ライフサイエンスコーパス: fatty acid amide hydrolase

1 ty and expression of the OEAdegrading enzyme fatty acid amide hydrolase.

2 1.80 fmol/mg protein) that is distinct from fatty acid amide hydrolase.

3 entiation of the anandamide catabolic enzyme fatty acid amide hydrolase.

4 ivity of the anandamide-catabolizing enzyme, fatty acid amide hydrolase.

5 e than N-arachidonoylserotonin in inhibiting fatty acid amide hydrolase.

6 y of the endocannabinoid metabolizing enzyme fatty acid amide hydrolase.

7 transporter while being a poor substrate for fatty-acid amide hydrolase.

8 tion of arachidonic acid and ethanolamine by fatty-acid amide hydrolase.

9 he intracellular anandamide-degrading enzyme fatty acid amide hydrolase-1 (FAAH-1), termed FAAH-like

10 Nicotine exposure had no effect on fatty acid amide hydrolase activity in the VTA, suggesti

11 EA synthesis, without concomitant changes in fatty acid amide hydrolase, an enzyme responsible for OE

12 These data contrast with blockade of fatty acid amide hydrolase, an enzyme that degrades the

13 pharmacological profile in that it inhibits fatty acid amide hydrolase and alpha/beta-hydrolase doma

14 ing protein 12, monoacylglycerol lipase, and fatty acid amide hydrolase and did not display affinity

15 duced synergistic antiallodynic effects with fatty acid amide hydrolase and monoacylglycerol lipase i

16 bitors of endocannabinoid-regulating enzymes fatty acid amide hydrolase and monoacylglycerol lipase p

17 verall, the MAH data are similar to those of fatty acid amide hydrolase and support the suggestion th

18 availability of the X-ray structures of Pam, fatty acid amide hydrolase, and malonamidase E2 has led

19 udies revealed that NAPE-phospholipase D and fatty acid amide hydrolase are expressed in intestinal e

20 s of NAGly and its degradation by the enzyme fatty acid amide hydrolase can be observed in rat brain

21 Fatty acid amide hydrolase (EC 3.5.1.4.) is the enzyme r

22 Preventing their degradation (by inhibiting fatty acid amide hydrolase) enhanced the effects of OEA

23 rgan radiation exposure for the irreversible fatty acid amide hydrolase enzyme probe (11)C-CURB is wi

24 Here we show that mice lacking the enzyme fatty acid amide hydrolase (FAAH(-/-)) are severely impa

25 ates a common human mutation in the gene for fatty acid amide hydrolase (FAAH) (C385A; rs324420), the

26 aint stress, which results in an increase in fatty acid amide hydrolase (FAAH) activity and a reducti

27 Fatty acid amide hydrolase (FAAH) activity in mammals ha

28 A decrease in fatty acid amide hydrolase (FAAH) activity increases the

29 el fluorescent assay to continuously monitor fatty acid amide hydrolase (FAAH) activity that is simpl

30 cells, and then anandamide is hydrolyzed by fatty acid amide hydrolase (FAAH) and 2-AG by monoacylgl

31 paradigm to exert combined activity at human fatty acid amide hydrolase (FAAH) and dopamine receptor

32 rotein that may modulate CB(1) function; and fatty acid amide hydrolase (FAAH) and N-acylethanolamine

33 hibitors 3-5 bound to a humanized variant of fatty acid amide hydrolase (FAAH) are disclosed and comp

34 Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH) are two enzymes from t

35 c enzymes, monoacylglycerol lipase (MAGL) or fatty acid amide hydrolase (FAAH) attenuates naloxone-pr

36 Inhibition of the enzyme fatty acid amide hydrolase (FAAH) counteracts reward-rel

37 Fatty acid amide hydrolase (FAAH) degrades NAE into etha

38 Fatty acid amide hydrolase (FAAH) degrades neuromodulati

39 Fatty acid amide hydrolase (FAAH) degrades the endocanna

40 Measuring uptake at 25 s, when fatty acid amide hydrolase (FAAH) does not appreciably a

41 dized by lipoxygenase (LOX) or hydrolyzed by fatty acid amide hydrolase (FAAH) during normal seedling

