ライフサイエンスコーパス: fat body

1 om an adipose/hepatic-like tissue called the fat body.

2 metalloproteinase 2 (MMP2) expression in the fat body.

3 eplication have been uncoupled in the larval fat body.

4 nse to a nutrition-dependent signal from the fat body.

5 r inter-adipocyte adhesion in the Drosophila fat body.

6 sufficient to block immune induction in the fat body.

7 ndicate that oenocytes act downstream of the fat body.

8 ajor GATA transcription factor in the larval fat body.

9 e following fungal challenge in the mosquito fat body.

10 etween circadian circuits and brain-proximal fat body.

11 s normal as is the patterning of the gut and fat body.

12 crude extracts prepared from the 3 days p.p. fat body.

13 d the role of a potential target tissue, the fat body.

14 arvation-induced autophagy in the Drosophila fat body.

15 s insulin-dependent signalling in peripheral fat body.

16 tivation of immunity genes in the Drosophila fat body.

17 ing when activated in the adult pericerebral fat body.

18 isition of competence to 20E in the mosquito fat body.

19 hila counterpart of the mammalian liver, the fat body.

20 n and the major immune organ of the fly, the fat body.

21 s as a cis-stimulatory element in the larval fat body.

22 anscript is present only in the adult female fat body.

23 sor (YPP) genes in the metabolic tissue, the fat body.

24 is, the arginase transcripts localize to the fat body.

25 iring characteristics and sxe2 levels in the fat body.

26 expression of a metabolic gene (sxe2) in the fat body.

27 ms in the mammalian liver and the Drosophila fat body.

28 ed the rate of protein synthesis only in the fat body.

29 veyance of essential amino acids from gut to fat body.

30 g and suppression of autophagy in the larval fat body.

31 by regulating Swim expression in the female fat body.

32 autophagy in salivary glands, but not in the fat body.

33 ues involved in lipid metabolism such as the fat body.

34 ffect on starvation-induced autophagy in the fat body.

35 e, AgTreT1 is predominantly expressed in the fat body.

36 icient autophagosome formation in the larval fat body.

37 to lower cytochrome P450 enzyme activity in fat bodies.

38 along with vitellogenins synthesized in the fat bodies.

39 and TEs increased with age in fly heads and fat bodies.

40 estine elicits a systemic immune reaction in fat bodies.

41 The fat body, a counterpart of mammalian liver and adipose t

42 The results uncovered changes in the larval fat body, a differentiated tissue that grows via endocyc

43 We report that the Drosophila fat body, a major immune organ, undergoes immunosenescen

44 They are essential components of the fat body, a metabolic tissue that is the insect analog o

45 a yolk protein synthesized in the abdominal fat body, acts as an antioxidant to promote longevity in

46 It is concluded that the lipolysis in fat body adipocytes is controlled by the activation of t

47 e and the lipid droplet, was investigated in fat body adipocytes.

48 levels in turn regulate lipid homeostasis in fat body/adipose and the intestine.

49 of S6 kinase increases in in vitro cultured fat bodies after stimulation with amino acids.

50 fication enzymes increases in the midgut and fat body after a blood meal.

51 both species, increased Akt signaling in the fat body after blood feeding significantly increased adu

52 such as the insulin receptor or Akt, in the fat body also increased susceptibility of the central cl

53 protein precursor (YPP) genes in the female fat body, an insect metabolic tissue.

54 In insects, most are synthesized in the fat body, an organ analogous to the liver of vertebrates

55 hin organs specialized for lipid metabolism (fat bodies and oenocytes).

56 and ADGF-D, which is mainly expressed in the fat body and brain.

57 ptericin is constitutively expressed in both fat body and gut tissue of normal and immune stimulated

58 la, reduced IIS decreased polysome levels in fat body and gut, but reduced the rate of protein synthe

59 ression, while Scys-B is present in both the fat body and gut.

60 6 and proHP8 are expressed constitutively in fat body and hemocytes and secreted into plasma, where t

61 hat PAP-2 and HP12 mRNA levels in the larval fat body and hemocytes increased after a bacterial chall

62 n1, 3, 5, 6, 9, 12, 13, 25, 27, 32 and 34 in fat body and hemocytes of larvae injected with bacteria.

