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1 ice through physiologic functions apart from fatty acid metabolism.
2 s well as SCD1, the rate-limiting enzyme for fatty acid metabolism.
3 of the hepatic genes involved in glucose and fatty acid metabolism.
4 ) is an essential facet in the regulation of fatty acid metabolism.
5 he tricarboxylic acid cycle (TCA) cycle, and fatty acid metabolism.
6 neogenesis, glyoxylate cycle, and long-chain fatty acid metabolism.
7 ys important roles in whole-body glucose and fatty acid metabolism.
8 evidence that CTRP1 is a novel regulator of fatty acid metabolism.
9 d the relation between GIP, 11beta-HSD1, and fatty acid metabolism.
10 d its application to (13)C-tracer studies of fatty acid metabolism.
11 novel and complex connection between PD and fatty acid metabolism.
12 luding the citric acid cycle, polyamine, and fatty acid metabolism.
13 hould be broadly applicable to investigating fatty acid metabolism.
14 rial DNA depletion, mutation, or a defect of fatty acid metabolism.
15 that serve as key determinants of myocardial fatty acid metabolism.
16 ay major roles in regulating cholesterol and fatty acid metabolism.
17 reflect tissue-specific aspects of lipid and fatty acid metabolism.
18 ty acids to acyl-CoAs in the initial step of fatty acid metabolism.
19 it altered expression of genes that regulate fatty acid metabolism.
20 ynthesis and for A2B receptors in decreasing fatty acid metabolism.
21 poptosis, reactive oxygen species (ROS), and fatty acid metabolism.
22 strating diabetes-induced changes in retinal fatty acid metabolism.
23 ll development after infection by modulating fatty acid metabolism.
24 ion levels of representative marker genes in fatty acid metabolism.
25 ivation of genes involved in cholesterol and fatty acid metabolism.
26 Bile acid (BA) signaling regulates fatty acid metabolism.
27 dentified fadR, which encodes a regulator of fatty acid metabolism.
28 in addition to possessing fas genes used in fatty acid metabolism.
29 the natriuretic peptides influence lipid and fatty acid metabolism.
30 s, gene silencing, life-span regulation, and fatty acid metabolism.
31 potentially other functions associated with fatty acid metabolism.
32 a gene that is central to the regulation of fatty acid metabolism.
33 terium tracing studies of redox cofactor and fatty acid metabolism.
34 variety of biosynthetic pathways, including fatty acid metabolism.
35 A carboxylases (ACCs) have crucial roles in fatty acid metabolism.
36 hat may play crucial roles in adipose tissue fatty acid metabolism.
37 their CoA derivatives play a central role in fatty acid metabolism.
38 at plays a pivotal role in the regulation of fatty acid metabolism.
39 SL) catalyzes the initial step in long chain fatty acid metabolism.
40 nd that ACC1 and ACC2 have distinct roles in fatty acid metabolism.
41 e in transcription of the genes of bacterial fatty acid metabolism.
42 dative stress generated from polyunsaturated fatty acid metabolism.
43 e acyltransferases have crucial functions in fatty acid metabolism.
44 A carboxylases (ACCs) have crucial roles in fatty acid metabolism.
45 the ELO family of genes that are involved in fatty acid metabolism.
46 ) is essential for the regulation of hepatic fatty acid metabolism.
47 ce entails dysregulation of both glucose and fatty acid metabolism.
48 ressed >1.5-fold, including many involved in fatty acid metabolism.
49 c phenotypes associated with perturbation in fatty acid metabolism.
50 ates well with their downregulated amino and fatty acid metabolism.
51 zation, extracellular matrix attachment, and fatty acid metabolism.
52 ) regulate genes involved in cholesterol and fatty acid metabolism.
53 AMPK in turn promotes glycolysis and alters fatty acid metabolism.
54 CoA synthetase 1 (ACSL1) plays a key role in fatty acid metabolism.
55 luding glycerophospholipid, glycerolipid and fatty acid metabolism.
56 esters and triglycerides, SCD is pivotal in fatty acid metabolism.
57 tion factor that regulates genes involved in fatty acid metabolism.
58 ofiles, consistent with severe disruption of fatty acid metabolism.
59 e enzyme stearoyl-CoA desaturase-1 (SCD1) in fatty acid metabolism.
