ライフサイエンスコーパス: fear conditioning

1 ontextual) and hippocampal-independent (cue) fear conditioning.

2 arly and late time points following auditory fear conditioning.

3 aradigms, e.g., two-way active avoidance and fear conditioning.

4 cessary for two distinct roles of context in fear conditioning.

5 ant role in regulating Nk3R signaling during fear conditioning.

6 resonance imaging during cued and contextual fear conditioning.

7 in an impairment of specifically noise-cued fear conditioning.

8 prefrontal cortex in extinction of auditory fear conditioning.

9 s were subjected to extinction of contextual fear conditioning.

10 iety paradigms, elevated plus maze (EPM) and fear conditioning.

11 including sexual drive, aggressiveness, and fear conditioning.

12 ry test or for items strongly encoded before fear conditioning.

13 57BL/6J mice after consolidation of auditory fear conditioning.

14 nt fear, we used a mouse model of contextual fear conditioning.

15 tinction training is delivered shortly after fear conditioning.

16 tion, consolidation, and extinction of trace fear conditioning.

17 and local field potentials during Pavlovian fear conditioning.

18 electively attenuated context (but not tone) fear conditioning.

19 etrosplenial cortex (RSC) engaged by context fear conditioning.

20 orris water maze, radial arm water maze, and fear conditioning.

21 rons reduced eIPSC/eEPSC ratios and impaired fear conditioning.

22 la, a brain region known to be essential for fear conditioning.

23 d fear learning following auditory Pavlovian fear conditioning.

24 n and placement without affecting contextual fear conditioning.

25 es, including those learned during Pavlovian fear conditioning.

26 BAergic transmission and inhibited tone-cued fear conditioning.

27 of excitatory mPFC neurons during contextual fear conditioning.

28 ocampal scopolamine (Scop) blocks contextual fear conditioning.

29 cilitated cued, but not trace or contextual, fear conditioning.

30 of the unconditional stimulus (UCS) in human fear conditioning.

31 lateral amygdala of rats 1 h after auditory fear conditioning.

32 in a mouse model of auditory discriminative fear conditioning.

33 ag neurons that are active during contextual fear conditioning.

34 ion and expression of memory after Pavlovian fear conditioning.

35 ctive odor was selectively facilitated after fear conditioning.

36 and storage of memories established through fear conditioning.

37 stimulus to lateral amygdala neurons during fear conditioning.

38 ving chemosensory stimuli, such as olfactory fear conditioning.

39 d, including spatial learning and memory and fear conditioning.

40 eyed to the mPFC and amygdala for contextual fear conditioning.

41 utative LA-ACx synaptic pairs after auditory fear conditioning.

42 gy was mediated by this perturbed pattern of fear conditioning.

43 in the BLA reduces anxiety-like behavior and fear conditioning.

44 le representations in aversive tasks such as fear conditioning.

45 ponse in laboratory animals during Pavlovian fear conditioning.

46 sus fro;5XFAD mice using contextual and cued fear conditioning.

47 ilitation effect (CPFE) and standard context fear conditioning (180 s context exposure-->shock).

48 ave been studied extensively using Pavlovian fear conditioning, a procedure that allows exploration o

49 Here we show that fear conditioning, a type of associative memory, can be

50 nsolidation and reconsolidation of Pavlovian fear conditioning, a widely studied rodent model of PTSD

51 edial prefrontal cortex (mPFC) in contextual fear conditioning, activity within these regions was map

52 e modeled in animal subjects using Pavlovian fear conditioning, allowing investigation of the underly

53 Trace fear conditioning also significantly enhanced the excita

54 During fear conditioning, amygdala responses evoked by footshoc

55 tion of CeL-projecting PVT neurons prevented fear conditioning, an effect that can be accounted for b

56 of non-NMDA receptor transmission following fear conditioning and a depotentiation upon fear extinct

57 xtrastriatal A2ARs in the forebrain inhibits fear conditioning and also affects anxiety-related behav

58 Using classic cued fear conditioning and an extinction paradigm in large co

59 t of the forebrain apparently spared context fear conditioning and attenuated tone fear conditioning

