ライフサイエンスコーパス: feedback mechanism

1 neurons are only essential for the positive feedback mechanism.

2 lfish equilibrium through a novel and robust feedback mechanism.

3 tion in response to injury via a mesenchymal feedback mechanism.

4 and gamma-secretase and the gamma --> alpha feedback mechanism.

5 e of endochondral ossification as a negative feedback mechanism.

6 osynthesis and signaling, through a positive feedback mechanism.

7 t Cbl-3/c, suggesting a potential inhibitory feedback mechanism.

8 stimulation then declined due to a negative feedback mechanism.

9 r complex and JNK pathway through a negative feedback mechanism.

10 release, and DA synthesis through a negative-feedback mechanism.

11 e presence during ALI, suggesting a positive feedback mechanism.

12 Dkk1, protects this state through a negative feedback mechanism.

13 ncreatic cancer cells, serving as a negative feedback mechanism.

14 ted at the transcriptional level by a sterol feedback mechanism.

15 may regulate protein biosynthesis through a feedback mechanism.

16 ine kinases (RTK) through an uncharacterized feedback mechanism.

17 ed RhoA to the PH domains acts as a positive feedback mechanism.

18 ns to the pre-activation state by a negative feedback mechanism.

19 ced PIP(3) production via a S6K-IRS positive feedback mechanism.

20 to modify the concept of estrogen's positive feedback mechanism.

21 neural networks using an external objective feedback mechanism.

22 pected through the classic vegetation-albedo feedback mechanism.

23 tive catalyst while establishing a catalytic feedback mechanism.

24 ing a role for the cerebellum in an internal feedback mechanism.

25 MAPK pathway due to attenuation of an IKBKE feedback mechanism.

26 entiated PKA activity, suggesting a positive feedback mechanism.

27 ontrol proteasome abundance by a homeostatic feedback mechanism.

28 emissions that have implications for climate-feedback mechanisms.

29 causality and possible carbonaceous aerosol feedback mechanisms.

30 anscription is tightly regulated by negative feedback mechanisms.

31 cerevisiae have suggested distinct positive feedback mechanisms.

32 and they showed increased reliance on slower feedback mechanisms.

33 ment, turnover rates of niche occupancy, and feedback mechanisms.

34 to its switch-like behavior due to positive feedback mechanisms.

35 metabolism, autophagy, mRNA translation and feedback mechanisms.

36 T1D, likely by affecting tubular-glomerular feedback mechanisms.

37 ressively in response to positive ice-albedo feedback mechanisms.

38 Conception 2, the circuits self-regulate via feedback mechanisms.

39 mited by heat shock factor 1 (HSF1)-mediated feedback mechanisms.

40 is indispensable for cellular regulatory and feedback mechanisms.

41 hasic AMPK signaling, suggestive of negative-feedback mechanisms.

42 ates their glutamatergic output via parallel feedback mechanisms.

43 ed bands at meter scale driven by ecological feedback mechanisms.

44 ole process, probably by triggering negative feedback mechanisms.

45 dynamics modeling to identify and prioritize feedback mechanisms.

46 n the size of these instruments due to their feedback mechanisms(9), which, if overcome, would enable

47 which are in turn stabilized by biophysical feedback mechanisms acting through pore characteristics

48 lines expressing crtI has revealed negative feedback mechanisms, acting predominantly at the level o

49 Through a unique feedback mechanism, activated fibroblasts then express F

50 frequencies and show that the stopped-light feedback mechanism allows for nanolasing without a cavit

51 These results suggest that a feedback mechanism allows granule cells to maintain the

52 Feedforward and feedback mechanism alterations each were associated with

53 n of CRAF was dependent on MEK, suggesting a feedback mechanism and explaining a key difference betwe

54 tion are an inherent property of the TRH/TSH feedback mechanism and indicate that only constant deliv

55 addressed both the nature of this "hotspot" feedback mechanism and its implications in a variety of

56 show similar vegetation patterns even if the feedback mechanisms and resulting soil-water distributio

57 ults demonstrated the robustness of positive feedback mechanisms and the significance of NCED express

58 procal side-effects between several integral feedback mechanisms and the subsystems they stabilise; a

59 FR2, by including SphK1 and calcium positive feedback mechanisms, and investigate their consequences

60 ove assessments of biosphere-aerosol-climate feedback mechanisms, and the air quality and climate eff

61 This feedback mechanism appears to be exploited by high level

62 Several negative feedback mechanisms are in place, including the Shh-indu

63 se important systems, and to predict whether feedback mechanisms are likely to regulate or exacerbate

64 ins, have been studied extensively, positive feedback mechanisms are not known.