60 nase/insulin pathway and an up-regulation of fatty acid metabolism.
61 fatty acid transport protein, CD36, altering fatty acid metabolism.
62 liver is a major metabolic organ involved in fatty acid metabolism.
63 0) T antigens and oncogenic Ras(12V), affect fatty acid metabolism.
64 1(-/-) mice was associated with altered free fatty acid metabolism.
65 r in lipotoxic diseases due to modulation of fatty acid metabolism.
66 acking its DNA-binding-dependent activity on fatty acid metabolism.
67 artners of ABCD2 involved in polyunsaturated fatty-acid metabolism.
68 cardiolipin, phosphonolipid, amino acid, and fatty acid metabolism; a partial Kreb's cycle; a reduced
69 and skeletal muscle, an accelerated rate of fatty acid metabolism, abnormal glucose metabolism, cons
71 phy (X-ALD) is a disorder of very-long-chain fatty acid metabolism, adrenal insufficiency, and cerebr
72 s, some of which include sucrose metabolism, fatty acid metabolism, amino acid metabolism, carbon fix
73 in pathways of branched-chain amino acid and fatty acid metabolism and (b) increased maximal capacity
74 ich plays a critical role in polyunsaturated fatty acid metabolism and (like another important target
75 is of IL-6 in males may inadvertently affect fatty acid metabolism and augment aging-related neuroinf
77 s involved in vesicle trafficking transport, fatty acid metabolism and cellular component biogenesis.
79 erall, this work demonstrates a link between fatty acid metabolism and E3 ligase activities in plants
80 dy, we tested the hypothesis that myocardial fatty acid metabolism and efficiency are abnormal in obe
81 udies suggest that alterations in myocardial fatty acid metabolism and efficiency in obesity can caus
82 d obesity and exhibit enhanced mitochondrial fatty acid metabolism and elevated oxidative capacity of
84 gs identify an intimate relationship between fatty acid metabolism and ER proteostasis that influence
85 P) functions both intracellularly as part of fatty acid metabolism and extracellularly as diazepam bi
86 t cycle, the diet-induced effects on growth, fatty acid metabolism and final eating quality were asse
88 We review new developments in adipose tissue fatty acid metabolism and how that might relate to cardi
90 tial for the expression of genes involved in fatty acid metabolism and ingestion-associated stress re
92 l-CoA carboxylase (ACC) has crucial roles in fatty acid metabolism and is an attractive target for dr
93 like acetyl-CoA, is a high energy product of fatty acid metabolism and is produced through a similar
94 T liver biopsies, intrahepatic expression of fatty acid metabolism and lipid transport genes was lowe
96 tional signature without normal increases in fatty acid metabolism and mitochondrial biogenesis genes
97 reases in expression of proteins involved in fatty acid metabolism and of mitochondrial chaperones.
99 ide hydrolase (sEH), opening a new branch of fatty acid metabolism and providing an additional site f
102 e compatible with a multilevel impairment of fatty acid metabolism and significant mitochondrial dysf
104 receptor (GPCR) pathways control glucose and fatty acid metabolism and the onset of obesity and diabe
106 acid uptake should consider the influence of fatty acid metabolism and the possible interactions betw
107 e, mitochondrial capacity around glucose and fatty acid metabolism and thermogenesis is found to decl
108 , and echium oil affects the biochemistry of fatty acid metabolism and thus the balance of proinflamm
110 I an association of downregulated genes with fatty acid metabolism and upregulated genes with inflamm
111 hich acts as a molecular brake that inhibits fatty acid metabolism and WAT browning.Histone deacetyla
112 cate that (i) MUC1 regulates cholesterol and fatty acid metabolism, and (ii) activation of these path
113 in cholesterol metabolism, 3 participate in fatty acid metabolism, and 4 have no known connection to
114 he effects of ethanol on SREBP-1 activation, fatty acid metabolism, and development of alcoholic fatt
116 oxidative phosphorylation, drug metabolism, fatty acid metabolism, and intestinal maturation, events
117 its of respiratory complexes, ATP machinery, fatty acid metabolism, and Krebs cycle, which further de
118 nsferase, a mitochondrial enzyme involved in fatty acid metabolism, and MED13, a component of the Med
119 EBP target genes, selective reprogramming of fatty acid metabolism, and suppression of inflammatory-r
120 gamma coactivator 1alpha, a key regulator of fatty acid metabolism, and that proliferator-activated r
121 luding amino acid, iron, and polyunsaturated fatty acid metabolism, and the biosynthesis of glutathio
122 ode connecting carbohydrate, amino acid, and fatty acid metabolism, and the regulation of pyruvate fl
123 indicate that variants in genes important in fatty acid metabolism are associated with SCA survival i