60 wo lentiviral approaches in mice, using both fear conditioning and cocaine-conditioned place preferen

61 ches significantly impaired consolidation of fear conditioning and cocaine-CPP, as well as extinction

62 vior of neuronal ensembles during contextual fear conditioning and demonstrate a dissociable role for

63 After associative fear conditioning and during early extinction (EE), when

64 Photoinhibition of CeM projectors impairs fear conditioning and enhances reward conditioning.

65 performed poorly on wire hang and contextual fear conditioning and exhibited a lower seizure threshol

66 future basic research on sex differences in fear conditioning and extinction but also to exposure-ba

67 ular techniques, we determined whether trace fear conditioning and extinction engages the SR/D-serine

68 the modulation of neural activity following fear conditioning and extinction in both human and anima

69 Here we characterized fear conditioning and extinction in rats selectively bre

70 thy adolescents and adults (N=114) completed fear conditioning and extinction in the clinic.

71 The fear conditioning and extinction neurocircuitry has been

72 Two-day fear conditioning and extinction paradigm.

73 mography scan 4 days before a functional MRI fear conditioning and extinction paradigm.

74 In novel Pavlovian fear conditioning and extinction paradigms, pharmacologi

75 lesion and electrophysiologic studies using fear conditioning and extinction paradigms, there has no

76 In preclinical studies using fear conditioning and extinction paradigms, women and fe

77 ers and 51 male control subjects underwent a fear conditioning and extinction protocol during functio

78 psychophysiological and neural correlates of fear conditioning and extinction recall in anxiety disor

79 esses and the neural circuitry that supports fear conditioning and extinction represent mechanisms th

80 A retrospective analysis of behavior during fear conditioning and extinction revealed that despite n

81 Neural correlates of fear conditioning and extinction were measured using fun

82 While some cells remapped in both fear conditioning and extinction, others responded predo

83 ty in the amygdala is required for pavlovian fear conditioning and extinction.

84 BLA neurons serve a well-accepted role in fear conditioning and fear extinction.

85 ning-dependent sensory responsiveness during fear conditioning and furthermore reveal an important ro

86 ial learning and memory in context-dependent fear conditioning and in the Barnes circular maze.

87 Using an array-based approach after auditory fear conditioning and microRNA (miRNA) sponge-mediated i

88 We observed stronger context fear conditioning and more generalization of fear to a s

89 ry to expectation, our studies of contextual fear conditioning and novel object recognition in I-2 he

90 Using contextual fear conditioning and optogenetic inhibition, we show th

91 Fear conditioning and other elements of basic learning t

92 disruption of the acquisition of contextual fear conditioning and prepulse inhibition of the acousti

93 (FPS) procedure, we examined the effects of fear conditioning and safety signal learning on subseque

94 ted cognitive impairments in both contextual fear conditioning and spatial learning and memory.

95 sed the rates of extinction learning of both fear conditioning and sucrose self-administration.

96 ated by threat-predicting sensory cues after fear conditioning and that activation of these neurons s

97 Rats underwent auditory fear conditioning and then received either immediate (30

98 ed with CRF in LA immediately after auditory fear conditioning and then tested 2 days later.

99 nce responses to the CS without shock during fear conditioning and to both the CS with shock and CS w

100 e TBI-induced deficits in cue and contextual fear conditioning and water maze retention.

101 er, how exactly these neurons participate in fear conditioning and whether they contribute to the gen

102 ed in the rodent hippocampus upon contextual fear-conditioning and identify the vesicular transport a

103 ficant spatial memory deficits in contextual fear-conditioning and Morris water maze tests compared w

104 ice during exposure to learned (differential fear conditioning) and innate (open field) anxiety.

105 h Pavlovian aversive conditioning (so-called fear conditioning), and then behaviors that reduce the f

106 phenotypes, including anxiety-like behavior, fear conditioning, and drug self-administration.

