ライフサイエンスコーパス: faulty

1 ounding the mutant condensations are clearly faulty.

2 Here, we show this premise to be faulty.

3 l assumptions, often implicitly, that may be faulty.

4 r these conditions, centriole structures are faulty.

5 dent cerebrovascular effects of apoE such as faulty Abeta clearance from brain to circulation by apoE

6 mal mitochondrial morphology indicative of a faulty actin cytoskeleton.

7 Faulty activation of MCUc may drive dysregulation of fir

8 e observed defects that were consistent with faulty activation of the spindle checkpoint, such as sho

9 ed more severe tic symptoms, suggesting that faulty activity in these circuits may result in their fa

10 nt response of a homeostatic system having a faulty activity sensor (the NMDAR).

11 hands of non-expert clinicians, we find that faulty AI can mislead the entire spectrum of clinicians,

12 stinguish epidemic clonality from PCE may be faulty and (ii) the evidence of deep phylogenies by micr

13 n of potentially toxic peptides derived from faulty and aberrant mRNAs.

14 attachment to a collagen substratum was also faulty and associated with elevated intracellular cyclic

15 lity control systems are dedicated to remove faulty and deleterious proteins to maintain cellular pro

16 odalities, the brain must infer which cue is faulty and recalibrate the corresponding sense.

17 In cancer cells, this regulation may be faulty, and cell division may proceed even in the presen

18 nce pathways preserve chromosomes, but their faulty application at nonallelic repeats could generate

19 matory disorder in which this process may be faulty as the major Crohn's disease-associated protein,

20 on, severely impaired DNA-end processing and faulty assembly and disassembly of HR factors.

21 However, overconfidence also leads to faulty assessments, unrealistic expectations and hazardo

22 how that these previous analyses rely upon a faulty assumption, and we propose a correct non-parametr

23 cience helps clarify intuitive but sometimes faulty assumptions about the social-level mechanisms of

24 pindle assembly checkpoint (SAC) responds to faulty attachments between kinetochores and the mitotic

25 roteins and identified the novel ECM protein faulty attraction (Frac).

26 sts dendritic Kv3.1a and even mutants with a faulty axonal targeting motif to penetrate the AIS.

27 both a glycosylase activity that removes the faulty base and an apyrimidinic/apurinic lyase activity

28 D brains implies a critical link between the faulty BBB and neuronal death through an autoimmune mech

29 That inference is faulty because of the ambiguous nature of partial EC num

30 ry in favor of particularism is based on the faulty beliefs that complex phenomena such as agricultur

31 what is seen may be dysfunctional because of faulty brain processing of that which is seen by normal

32 n-dividing cells in the human body and, when faulty, cause a wide range of pathologies called ciliopa

33 n of hob1+ led to slight cell elongation and faulty cell cycle arrest upon nutrient starvation.

34 ticular, the inability to readily obtain the faulty cell types most relevant to these diseases has im

35 adative process that recycles long-lived and faulty cellular components.

36 provides quality control of mRNA, targeting faulty cellular transcripts for degradation by multiple

37 -A and CENP-C at the targeted centromere via faulty CENP-A loading, arresting cells before mitosis.

38 the allosteric mechanism that is manifest as faulty channel regulation may be explained by altered pr

39 This argument relies on both a faulty characterization of these studies and indirect co

40 This was not related to a faulty checkpoint response, but mutation in the checkpoi

41 These findings indicate that weak or faulty checkpoints for central tolerance can be overcome

42 Embryos derived from I-2 mutant mothers show faulty chromosome segregation and loss of mitotic synchr

43 ailure in mitotic entry and progression, and faulty chromosome transmission.

44 Faulty cilia also prevent the development of proper left

45 Faulty circadian expression of HNF4alpha- either by isof

46 rovascular hypothesis of AD, suggesting that faulty clearance of amyloid beta peptide (A beta) across

47 deaths often facilitate CO(2) elevation, and faulty CO(2) arousal mechanisms could, at least in part,

48 the current political and media environment faulty communication is no longer the core of the proble

49 nterpretation of experimental results and to faulty conclusions.

50 mulating global condensin depletion or local faulty condensin loading gives phenotypes seen experimen

51 arly, if the loss incurred when specifying a faulty confidence interval is not fixed in advance, stan

52 than 2-fold) of extra micronuclei, implying faulty control of micronuclear division in the KO cells.

53 peutic compounds able to restore function to faulty copper transport proteins.