65 However, interactions between these feedback mechanisms are unclear.

66 eretofore unrecognized, homeostatic negative feedback mechanism at the interface of adaptive and inna

67 n the basal ganglia (BG) and is endowed with feedback mechanisms at three levels: cortical microcircu

68 This suggests a localized feedback mechanism based on enhanced stability of Fat4-D

69 he testis stem cell niche and is a potential feedback mechanism, based on germ cell input, that gover

70 ing because of a disturbance in the negative-feedback mechanism between dietary iron absorption and i

71 y release via 'magnetic breakout'-a positive-feedback mechanism between filament ejection and reconne

72 n monoculture, suggesting an interaction and feedback mechanism between Huh7.5.1 and LX2 cells.

73 and reductants in diatoms is controlled by a feedback mechanism between intermediate metabolites, the

74 A complex feedback mechanism between parathyroid hormone (PTH), 1,

75 Here we report an "auto"-regulatory feedback mechanism between plasmacytoid dendritic cells

76 TRPV4 sensing may provide a feedback mechanism between sensing shear flow and eicosa

77 We show that there is an active feedback mechanism between the apical ECM (aECM) and the

78 he fractional derivative provides a negative feedback mechanism between the voltage trace and the act

79 Feedback mechanisms between interferons alpha and lambda

80 a framework for understanding the intrinsic feedback mechanisms between the actions of humans and th

81 of RasGAP, and that preventing this negative feedback mechanism by inhibiting Abl family kinases lead

82 These retrograde signals comprise a feedback mechanism by which excitatory sensory activity

83 bstrate 2 (IRS2) levels and identify a novel feedback mechanism by which mTORC1 signaling increases I

84 This work reveals intrinsic force feedback mechanisms by which mechanical resistance makes

85 normal Zap70 autoinhibition engaged negative feedback mechanisms by which negative selection and inhi

86 rons caused by disturbances in outer retinal feedback mechanisms can enhance patterned visual halluci

87 nhibition of MT polymerization, suggesting a feedback mechanism caused by cellulose interference.

88 r of tissue cells at equilibrium because the feedback mechanism compensates for virus-induced cells d

89 The same feedback mechanism contributes to PGE2-mediated suppress

90 ed microbial lineages may work as a positive-feedback mechanism contributing to the sexual dimorphism

91 Thus, GATA3-mediated positive and negative feedback mechanisms control human T-cell lineage commitm

92 l interactions, the question arises of which feedback mechanisms control the early entrainment of pre

93 JAK-dependent induction of IL-10 as a potent feedback mechanism controlling IL-6-induced MMP-9 expres

94 ics that are further influenced by intrinsic feedback mechanisms controlling their interaction.

95 A PP2A-mediated feedback mechanism controls Ca(2+)-dependent NO synthesi

96 We propose that this feedback mechanism could regulate excitability of the in

97 lso found that different Ras-to-GEF positive feedback mechanisms could reshape output dynamics in dis

98 likely presence of a previously unrecognized feedback mechanism dependent on Ca2+c.

99 nsition to force production via the positive-feedback mechanism described above.

100 mportant, yet relatively unexplored, climate feedback mechanisms during major climate transitions.

101 proach revealed a prominent role of negative feedback mechanisms during the immediate (</=60 min) IFN

102 r mating, when failure of the corticosteroid feedback mechanism elevates stress hormone levels during

103 This positive-feedback mechanism--enabled by the functional coupling b

104 e contribution of the partner increases, the feedback mechanism enhances cooperation levels.

105 receptor genes are suppressed by a negative feedback mechanism, ensuring a stable functional identit

106 subsequent MMP1 induction creates a positive feedback mechanism established between tumor and stromal

107 This feedback mechanism eventually leads to the collapse of t

108 ondary mediators and PF4 serve as a positive feedback mechanism for activation through an IgG-depende

109 NEMO, MCPIP1 induction serves as a negative feedback mechanism for attenuating genotoxic NF-kappaB a

110 (V)1.2, thus providing an important negative feedback mechanism for Ca(2)(+) influx.