107 ct male and female rats were trained on cued fear conditioning, and received an intraperitoneal injec

108 eversed the behavioral deficit in contextual fear conditioning, and reduced brain Abeta levels, plaqu

109 r the noted increases in amygdala BDNF after fear conditioning are due to local gene transcription an

110 Using fear conditioning as a neurofunctional probe, the author

111 splayed a selective impairment in contextual fear conditioning, as both cue fear and spatial learning

112 onsiveness of the amygdala and insula during fear conditioning, as well as hyporesponsiveness of the

113 ent also induced the recovery of memory in a fear conditioning assay.

114 Traditional rodent models of Pavlovian fear conditioning assess the strength of learning by qua

115 f the Morris water maze (MWM) and contextual fear conditioning at 85 weeks of age showed that these m

116 stabilization of context- and cue-triggered fear conditioning based in the hippocampus and amygdala,

117 We subjected F0 mice to odor fear conditioning before conception and found that subse

118 gating, anxiety, motor balance/learning and fear conditioning behaviors.

119 ng A2ARs in the striatum increased Pavlovian fear conditioning (both context and tone) in st-A2AR KO

120 After cued fear conditioning, both acute and 2-week administration

121 n-deficient mice exhibited normal contextual fear conditioning but displayed slower extinction learni

122 mice showed a deficit in contextual and cue fear conditioning but had normal latent inhibition.

123 la, and dorsomedial prefrontal cortex during fear conditioning but negatively correlated with respons

124 components of PNNs were enhanced 4 hr after fear conditioning but were no longer different from the

125 tants are not defective in motor learning or fear conditioning, but do exhibit mild impairment of mot

126 ve been used as conditioned stimuli (CS) for fear conditioning, but researchers have largely neglecte

127 mally in several behavioral tasks, including fear conditioning, but showed enhanced contextual fear e

128 ockout [PS cDKO]) after one-trial contextual fear conditioning by using biochemical, immunohistochemi

129 This led to recall deficit after contextual fear conditioning (cFC) at 2 months of age in APPswe/PS1

130 an extinction training session of contextual fear conditioning (CFC) blocks retrieval but not consoli

131 Using a contextual fear conditioning (CFC) paradigm, mice were administered

132 the hours following single-trial contextual fear conditioning (CFC), fast-spiking interneurons (whic

133 s (D1R and D5R) are implicated in contextual fear conditioning (CFC).

134 indicate underlying dysfunction in primitive fear conditioning circuits in the cerebellum.

135 ovements in hippocampal-dependent contextual fear conditioning compared with control-treated APP mice

136 M) study of Thy1-YFP mice following auditory fear conditioning complemented by confocal microscopy an

137 In this study, mice underwent trace fear conditioning consisting of an auditory CS paired wi

138 A variant of contextual fear conditioning, context pre-exposure facilitation, al

139 lasping behavior, as well as normalizes cued fear-conditioning defects.

140 ficient to diminish synaptic dysfunction and fear conditioning deficits in PV-ErbB4-/- mice.

141 Such models have shown fear conditioning disrupts subsequent rapid eye movement

142 We found that fear conditioning drove expression of the immediate earl

143 n of PTSD should include an understanding of fear conditioning, dysregulated circuits, memory reconso

144 Using Pavlovian fear conditioning (electric shock), we quantify generali

145 Mice received two distinct fear conditioning events separated by different interval

146 Moreover, rats that darted during initial fear conditioning exhibited lower freezing during the se

147 In auditory fear conditioning, experimental subjects learn to associ

148 Parallel trace fear conditioning experiments showed that spine loss pre

149 ctivity from the BLA-HPC-mPFC circuit during fear conditioning, extinction, and exposure to an open f

150 Although a few paradigms probed fear conditioning/extinction or utilized peripheral immu

151 n of immobilization stress (IMO) followed by fear conditioning (FC) a week later.

152 Using three fear-conditioning (FC) paradigms (signaled, unsignaled,

153 uch compensation is exemplified by Pavlovian fear conditioning following damage to the dorsal hippoca

154 elated behaviors, as well as cued and social fear conditioning from a translational perspective.