63 The HP14 mRNA exists in fat body and hemocytes of the naive larvae, and its leve

64 essed at a low level in larval hemocytes and fat body and increased dramatically upon bacterial chall

65 dHNF4 is required in the fat body and insulin-producing cells to maintain glucose

66 ls and autophagy independent of TFEB/MitF in fat body and larval gut tissues.

67 dentify an endocrine interaction between the fat body and liver-like oenocytes that regulates the mob

68 activity in head, ovaries, gut, cuticle plus fat body and malpighian tubules.

69 replication in isolated and purified larval fat body and midgut tissues of Drosophila, and we compar

70 a broad range of antimicrobial agents in the fat body and more restricted responses in tissues such a

71 Hence, lipid-metabolic coupling between the fat body and oenocytes is bidirectional.

72 approximately 1.4-kb transcript in X. laevis fat body and oocytes, whereas a weaker signal was obtain

73 Cv-d is made in the liver-like fat body and other tissues, and can diffuse into the pup

74 levels in the ovaries and in lower levels in fat body and other tissues.

75 Nlst6 knockdown also significantly decreased fat body and ovarian (particularly vitellogenin) protein

76 es, and significant decrease in body weight, fat body and ovarian protein content, yeast-like symbion

77 5 suppression in males also led to decreased fat body and ovarian protein content, yeast-like symbion

78 show that TOR activity strongly increases in fat body and ovaries after a blood meal in vivo.

79 Strong expression was observed in the fat body and ovaries.

80 AgAQP1 expression is up-regulated in fat body and ovary by blood feeding but not by sugar fee

81 In the fat body and ovary, USP-A mRNA is highly expressed durin

82 expression in the immune responsive tissues fat body and proventriculus (cardia) following microbial

83 This protein is constitutively expressed in fat body and secreted into hemolymph.

84 retion of lipophorin and vitellogenin by the fat body and subsequent accumulation of these yolk prote

85 mber (ADGF-A) leads to disintegration of the fat body and the development of melanotic tumors in muta

86 Our work supports a critical role for the fat body and the Drosophila carbohydrate response elemen

87 d Cav-2 are most abundantly expressed in the fat body and the lungs, while Xenopus Cav-3 is primarily

88 o two subclasses: those that target the host fat body and those that target host hemocytes.

89 sodermal precursors to body wall muscles and fat body and together direct expression in other tissues

90 ankyrin-specific Abs localized to 3-day p.p. fat-body and hemocyte nuclei, suggesting a role for vank

91 enylation in two somatic tissues (midgut and fat body) and one germline tissue (ovary).

92 ize, lipid vesicle aggregation in the larval fat body, and a cell type-specific pattern of cell cycle

93 mesoderm, gastric caecae, somatic mesoderm, fat body, and central nervous system.

94 to drive cycling of sxe1 and Cyp6a21 in the fat body, and its mammalian ortholog, Npy, functions sim

95 al stem cells leads to wasting of the ovary, fat body, and muscle.

96 ite of synthesis in vertebrate liver, insect fat body, and nematode intestine; however, the mechanism

97 increased lipid accumulation in the midgut, fat body, and oenocytes (specialized hepatocyte-like cel

98 eeding-induced protein expression in midgut, fat body, and ovary tissues of COPI-deficient mosquitoes

99 acterized hexokinase genes unique to muscle, fat body, and testis in Drosophila melanogaster, D. simu

100 FOXO is expressed predominantly in the fat body, and transgenic expression in this tissue rescu

101 , C/EBP and Doublesex, typically involved in fat body- and female-specific gene activity in Diptera.

102 flyabetes' candidates that we classify using fat body- and muscle-specific knockdown and biochemical

103 insulin receptor (InR) was reduced in larval fat bodies, animals exhibited developmental delay and re

104 al genes are expressed at high levels in the fat body, apparently not affecting the viability of para

105 Individual cells of the underdeveloped fat body are characterized by increased size and ultrast

106 insects, excrete waste nitrogen within their fat bodies as uric acids, postulated to be a supplement

107 ivation of programmed autophagy in the Aedes fat body at the end of vitellogenesis.

108 PAP-2 transcripts in cultured fat body became less abundant after 20-hydroxyecdysone t

109 critical transcriptional switch in the adult fat body between metabolism and immunity.