54 ings suggest a biochemical mechanism for the faulty cytokine balance seen in Crohn's disease.

55 lcNAc, results in a polyploid phenotype with faulty cytokinesis.

56 affecting the treatment process by utilizing faulty datasets.

57 DDR and ICB are closely linked-faulty DDR produces immunogenic cancer neoantigens that

58 processing and fundamental insights into the faulty degradation and clearance of Abeta in AD, pivotal

59 ack of an effective strategy for identifying faulty devices from preselected uniform devices based on

60 implemented neural networks that suffer from faulty devices, device-to-device variability, random tel

61 r arrays and the efficient identification of faulty devices.

62 ag-of-marbles (bam) expression, resulting in faulty differentiation and loss of GSCs.

63 ense-mediated mRNA decay (NMD) in destroying faulty, disease-causing mRNAs and maintaining normal, ph

64 neoplasia is well recognized, evidence that faulty DNA polymerase activity is important in cancer de

65 The cause of the correlation is unknown, but faulty DNA repair has been suggested in other systems in

66 risis, the causes of genomic instability and faulty DNA repair, the phenomenon of stem cell quiescenc

67 This may arise from faulty dopaminergic gating of the amygdala, resulting in

68 e underrepresentation of mutations caused by faulty double-strand break repair might explain the high

69 hysiological importance, the extent to which faulty DSB repair alters the genome, and the mechanisms

70 pensatory mutations within gene D suppressed faulty elongation.

71 ssion and violence arise as a consequence of faulty emotion regulation.

72 edures, e.g. dialysis, due to human error or faulty equipment, and it can cause significant harm to t

73 Could faulty estimation of these outcomes predispose to suicid

74 ty in Parkinson's disease may be mediated by faulty evaluation of rewards or the failure to inhibit i

75 Aberrant mRNPs resulting from faulty events are retained in the nucleus with ensuing e

76 ication and informed consent, systematically faulty exchange of information among caregivers, and poo

77 Faulty execution of lysosomal growth and catabolic progr

78 Aiming to correct the faulty expression of KDM5C, we studied the effect of the

79 the sequence and not an artifact related to faulty expression.

80 defective recovery from replication stress, faulty fork restart, slow S-phase progression and decrea

81 ic arch (IAA), which are associated with the faulty function of cardiac neural crest cells (CNCCs).

82 equal daughter cell partitioning, as well as faulty furrow contraction and multinucleation.

83 water table, or industrial accidents such as faulty gas well casings.

84 thality resulting only beyond a threshold of faulty gene reprogramming encompassing multiple loci.

85 Although research has identified a single faulty gene, the huntingtin gene, as the cause of the di

86 rapy-an approach to treat diseases caused by faulty genes-is a lack of technologies that deliver heal

87 l tool to correct the detrimental effects of faulty genes; several RNAi are undergoing clinical evalu

88 disorders of glycosylation, that result from faulty glycan biosynthesis.

89 during DNA replication and are likely due to faulty homologous recombination by RAD52.

90 A faulty identification of the total entropy change on rea

91 response to pathogens, a process that may be faulty in certain inflammatory diseases.

92 hibitory control of the basal ganglia may be faulty in focal hand dystonia, and that the increases we

93 ctin-dependent leukocyte trafficking, and is faulty in leukocyte adhesion deficiency (LAD) type II, a

94 that at least some censoring mechanisms are faulty in SLE.

95 gest that Apaf-1 recruitment of caspase 9 is faulty in the presence of Bcr-Abl and that cytochrome c/

96 that BSE is a result of cannibalism in which faulty industrial practices produced prion-contaminated

97 ulting reliability estimates and can lead to faulty inference.

98 decisions guided by individual bison sharing faulty information about habitat quality promoted the us

99 tors, FAD mutations in APP may contribute to faulty information processing by modifying the dynamic r

100 signal can be lost (missing data) or convey faulty information.

101 red to the desired tissue and also detecting faulty injections.

102 As most synthesis errors arise from faulty insertions and deletions, we developed a length-b

103 nisms trigger insulitis, insulin resistance, faulty insulin signaling, and the loss of immune toleran

104 e than for a nonA-null mutant, implying that faulty interpolypeptide interactions might accompany the

105 hat use of fishery landings data can lead to faulty interpretations about the condition of fishery ec

106 network functions can compensate missing or faulty ion channels.

107 utated gene family found in human cancer and faulty kinase enzymes are being investigated as promisin

108 ing adaptor function in hepatocytes leads to faulty LDL receptor traffic and hypercholesterolemia.