124 We conclude that fadR and regulation of fatty acid metabolism are essential for V. vulnificus to
125 trophic acetate, propionate and longer chain fatty acid metabolism are mostly understood, but key ste
126 lved in lipid metabolism, especially omega-6 fatty acid metabolism, are up-regulated in livers of mic
127 his review is to highlight the importance of fatty acid metabolism as a major determinant in fatty ac
129 derivative, which is an essential factor in fatty acid metabolism as acyltransferase cofactor and in
131 ogether, our studies identify HIF control of fatty acid metabolism as essential for ccRCC tumorigenes
132 e Hippo pathway in lung cancer, and point to fatty acids metabolism as a key regulator of lung cancer
133 iferator-activated receptor signalling' and 'fatty acid metabolism' as the three most enriched pathwa
134 ive and respiratory capacities, nitrogen and fatty acid metabolism, as well as the first complete ele
135 ly suppressed TCA cycle, altered glucose and fatty acids metabolism, as well as nucleic acids metabol
136 implications in the chronic abnormalities of fatty acid metabolism associated with obesity and diabet
137 dge of the complex mechanisms of peroxisomal fatty acid metabolism at a molecular level and elucidate
138 al DOCK gene, regulates postprandial TAG and fatty acid metabolism by controlling activation of its p
139 urrent knowledge regarding the regulation of fatty acid metabolism by distinct cell autonomous circad
141 diator co-activator subunit in regulation of fatty acid metabolism by nuclear receptor-like transcrip
143 DT-15 plays a critical role in regulation of fatty acid metabolism by the nematode PPAR-like nuclear
144 cyclic and acyclic products generated during fatty acid metabolism can also function as important che
146 with type 1 diabetes, myocardial glucose and fatty acid metabolism can be manipulated by altering pla
147 lestatic disease progression because altered fatty acid metabolism can enhance reactive oxygen specie
148 including gene silencing, regulation of p53, fatty acid metabolism, cell cycle regulation, and life s
149 odds ratio, 2.04; P = 1.24 x 10(-7)) with a fatty acid metabolism; confirmation of PDE4DIP was obser
150 lved in cholesterol efflux (ABCA1 and NPC1), fatty acid metabolism (CROT and CPT1a), and insulin sign
151 riants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along
152 rohumoral activation, increased adverse free fatty acid metabolism, decreased protective glucose meta
153 nimals have shown that, with age, myocardial fatty acid metabolism decreases, and glucose metabolism
154 thways for steroid biosynthesis, cell cycle, fatty acid metabolism, DNA replication, and biosynthesis
155 where they have been postulated to regulate fatty acid metabolism due to their ability to form stabl
156 in muscle during contracture, alterations in fatty acid metabolism during cardiac ischemia and postis
157 in coordinately regulating carbohydrate and fatty acid metabolism during the progression from fastin
159 seases known for abnormalities in long-chain fatty acid metabolism, e.g., the Sjogren-Larsson syndrom
160 R)alpha is known primarily as a regulator of fatty acid metabolism, energy balance, and inflammation,
161 ease in gene expression of mitochondrial and fatty acid metabolism enzymes in hepatocytes with reduce
163 tionship between iron, oxidative injury, and fatty acid metabolism exists, but transduction mechanism
164 gulation (ZMIZ1), genome maintenance (FEN1), fatty acid metabolism (FADS1 and FADS2), cancer cell mot
166 in in inflammation, insulin sensitivity, and fatty acid metabolism, future studies should examine mil
167 translocation, DNA binding, and induction of fatty acid metabolism genes acyl coenzyme A oxidase and
172 oA carboxylases (ACCs), a crucial enzyme for fatty acid metabolism, has been shown to promote fatty a
174 pharmacologic manipulation of the enzymes of fatty acid metabolism have led to the hypothesis that ne
175 alities such as metabolic acidosis, abnormal fatty acid metabolism, hyperlipidemia, and hyperglycemia
176 , depressed myocardial contractile function, fatty acid metabolism, hypertrophic remodeling, and redu
177 ependent mechanisms that result in increased fatty acid metabolism: (i) elevated levels of Fiaf, whic
178 creen of the genes that regulate glucose and fatty acid metabolism identified an ACC necessary for sa
179 The results indicate that alterations in fatty-acid metabolism, impaired Akt activation by insuli
185 eficiency did not alter hepatic ceramide and fatty acid metabolism in high cholesterol atherogenic di
187 ted to analyze the role of PPAR-alpha-linked fatty acid metabolism in islet function in health and in
188 etabolic syndrome due to positive effects on fatty acid metabolism in liver and white adipose tissue.