110 These results showed that, in the mosquito fat body, both Lp and LpRfb gene expression were regulat

111 e release large quantities of lipid from the fat body but it is unclear how and where this is process

112 e 29-kDa proteins are also present in larval fat body but not in epidermis from either wandering stag

113 DefA transgene was strongly activated in the fat body by a blood meal.

114 squitoes activate Toll immune pathway in the fat body by blood feeding.

115 contrast, increasing the fat content of the fat body by knockdown of king-tubby was associated with

116 s were determined in the pheromone gland and fat body by real-time PCR and the resulting patterns are

117 munity genes are activated in the Drosophila fat body by Rel and GATA transcription factors.

118 large number of immunity genes in Drosophila fat bodies can be regulated by a simple code, REL-GATA.

119 loss of V-ATPase subunits in the Drosophila fat body causes an accumulation of non-functional lysoso

120 function, we cloned serpin-6 from an induced fat body cDNA library using a PCR-derived probe.

121 an Escherichia coli-induced M. sexta larval fat body cDNA library.

122 ssing H. zea APN1 (HzAPN1) in the midgut and fat body cell lines of H. zea and the ovarian cell line

123 nd triglycerides in the adipocytes, the main fat body cell.

124 e small, with low triglyceride levels, small fat body cells and early pupal lethality.

125 Vg was expressed in thorax and head fat body cells in an age-dependent manner, with old quee

126 rvae in turn show a loss of BMP signaling in fat body cells indicating that Gbb/BMP signaling is a ce

127 e NF-KB-like Relish pathway, indicating that fat body cells integrate the activity of NF-KB and JAK/S

128 mo-2 transcription both in the midgut and in fat body cells of the spermatheca (a female-specific tis

129 sociated increase in TE transposition in fly fat body cells that was delayed by dietary restriction.

130 immune-related cell types: adult hemocytes, fat body cells, and midgut epithelial cells.

131 In fat body cells, Ema localizes to the Golgi complex and i

132 Dmp53 in adult neurons, but not in muscle or fat body cells, extends lifespan.

133 associated lamin-B reduction specifically in fat body cells, which then contributes to heterochromati

134 icient to promote DNA synthesis in wild-type fat body cells.

135 tophagosome/autolysosome formation in larval fat body cells.

136 from the cytoplasm to the plasma membrane of fat body cells.

137 d leads to additional SGPs at the expense of fat body cells.

138 e show that free-running oscillations of the fat body clock require clock function in the PDF-positiv

139 ed Mstn(Ln/Ln) mice exhibited high lean, low-fat body compositions compared with wild types.

140 In vitro fat body culture experiments have shown that betaFTZ-F1

141 In in vitro fat body culture, AaFTZ-F1 expression is inhibited by 20

142 n of LPE genes were validated by an in vitro fat-body culture experiment using Met RNAi.

143 This increase was also reproduced in the fat-body culture stimulated with amino acids.

144 In the fat body, dE2F/dDP limits cell-cycle progression by supp

145 ation of engulfed bacteria and activation of fat-body Defensin.

146 Furthermore, we find that fat body-derived Drosophila insulin-like peptide 6 (dILP

147 n of insulin/IGF signaling in oenocytes by a fat body-derived peptide represents a previously unident

148 get of rapamycin (TOR) signalling activate a fat-body-derived signal (FDS) required for neuroblast re

149 pin) is essential for normal adipose tissue (fat body) development and TAG storage.

150 educed or elevated Pdp1epsilon levels in the fat body display courtship defects, identifying Pdp1epsi

151 Knockdown of O-GlcNAc cycling enzymes in the fat body dramatically reduced neutral lipid stores.

152 In the larval fat body, dUbc9 negatively regulates the expression of t

153 required for depleting stored lipid from the fat body during fasting.

154 e antibacterial-peptide gene Defensin in the fat body during infection requires blood-cell contributi

155 AaFTZ-F1 is expressed highly in the mosquito fat body during pre- and postvitellogenic periods when e

156 The molecular mechanisms by which the fat body escapes programmed cell death have not yet been

157 t lacks any AF1, supports development in the fat body, eye discs, salivary glands, EH-secreting neuro

158 sensitivity index (ISI), percentage of body fat (%body fat), visceral (VAT) and subcutaneous (SAT) a

159 low levels are permissive for gut muscle and fat body fate.