109 ants expressed in neuroblastoma cells showed faulty ligand-induced regulation of intracellular Ca(2+)

110 leukocyte extravasation in inflammation, and faulty lymphocyte homing.

111 ght into the pathogenic mechanism underlying faulty lysosomes in all forms of AD.

112 iased mutation, and propose an alternative, 'faulty male' hypothesis.

113 ligo arrays, it is important to identify any faulty manufacturing step.

114 al quality control designs that identify any faulty manufacturing step.

115 endogenous mesenchymal stem cells (MSCs) and faulty maturation of myofibroblasts.

116 es retinal vascular malformations typical of faulty maturation, mimicking the vascular alterations of

117 lt of altered synaptic development or simply faulty mature circuits remains unknown.

118 They also suggest that faulty mechanisms of neural timing at the brainstem may

119 res, which probably contribute, possibly via faulty mechanosensor function, to the development of man

120 s provided evidence that people often have a faulty mental model of how they learn and remember, maki

121 scribe how these simulations were based on a faulty metric of prediction success and reinforce the im

122 totic inhibitors of Cdc20, and correction of faulty microtubule attachments.

123 For example, faulty migration of cardiac neural crest cells and defec

124 DNA structures that accumulate in cells with faulty mismatch repair mechanisms(1-5).

125 I) transactivator/oncoprotein, Tax, leads to faulty mitosis as reflected by chromosome aneuploidy, cy

126 oping brain of Bub1b(H/H) mice, which have a faulty mitotic checkpoint, and Ercc1(-/Delta7) mice, def

127 Schizophrenia may be characterized by faulty modulation of associative links within a putative

128 ermine whether this deficit is attributed to faulty motor programming, a two-segment movement was exa

129 s, as damage to these pathways can result in faulty movements.

130 erved mechanisms that lead to degradation of faulty mRNA and partially synthesized polypeptides.

131 Inability to block translation of faulty mRNAs and subsequent accumulation of partially sy

132 rs, consistent with a function in preventing faulty mRNAs from reaching translation.

133 egradation of potentially toxic peptides and faulty mRNAs.

134 ated with elevated IFN-gamma signaling and a faulty mucosal barrier.

135 We suggest that faulty myelin compaction during this critical developmen

136 pigmentosum group E cells contributes to the faulty NER in these skin cancer-prone patients.

137 ominantly cytoplasmic localization caused by faulty nuclear import mechanism, which, at least in part

138 Accordingly, faulty nucleome maturation, including persistent insulat

139 ocesses that generate strand breaks, such as faulty Okazaki fragment processing or DNA repair, are an

140 Faulty operation of signal pathways mediated by protein

141 Faulty or damaged messenger RNAs are detected by the cel

142 ssion, as the majority of human cancer has a faulty p53.

143 ative ability in schizophrenia may stem from faulty perception of biological motion and transformatio

144 n be exactly transferred to arbitrary highly faulty photonic NNs with hardware errors up to five time

145 sults suggest a direct mechanistic effect of faulty piRNA processing on meiosis and spermatogenesis i

146 The only cure is removal of the faulty placenta, i.e., delivery.

147 Faulty placentation manifests in the mother as preeclamp

148 8% of first pregnancies, is associated with faulty placentation.

149 regulators, defective granule biogenesis, or faulty platelet activation.

150 eeding disorder that is shown to result from faulty platelet aggregation.

151 omy are erroneous scientific conclusions and faulty policy decisions.

152 s in a stop codon, leading to release of the faulty polypeptide and recycling of the ribosome.

153 The role of PQC machinery in recognizing faulty polypeptides is becoming increasingly understood.

154 ates protein-protein interactions and causes faulty pre-LSU rRNA processing, thus revealing one aspec

155 ecordings to establish a causal link between faulty prediction error signaling and learning deficits

156 chanistic models risk overfitting and making faulty predictions.

157 city and increased transition rates into the faulty primed state, reproduces all aberrations of trans

158 nt internal scaffolding protein B binding to faulty procapsid elongation reactions mediated by extern

159 We report here that faulty processing by FEN-1 initiates repeat instability

160 We have proposed that faulty processing of arrested replication forks leads to

161 rget production gases that seem to implicate faulty production casings, and one to an underground gas

162 synergistically to minimize the formation of faulty proteasomes, thereby preventing recognition and i

163 k defective extracellular matrix assembly to faulty protein processing and cellular trafficking cause

164 s under exploration that modulate downstream faulty protein products affected in cardiomyopathies.