111 omeostatic synaptic plasticity is a negative-feedback mechanism for compensating excessive excitation

112 tion of TCR expression represents a negative feedback mechanism for constraining T cell effector func

113 and PITX2 gain of function studies reveal a feedback mechanism for controlling Dact2 expression.

114 efficacy for a given process, with a digital feedback mechanism for device optimization.

115 indings identify a MEF2C-dependent, positive-feedback mechanism for Endothelin induction and establis

116 wetland CH4 emissions can act as a negative feedback mechanism for future climate warming and vice v

117 l readout of cell size could provide a novel feedback mechanism for growth control.

118 s super-resolution imaging offer a secondary feedback mechanism for measuring the tip-sample gap duri

119 These findings implicate eEF1A in a feedback mechanism for regulating translation at initiat

120 es the number of dimers, thereby providing a feedback mechanism for reinforcing binding to collagen a

121 min5 is dependent on SMN levels, providing a feedback mechanism for SMN to regulate its own expressio

122 ere, we present a self-assembly route with a feedback mechanism for the bottom-up synthesis of a new

123 highly expressed genes initiates a negative feedback mechanism for the modulation of their expressio

124 such as CCL5 and CCR1, suggesting a possible feedback mechanism for the recruitment of CD8(+) T cells

125 e PCs in immune cells, suggesting a positive feedback mechanism for TLR7 processing during infection.

126 ensional materials, and the incorporation of feedback mechanisms for designing robust responses.

127 Whereas negative feedback mechanisms for microtubule length control, base

128 eletal dynamics in T cells provides positive feedback mechanisms for T-cell activation and allows for

129 ) in the mouse retina is shaped by different feedback mechanisms from postsynaptic GABAergic horizont

130 landin E2 promotes cancer invasion, and in a feedback mechanism, GAL released by cancer induces neuri

131 histone modifications that, through positive feedback mechanisms, generate bistable states.

132 interactions between central and peripheral feedback mechanisms governing cardiorespiratory control

133 e elastic nature of Rayleigh scattering, the feedback mechanism has been insofar deemed incoherent, w

134 Three alternative feedback mechanisms have been proposed: regulation by th

135 ored and prioritized, with the most dominant feedback mechanism identified as Water System Functional

136 ition of this newly identified physiological feedback mechanism illuminates the pathophysiology of pl

137 reening strategy and could define a negative feedback mechanism in Gq/Phospholipase C signaling throu

138 ose that SRA serves as an important negative feedback mechanism in liver immune homeostasis, and may

139 protein levels suggests a potential positive feedback mechanism in nucleated cell types.

140 NFR1 ectodomain shedding is not an essential feedback mechanism in preventing the development of hepa

141 ate repression of ainS, providing a negative feedback mechanism in the Ain/Lux signaling cascade.

142 These studies reveal an adaptive feedback mechanism in tyrosine kinase-driven cancers ass

143 ions, we identify a molecular-scale positive feedback mechanism in which exchange of the larger Cs(+)

144 ed in germ-free conditions reveal a negative feedback mechanism in which MZ and B1 cell numbers are u

145 Here we identify a powerful feedback mechanism in which N2 fixation can overcome eco

146 vide such regulation is through an autocrine feedback mechanism in which the secreted hormone is "sen

147 sensor to provide the cell with a regulatory feedback mechanism in which translational activity is al

148 Thus, this feedback mechanism in which Treg cells are highly activa

149 s tempered by G protein-dependent inhibitory feedback mechanisms in DA neurons of the ventral tegment

150 esults reveal an important role for negative feedback mechanisms in protecting the information transf

151 us, targeting MLL1 may block a HSF1-mediated feedback mechanism induced by HSP90 inhibition and provi

152 eness as single agent cancer therapies, with feedback mechanisms inherent to the signaling network th

153 lated in the mutant, suggesting an important feedback mechanism involved in setting the positional bo

154 These data suggest a reciprocal feedback mechanism involving AMPK and the PLD/mTOR signa

155 ing NR4A2 and suggest a network and possible feedback mechanism involving p53, miR-34, and NR4A2.

156 This is mediated via a feedback mechanism involving the binding of lysine to th

157 Our results identify a new negative feedback mechanism involving the miR-146a/b-TRAF6/IRAK1-

158 sometimes activate survival pathways through feedback mechanisms involving mTORC2.