160 In Drosophila, the fat body (FB), a functional analog of the vertebrate adi

161 Here we address its role in the fat body (FB), a metabolic tissue that functions as a se

162 1A were specifically induced in the mosquito fat body following fungal challenge.

163 We show that Mef2 is required in the fat body for anabolic function and the immune response.

164 Gbb/BMP signaling is required in the larval fat body for maintaining proper metabolism, yet interest

165 brates, is critical in the Drosophila larval fat body for regulating energy homeostasis.

166 ed that 20E signaling is required within the fat body for the cell-shape changes and cell detachment

167 Surprisingly, analysis of the fat body from dsRNA-XDH1-injected mosquitoes fell into 2

168 , all phenotypes associated with compromised fat body function.

169 osquito Aedes aegypti, the expression of two fat body genes involved in lipid metabolism, a lipid car

170 l cycle re-entry of neural progenitors via a fat-body-glia-neuroblasts relay.

171 Experimental BPHs accumulated less fat body glucose compared to controls.

172 Ablation of abdominal fat bodies had a strong and persistent effect on energy

173 Hex-A is the most conserved followed by the fat body hexokinase Hex-C and testis-specific hexokinase

174 e epidermis, midgut, Malpighian tubules, and fat body, i.e., tissues known to be major sites of E20MO

175 Further, fat body immunosenecence is caused by age-associated lam

176 n transformed Drosophila third-instar larval fat body in a bacterially inducible manner.

177 We tested the role of the fat body in larval tolerance of caloric excess.

178 g mobilization of energy substrates from the fat body in many insects.

179 ons in S2 cells and activation in the larval fat body in response to bacterial infection.

180 sphorylated after in vitro incubation of the fat body in the presence of amino acids; this phosphoryl

181 ntity) with the metabolic Z9-desaturase from fat body in this species.

182 omatic piRNA pathway in the adult Drosophila fat body including the presence of the piRNA effector pr

183 Inhibiting Maf1 in the fat body increases growth by promoting the expression of

184 yme 1 (sxe1) and Cyp6a21, which cycle in the fat body independently of the local clock, depends upon

185 Reduced innate immunity was dependent on fat body InR expression.

186 Fat body InR knockdown also led to reduced survival on h

187 The Drosophila fat body is a liver- and adipose-like tissue that stores

188 ecdysone-response competence in the mosquito fat body is correlated with the appearance of the functi

189 The larval fat body is involved in fueling metamorphosis, and thus

190 ution of the two sarcocystatins differs: the fat body is the major site of Scys-A expression, while S

191 ) stored in the lipid droplets of the insect fat body is under hormonal regulation by the adipokineti

192 essed at similar levels in hemocytes, but in fat body isoform B mRNA was present at significantly hig

193 Fat body lipid profiling revealed changes in both carbon

194 females were sterile, which correlates with fat body loss, and they died prematurely.

195 were found between CRP and measures of body fat (body mass index, waist circumference), S(I), and fa

196 ic disorder with profound loss of muscle and fat body mass resulting from a simultaneous reduction in

197 on analyses demonstrated that total lean and fat body mass were greater in knock-out animals, but the

198 e hypothalamus--increased appetite, lean and fat body mass, linear growth, and insulin resistance tha

199 ts are characterized by reductions in larval fat body mass, whole-animal TAG content, and lipid dropl

200 global assessment, near-infrared (NIR) body fat, body mass index (BMI), and pertinent laboratory val

201 HDL cholesterol and baseline percentage body fat, body mass index, and insulin.

202 n model examining the effect of percent body fat, body mass index, anorexia nervosa subtype, waist-to

203 vor differentially altered body weight, body fat, body mass index, heart rate, or blood indexes in th

204 cholesterol with increasing percentage body fat, body mass index, or insulin concentrations.

205 relations between higher levels of abdominal fat/body mass index and reduced fMRI activation to sucro

206 diet differentially affected body size, body fat:body mass ratios, liver size and liver metabolism, a

207 anisms for sex-specific transcription in the fat body may be well conserved between flies and mosquit

208 Indy was most abundantly expressed in the fat body, midgut, and oenocytes: the principal sites of

209 al tissues of fifth-instar larvae, including fat body, midgut, integument, testis, silk gland and hae

210 ncluded MET and CYC from the female mosquito fat body nuclear extract.