42 In this report, we isolated the enzyme fatty acid amide hydrolase (FAAH) from mouse serum as an

43 he action of diverse hydrolases, among which fatty acid amide hydrolase (FAAH) has been well characte

44 The integral membrane enzyme fatty acid amide hydrolase (FAAH) hydrolyzes the endocan

45 tigated the role of the AEA-degrading enzyme fatty acid amide hydrolase (FAAH) in AEA-induced cell de

46 holipase D (NAPE-PLD) and its degradation by fatty acid amide hydrolase (FAAH) in mouse embryos and o

47 holipase D (NAPE-PLD) and its degradation by fatty acid amide hydrolase (FAAH) in mouse embryos and o

48 ain lipids regulated by the mammalian enzyme fatty acid amide hydrolase (FAAH) in vivo, including kno

49 lly mediated by the integral membrane enzyme fatty acid amide hydrolase (FAAH) in vivo.

50 Fatty acid amide hydrolase (FAAH) inactivates a large an

51 Fatty acid amide hydrolase (FAAH) inactivates the endoge

52 A recent phase 1 trial of the fatty acid amide hydrolase (FAAH) inhibitor BIA 10-2474

53 We found that both the fatty acid amide hydrolase (FAAH) inhibitor URB597 and t

54 l finding that posttraining infusions of the fatty acid amide hydrolase (FAAH) inhibitor URB597, whic

55 The peripherally restricted fatty acid amide hydrolase (FAAH) inhibitor URB937 (3, c

56 ntified benzothiazole analogue 3 as a potent fatty acid amide hydrolase (FAAH) inhibitor.

57 nd characterization of alpha-ketoheterocycle fatty acid amide hydrolase (FAAH) inhibitors are disclos

58 nd urea derivatives are important classes of fatty acid amide hydrolase (FAAH) inhibitors that carbam

59 Fatty acid amide hydrolase (FAAH) is a degradative enzym

60 The metabolism of these lipids by fatty acid amide hydrolase (FAAH) is a key regulatory po

61 Fatty acid amide hydrolase (FAAH) is a mammalian amidase

62 Fatty acid amide hydrolase (FAAH) is a mammalian integra

63 Fatty acid amide hydrolase (FAAH) is a mammalian integra

64 Fatty acid amide hydrolase (FAAH) is a mammalian integra

65 Fatty acid amide hydrolase (FAAH) is a membrane-bound en

66 Fatty acid amide hydrolase (FAAH) is a membrane-bound en

67 Fatty acid amide hydrolase (FAAH) is a pharmaceutical ta

68 Fatty acid amide hydrolase (FAAH) is a serine hydrolase

69 Fatty acid amide hydrolase (FAAH) is a serine hydrolase

70 Fatty acid amide hydrolase (FAAH) is an integral membran

71 Fatty acid amide hydrolase (FAAH) is an integral membran

72 Fatty acid amide hydrolase (FAAH) is an integral membran

73 evels of endocannabinoids with inhibitors of fatty acid amide hydrolase (FAAH) is analgesic in models

74 Fatty acid amide hydrolase (FAAH) is one of the main enz

75 Once transported into the cytoplasm, fatty acid amide hydrolase (FAAH) is responsible for met

76 Fatty acid amide hydrolase (FAAH) knockout mice are pron

77 y-state time points (5 min), suggesting that fatty acid amide hydrolase (FAAH) may be responsible for

78 liana, and they can be metabolized by either fatty acid amide hydrolase (FAAH) or by lipoxygenase (LO

79 cal inhibition or genetic deletion of either fatty acid amide hydrolase (FAAH) or monoacylglycerol li

80 Fatty acid amide hydrolase (FAAH) plays a key role in re

81 ngle nucleotide polymorphisms CNR1 rs806378, fatty acid amide hydrolase (FAAH) rs324420, and MGLL rs4

82 Fatty acid amide hydrolase (FAAH) terminates the endocan

83 were prepared and examined as inhibitors of fatty acid amide hydrolase (FAAH) that additionally targ

84 A binding assay for human fatty acid amide hydrolase (FAAH) using the scintillatio

85 eral principle, the serine hydrolytic enzyme fatty acid amide hydrolase (FAAH) was found to degrade a

