ライフサイエンスコーパス: fatty acid desaturase

1 emN, and desF (the latter encodes a putative fatty acid desaturase).

2 abditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase.

3 coli to support the activities of the plant fatty acid desaturase.

4 re domain of OLE1, the S. cerevisiae Delta-9 fatty acid desaturase.

5 enzymes such as ribonucleotide reductase and fatty acid desaturase.

6 g a unique delta 9 14:0-acyl carrier protein fatty acid desaturase.

7 ated acyl-CoA precursors by Ole1p, a delta-9 fatty acid desaturase.

8 resembling those of metalloproteins such as fatty acid desaturases.

9 4 is the founding member of a novel class of fatty acid desaturases.

10 nserved histidine clusters characteristic of fatty acid desaturases.

11 uishes them from all known Delta12 or omega3 fatty acid desaturases.

12 scriptional network that upregulates delta-9 fatty acid desaturases.

13 at are characteristic of a group of membrane fatty acid desaturases.

14 fs that are characteristic of membrane-bound fatty acid desaturases.

15 Fatty acid desaturase 1 and 2 (FADS1 and FADS2) code for

16 ut also by the polymorphisms of coding genes fatty acid desaturase 1-3 for the desaturase enzymes tha

17 luding stearoyl-coenzyme A desaturase (SCD), fatty acid desaturases 1 and 2 (FADS1 and FADS2), and di

18 chemical pathway requiring repeated use of a fatty acid desaturase 2 (FADS2) protein to perform Delta

19 Overexpression of fatty acid desaturase 2 (fads2), which metabolizes LA to

20 the transferrin (TF), hemochromatosis (HFE), fatty acid desaturase 2 (FADS2)/myelin regulatory factor

21 so observed for eSNPs in 3 additional genes: fatty acid desaturase 2 (FADS2; P = .002), N-acetyl-alph

22 Delta-6 desaturase, also known as fatty acid desaturase-2 (FADS2), is a component of a lip

23 The fatty acid desaturase-2 rs1535 variant, associated with

24 ces cerevisiae OLE1 gene encodes the Delta-9 fatty acid desaturase, a highly regulated integral membr

25 ers of oxidative stress, and a modulation of fatty acid desaturase activities and plasma and membrane

26 provides a rapid means of isolating variant fatty acid desaturase activities for modification of see

27 is the first study to demonstrate decreased fatty acid desaturase activity in humans with asthma.

28 Saccharomyces OLE1 gene encodes the Delta-9 fatty acid desaturase, an enzyme that converts saturated

29 ntial yeast chromosomal gene encoding delta9 fatty acid desaturase, an integral ER membrane protein a

30 -carrier protein synthetase, and two each to fatty acid desaturase and either desaturase or fatty acy

31 r protein thioesterase, or by suppression of fatty acid desaturases and elongases, resulted in new ov

32 led that tung FADX is grouped with delta(12) fatty acid desaturases and hydroxylases rather than conj

33 Membrane fatty acid desaturases are responsible for inserting dou

34 We developed a fatty acid desaturase assay based on measurement of desa

35 rs to be unrelated to classic membrane bound fatty acid desaturases based on overall sequence conserv

36 In animals, fatty acid desaturases catalyze key reactions in the syn

37 X5 was shown to physically interact with the fatty acid desaturases CrDelta4FAD and CrFAD6, likely do

38 FATTY ACID DESATURASE7 (FAD7), SUPPRESSOR OF FATTY ACID DESATURASE DEFICIENCY1 (SFD1) and SFD2 genes

39 sor, we identified and cloned three putative fatty acid desaturases, designated SbDES1, SbDES2, and S

40 erver identified a low stringency match to a fatty acid desaturase domain in the N-terminal sequence

41 ein), encodes a member of the SUR4 family of fatty acid desaturases, enzymes involved in elongation o

42 results show that CrFAD7 is the only omega-3 fatty acid desaturase expressed in C. reinhardtii, and w

43 that members of the plant integral membrane fatty acid desaturase (FAD) family, FAD2, FAD3, FAD6, FA

44 The embryo-specific Delta-12 fatty acid desaturase FAD2-1 gene was targeted because i

45 vities of the microsomal omega-6 and omega-3 fatty acid desaturases, FAD2 and FAD3.