189 In light of these findings, we have studied fatty acid metabolism in MCF7 human breast cancer cells
190 al expression of genes involved in lipid and fatty acid metabolism in men with insulin resistance.
192 licated in the regulation of cholesterol and fatty acid metabolism in multiple tissues, including liv
193 dies demonstrate a pivotal role of essential fatty acid metabolism in myocardial phospholipid remodel
195 These data show that ACOT7 counterregulates fatty acid metabolism in neurons and protects against ne
196 ism; however, the basic metabolic control of fatty acid metabolism in neurons remains enigmatic.
198 al oxygen consumption (MVo(2)), glucose, and fatty acid metabolism in nondiabetic subjects and three
199 ide evidence for the importance of lipid and fatty acid metabolism in OC and serve as the foundation
201 ceptor (PR) signaling and 12/15-LOX-mediated fatty acid metabolism in preimplantation mouse uterus.
202 aerobic desaturases to the enzymes used for fatty acid metabolism in proteobacteria: DesA, a 2-posit
203 chanism parallels a phenotypic disruption in fatty acid metabolism in SIRT6 null mice as revealed by
204 d body composition, glucose homeostasis, and fatty acid metabolism in Sost(-/-) mice as well as mice
205 me functional prediction supported decreased fatty acid metabolism in the gut microbiome of subjects
206 ctional intracellular protein that regulates fatty acid metabolism in the nucleus via interactions wi
208 hetase (ACSL) family that plays key roles in fatty acid metabolism in various tissues in an isozyme-s
209 been documented to play an important role in fatty acid metabolism in vivo and subsequently may be in
210 the importance of Clk2 in the regulation of fatty acid metabolism in vivo and suggest that inhibitio
213 multiple P450s and suppression of genes for fatty acid metabolism) in response to CPR loss in the tw
215 nase plays a central role in polyunsaturated fatty acid metabolism, inaugurating the biosynthesis of
216 n of expression of numerous genes modulating fatty acid metabolism, including ADIPOR1 (adiponectin re
217 was strongly associated with markers of n-3 fatty acid metabolism, including degree of unsaturation
218 e used (13)C tracers and lipidomics to probe fatty acid metabolism, including desaturation, as a func
219 display features indicative of altered lipid/fatty acid metabolism, including differential adiposity
220 rular gene expression of enzymes involved in fatty acid metabolism, including induction of stearoyl-C
221 olic disorders characterized by dysregulated fatty acid metabolism, including nonalcoholic steatohepa
222 gested that enhanced capacity for energy and fatty acid metabolism, increased protein degradation, re