211 However, the coimmunoprecipitation using fat body nuclear extracts reveals that at 33-36 h postbl

212 in associates with AHR38 instead of AaEcR in fat body nuclei at the state-of-arrest.

213 mutants arrest as second instar larvae, and fat body nuclei of dm(4)/Y mutants fail to attain normal

214 e target-of-rapamycin signalling pathway and fat body nutrient sensor, but its substrate specificity

215 rane with most prominent expression in adult fat body, oenocytes, and the basolateral region of midgu

216 defensin-2, and lysozyme, in the midguts and fat bodies of D. variabilis ticks that were challenged w

217 Kr-h1 and Hairy gene expression in vitro in fat bodies of female mosquitoes with RNAi-depleted CYC,

218 ein and glycerin contents in the ovaries and fat bodies of JGM + dsAtgl females required for reproduc

219 The fat bodies of most cockroaches are inhabited by Blattaba

220 rship through increased Akt signaling in the fat bodies of multiple mosquito genera and provides new

221 the impact of increased Akt signaling in the fat body of 2 mosquito species, the Asian malaria mosqui

222 characterization of AaCAT1, cloned from the fat body of A. aegypti.

223 pression and potential targets in the female fat body of Ae. aegypti, as well as their changes postbl

224 e GATA protein increased dramatically in the fat body of blood-fed mosquitoes.

225 during posteclosion (PE) development in the fat body of female Aedes aegypti.

226 ents of the nutrient signaling system in the fat body of fruit flies and the yellow fever mosquito, A

227 -rich antimicrobial peptides produced in the fat body of insects.

228 ceptor gene betaFTZ-F1 is transcribed in the fat body of newly emerged mosquito females; however, the

229 igh levels in the muscle, epidermis, gut and fat body of the developing Drosophila embryo.

230 ectively modulating insulin signaling in the fat body of the fruit fly, Drosophila melanogaster.

231 by extraneous insulin in an ex vivo cultured fat body of third instar larvae was diminished in strain

232 m of A. stephensi and Ae. aegypti Akt in the fat body of transgenic mosquitoes led to activation of t

233 PAP-2 mRNA was not detected in naive larval fat body or hemocytes, but it became abundant in these t

234 signaling is required in muscles, but not in fat body or hemocytes, during larval development for an

235 exclusively or preferentially in the midgut, fat bodies, or ovaries.

236 ons derived from the fungus on the B. tabaci fat body, ovary, and vitellogenin were also investigated

237 The piwi mutants exhibit depletion of fat body piRNAs, increased TE mobilization, increased le

238 The fat body plays major roles in the life of insects.

239 AaGATAa mRNA accumulated in the fat body prior to blood feeding.

240 Downregulating PGRP-SB2 selectively in the fat body protected animals from the deleterious effects

241 n and target dynamics in the female mosquito fat body, providing a solid foundation for future functi

242 that silencing of RHBP expression in female fat bodies reduced total RHBP circulating in the hemolym

243 a key modulator of 20E hormonal induction of fat body remodeling and Matrix metalloproteinase 2 (MMP2

244 described, but it has been established that fat-body remodeling requires 20-hydroxyecdysone (20E) si

245 d cell detachment that are characteristic of fat-body remodeling.

246 t MMP2 is necessary and sufficient to induce fat-body remodeling.

247 NO induction of Diptericin reporters in the fat body required immune deficiency (imd) and domino.

248 how that induction of MMP2 expression in the fat body requires 20E signaling, and that MMP2 is necess

249 ingly, reducing dATM levels in dDP-deficient fat bodies restores cell-cycle control, improves tissue

250 ncing (RNA-seq) studies in insulin-resistant fat bodies revealed differential expression of genes, in

251 nfection of secondary tissues and identified fat body, salivary glands, tracheal cells, and midgut mu

252 Inflamed old fat bodies secrete circulating peptidoglycan recognition

253 ethod that Collagen IV is synthesized by the fat body, secreted to the hemolymph (insect blood), and

254 deriving from the non-dorsal mesoderm - the fat body, somatic cells of the gonad, and a specific sub