155 Standard context fear conditioning groups showed much greater freezing th

156 Fear conditioning has been commonly used as a model of e

157 Although the circuit mediating contextual fear conditioning has been extensively described, the pr

158 The neuroplasticity induced by Pavlovian fear conditioning has likewise been shown to rely on int

159 Research in fear conditioning has provided a comprehensive picture o

160 Neural circuits underlying auditory fear conditioning have been extensively studied.

161 Using auditory Pavlovian fear conditioning in a rodent model, we examined the reg

162 minate between threat and safety cues during fear conditioning in children.

163 ne how trauma or neural structure relates to fear conditioning in children.

164 ontext fear conditioning and attenuated tone fear conditioning in fb-A2AR KO mice.

165 vity during contextual, but not during cued, fear conditioning in female participants carrying the PA

166 In addition, context preexposure increased fear conditioning in males and decreased generalization

167 We found that auditory fear conditioning in mice elicited either an increase or

168 Using auditory fear conditioning in mice, we investigated the role of e

169 on is further supported by studies examining fear conditioning in rodent models.

170 A conception of so-called fear conditioning in terms of circuits that operate nonc

171 9 transcription was studied after contextual fear conditioning in the adult animals.

172 n a time- and learning-specific manner after fear conditioning in the amygdala.

173 complex 1 (mTORC1) activity after contextual fear conditioning in the CA1 but not CA3 area of the dor

174 ne H2A, is actively exchanged in response to fear conditioning in the hippocampus and the cortex, whe

175 PR68 modulator, ogerin, suppressed recall in fear conditioning in wild-type but not in GPR68-knockout

176 ession of PVs during discriminative auditory fear conditioning increased generalization of conditione

177 We found that contextual fear conditioning increased ripple-spindle coupling in m

178 in vivo in the dorsal hippocampus inhibited fear conditioning, indicating that AMPAR diffusion is im

179 Fear conditioning induced both up- and down-regulation o

180 Our findings support a model in which fear conditioning-induced synaptic modifications in CeL

181 mory and postreactivational stabilization of fear-conditioning-induced synaptic enhancements mediatin

182 hat can be accounted for by an impairment in fear-conditioning-induced synaptic potentiation onto som

183 Specifically, fear conditioning induces cell-type-specific synaptic pl

184 ng in wild-type mice suggest that contextual fear conditioning initiates a transcriptional program in

185 econsolidation derives from studies based on fear conditioning instead of avoidance-learning paradigm

186 Our primary analyses demonstrate that human fear conditioning is associated with a consistent and ro

187 Fear conditioning is considered an animal model of post-

188 Stimulus processing in fear conditioning is constrained by parvalbumin interneu

189 Kim and Cho (2017) now show that fear conditioning is mediated by synapse-specific LTP in

190 Pavlovian fear conditioning is one of the most common and well-und

191 ala (LA) plays an essential role in auditory fear conditioning, it is unknown whether LTP is induced

192 wever, while antagonism of mGluR5 may reduce fear conditioning, it may also reduce fear extinction.

193 We find that sub-threshold fear conditioning leads to dopamine receptor D4-dependen

194 have previously demonstrated that olfactory fear conditioning leads to increased odorant-specific re

195 ditory cortex, confocal analysis showed that fear conditioning led to a significantly increased densi

196 Fear conditioning (light paired with shock) occurred in

197 We show here that contextual fear conditioning markedly increases MMP-9 transcription

198 hat part of the molecular program induced by fear conditioning may initiate homeostatic plasticity.

199 rris water maze) and associative (contextual fear conditioning) memory were observed in lesioned P301

200 studied learning and memory using contextual fear-conditioning, Morris water maze, and novel object r

201 animals and behavioral experiments in which fear conditioning naturally activated the PAG.