86 We show here that mice devoid of fatty acid amide hydrolase (FAAH) with elevated levels o

87 rease in side population (SP) cells, whereas fatty acid amide hydrolase (FAAH)(-/-) mice, which have

88 Fatty acid amide hydrolase (FAAH), a gene in the minimal

89 azole inhibitors (1 (OL-135) and 2) bound to fatty acid amide hydrolase (FAAH), a key enzymatic regul

90 ce of the eCB N-arachidonoylethanolamine via fatty acid amide hydrolase (FAAH), although it is unclea

91 Fatty acid amide hydrolase (FAAH), an amidase-signature

92 AEA is hydrolyzed by fatty acid amide hydrolase (FAAH), an enzyme localized o

93 l structure of the integral membrane protein fatty acid amide hydrolase (FAAH), an enzyme that degrad

94 endocytosis, and finally, to be degraded by fatty acid amide hydrolase (FAAH), an integral membrane

95 ting that following metabolism by the enzyme fatty acid amide hydrolase (FAAH), anandamide metabolite

96 endocannabinoid anandamide is hydrolysis by fatty acid amide hydrolase (FAAH), and inhibitors of the

97 erminated following hydrolysis by 2 enzymes: fatty acid amide hydrolase (FAAH), and the less-studied

98 L activity as well as their selectivity over fatty acid amide hydrolase (FAAH), another endocannabino

99 mes have been considered to serve this role: fatty acid amide hydrolase (FAAH), cyclooxygenase-2 (COX

100 The intracellular serine amidase, fatty acid amide hydrolase (FAAH), degrades a heterogene

101 nships of 2b (OL-135), a potent inhibitor of fatty acid amide hydrolase (FAAH), is detailed targeting

102 (SAR) of 2f (OL-135), a potent inhibitor of fatty acid amide hydrolase (FAAH), is detailed, targetin

103 ated by several metabolic enzymes, including fatty acid amide hydrolase (FAAH), monoacylglycerol lipa

104 inhibition of cyclooxygenase-2 (COX-2), not fatty acid amide hydrolase (FAAH), prolongs DSI, suggest

105 on, cloning, and expression of a rat enzyme, fatty acid amide hydrolase (FAAH), that degrades bioacti

106 incipal endocannabinoid-inactivating enzyme, fatty acid amide hydrolase (FAAH), that in homozygous fo

107 TFNO, an inhibitor of fatty acid amide hydrolase (FAAH), the enzyme responsibl

108 opment of exceptionally potent inhibitors of fatty acid amide hydrolase (FAAH), the enzyme responsibl

109 eripherally restricted inhibitor (URB937) of fatty acid amide hydrolase (FAAH), the enzyme responsibl

110 issense variant Pro129Thr of the gene coding fatty acid amide hydrolase (FAAH), the major degrading e

111 cluding the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH), triacylglycerol hydro

112 inhibition of endocannabinoid transport and fatty acid amide hydrolase (FAAH), two mechanisms of end

113 ignaling related to a common polymorphism in fatty acid amide hydrolase (FAAH), which alters endocann

114 HR1), evokes a rapid induction of the enzyme fatty acid amide hydrolase (FAAH), which causes a reduct

115 that promotes the cellular uptake of AEA and fatty acid amide hydrolase (FAAH), which hydrolyzes AEA

116 g activity is terminated by an enzyme called fatty acid amide hydrolase (FAAH), which hydrolyzes NAEs

117 bition of endocannabinoid hydrolyzing enzyme fatty acid amide hydrolase (FAAH), which leads to increa

118 hypoxic pulmonary vasoconstriction (HPV) via fatty acid amide hydrolase (FAAH)-dependent metabolites.

119 d 2-arachidonylglycerol) degradative enzyme, fatty acid amide hydrolase (FAAH)-IR, in the rat retina.

120 t negative growth-regulating properties, and fatty acid amide hydrolase (FAAH)-mediated hydrolysis is

121 ovalent inhibitor of the EC-degrading enzyme fatty acid amide hydrolase (FAAH).

122 ediate AEA transport to its catabolic enzyme fatty acid amide hydrolase (FAAH).