159 advanced our understanding of interdependent feedback mechanisms involving the heart, lung, and kidne

160 However, it is unclear whether the positive feedback mechanism is common for other lysosomal storage

161 , we identify that a self-enhanced transport feedback mechanism is critical to XCI fate decision.

162 potential for a sink (CO2) to source (PSII) feedback mechanism is discussed.

163 The negative feedback mechanism is essential to maintain effective im

164 The lipid sensed by the ORMDL-mediated feedback mechanism is medium or long chain ceramide or a

165 This feedback mechanism is suggested to maintain the circadia

166 This positive feedback mechanism is thus highly efficient to promote t

167 le or because they employ specialized neural feedback mechanisms is an active research question.

168 otemporal interaction between these distinct feedback mechanisms is illustrated by the fact that expr

169 lus contrasts and that the efficacy of these feedback mechanisms is likely modulated by GABA release

170 observation that the integration of multiple feedback mechanisms leads to a variety of non-linear res

171 This negative feedback mechanism likely restricts cell motility.

172 timulates CL remodeling, identifying a novel feedback mechanism linking CL remodeling to oxidative ph

173 e prp8 mutation perturbs a cotranscriptional feedback mechanism linking COOLAIR processing to FLC gen

174 lator of IRS2 stability, demonstrate a novel feedback mechanism linking mTORC1 signaling with IRS2, a

175 via self-attenuation, a protective negative feedback mechanism, masking EADs.

176 This feedback mechanism may curtail futile ATP consumption be

177 This AhR-mediated anti-inflammatory feedback mechanism may dampen the allergen-induced infla

178 This hyperphosphorylation-dependent feedback mechanism may serve as a molecular clock ensuri

179 m is the amount of phosphorylated regulator, feedback mechanisms may alter the amount of regulator, a

180 Our data indicate that a protective feedback mechanism mitigates the apoptotic effect of IR-

181 an AR-V target gene demonstrating a positive feedback mechanism of androgenic signalling in CRPC.

182 Our hypothesis is that in aging there is a feedback mechanism of autocrine inflammatory cytokines (

183 To date, feedback mechanisms of Rho down-regulation critical for

184 level model to investigate the impact of the feedback mechanism on future AIS retreat over centennial

185 e formation is regulated by a novel negative-feedback mechanism on membrane lipids.

186 -cell proliferation, suggesting a regulatory feedback mechanism on T-cell expansion.

187 Also, SIK1 participates in a negative feedback mechanism on the transforming growth factor-bet

188 This irreversibility implies that positive feedback mechanisms operate to allow commitment (i.e., t

189 Thus an auto-regulatory feedback mechanism operates to induce its own inhibitor

190 ase activation, providing evidence that this feedback mechanism operative in other cancers is not a g

191 the target is of focus but also any inherent feedback mechanisms or mechanisms of acquired resistance

192 Additionally, competition alone (without feedback mechanisms or spatial parameters) could replica

193 lation of CaV channels is a prominent Ca(2+) feedback mechanism orchestrating vital adjustments of Ca

194 These data define a feedback mechanism, originating from epithelial FGF liga

195 -Planck formalism, we find no evidence for a feedback mechanism present to maintain specific domain r

196 onic signature, our self-assembly route with feedback mechanism promotes the assembly of desired meta

197 ferentiation pattern in which BMP2 acts as a feedback mechanism promoting ovarian CSC expansion and s

198 In contrast, a positive feedback mechanism provides the highest precision in tim

199 rylation, thus constituting a novel negative feedback mechanism regulating eNOS activity not present

200 ularly in later phases, as a potent negative-feedback mechanism regulating inflammasome activation.

201 a suggest that AED1 is part of a homeostatic feedback mechanism regulating systemic immunity.

202 ver, cell-specific functions, redundancy and feedback mechanisms regulating bone growth are poorly un

203 This feedback mechanism represents a fundamental reinterpreta

204 a complete failure of the estrogen positive feedback mechanism responsible for the preovulatory GnRH

205 down either Bcl-2 or DARPP-32 abrogates this feedback mechanism, resulting in increased Ca(2+) elevat

206 ys not only sense the error, but also engage feedback mechanisms, resulting in corrective motor respo

207 light engenders an inherent and cavity-free feedback mechanism, similar in effect to the feedback th

208 of Ca ions (faster) and the kinetics of the feedback mechanisms (slower).

