ライフサイエンスコーパス: faulty

1 ounding the mutant condensations are clearly faulty.

2 r these conditions, centriole structures are faulty.

3 dent cerebrovascular effects of apoE such as faulty Abeta clearance from brain to circulation by apoE

4 mal mitochondrial morphology indicative of a faulty actin cytoskeleton.

5 e observed defects that were consistent with faulty activation of the spindle checkpoint, such as sho

6 ed more severe tic symptoms, suggesting that faulty activity in these circuits may result in their fa

7 nt response of a homeostatic system having a faulty activity sensor (the NMDAR).

8 stinguish epidemic clonality from PCE may be faulty and (ii) the evidence of deep phylogenies by micr

9 attachment to a collagen substratum was also faulty and associated with elevated intracellular cyclic

10 In cancer cells, this regulation may be faulty, and cell division may proceed even in the presen

11 nce pathways preserve chromosomes, but their faulty application at nonallelic repeats could generate

12 matory disorder in which this process may be faulty as the major Crohn's disease-associated protein,

13 on, severely impaired DNA-end processing and faulty assembly and disassembly of HR factors.

14 However, overconfidence also leads to faulty assessments, unrealistic expectations and hazardo

15 how that these previous analyses rely upon a faulty assumption, and we propose a correct non-parametr

16 cience helps clarify intuitive but sometimes faulty assumptions about the social-level mechanisms of

17 pindle assembly checkpoint (SAC) responds to faulty attachments between kinetochores and the mitotic

18 roteins and identified the novel ECM protein faulty attraction (Frac).

19 sts dendritic Kv3.1a and even mutants with a faulty axonal targeting motif to penetrate the AIS.

20 both a glycosylase activity that removes the faulty base and an apyrimidinic/apurinic lyase activity

21 D brains implies a critical link between the faulty BBB and neuronal death through an autoimmune mech

22 That inference is faulty because of the ambiguous nature of partial EC num

23 ry in favor of particularism is based on the faulty beliefs that complex phenomena such as agricultur

24 what is seen may be dysfunctional because of faulty brain processing of that which is seen by normal

25 n-dividing cells in the human body and, when faulty, cause a wide range of pathologies called ciliopa

26 n of hob1+ led to slight cell elongation and faulty cell cycle arrest upon nutrient starvation.

27 ticular, the inability to readily obtain the faulty cell types most relevant to these diseases has im

28 adative process that recycles long-lived and faulty cellular components.

29 provides quality control of mRNA, targeting faulty cellular transcripts for degradation by multiple

30 -A and CENP-C at the targeted centromere via faulty CENP-A loading, arresting cells before mitosis.

31 the allosteric mechanism that is manifest as faulty channel regulation may be explained by altered pr

32 This argument relies on both a faulty characterization of these studies and indirect co

33 This was not related to a faulty checkpoint response, but mutation in the checkpoi

34 These findings indicate that weak or faulty checkpoints for central tolerance can be overcome

35 Embryos derived from I-2 mutant mothers show faulty chromosome segregation and loss of mitotic synchr

36 ailure in mitotic entry and progression, and faulty chromosome transmission.

37 rovascular hypothesis of AD, suggesting that faulty clearance of amyloid beta peptide (A beta) across

38 than 2-fold) of extra micronuclei, implying faulty control of micronuclear division in the KO cells.

39 peutic compounds able to restore function to faulty copper transport proteins.

40 ings suggest a biochemical mechanism for the faulty cytokine balance seen in Crohn's disease.

41 lcNAc, results in a polyploid phenotype with faulty cytokinesis.

42 processing and fundamental insights into the faulty degradation and clearance of Abeta in AD, pivotal

43 neoplasia is well recognized, evidence that faulty DNA polymerase activity is important in cancer de

44 The cause of the correlation is unknown, but faulty DNA repair has been suggested in other systems in

45 risis, the causes of genomic instability and faulty DNA repair, the phenomenon of stem cell quiescenc

46 This may arise from faulty dopaminergic gating of the amygdala, resulting in

47 e underrepresentation of mutations caused by faulty double-strand break repair might explain the high

48 pensatory mutations within gene D suppressed faulty elongation.