202 icits in learning or memory in tests of cued fear conditioning, novel object recognition, object loca

203 e full recovery of behavioral performance in fear conditioning, object location, and novel object rec

204 short-term and long-term memories, including fear conditioning, object recognition, object placement,

205 This prior fear conditioning of CSA reduced the prediction error du

206 vo electrophysiology to reveal the impact of fear conditioning on BLA excitatory and feedforward inhi

207 mp recordings to examine the effect of trace fear conditioning on the intrinsic excitability of layer

208 To examine the effect of discriminative fear conditioning on the shape of the generalization gra

209 A1R antagonist), treatment for 7 days before fear conditioning onwards, to attenuate the retrieval of

210 animals were either exposed to single-trial fear conditioning or elevated plus maze or sacrificed fo

211 ala (3, 10, or 30 mug/side) following either fear conditioning or fear extinction training.

212 fter either threat conditioning (also called fear conditioning) or conditioned inhibition in adult ra

213 imately three weeks later, learned fear (via fear conditioning) or depressive-like behavior (via tail

214 as not found in animals that did not undergo fear conditioning, or when extinction was conducted outs

215 treatment, we performed classical Pavlovian fear conditioning pairing auditory cues with footshocks

216 To test this prediction, we developed a fear conditioning paradigm for mice based on gap detecti

217 al abuse, or domestic violence), completed a fear conditioning paradigm utilizing blue and yellow bel

218 behavior analysis in the cued and contextual fear conditioning paradigm, as well as immunohistologica

219 This indicates that, under the current fear conditioning paradigm, early-life FGF2 has protecti

220 Recently, in a classical Pavlovian fear conditioning paradigm, Gruene and colleagues descri

221 ar learning using a combined trace and delay fear conditioning paradigm.

222 expressed greater associative learning in a fear conditioning paradigm.

223 agia test, and cognition, using a contextual fear conditioning paradigm.

224 provide details for a novel context threat (fear) conditioning paradigm in humans using a commercial

225 sted in the hippocampus-dependent contextual fear-conditioning paradigm in adulthood.

226 We used a fear-conditioning paradigm in mice to condition footshoc

227 wake-behaving mice during training in a cued fear-conditioning paradigm slowed the extinction of lear

228 zing behavior to the tone was increased in a fear-conditioning paradigm.

229 performance in an open-field and contextual fear-conditioning paradigm.

230 CeM neurons and reduced fear expression in a fear-conditioning paradigm.

231 its in learning and memory in the contextual fear-conditioning paradigm.

232 receptor-dependent long-term potentiation in fear conditioning pathways.

233 ired spatial and episodic memory, as well as fear conditioning performance.

234 Notably, fear conditioning potentiates excitatory synaptic transm

235 community advertisements, to a differential fear conditioning procedure and assessed the relationshi

236 Here, we used a fear conditioning procedure in juvenile rats before matu

237 patterns of olfactory bulb stimulation in a fear conditioning procedure in the rat, we tested the ef

238 Notably, using a fear conditioning procedure, we found that photostimulat

239 view that they may inform ongoing studies of fear-conditioning processes both in healthy and clinical

240 During Pavlovian threat (fear) conditioning (PTC), sensory and neuromodulatory in

241 After fear conditioning, PV-INs exhibit nucleus- and target-se

242 Here we demonstrate that aversive fear conditioning rapidly and persistently alters sponta

243 netic inhibition of dorsal DG during context fear conditioning, recall, generalization, and extinctio

244 In contrast, trace fear conditioning reduced the excitability of regular sp

245 ce of brain-based markers of overgeneralized fear conditioning related to PTSD.

246 animal studies, the neurobiological basis of fear conditioning remains only partially understood.

247 Classical Pavlovian fear conditioning remains the most widely employed exper

248 ing on two paradigms: social recognition and fear conditioning, representing approach and avoidance b

249 We previously demonstrated that contextual fear conditioning results in hippocampal place cell rema

250 ciently to the basal amygdala for contextual fear conditioning.SIGNIFICANCE STATEMENT This work demon

251 is the first study to demonstrate that trace fear conditioning significantly alters the intrinsic exc

252 Trace fear conditioning significantly enhanced the intrinsic e

253 Cue and contextual fear conditioning significantly increased phosphorylated

254 Animal fear conditioning studies have illuminated neuronal mech

255 discuss whether the inferences we draw from fear conditioning studies operate in the natural world.