46 endoplasmic reticulum (ER)-localized omega-3 fatty-acid desaturases (Fad3) increase the production of

47 Transgenic over-expression of a fatty acid desaturase (fad3C) gene of soybean driven by

48 ncestry participants, 31 SNPs in or near the fatty acid desaturase (FADS) 1 and 2 cluster were associ

49 Two of these steps are encoded for by the fatty acid desaturase (FADS) cluster (chromosome 11, 11q

50 ingle nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene affect the activity an

51 Minor alleles of polymorphisms in the fatty acid desaturase (FADS) gene cluster have been asso

52 ymorphisms (SNPs) rs1535 and rs174448 in the fatty acid desaturase (FADS) gene cluster have opposite

53 Fatty acid desaturase (FADS) genes and their variants ha

54 Genetic components, such as variants of fatty acid desaturase (FADS) genes, determine the compos

55 biosynthesis of LC-PUFAs is regulated by the fatty acid desaturase (FADS) genes, of which a human-spe

56 l-length genes coding for microsomal Delta12 fatty acid desaturases (FADs) from the two Santalaceae s

57 ple of such an event is the evolution of the fatty acid desaturases (FADS) genes, which have been cla

58 We identified pheromone-biosynthetic fatty acid desaturases (FADs) MsexD3, MsexD5, and MsexD6

59 tinct subset of nematode C-lectin (clec) and fatty acid desaturase (fat) genes.

60 We have isolated a cDNA encoding the Delta5-fatty acid desaturase from M. alpina via a polymerase ch

61 Further, fatty acid desaturases from different kingdoms and with

62 these processes, we have studied the Delta9 fatty acid desaturase gene OLE1 in Saccharomyces cerevis

63 e many lipid metabolism genes, including the fatty acid desaturase gene OLE1, which is essential for

64 3p, which direct transcription of the Delta9-fatty acid desaturase gene OLE1.

65 anisms is achieved by feedback regulation of fatty acid desaturase gene transcription through signall

66 eved through overexpressing a C. elegans n-3 fatty acid desaturase gene, mfat-1.

67 x-ray mutant, M23, with a known FAD2-1A (for fatty acid desaturase) gene deletion.

68 turated fatty acids and strongly express two fatty acid desaturase genes, omega3 FATTY ACID DESATURAS

69 It was found that a C. albicans fatty acid desaturase homolog (Ole2) and a multicopper o

70 tifies Delta-6 desaturase/FADS2 as the major fatty acid desaturase in human sebaceous glands and sugg

71 GF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic process

72 ScOle1p is the only long chain fatty acid desaturase in Saccharomyces and its membrane

73 ory machinery governing the transcription of fatty acid desaturases in bacteria, yeasts and animals t

74 The three putative fatty acid desaturases in the M. tuberculosis genome, de

75 phyll content suggests a role for plastidial fatty acid desaturases in thylakoid formation.

76 habditis elegans fat-1 gene encoding an n--3 fatty acid desaturase into mammalian cells can quickly a

77 Fatty acid desaturases introduce a double bond in a spec

78 nstrate here that Spr2 encodes a chloroplast fatty acid desaturase involved in JA biosynthesis.

79 DS) gene family contains nine genes encoding fatty acid desaturase-like proteins.

80 lentivirus-mediated expression of an omega-3 fatty acid desaturase, mfat-1, normalized blood glucose

81 Taking advantage of an Arabidopsis thaliana fatty acid desaturase mutant (fad5) that constitutively

82 to have temperature-related phenotypes (e.g. fatty acid desaturase mutants, uvh6).

83 Introduction of the ER fatty acid desaturase mutation, fad2, and to a lesser ex

84 ene-specific activator, SWI5, and the Delta9 fatty acid desaturase of yeast, OLE1, as multicopy suppr

85 ist of Rsp5, which promotes synthesis of the fatty acids desaturase Ole1.

86 Regulation of expression of the fatty acid desaturase Ole1p was hitherto the only known

87 ycerol molecular species lacks the necessary fatty acid desaturase, or a component thereof.

88 Fatty acid desaturases regulate the unsaturation status

89 present results strongly suggest that these fatty acid desaturases represent key enzymes involved in

90 tearoyl-coenzyme A desaturase 1 is a delta-9 fatty acid desaturase that catalyzes the synthesis of mo

91 cOLE1, a gene that encodes scOle1p, a Delta9 fatty acid desaturase that forms cis-monounsaturated fat

92 the strongest signal located in a cluster of fatty acid desaturases that determine PUFA levels.

93 A fatty acid desaturase triple mutant that is defective in

94 nzymes function, whereas Ole1, the essential fatty acid desaturase, was resistant to iron depletion.

95 express the fat-1 gene encoding for omega-3 fatty acid desaturase, which leads to an increase in end

96 e OLE1 gene encodes a membrane-bound Delta-9 fatty acid desaturase, whose expression is regulated by

97 ae OLE1 gene encodes a membrane-bound Delta9 fatty-acid desaturase, whose expression is regulated thr