209 integrated with meiotic progression and how feedback mechanisms spatially pattern DSB formation and

210 ic products, or stimulate conserved negative feedback mechanisms, such as through Programmed Cell Dea

211 We describe a negative-feedback mechanism targeting RIG-I activity, which is me

212 In particular, a positive feedback mechanism termed auxin transport canalization,

213 SP/SA remodeling could be part of a negative feedback mechanism that aims at adjusting the strength o

214 sferase of Arabidopsis1 pathway, providing a feedback mechanism that allows the plant to compensate f

215 and may represent a bone-restricted positive feedback mechanism that amplifies bone resorption in pat

216 eta-TrCP are mutually regulated, providing a feedback mechanism that amplifies the suppressive effect

217 YK2/MEK/ERK signalling pathway as a positive feedback mechanism that amplifies the TRPM2 channel acti

218 these observations point to a physiological feedback mechanism that attenuates oncogene addiction-me

219 sphatase PTP1B and mediates a novel negative feedback mechanism that attenuates receptor tyrosine kin

220 sulting enzyme inhibition creates a negative feedback mechanism that can suppress the activation of J

221 y unrecognized NFATc1-->Nur77-->Cblb-*NFATc1 feedback mechanism that confers NFATc1 signaling autores

222 ulate on these enzymes to create a potential feedback mechanism that contributes to the buildup and r

223 ty generates an error signal in the negative feedback mechanism that controls firing rates.

224 on PYY secretion supports an autoinhibitory feedback mechanism that controls L cell secretion; the e

225 hese data reveal a self-reinforcing positive feedback mechanism that coordinates TBK1-dependent autop

226 osomal passenger complex (CPC), uncovering a feedback mechanism that couples furrowing with microtubu

227 identified NMI induction as a novel negative feedback mechanism that decreases IRE1alpha-dependent ac

228 ions is sufficient to implement a corrective feedback mechanism that enables persistent activity to b

229 Dilp8/Lgr3 neuronal circuitry involved in a feedback mechanism that ensures coordination between org

230 esin-II from IFT trains serves as a negative feedback mechanism that facilitates flagellar length con

231 ally, we propose the existence of a negative feedback mechanism that governs the pore formation proce

232 rease of oscillatory domains with a positive feedback mechanism that incorporates a reversible reacti

233 ent in tissues of eosinophilic patients in a feedback mechanism that likely limits tissue damage unde

234 merular stromal cells is a critical negative feedback mechanism that limits inflammatory renal pathol

235 demonstrate a novel CypD-dependent negative feedback mechanism that limits platelet aggregation and

236 h sclerostin antibody, suggesting a negative feedback mechanism that limits Wnt-driven bone formation

237 These findings point to the existence of a feedback mechanism that links DSB number and distributio

238 ostatic synaptic regulation, a slow negative feedback mechanism that maintains neural activity within

239 PolIV-RdDM involves a self-reinforcing feedback mechanism that maintains TE silencing, but cann

240 of the hindbrain and that they provide a key feedback mechanism that makes signaling robust as they a

241 Our study suggests a leptin-dependent feedback mechanism that may be essential to facilitate a

242 of synaptic plasticity represents a negative feedback mechanism that may limit runaway enhancement of

243 interactions, represents a relevant negative feedback mechanism that might function to prevent excess

244 r is also presumed to partake in mediating a feedback mechanism that negatively regulates bacterial i

245 These findings reveal a regulatory feedback mechanism that place beta-catenin at a key cell

246 s findings in autoimmune diabetes revealed a feedback mechanism that renders Tconvs able to stimulate

247 Homeostatic plasticity is a negative feedback mechanism that stabilizes neurons during period

248 ation, suggesting the presence of a negative-feedback mechanism that stabilizes the SirT1-DBC1 comple

249 tic ATP release, but is instead an autonomic feedback mechanism that suppresses excitatory transmissi

250 ons of malic enzymes, demonstrate a positive-feedback mechanism that sustains p53 activation, and rev

251 Our results establish a positive feedback mechanism that sustains PI3K/Akt signaling in t

252 driven by an autoregulatory transcriptional feedback mechanism that takes approximately 24 hours to

253 pport a subcritical Hopf bifurcation, with a feedback mechanism that tunes an internal control parame

254 ne expression, suggesting a counterintuitive feedback mechanism that would result in further HS reduc

255 h avoid unwanted side reactions and positive feedback mechanisms that can prove problematic for tradi

256 blishment of cell polarity involves positive-feedback mechanisms that concentrate polarity regulators

257 These processes are regulated by feedback mechanisms that decipher topographical informat

258 Feedback mechanisms that dissipate excess photoexcitatio

259 intaining endocrine cell homeostasis through feedback mechanisms that govern cell fate stability.