165 zation, diminished/constitutive activity, or faulty protein-protein interactions.

166 ctivation during normal development and that faulty proteinase expression may be at least partially r

167 ays lead to the accumulation of misfolded or faulty proteins that may become insoluble and aggregate

168 Faulty RAM programming in the absence of IL-6 or inflamm

169 single-cell transcriptomic analyses revealed faulty RAM programming in the absence of IL-6 signaling.

170 truly pluripotent embryonic cells because of faulty reactivation of key embryonic genes such as Oct4.

171 ion due to misinformation has been linked to faulty reconstructive processes during memory retrieval

172 The faulty regulation of 9G4 B cells was not shared by RA pa

173 Individuals vulnerable to faulty regulation of negative emotion are at risk for vi

174 Faulty regulation of the central extrahypothalamic corti

175 res exquisite control of gene expression and faulty regulation of transcriptional programs underpins

176 dilation of the pelviureteral junction, not faulty renal puncture.

177 at a lack of gap filling by polbeta leads to faulty repair events and the formation of deleterious DN

178 beta nucleotide insertion products, leads to faulty repair events.

179 etween polbeta and the BER ligases result in faulty repair events.

180 related transcription factors, are caused by faulty repair of abasic sites.

181 at processes additional to slippage, such as faulty repair, contribute to mutations.

182 dentical and mismatched repeats, implicating faulty replication as a causal mechanism for both pathwa

183 Faulty replication of the human mitochondrial genome is

184 has the potential to propagate misleading or faulty research that has been conducted or interpreted i

185 ially transferred to the exo site, where the faulty residue is excised, allowing the shortened primer

186 assembly in human cells and discovered that faulty ribosomes are degraded via the ubiquitin-proteaso

187 sitive to UV, which supports the notion that faulty RNA synthesis at damaged sites is harmful to the

188 Formation of a faulty RNAP in the presence of mutant omega results in d

189 rator in a checkpoint mechanism that removes faulty RNAPII complexes at promoter-proximal pause sites

190 RNA quality-control pathways get rid of faulty RNAs and therefore must be able to discriminate t

191 equent chromosome missegregation ensues from faulty SAC silencing.

192 "nonconservative" mode of synthesis in which faulty sections of DNA are replaced.

193 olume estimation, and automated detection of faulty segmentations (mainly caused by scans of very low

194 ns from this study are troubling in terms of faulty sequence identification.

195 nitors are able to expand and compensate for faulty sinus venosus development in Apj mutants, leading

196 A protein known for its role in dismantling faulty SNARE complexes can also help to maintain complex

197 A widely distributed faulty software update for enterprise cybersecurity soft

198 VZ during mid-neurogenesis, indicating that faulty specification of this progenitor pool is a centra

199 are suggested to signal the dissociation of faulty splicing complexes.

200 pathogenesis, and whether we can manipulate faulty splicing for therapeutic advantage.

201 One such faulty state is translocon clogging, in which the substr

202 h stimuli are incorrectly not presented, and faulty stop-signal delays.

203 ts ablation facilitates the generation of a "faulty" SV fusion apparatus.

204 The results support a model in which (i) faulty synthesis by Poldelta-R696W leads to a checkpoint

205 ls in the LN3alphabeta thymus compensate for faulty T cell development driven by early TCR expression

206 rate that this loss in activity is caused by faulty targeting of CIRB-deleted mutants to intracellula

207 Third, we provide evidence for a faulty template switch model by studying mutants of DNA

208 n inappropriately active Exo1 may facilitate faulty template switching between nearby inverted repeat

209 replication-based mechanism (which we term "faulty template switching").

210 ogenesis, which drives more changes; ii) the faulty tissue architecture of neoplastic lesions results

211 complex adjacent to the nick and subsequent faulty Top1 religation led to the short deletions.

212 e O-fucose site in EGF repeat 27 resulted in faulty trafficking of the Notch receptor to the cell sur

213 has always been thought to be the result of faulty transcription-coupled repair.

214 ial outer membrane-associated mRNAs, removes faulty translation products causal of disease, and impro

215 somes, abort stalled translation, and remove faulty translation products causative of disease in thes

216 ation of stalled translation, and removal of faulty translation products.

217 the quality control mechanisms that resolve faulty translocational states.

218 hat the molecular defect in these animals is faulty V(D)J recombination.

219 s, the high volume of specimen handling, and faulty ventilation accounted for these laboratory-associ