 ice from five other inbred strains developed fasting-induced steatosis like the C57BL/6J mice.

76 hat regulate fatty acid oxidation, decreased fasting-induced steatosis, reduced obesity, increased en

77 resistant to acetaminophen hepatotoxicity or fasting-induced steatosis.

78 ng of alpha-MSH every 6 hr for 3 d prevented fasting-induced suppression of pro-TRH in the PVN but ha

79 CART prevented fasting-induced suppression of pro-TRH in the PVN when a

80 act fed GH release; however, it reversed the fasting-induced suppression of pulsatile GH secretion.

81 r5, Bmi1, or HopX expression, contributed to fasting-induced survival.

82 alleled by an increase in spines, suggesting fasting induced synaptogenesis and spinogenesis.

83 um TH levels, both CAR agonist treatment and fasting induced the expression of CAR target genes (nota

84 In PPARalpha+/+ mice, fasting induced the hepatic and cardiac expression of PP

85 Glucocorticoid receptor blockade prevented fasting-induced tissue Angptl4 expression and WAT TG hyd

86 no]-2S-2-propa nol oxalate] severely blunted fasting-induced torpor in control mice, whereas other AR

87 ed the effect of chronic leptin treatment on fasting-induced torpor in leptin-deficient A-ZIP/F-1 and

88 In ob/ob mice, fasting-induced torpor was completely reversed by leptin

89 se effects are associated with inhibition of fasting-induced up-regulation and down-regulation, respe

90 effect seems to be due to inhibition of the fasting-induced up-regulation of expression of hypothala

91 completely blocked food intake and prevented fasting-induced up-regulation of hypothalamic AgRP and N

92 ibitor of fatty acid synthase (FAS), blocked fasting-induced up-regulation of orexigenic neuropeptide

93 Thus, fasting-induced WAT TG hydrolysis requires glucocorticoi

94 that the MC3-R(-/-) mouse exhibits defective fasting-induced white adipose tissue lipolysis, fasting-