49 ssion and violence arise as a consequence of faulty emotion regulation.

50 Could faulty estimation of these outcomes predispose to suicid

51 Aberrant mRNPs resulting from faulty events are retained in the nucleus with ensuing e

52 ication and informed consent, systematically faulty exchange of information among caregivers, and poo

53 the sequence and not an artifact related to faulty expression.

54 ic arch (IAA), which are associated with the faulty function of cardiac neural crest cells (CNCCs).

55 equal daughter cell partitioning, as well as faulty furrow contraction and multinucleation.

56 water table, or industrial accidents such as faulty gas well casings.

57 thality resulting only beyond a threshold of faulty gene reprogramming encompassing multiple loci.

58 Although research has identified a single faulty gene, the huntingtin gene, as the cause of the di

59 l tool to correct the detrimental effects of faulty genes; several RNAi are undergoing clinical evalu

60 disorders of glycosylation, that result from faulty glycan biosynthesis.

61 A faulty identification of the total entropy change on rea

62 response to pathogens, a process that may be faulty in certain inflammatory diseases.

63 hibitory control of the basal ganglia may be faulty in focal hand dystonia, and that the increases we

64 ctin-dependent leukocyte trafficking, and is faulty in leukocyte adhesion deficiency (LAD) type II, a

65 that at least some censoring mechanisms are faulty in SLE.

66 gest that Apaf-1 recruitment of caspase 9 is faulty in the presence of Bcr-Abl and that cytochrome c/

67 that BSE is a result of cannibalism in which faulty industrial practices produced prion-contaminated

68 ulting reliability estimates and can lead to faulty inference.

69 decisions guided by individual bison sharing faulty information about habitat quality promoted the us

70 red to the desired tissue and also detecting faulty injections.

71 nisms trigger insulitis, insulin resistance, faulty insulin signaling, and the loss of immune toleran

72 e than for a nonA-null mutant, implying that faulty interpolypeptide interactions might accompany the

73 hat use of fishery landings data can lead to faulty interpretations about the condition of fishery ec

74 network functions can compensate missing or faulty ion channels.

75 utated gene family found in human cancer and faulty kinase enzymes are being investigated as promisin

76 ing adaptor function in hepatocytes leads to faulty LDL receptor traffic and hypercholesterolemia.

77 leukocyte extravasation in inflammation, and faulty lymphocyte homing.

78 ligo arrays, it is important to identify any faulty manufacturing step.

79 al quality control designs that identify any faulty manufacturing step.

80 endogenous mesenchymal stem cells (MSCs) and faulty maturation of myofibroblasts.

81 es retinal vascular malformations typical of faulty maturation, mimicking the vascular alterations of

82 lt of altered synaptic development or simply faulty mature circuits remains unknown.

83 They also suggest that faulty mechanisms of neural timing at the brainstem may

84 s provided evidence that people often have a faulty mental model of how they learn and remember, maki

85 totic inhibitors of Cdc20, and correction of faulty microtubule attachments.

86 For example, faulty migration of cardiac neural crest cells and defec

87 I) transactivator/oncoprotein, Tax, leads to faulty mitosis as reflected by chromosome aneuploidy, cy

88 oping brain of Bub1b(H/H) mice, which have a faulty mitotic checkpoint, and Ercc1(-/Delta7) mice, def

89 Schizophrenia may be characterized by faulty modulation of associative links within a putative

90 ermine whether this deficit is attributed to faulty motor programming, a two-segment movement was exa

91 ated with elevated IFN-gamma signaling and a faulty mucosal barrier.

92 pigmentosum group E cells contributes to the faulty NER in these skin cancer-prone patients.

93 ominantly cytoplasmic localization caused by faulty nuclear import mechanism, which, at least in part

94 ocesses that generate strand breaks, such as faulty Okazaki fragment processing or DNA repair, are an

95 Faulty operation of signal pathways mediated by protein

96 ssion, as the majority of human cancer has a faulty p53.

97 ative ability in schizophrenia may stem from faulty perception of biological motion and transformatio

98 The only cure is removal of the faulty placenta, i.e., delivery.

99 Faulty placentation manifests in the mother as preeclamp

100 8% of first pregnancies, is associated with faulty placentation.