223 CD36 is a scavenger receptor involved in fatty acid metabolism, innate immunity and angiogenesis.
224 ly represented categories included lipid and fatty acid metabolism, insulin action, and cell-cycle re
226 However, interference with adipose tissue fatty acid metabolism is not to be undertaken lightly an
229 dings of this study suggest that unsaturated fatty acid metabolism is significantly dysregulated in t
230 transcription factor involved in sustaining fatty acid metabolism, is upregulated in Salmonella-infe
231 associated with glycolysis (Warburg effect), fatty acid metabolism (lipogenesis, oxidation, lipolysis
232 ased, and that this dependence on myocardial fatty acid metabolism may be detrimental to cardiac func
233 yocardial ischemia, prolonged suppression of fatty acid metabolism may persist despite restoration of
234 eficiency primarily affected very long chain fatty acid metabolism, mutant fibroblasts also showed re
235 nvolved in amino sugar, nucleotide sugar and fatty acid metabolism, one carbon pool for folate metabo
236 ments in our understanding of adipose tissue fatty acid metabolism open up the possibility of new pha
237 bolism and the possible interactions between fatty acid metabolism or metabolites and fatty acid tran
239 the acetyl-proteins are enzymes involved in fatty acid metabolism, oxidative phosphorylation or the
240 mechanism of D/SD include Malassezia-induced fatty acid metabolism, particularly lipase-mediated brea
241 We investigated whether genetic variation in fatty acid metabolism pathways was associated with SCA s
244 uding protein-glycosylation, polyunsaturated fatty acid metabolism, phospholipid modeling, and glucos
246 t in branched-chain amino acid catabolism or fatty acid metabolism possessed altered susceptibility t
247 iated with dysregulation of intramyocellular fatty acid metabolism, possibly because of an inherited
248 iated with dysregulation of intramyocellular fatty acid metabolism, possibly because of an inherited
249 target of azole antifungals) and a putative fatty acid metabolism protein (and a potential azole dru
250 with lipid metabolism, sterol biosynthesis, fatty acid metabolism, protein transport, oxidoreductase
251 Acyl-CoA synthetases play a pivotal role in fatty acid metabolism, providing activated substrates fo
252 in gene expression consistent with preserved fatty acid metabolism, reduced endogenous DNA damage, de
253 lpha), a transcription factor that modulates fatty acid metabolism, regulates substrate preference in
254 ntified oxidative stress and polyunsaturated fatty acid metabolism-related pathways, as well as tryps
256 idome and demonstrate immediate responses in fatty acid metabolism represented by increases in eicosa
259 ndrial dysfunction is linked to dysregulated fatty acid metabolism, resulting in increased levels of
260 othesis that TNT exposure affected lipid and fatty acid metabolism, showing that hormetic effects cou
262 eir toxic levels in peroxisomal disorders of fatty acid metabolism, such as adrenoleukodystrophy and
265 eotide-dependent deacetylase SIRT1 regulates fatty acid metabolism through multiple nutrient sensors.
270 hysiological processes including glucose and fatty acid metabolism, transcription, cell growth, mitoc
271 lant infection in M. oryzae by regulation of fatty acid metabolism, turgor establishment and inductio
273 about how LRH-1 controls hepatic glucose and fatty acid metabolism under physiological conditions.
274 decrease in expression of enzymes related to fatty acid metabolism, urea cycle, cell replication, and
277 r characterization revealed that a switch to fatty acid metabolism was a central driver of cardiac ma
278 ssure has affected the genetic regulation of fatty acid metabolism, we assessed 233 serum metabolic p
279 action of nuclear receptors, in glucose and fatty acid metabolism, we generated skeletal muscle-spec
280 To elucidate the specific roles of ACSL5 in fatty acid metabolism, we used adenoviral-mediated overe
282 Several genes involved in lipid droplet and fatty acid metabolism were differentially expressed in I
283 wn to have a central role in regulating free fatty acid metabolism were downregulated in the livers,
284 itric acid cycle, amino acid metabolism, and fatty acid metabolism were found to be highly enriched h
285 l known PPARalpha target genes involved with fatty acid metabolism were observed, reflecting the expe
286 c glycolysis, oxidative phosphorylation, and fatty acid metabolism, were also reduced in T cells lack
288 itine O-octanoyltransferase, are involved in fatty acid metabolism, whereas down-regulated proteins,
289 sis by coordinated regulation of glucose and fatty acid metabolism, which provide a molecular basis f
290 nd decreased expression of genes involved in fatty acid metabolism, which was prevented by blockade o
293 To examine the association of endogenous fatty acid metabolism with future development of metabol
295 tyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism with multiple isozymes often expre
296 ain, which would represent a novel branch of fatty acid metabolism with potential signaling functions
297 proteins are clearly important in regulating fatty acid metabolism, with striking protection against
298 and more effective methods to interfere with fatty-acid metabolism, with insulin resistance, hyperlip
299 is growing evidence supporting the idea that fatty acid metabolism within discrete hypothalamic regio
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