255 CH DESIGN AND With two parallel approaches-a fat body-specific green fluorescent protein enhancer tra

256 d RNA construct of REL1 driven by the female fat body-specific vitellogenin (Vg) promoter with the pB

257 We analyzed insulin signaling in the fat body studying loss and gain of function.

258 thoxycoumarin-O-deethylase activity in adult fat bodies suggests that the higher percentage of unmeta

259 Toll signaling in the fat body suppresses insulin signaling both within these

260 Polyclonal antibodies raised against a fat-body targeting vankyrin detected a 19-kDa protein in

261 id droplets isolated from hormone-stimulated fat bodies than against lipid droplets isolated from uns

262 n-gonadal somatic piRNA pathway in the adult fat body that affects normal metabolism and overall orga

263 ls expression of signals from the developing fat body that direct posterior migration of the glands.

264 iate with the endogenous fat cells to form a fat body that is expanded in both the dorsal/ventral and

265 tumor suppressors or activation of Yorkie in fat bodies, the Drosophila immune organ, leads to elevat

266 nstar larvae, krz message is detected in the fat bodies, the ventral portion of the thoracic-abdomina

267 YPPs are synthesized in the fat body, the insect analogue of the vertebrate liver.

268 -autonomous effect of Maf1 inhibition in the fat body, the main larval endocrine organ.

269 he Toll signaling pathway selectively in the fat body, the major immune and lipid storage organ of th

270 Tissue-specific knockdown of zfh2 in the fat body, the major immune and metabolic organ of the fl

271 It is expressed exclusively in the female fat body, the tissue producing most of mosquito hemolymp

272 ulo, affect the cellular organization of the fat body, the tissue responsible for antimicrobial pepti

273 mRNA and protein levels of ALAT1 or ALAT2 in fat body, thorax, and Malpighian tubules compared with d

274 asses: those expressed primarily in the host fat body (three genes) and those expressed in host hemoc

275 ective induction of STAT target genes in the fat body through the cytokine Upd3 and its JAK/STAT-coup

276 sex-specific takeout transcripts derive from fat body tissue closely associated with the adult brain

277 Two P[Switch] lines were used to ablate fat body tissue in adult females through the induced exp

278 tacin, defensin, and diptericin, from tsetse fat body tissue obtained by subtractive cloning after im

279 h hexamerin genes are primarily expressed in fat body tissue, but only Hex-2 expression is substantia

280 native M. sexta juvenile hormone esterase in fat body tissue, where the enzyme is synthesized.

281 including mRNAs localized to brain-proximal fat-body tissue and brain courtship centers.

282 nificant inhibition of Vg expression in both fat-body tissue culture and blood-fed mosquitoes.

283 e in GS transcription observed in midgut and fat body tissues of female mosquitoes following a blood

284 these cellular processes in both midgut and fat body tissues triggered by DvSnf7 RNAi were the main

285 Synthesized in the fat body, trehalose is the predominant sugar in mosquito

286 and Oga in insulin-producing cells (IPCs) or fat bodies using the GAL4-UAS system.

287 Two fat body vankyrins also produced unique biological effec

288 a acutely activate Hippo-Yorkie signaling in fat bodies via the Toll-Myd88-Pelle cascade through Pell

289 n of active Akt also increased expression of fat body vitellogenin, but the number of viable eggs did

290 stingly, CanA1 RNAi in hemocytes but not the fat body was sufficient to block immune induction in the

291 Thus, for many women who lost fat, body weight did not change or increased.

292 Ectopic expression of dGATAe in the larval fat body, where it is normally absent, causes dramatic u

293 was constitutively expressed in the mosquito fat body, whereas Spz1B and Toll4 were primarily express

294 activates a nutrient signaling system in the fat bodies, which subsequently derepresses yolk protein

295 eam effector of IIS, in the adult Drosophila fat body, which increased life-span and reduced fecundit

296 prevent starvation-induced autophagy in the fat body, which is associated with survival.

297 ion induces NFkappaB/Relish signaling in the fat body, which is required for recovery of IIS activity

298 The amnioserosa, yolk, midgut and fat body, which play major roles in lipid storage, metab

299 s and reduced insulin signaling (IIS) in the fat body, which suggests that Dmp53 may affect lifespan

300 more, in nuclear extracts of previtellogenic fat bodies with transcriptionally repressed YPP genes, t