256 l models of fear stem largely from Pavlovian fear conditioning studies that focus on how a particular

257 nding motivates a reinterpretation of rodent fear conditioning studies, particularly in females, and

258 ovide a comprehensive meta-analysis of human fear-conditioning studies carried out with functional ma

259 Meta-analytic results of fear-conditioning studies in the anxiety disorders impli

260 vations-a scarcely addressed dynamic in fMRI fear-conditioning studies-also suggests the existence of

261 More importantly, a fear conditioning study demonstrated that contextual ass

262 ed in IL after fear extinction compared with fear conditioning, suggesting that EphB2 signaling in IL

263 ase in FTO observed shortly after contextual fear conditioning suggests that FTO normally constrains

264 ague-Dawley rats were trained on an auditory fear conditioning task followed by 1 to 10 days of extin

265 acquisition and the extinction phases of the fear-conditioning task for the whole brain yielded good

266 ction or a control task before repeating the fear-conditioning task using these newly acquired regula

267 nt signal was measured during a differential fear-conditioning task.

268 ormance in the objection location memory and fear conditioning tasks and in a complex spatial environ

269 he formation of stimulus associations during fear-conditioning tasks where the timing of conditioned

270 freezing time relative to control in the cue fear conditioning test, and deregulation of noradrenergi

271 d improvement in their memory as assessed by fear conditioning test, both in the cue and recall phase

272 tory cortex neurons induced by auditory-cued fear conditioning; they also show that retrieval of an a

273 ats with acquisition and extinction of trace fear conditioning to determine how specific neurons chan

274 We used western blot analyses and trace-fear conditioning to determine whether 5 days of VU04095

275 C57BL/6 mice that combines acute stress with fear conditioning to precipitate traumatic-like memories

276 Furthermore, we used fear conditioning to study learning and memory in these

277 tressor nonassociatively enhances subsequent fear conditioning training with only a single trial.

278 Next, we found that contextual fear conditioning transiently (0.5 h) decreased Fto leve

279 novel experience consisting of a contextual fear conditioning trial.

280 Here we investigate human Pavlovian fear conditioning under the blood-brain barrier crossing

281 , healthy adult volunteers underwent threat (fear) conditioning using a tone-conditioned stimulus pai

282 ons in the BLA, would differentially support fear conditioning versus fear inhibition/extinction.

283 Contextual fear conditioning was also strongly augmented following

284 The fragment-induced augmentation of fear conditioning was attenuated by coadministration of

285 e role of GPR171 in anxiety-like behavior or fear conditioning was evaluated following systemic or in

286 lopment, acquisition of one-trial contextual fear conditioning was impaired after deletion of alpha-C

287 uced freezing behavior in Tg2576 mice during fear conditioning was partially reversed after subchroni

288 hibitor or vehicle before cue and contextual fear conditioning, water maze training and a spatial wor

289 ific changes in activity, because effects on fear conditioning were assessed in a drug-free state, an

290 gulated genes, cFos, Zif268, and Bdnf, after fear conditioning were diminished in aged mice.

291 Neurons that were active during context fear conditioning were tagged with the long-lasting fluo

292 ories, including novel object recognition or fear conditioning, were not affected by these genetic ma

293 resulted in learning and memory deficits in fear conditioning, whereas CREB deletion in the ventral

294 e found cells that remapped primarily during fear conditioning, which could facilitate reacquisition

295 during extinction and in female rats during fear conditioning, which does not involve infralimbic-ba

296 ditionally, retrieval of standard contextual fear conditioning, which does not require context discri

297 ibited increased expression of auditory-cued fear conditioning, which specifically emerged as attenua

298 tion of striatal A2ARs facilitates Pavlovian fear conditioning, while inactivation of extrastriatal A

299 e PVT or Trkb in SOM(+) CeL neurons impaired fear conditioning, while infusion of BDNF into the CeL e

300 prepulse inhibition of startle responses, or fear conditioning with pure tones.