123 strates for firefly luciferase by the enzyme fatty acid amide hydrolase (FAAH).

124 reduced activity of the AEA-degrading enzyme fatty acid amide hydrolase (FAAH).

125 es higher levels of the anandamide hydrolase fatty acid amide hydrolase (FAAH).

126 andamide is degraded by the catabolic enzyme fatty acid amide hydrolase (FAAH).

127 ing the anandamide-degrading membrane enzyme fatty acid amide hydrolase (FAAH).

128 s a potent in vitro and in vivo inhibitor of fatty acid amide hydrolase (FAAH).

129 nhibits cyclooxygenase-1 (COX-1), COX-2, and fatty acid amide hydrolase (FAAH).

130 bitors of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH).

131 tors of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH).

132 AEs) are primarily inactivated by the enzyme fatty acid amide hydrolase (FAAH).

133 unction with increased degradation of AEA by fatty acid amide hydrolase (FAAH).

134 were prepared and examined as inhibitors of fatty acid amide hydrolase (FAAH).

135 gulated by monoacylglycerol lipase (MGL) and fatty acid amide hydrolase (FAAH).

136 potent and systemically active inhibitor of fatty acid amide hydrolase (FAAH).

137 Fatty acid amide hydrolase (FAAH, EC 3.5.1.99) is the ma

138 Fatty-acid amide hydrolase (FAAH) is a membrane-bound en

139 in those cells containing an amidase called fatty-acid amide hydrolase (FAAH) is hydrolysis to arach

140 internalization, anandamide is hydrolyzed by fatty-acid amide hydrolase (FAAH), an intracellular memb

141 Mice lacking the enzyme fatty acid amide hydrolase [FAAH (-/-) mice] are severel

142 dentified at the molecular level (designated fatty acid amide hydrolase, FAAH), and although an analo

143 chemically and described as an inhibitor of fatty acid amide hydrolase, had previously been found in

144 f uptake (resulting in signal termination by fatty acid amide hydrolase) has been elusive.

145 ill hereafter refer to oleamide hydrolase as fatty-acid amide hydrolase, in recognition of the plural

146 pathways can be suggested: 1) inhibition of fatty acid amide hydrolase-induced increases in anandami

147 modulation of emotional states and point to fatty acid amide hydrolase inhibition as an innovative a

148 ferences following the administration of the fatty acid amide hydrolase inhibitor AM374.

149 ibiting their metabolizing enzymes URB597 (a fatty acid amide hydrolase inhibitor) and JZL184 (a mono

150 Independently of E2, a fatty acid amide hydrolase inhibitor, which blocks break

151 is of a retinoic acid receptor agonist and a fatty acid amide hydrolase inhibitor.

152 e phytocannabinoid cannabidiol and selective fatty acid amide hydrolase inhibitors has been proposed,

153 PalGly was up-regulated in fatty acid amide hydrolase knockout mice, suggesting a p

154 , N-acyltaurines, was recently discovered in fatty acid amide hydrolase knockout mice.

155 As with another member of this family, fatty acid amide hydrolase, MAH has the uncommon ability

156 ve MAGL inhibitor JZL184, in Mgll(-/-) mice, fatty acid amide hydrolase(-/-) mice, and in cannabinoid

157 By combining fatty acid amide hydrolase or monoacyl glycerol lipase i

158 AEs are hydrolyzed intracellularly by either fatty acid amide hydrolase or N-acylethanolamine-hydroly

159 cerol lipase paralogs (DAGLalpha, DAGLbeta), fatty acid amide hydrolase paralogs (FAAH1, FAAH2), mono

160 sion of the Arabidopsis NAE degrading enzyme fatty acid amide hydrolase resulted in seedlings that we

161 oxylipin metabolites were identified in FAAH fatty acid amide hydrolase seedlings but not in wild-typ

162 also show that dCAD cells express functional fatty acid amide hydrolase, the enzyme primarily respons

163 ective and systemically active inhibitors of fatty acid amide hydrolase, the enzyme responsible for t

164 th as oleamide agonists and as inhibitors of fatty acid amide hydrolase, which is responsible for the

165 bitors of the anandamide-deactivating enzyme fatty-acid amide hydrolase, which selectively elevate an