260 mands a close examination of the forcing and feedback mechanisms that maintained this warmth and the

261 hese findings call for further research into feedback mechanisms that might remain active in cancers

262 We analyze the feedback mechanisms that modulate the activity and thus

263 nd is accomplished through a set of negative feedback mechanisms that sense and compensate for pertur

264 The resulting model identified 101 feedback mechanisms that were dominated primarily by thr

265 Through this feedback mechanism, the ubiquitin-proteasome system is a

266 daptive response, eIF2alpha-P also induces a feedback mechanism through enhanced transcriptional and

267 17) delineate an elegant histamine-dependent feedback mechanism through which myeloid bone marrow cel

268 Here, we dissect feedback mechanisms through which the transcription fact

269 Thus, Hh engages Igf signaling in a positive feedback mechanism to activate the osteogenic program.

270 red for cochlear amplification, a mechanical feedback mechanism to boost auditory performance.

271 ated by IL-1alpha, IL-36alpha acts through a feedback mechanism to boost IL-1alpha levels.

272 by pancreatic beta-cells acts as a negative feedback mechanism to counteract the stimulatory effects

273 up-regulation of STUB1 might be an important feedback mechanism to dampen IL-4R signaling in airway i

274 regulates c-Myc expression, which provides a feedback mechanism to enhance Axl expression.

275 osomal K(+) channel that provides a positive feedback mechanism to facilitate TRPML1-mediated Ca(2+)

276 iption and that gamma-herpesviruses use this feedback mechanism to facilitate viral gene expression.

277 ein 1 (WAVE1 or WASF1) as part of a negative feedback mechanism to limit Abeta production.

278 -beta1-induced Hic-5 functions as a negative feedback mechanism to limit myofibroblast differentiatio

279 ts utilize this conserved phospho-regulatory feedback mechanism to optimize the balance of growth and

280 t induction of miR-576-3p by IRF3 triggers a feedback mechanism to reduce interferon expression and s

281 uld explain self-acetylation as an important feedback mechanism to regulate acetyltransferases.

282 -Flt1-Flk1 cascade that serves as a negative feedback mechanism to regulate Etv2 gene expression.

283 a model where the checkpoint functions as a feedback mechanism to remodel the cell cycle in response

284 ation is regulated by IL-1R1 in a regulatory feedback mechanism to resolve inflammation.

285 to the innate immune response in a negative feedback mechanism to restore normal homeostasis followi

286 ulator of ASS1, but elevated ASS1 provides a feedback mechanism to suppress c-Myc and Axl.

287 PDGF gradient, but it synergizes with other feedback mechanisms to enhance amplification.

288 cal transduction includes one or more active feedback mechanisms to keep the mechanically gated ion c

289 it remains unclear whether scaling requires feedback mechanisms to regulate organ growth in response

290 employs system dynamics modeling, which uses feedback mechanisms to understand how these factors inte

291 The model showed that this feedback mechanism, together with rapid stress transmiss

292 ds that change with age suggesting a complex feedback mechanism underlying infant growth.

293 Feedback mechanisms underlying these processes and their

294 These feedback mechanisms were then scored and prioritized, wi

295 Evidence for a feedback mechanism where hydrogen peroxide generated dur

296 , light-harvesting complex II (LHCII), has a feedback mechanism, which determines the proportion of a

297 oteoglycans is tightly regulated by multiple feedback mechanisms, which support robust developmental

298 Self-reinforcing feedback mechanisms--which often protect plant communiti

299 oprotein A-I may participate in a regulatory feedback mechanism with retinoic acid to control the act

300 o be the result of an interleukin 10 (IL-10) feedback mechanism, with endogenously produced IL-10 pro