101 regulators, defective granule biogenesis, or faulty platelet activation.

102 eeding disorder that is shown to result from faulty platelet aggregation.

103 omy are erroneous scientific conclusions and faulty policy decisions.

104 s in a stop codon, leading to release of the faulty polypeptide and recycling of the ribosome.

105 The role of PQC machinery in recognizing faulty polypeptides is becoming increasingly understood.

106 ates protein-protein interactions and causes faulty pre-LSU rRNA processing, thus revealing one aspec

107 ecordings to establish a causal link between faulty prediction error signaling and learning deficits

108 chanistic models risk overfitting and making faulty predictions.

109 nt internal scaffolding protein B binding to faulty procapsid elongation reactions mediated by extern

110 We report here that faulty processing by FEN-1 initiates repeat instability

111 We have proposed that faulty processing of arrested replication forks leads to

112 rget production gases that seem to implicate faulty production casings, and one to an underground gas

113 synergistically to minimize the formation of faulty proteasomes, thereby preventing recognition and i

114 k defective extracellular matrix assembly to faulty protein processing and cellular trafficking cause

115 zation, diminished/constitutive activity, or faulty protein-protein interactions.

116 ctivation during normal development and that faulty proteinase expression may be at least partially r

117 truly pluripotent embryonic cells because of faulty reactivation of key embryonic genes such as Oct4.

118 The faulty regulation of 9G4 B cells was not shared by RA pa

119 Individuals vulnerable to faulty regulation of negative emotion are at risk for vi

120 Faulty regulation of the central extrahypothalamic corti

121 res exquisite control of gene expression and faulty regulation of transcriptional programs underpins

122 dilation of the pelviureteral junction, not faulty renal puncture.

123 at processes additional to slippage, such as faulty repair, contribute to mutations.

124 dentical and mismatched repeats, implicating faulty replication as a causal mechanism for both pathwa

125 Faulty replication of the human mitochondrial genome is

126 ially transferred to the exo site, where the faulty residue is excised, allowing the shortened primer

127 sitive to UV, which supports the notion that faulty RNA synthesis at damaged sites is harmful to the

128 Formation of a faulty RNAP in the presence of mutant omega results in d

129 RNA quality-control pathways get rid of faulty RNAs and therefore must be able to discriminate t

130 equent chromosome missegregation ensues from faulty SAC silencing.

131 "nonconservative" mode of synthesis in which faulty sections of DNA are replaced.

132 ns from this study are troubling in terms of faulty sequence identification.

133 nitors are able to expand and compensate for faulty sinus venosus development in Apj mutants, leading

134 A protein known for its role in dismantling faulty SNARE complexes can also help to maintain complex

135 VZ during mid-neurogenesis, indicating that faulty specification of this progenitor pool is a centra

136 are suggested to signal the dissociation of faulty splicing complexes.

137 pathogenesis, and whether we can manipulate faulty splicing for therapeutic advantage.

138 One such faulty state is translocon clogging, in which the substr

139 The results support a model in which (i) faulty synthesis by Poldelta-R696W leads to a checkpoint

140 ls in the LN3alphabeta thymus compensate for faulty T cell development driven by early TCR expression

141 rate that this loss in activity is caused by faulty targeting of CIRB-deleted mutants to intracellula

142 Third, we provide evidence for a faulty template switch model by studying mutants of DNA

143 n inappropriately active Exo1 may facilitate faulty template switching between nearby inverted repeat

144 replication-based mechanism (which we term "faulty template switching").

145 ogenesis, which drives more changes; ii) the faulty tissue architecture of neoplastic lesions results

146 complex adjacent to the nick and subsequent faulty Top1 religation led to the short deletions.

147 e O-fucose site in EGF repeat 27 resulted in faulty trafficking of the Notch receptor to the cell sur

148 has always been thought to be the result of faulty transcription-coupled repair.

149 the quality control mechanisms that resolve faulty translocational states.

150 hat the molecular defect in these animals is faulty V(D)J recombination.

151 s, the high volume of specimen handling, and faulty ventilation accounted for these laboratory-associ